• Genomics & Informatics
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• 제17권4호
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• pp.41.1-41.12
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• 2019

Survival analysis mainly deals with the time to event, including death, onset of disease, and bankruptcy. The common characteristic of survival analysis is that it contains "censored" data, in which the time to event cannot be completely observed, but instead represents the lower bound of the time to event. Only the occurrence of either time to event or censoring time is observed. Many traditional statistical methods have been effectively used for analyzing survival data with censored observations. However, with the development of high-throughput technologies for producing "omics" data, more advanced statistical methods, such as regularization, should be required to construct the predictive survival model with high-dimensional genomic data. Furthermore, machine learning approaches have been adapted for survival analysis, to fit nonlinear and complex interaction effects between predictors, and achieve more accurate prediction of individual survival probability. Presently, since most clinicians and medical researchers can easily assess statistical programs for analyzing survival data, a review article is helpful for understanding statistical methods used in survival analysis. We review traditional survival methods and regularization methods, with various penalty functions, for the analysis of high-dimensional genomics, and describe machine learning techniques that have been adapted to survival analysis.

• Nuclear Engineering and Technology
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• 제49권8호
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• pp.1589-1599
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• 2017

Field programmable gate arrays (FPGAs) are getting more attention in safety-related and safety-critical application development of nuclear power plant instrumentation and control systems. The high logic density and advancements in architectural features make static random access memory (SRAM)-based FPGAs suitable for complex design implementations. Devices deployed in the nuclear environment face radiation particle strike that causes transient and permanent failures. The major reasons for failures are total ionization dose effects, displacement damage dose effects, and single event effects. Different from the case of space applications, soft errors are the major concern in terrestrial applications. In this article, a review of radiation effects on FPGAs is presented, especially soft errors in SRAM-based FPGAs. Single event upset (SEU) shows a high probability of error in the dependable application development in FPGAs. This survey covers the main sources of radiation and its effects on FPGAs, with emphasis on SEUs as well as on the measurement of radiation upset sensitivity and irradiation experimental results at various facilities. This article also presents a comparison between the major SEU mitigation techniques in the configuration memory and user logics of SRAM-based FPGAs.

• 대한한방부인과학회지
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• 제21권2호
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• pp.252-262
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• 2008

Purpose: This paper is aim to report that menopausal disorder can be effectively diagnosed and treated by referring to the life event stress of patient. Methods: Researchers got a grip on the life event stress of patient by using medical examinations by interview and compared the conditions of patient before and after treatment by using Kupperman's Index. The prescription of the Gamidangguisu-san hap samhap-tang( Jiaweidangguixu-san he sanhetang) and the Gamisoyo-san (Jiaweixiaoyao-san) and the acupuncture therapy and the moxibustion therapy were used for the treatment. Results: The serious musculoskeletal systemic pains, which includes back pain, lumbago, and myalgia, and other menopausal troubles were improved remarkably. Conclusion: The menopausal disorder could be caused by not only the change of hormone but also complex factors of environmental matters which includes social cultural surroundings, mentality etc. Therefore the life event stress could be one of critical factors of menopausal disorder. The diagnosis and treatment considering the life event stress could be effective method to relieve patient's menopausal disorder.

• 한국가스학회지
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• 제10권3호
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• pp.48-53
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• 2006

본 연구에서는 LPG용기를 취급판매 하는 소매상점에의 화재 및 폭발 상황시 인근 아파트 단지에 얼마나 영향을 주는지에 관한 피해 분석을 하였다. 위험성 평가는 피해분석과 빈도분석으로 이루어지는데 여기서는 피해분석에 중점을 두고 수행하였다. 피해분석을 위하여 두 개의 최악시나리오를 Event Tree Analysis를 통하여 선정하였다. 선정된 시나리오를 바탕으로 W equivalent Method와 컴퓨터 모델링을 통하여 과압과 비산정도를 예측하였다. 이를 바탕으로 소매상점으로부터 거리별 영향분석을 실시하여 폭발사고 발생시 실제 얼마만큼의 위험 영향이 미치는지를 정량적 분석으로 표현하였다.

