• 한국응용과학기술학회지
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• 제40권6호
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• pp.1567-1579
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• 2023

Sucralose는 식품 분야에서 sucrose 대체물로 사용되며 세계적으로 승인된 무열량 고강도 인공 감미료이다. 하지만 감미료가 뇌에 미치는 영향에 대한 조사는 미비하여 본 연구에서 scopolamine으로 유발된 기억력 손상 동물모델에서 sucralose 단기 섭취가 인지 및 기억 보호 효과를 가지는지 확인하였다. Sucralose 2, 5, 10 mg/kg를 경구투여하였으며 30분 후 대조군, 약물군에 scopolamine (1mg/kg) 복강투여를 진행하였고 정상군에는 식염수로 복강투여 후 행동실험을 수행하였다. 결과적으로 Y-maze, passive avoidance, Morris water maze에서 대조군과 비교해 10% 이상의 인지기능이 회복되는 결과를 도출하였다. 또한, 전염증성 사이토카인을 측정한 결과 sucralose가 IL-6와 TNF-α를 30% 이상 억제하는 것을 보였으며 세포 내 신호 메커니즘으로 ERK-CREB의 발현량을 관찰한 결과 농도 의존적으로 증가하였다. 따라서 sucralose는 건망증 환자의 예방과 치료를 위한 기능성 식품과 관련이 있다고 시사된다.

• 인지과학
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• 제27권3호
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• pp.441-467
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• 2016

본 연구에서는 fMRI 기법을 이용하여 경쟁 상황 노출 여부에 따라 개인이 타인의 상황을 이해하고 인지적 공감을 유발하는 신경학적 기제의 차이를 조사하였다. 공감은 타인에 대한 이해를 바탕으로 적절한 반응을 보이는 심리적 반응이며, 인간의 생존에 있어서 적응적 요소로 알려져 있다. 연구의 목적은 Preston과 de Waal(2002)에 기초하여 거의 자동적인 반응인 공감이 타인을 이겨야 하고 본인의 수행에 따라 보상이 달라지는 경쟁 상황에서도 1) 타인이 처한 상황을 인지할 수 있는지, 2) 인지한다면 인지적 공감이 유발되는지를 확인해 보는 것이다. 대학생 21명(남:여=9:12)을 대상으로, 일상생활에서 경험할 수 있는 6가지 정서가 제시된 그림자극을 보고 '나'의 관점에서 유발되는 정서가 긍정정서인지 부정정서인지 평정하는 과제 수행동안 뇌 활성화를 촬영하였다. 경쟁 유무에 따라 공감과정에서 두뇌 활동의 차이를 비교하기 위해 실험보조자 1인이 경쟁자 역할을 수행하고, 수행 결과의 정확도와 반응 시간을 기준으로 피험자가 경쟁자(실험보조자)를 이길 경우 보상(돈)을 제공하는 조건으로 경쟁심을 유발하여 경쟁 조건을 조작하였다. 연구결과, 피험자들의 판단 반응시간은 비경쟁 상황보다 경쟁에 노출되었을 때 통계적으로 유의하게 빠름을 확인하였고, 경쟁 상황에서는 전대상회(ACC, BA 32), 내측전두엽(mPFC, BA 6), 측두두정연합부의 한 부분인 연상회(SMG, BA 40), 시상(thalamus), 중전두엽(middle frontal gyrus, BA 10) 등이 활성화 된 반면, 비경쟁 상황에서는 인접대상회(paracingulate, BA 32), 측두엽극(temporal pole, BA 38), 복내측전전두엽(vmPFC, BA 11), 상후두엽/쐐기소엽(superior occipital gyrus/cuneus, BA 19) 등의 영역에서 활성화가 관찰되었다. 또한 경쟁상황에서 개인의 공감 수준에 따라 두뇌 영역과의 상관을 알아보기 위해 공감에 대한 자기 보고식 반응 점수를 공변량으로 이용하여 중다회귀분석을 실시한 결과, 경쟁 상황에서는 우측 연상회(rSMG, BA 40), 하전두엽(inferior frontal gyrus, BA 47/45), 내측전두엽(mPFC, BA 10/6), 시상(thalamus), 피각(putamen), 방추형회(fusiform gyrus, BA 20/21)영역과의 상관이 높은 반면, 비경쟁 상황에서는 공감 수준이 높을수록 측두두정연합부/상측두엽(temporoparietal junction/superior temporal gyrus) 영역이 높은 상관을 보였다. 이 연구의 결과를 통해 경쟁 노출 여부에 따라서 타인에 대한 공감적 인지과정에 서로 다른 두뇌영역이 사용되며, 특히 개인의 공감 수준이 높을수록 경쟁 상황에서도 타인의 상황에 대해 이해하는 인지적 공감과 관련한 두뇌 영역이 높은 상관을 보여 개인차에 따라 경쟁 지각이 다르게 반응함을 알 수 있었다.

