• Title/Summary/Keyword: combined preparation of crude drugs

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXVII) -The effects of Chunwangboshimdan on the central nervous system and cardio-vascular system- (생약복합제제(生藥複合製劑)의 약효연구(藥效硏究)(제37보)(第37報) -천왕보심단(天王補心丹)이 중추신경계(中樞神經系) 및 순환기계(循環器系)에 미치는 영향(影響)-)

  • Kim, Nam-Jae;Kong, Yeong-Yun;Chang, Soon-Wook
    • Korean Journal of Pharmacognosy
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    • v.19 no.3
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    • pp.208-215
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    • 1988
  • To investigate the experimental effects of Chunwangboshimdan which have been widely used for aterial or auricular flutter, neurosis, insomnia and disease caused by cardiac malfunction, we have done the effects on the central nervous and cardiovascular system. The result as follow; It inhibited the convulsion induced by caffeine, the writhing syndrome induced by acetic acid and the spontaneous movement. Furthermore it prolonged the sleeping time induced by thiopental-Na in mice. It also showed the negative inotropic action on the isolated heart of frog, the vasodilative action as to peripheral bloods of rabbit ear and the hypotensive action in the anesthetized rabbit.

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXI) -Effects of Yijin-Tang on the Central Nervous System, Blood Vessels and Blood Pressure- (생약(生藥) 복합제제(複合製劑)의 약효(藥效) 연구(硏究)(제21보)(第21報) -이진탕(二陳湯)이 중추신경계(中樞神經系), 혈관(血管) 및 혈압(血壓)에 미치는 영향(影響)-)

  • Hong, Nam-Doo;Chang, In-Kyu;Ryu, Seong-Kyu;Kim, Chang-Min
    • Korean Journal of Pharmacognosy
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    • v.16 no.1
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    • pp.26-30
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    • 1985
  • These studies were conducted to investigate the effect of Yijin-tang on the anticonvulsion, analgesic, sedative actions, effect on blood vessels and blood pressure. The result of these studies was summarized as follows; Suppressive action was shown on convulsion due to cerebrocortical causes, but no such actions were noted either myelic or diencephaltic causes in mice. Analgesic and sedative actions were significantly recognized in mice. Increasing of blood pressure and vasocontractive actions were noted.

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Studies on the Anti-inflammatory and Analgesic Activities of Ohyaksungisan (오약순기산(烏藥順氣散)의 소염 진통작용에 관한 연구)

  • Lee, Don-Il;Lee, Seong-Yim;Moon, Young-Hee
    • Korean Journal of Pharmacognosy
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    • v.27 no.3
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    • pp.184-189
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    • 1996
  • Ohyaksungisan, combined preparation of crude drugs, has been used for hemiplegia, arthralgia and paralysis in traditional Korean medicine. The anti-inflammatory activity of the aqueous extract from Ohyaksungisan(OSSE) was investigated on acetic acid-induced edema and adjuvant arthritis in rats. Acute toxicity and analgesic action in mice were also examined. Its anti-inflammatory activity on 5% acetic acid-induced edema and adjuvant arthritis was observed with oral administration. The acute toxicity showed 10% mortality at 2400 mg/kg (p.o), but was not showed at 1200 mg/kg (i.p). OSSE was showed to have significant analgesic action (P<0.05) at 150 mg/kg and this action was strengthened at 300, 600 mg/kg. The anti-inflammatory effect was showed significant preventive effect on the hind paw edema from 90 min. and the adjuvant arthritis, when orally administered for 19 days. showed significant inhibitory effect on the hind paw edema from the 5th day.

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXVIII) -Effects of Paeryung-tang and Kamipaeryung-tang on Diuresis, Antipyretic, Anti-inflammatory and Analgesic Activity- (생약(生藥) 복합(複合) 제제(製劑)의 약효(藥效) 연구(硏究)(제28보)(第28報) -패령탕(敗岺湯) 및 가미패령탕(加味敗岺湯)의 이뇨(利尿), 해열(解熱), 소염(消炎) 및 진통작용(鎭痛作用)에 대하여-)

  • Hong, Nam-Doo;Doo, Ho-Kyung;Cho, Young-Whan;Kim, Chul-Chung;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.17 no.3
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    • pp.206-214
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    • 1986
  • These studies were conducted an attempt to investigate effects of 'Paeryungtang' and 'Kamipaeryungtang' water extracts on diuretic, antipyretic, antiinflammatory and analgesic actions. The results of these studies were summarized as follows; Increase in urinary volume, urinary $Na^+$ excretions were significantly recognized in normal rat. Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly shown in rat with 2mg/kg $HgCl_2$-induced acute renal failure. Antipyretic, anti-inflammatory and analgesic effects of 'Paeryungtang' and 'Kamipaeryungtang' were recognized in mice, rats and rabbits.