• 한국가구학회지
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• 제22권4호
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• pp.308-316
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• 2011

The purpose of this study, which has been conducted as a government and academic joint project, is to introduce the design, production and installation of the structures exhibited to let people know the meaning the environment-friendly eco-park - Haneul Park that is located in Mapo-gu, Seoul. The exhibition was held as a part of Green Garden Panorama of Seoul Design Fair 2010 and used the stands of Jamsil Sports Complex as the exhibition space. The key contents of the exhibition consist of four elements; firstly, green plants were placed on the first and second floor stands of the complex in order to create the space inside the main stadium as a space that symbolized green environment. Secondly, the usability of the containers of food was maximized to attract the spectator's interest and induce desire to have it. Thirdly, the efforts of the Mapo-gu office for green environment were emphasized using environment-friendly materials. The process and meaning of the transformation of Nanji Island that had been a waste dump site in the past into Haneul Park - an environment-friendly eco-park were expressed by a four-stage space structure. The majority of installations placed in each stage were sold to visitors during the event so as to minimize the generation of wastes after the event.

• 한국컴퓨터정보학회논문지
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• 제24권7호
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• pp.125-133
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• 2019

Because military weapons systems for special purposes are small and complex, they are not easy to maintain. Therefore, it is very important to maintain combat strength through quick maintenance in the event of a breakdown. In particular, naval ships are complex weapon systems equipped with various equipment, so other equipment must be considered for maintenance in the event of equipment failure, so that skilled maintenance personnel have a great influence on rapid maintenance. Therefore, in this paper, we analyzed maintenance data of defense equipment maintenance information system through text mining and social network analysis(SNA), and tried to identify the naval ship maintenance expertise. The defense equipment maintenance information system is a system that manages military equipment efficiently. In this study, the data(2,538cases) of some naval ship maintenance teams were analyzed. In detail, we examined the contents of main maintenance and maintenance personnel through text mining(word cloud, word network). Next, social network analysis(collaboration analysis, centrality analysis) was used to confirm the collaboration relationship between maintenance personnel and maintenance expertise. Finally, we compare the results of text mining and social network analysis(SNA) to find out appropriate methods for finding and finding naval ship maintenance expertise.

• Genomics & Informatics
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• 제20권4호
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• pp.40.1-40.8
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• 2022

The concepts of phylogeny and floral genetics play a crucial role in understanding the origin and diversification of flowers in angiosperms. Angiosperms evolved a great diversity of ways to display their flowers for reproductive success with variations in floral color, size, shape, scent, arrangements, and flowering time. The various innovations in floral forms and the aggregation of flowers into different kinds of inflorescences have driven new ecological adaptations, speciation, and angiosperm diversification. Evolutionary developmental biology seeks to uncover the developmental and genetic basis underlying morphological diversification. Advances in the developmental genetics of floral display have provided a foundation for insights into the genetic basis of floral and inflorescence evolution. A number of regulatory genes controlling floral and inflorescence development have been identified in model plants such as Arabidopsis thaliana and Antirrhinum majus using forward genetics, and conserved functions of many of these genes across diverse non-model species have been revealed by reverse genetics. Transcription factors are vital elements in systems that play crucial roles in linked gene expression in the evolution and development of flowers. Therefore, we review the sex-linked genes, mostly transcription factors, associated with the complex and dynamic event of floral development and briefly discuss the sex-linked genes that have been characterized through next-generation sequencing.