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Studies on the Efficacy of Combined Preparation of Crude Drugs (XVI) -Effects of ‘Bojungikgi-Tang’ on the Central Nervous System- (생약(生藥) 복합(複合) 제제(製劑)의 약효(藥效) 연구(硏究)(제16보)(第16報) -보중익기탕(補中益氣湯)이 중추신경계(中樞神經系)에 미치는 영향(影響)-)

  • Hong, Nam-Doo;Chang, In-Kyu;Lee, Sang-Il;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.15 no.3
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    • pp.115-120
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    • 1984
  • 'Bojungikgi-tang' consists of Astragali Radix, Ginseng Radix, Atractylodis Rhizoma alba, Glycyrrhizae Radix, Angelicae gigantis Radix, Aurantii nobilis Pericarpium, Cimicifugae Rhizoma and Bupleuri Radix. It has been widely prescribed in oriental medicine for controlling digestive functions and for health. Experimental studies were implemented on analgesic, sedative and antipyretic actions. The results showed significant analgesic and antipyretic actions were recognized. Sedative actions were significantly noted.

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Pharmacological Studies on the Sopunghwalhul-Tang -On Analgesic, Antiinflammation and Hypotension- (소풍활혈탕(疎風活血湯)의 약효에 관한 연구(硏究) -진통(鎭痛), 항염증(抗炎症) 및 혈압(血壓)에 미치는 효과에 대하여-)

  • Moon, Young-Hee;Kim, Gyung-Wan;Um, Kie-Jin
    • Korean Journal of Pharmacognosy
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    • v.22 no.4
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    • pp.240-245
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    • 1991
  • This study was attempted to examine the acute toxicity and the effect of Sopunghwalhul-Tang water extract(SHTE) on analgesic action in mice, anti- inflammatory action in rats and blood pressure in rabbits. The results were as follows; SHTE showed 10% mortality at 2,000mg/kg(p.o.), had significant analgesic activity in the pain caused by 0.7% acetic acid and was shown to have significant anti-inflammatory activity in the edema-induced by 5% acetic acid at 450mg/kg. SHTE given into a ear vein of rabbits produced a dose-related vasodepressur responses. SHTE-induced hypotension was significantly inhibited by pretreatment with atropine, but was not affected by chlorisondamine, phentolamine, propranolol, and dephenhydramine.

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Studies on the Efficacy of Combined Preparation of Crude Drugs (V) -Effect of ‘Whangryonhaedok-Tang’ on the Anti-inflammatory, Ileum of Mice, Blood Pressure, Blood Glucose, Total Cholesterol and Antibacterial Activity- (생약복합제(生藥複合劑)의 약효연구(藥效硏究) 제5보(第5報) -황연해독탕(黃連解毒湯)이 부종(浮腫), 장관(腸管), 혈압(血壓), 혈당량(血糖量), 총(總)코레스테롤 함량(含量) 및 항균작용(抗菌作用)에 대(對)하여-)

  • Hong, N.D.;Kim, J.W.;Doo, H.K.;Kim, N.J.
    • Korean Journal of Pharmacognosy
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    • v.13 no.1
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    • pp.26-32
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    • 1982
  • In order to investigate the effect of 'Whangryonhaedok-Tang' on the anti-inflammatory, ileum of mice, blood pressure, blood glucose, total cholesterol and antibacterial activity, those pharmacological actions were conducted. The results of this studies were summarized as follows; Rat hind paw edema induced by acetic acid was inhibited. In mice, tone of intestinal smooth muscle was suppressed with the treatment of sample and intestinal contractions induced by $BaCl_2$ was inhibited. Hypertensive effect was not observed in rabbits but was observed by the water extract of 'Whangryonhaedok-Tang' excluded Phellodendri Cortex in rabbits. The increased blood glucose levels in alloxandiabetic rabbits were significantly decreased by the oral administration of the sample I after 6 days. The total cholesterol levels in alloxan-induced rabbits were significantly decreased by the oral administration of the sample I after 9 days. Antibacterial activity was observed. In addition, we thought the pharmacological actions were significantly noted by the sample III (Methanol soluble fraction) because of the purification of effective components.