• Journal of Acupuncture Research
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• 제27권4호
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• pp.195-202
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• 2010

Objectives : This study was performed to report adverse events in Ojeok-san extract powders RCT. Methods : 180 patients with LBP were randomized into groups for a double blind, placebo-controlled clinical study. They received Ojeok-san simple Extract, Ojeok-san complex Extract or placebo in powders, orally dissolved 3times a day for 4weeks. During 4weeks, we researched the symptoms and duration of adverse events and Digest ability, Milk hypersensitivity, Starch hypersensitivity, Caramel hypersensitivity, West-med hypersensitivity, Herb-med hypersensitivity in patients who had adverse events. Results : 52patients(28.9%) had adverse events and of them 44patients(28.9%) had lost adverse events naturally. But 5patients(2.8%) were withdrawn from the research because of the adverse events. Most of the symptoms of adverse event was Gastrointestinal symptom(88.3%) and adverse events frequency was not different from Ojeok-san simple Extract, Ojeok-san complex Extract and placebo. Conclusions : Ojeok-san extract powders had adverse events no different from the placebo, which shows that it is a safe drug.

• 유기물자원화
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• 제30권1호
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• pp.41-47
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• 2022

본 연구는 강우시 산업단지에서 발생하는 비점오염원 유출 특성을 평가하여 비점오염원 부하량 및 원단위 산정을 위한 기초자료로 활용하기 위하여 C 산업단지에 대하여 강우유출수 수질모니터링을 수행하였다. 강우 사상별 유출량에 따른 EMC 산정 결과, 1차 강우시 BOD, COD_Mn, SS, T-N, T-P의 EMCs 범위는 각각 1.32~48.76, 3.32~43.75, 2.89~199.43, 2.76~8.93, 0.08~068 mg/L로 나타났으며, 2차 강우시는 각각 0.5~2.9, 2.71~7.13, 2.82~174.94, 1.33~4.03, 0.01~1.28 mg/L로 나타났다. 누적 유출량과 누적 오염부하량 비율 산정 결과, 강우 초기 유출량이 적은 시간에는 대부분 오염부하량이 강우 유출량보다 적지만 시간이 지남에 따라 강우 누적 유출량과 누적 오염부하량의 비가 1보다 커지면서 초기세척 현상이 일어났다.

• 대기
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• 제29권3호
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• pp.325-342
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• 2019

Precipitation and no-precipitation events under the influence of the Siberian high pressure system in Yeondong region, were analysed and classified as four types [obvious precipitation event (OP) type, obvious no-precipitation event (ON) type, ambiguous precipitation event (AP) type and ambiguous no-precipitation event (AN) type], according to the easiness in determining whether to have precipitation or not in Yeongdong region, to help in improving the forecast skill. Concerning the synoptic pressure pattern, for OP type, the ridge of Siberian high extends from Lake Baikal toward Northeast China, and there is a northerly wind upstream of the northern mountain complex (located near the Korean-Chinese border). On the other hand, for ON type, the ridge of Siberian high extends southeastward from Lake Baikal, and there is a westerly wind upstream of the northern mountain complex. The pressure pattern of AP type was similar to the OP type and that of AN type was also similar to ON type. Thus it was difficult to differentiate AP type and OP type and AN type and ON type based on the synoptic pressure pattern only. The four types were determined by U (wind speed normal to the Taebaek mountains) and Froude number (FN). That is, for OP type, average FN and U at Yeongdong coast are ~2.0 and ${\sim}6m\;s^{-1}$, and those at Yeongseo region are 0.0 and $0.1m\;s^{-1}$, respectively. On the contrary, for ON type, average FN and U at Yeongdong coast are 0.0 and $0.2m\;s^{-1}$, and those at Yeongseo region are ~1.0 and ${\sim}4m\;s^{-1}$, respectively. For AP type, average FN and U at Yeongdong coast are ~1.0 and ${\sim}4m\;s^{-1}$, and those at Yeongseo region are 0.0 and $0.2m\;s^{-1}$, whereas for AN type, average FN and U at Yeongdong coast are 0.1 and $0.6m\;s^{-1}$ and those at Yeongseo region are ~1.0 and ${\sim}3m\;s^{-1}$, respectively. Based on the result, a schematic diagram for each type was suggested.