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXX) -Effects of Mahaengkamsuk-tang on Analgesic, Antipyretic, Antiinflammatory, Secretion of Repiratory Tract, Isolated Ileum and Blood Pressure- (생약(生藥) 복합(複合) 제제(製劑)의 약효(藥效) 연구(硏究)(제30보)(第30報) -마행감석탕(麻杏甘石湯)이 진통(鎭痛), 해열(解熱), 소염(消炎), 거담, 적출장관(摘出腸管) 및 혈압(血壓)과 호흡(呼吸)에 미치는 영향(影響)-)

  • Hong, Nam-Doo;Jeong, Gyu-Mahn;Moon, Jeong-Ho;Joo, Soo-Man
    • Korean Journal of Pharmacognosy
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    • v.17 no.3
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    • pp.223-231
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    • 1986
  • Experimental studies were conducted to investigate for the effect of Mahaengkamsuk-tang on analgesic, antipyretic, antiinflammatory, secretion of respiratory tract, isolated ileum. Mahaengkamsuk-tang was composed of Ephedrae Herba, Armenicae Semen, Glycyrrhizae Radix, Gypsum Fibrosum. The following results has been obtained; analgesic and antipyretic actions were obtained. Anti-inflammatory effects in the paw edema induced by 1% dextran was significantly shown in rats. Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contractions of isolated ileum of mice induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Expectorant effect was shown in rabbits. Continuous hypotensive action was seen.

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXI) -The Effect of Taeksa-tang on Diuresis, Serum Lipid, Isolated Ileum, Heart, Blood Vessel, Blood Pressure and Respiration- (생약(生藥) 복합제제(複合製劑)의 약효(藥效) 연구(硏究)(제31보)(第31報) -택사탕(澤瀉湯)이 이뇨(利尿), 고지혈증(高脂血症), 적출장관(摘出腸管), 적출심장(摘出心臟), 혈관(血管), 혈압(血壓) 및 호흡(呼吸)에 미치는 영향(影響)-)

  • Nam, Sang-Kyung;Lee, Dong-Suk;Kim, Nam-Jae;Lee, Kyung-Sup;Hong, Nam-Doo
    • Korean Journal of Pharmacognosy
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    • v.17 no.4
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    • pp.263-271
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    • 1986
  • In order to investigate experimentally the clinical effects of Taeksa-Tang that was prescribed to cure the severe dizziness, the water extract of Taeksa-Tang was experimented about the effects on the diuretic action, the serum lipid, the isolated ileum and heart, the blood vessel, the blood pressure and respiration. The results of this study were obtained as follows: The diuretic action was significantly shown in rabbits. The level of total cholesterol, triglyceride and phopholipid in serum of rabbits given high cholesterol diet were significantly decreased. The contraction of the isolated ileum of mice induced by acetylcholine chloride and barium chloride was remarkably inhibited. The vasodilating and hypotensive actions were noted in rabbits. Negative inotropic action on the isolated frog heart was recognized.

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Studies on the Efficacy of Combined Preparation of Crude Drugs (XXVI) -Effects of Choweesungchung-Tang on Anti-convulsion, Analgesic, Sedative, Isolated Ileum, Blood Vessels and Blood Pressure- (생약(生藥) 복합제제(複合製劑)의 약효(藥效) 연구(硏究)(제26보)(第26報) -조위승청탕(調胃升淸湯)의 항경련(抗痙攣), 진통(鎭痛), 진정(鎭靜), 적출장관(摘出腸管), 혈관(血管), 혈압(血壓) 및 호흡(呼吸)에 대(對)한 영향(影響)-)

  • Yoo, Ji-Geol;Kim, Nam-Jae;Kim, Jong-Woo;Lee, Kyung-Sub;Hong, Nam-Doo
    • Korean Journal of Pharmacognosy
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    • v.17 no.1
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    • pp.12-18
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    • 1986
  • In order to investigate experimentally the clinical effects of Choweesungchung-Tang that has been widely used in the cardiovascular and neuropsychogenic disease, experimental studies with experimental animals were carried out. The results of these studies were summarized as follows; Suppressive action was not shown on the convulsion induced by strychnine, but significant effect was noted on the convulsion induced by picrotoxin and caffeine. In acetic acid method, analgesic effect was noted. By the rotor rod and wheel cage method, sedative action was noted. A prolongation of hypnotic time induced by pentobarbital-Na was obtained. Relaxing action was noted remarkably on the ileum of mice, also about mice and guinea-pigs, the same effect was recognized on the smooth muscle of the ileum. The expansion of blood vessels by relaxation of smooth muscle and hypotensive action were noted.

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