• 마케팅과학연구
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• 제19권4호
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• pp.44-56
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• 2009

冲动购买是指一个没有预先购物意向的立即购买. 以往对冲动购买的研究主要集中于和营销组合变量, 环境因素, 消费人口和特征相关的因素. 在以前的研究中, 营销组合变量如产品种类, 产品类型和氛围, 包括广告, 优惠券, 销售活动, 促销刺激销售点, 和媒体格式都已被用于评估产品信息. 有些作者还着重围绕消费者的情境因素. 如信用卡的使用, 时间, 产品运输性, 发现购物同伴的存在和数量对冲动购买/冲动趋势有积极的影响. 研究也已评估了个体特征的影响, 如年龄, 性别, 以及消费者的教育程度, 以及拥挤的感知, 刺激和接触的需要等因素对冲动购买的影响. 概括来说, 以前的研究发现所有的产品都可以被冲动地购买(Vohs and Faber, 2007), 即环境因素可以影响或至少促使冲动购买行为. 最近新的分销渠道的推出, 例如家庭购物渠道, 折扣店和网上商店, 这些24小时都营业的形式增加了冲动购买的可能性. 然而, 以前的文献重点关注情境和营销变量, 因此这些研究所考虑的消费者的主要特征仍然是缺乏的. 为了弥补这个缺陷, 本研究根据研究的第三个惯例并关注个体特质变量, 这些是很少被研究的. 更具体地来说, 本研究探索了冲动购买趋势对冲动购买行为是否有积极的影响, 并评估了消费者特点例如认知闭合需要(NFCC), 心理健康和人际敏感性是如何影响消费者冲动购买的趋势. 这项调查结果显示, 消费者的情感冲动, 对冲动购买行为产生积极的影响, 而认知冲动并没有对冲动购买行为的影响. 此外, 情感冲动购买倾向是被认知闭合需要的构成因素所推动的, 如果断和模糊不适; 心理健康, 如环境控制和生活的目标, 以及规范和信息的影响. 此外, 认知冲动倾向是被认知闭合需要的构成因素所驱动的决断, 模棱两可的不适和密切的态度, 心理健康和环境控制, 以及规范性和信息的影响. 本研究具有重要理论意义. 第一, 情感冲动对冲动购买行为有巨大影响. 以前的研究根据情感和流动理论提出, 低到中等程度的冲动是自我控制减少或自我监管机制失败所造成的. 本研究证实了上述观点. 二, 本研究通过确认冲动购买趋势可以看做是情感和认知两个维度的二维概念, 并说明冲动购买行为主要是由情感冲动解释, 而不是认知冲动. 第三, 目前的研究有新的概念, 如在本研究的模型中作为潜在影响因子的心理健康和认知闭合需要, 从而对现有的文献做出了贡献. 通过多维概念例如心理健康和认知闭合需要, 有关消费者信息过程的多个方面可以被评估. 第五, 本研究通过确定规范和信息这两个竞争路线扩展了现有的文献. 规范影响发生在个人符合别人的期望或提高他们的自我形象时. 而信息的影响发生在个人搜索来自他人知识信息和观察他人行为之后的推论. 本研究显示了这两个相互竞争的社会影响力的路线, 可以归因于不同影响力的来源. 目前的研究也有许多实际的启示. 首先, 它表明, 公司应该更多关注其首要的目标, 有情感冲动的消费者. 这一方面公司可以创造更振奋精神的购物环境. 二, 目前的结果表明, 认知闭合需要与认知方面的冲动有密切相关的. 这些人是被不经意的想法所驱动的, 而不是感觉或兴奋. 在购买点理性的广告会吸引这些客户. 第三, 容易受规范性影响的消费群是另一个潜在的目标市场. 零售商和制造商, 通过宣传其产品和/或可用于识别或符合愿望组在对他人的期望的产品服务. 但是, 作为一个细分市场, 零售商应避免目标消费群易受信息的影响. 这些人对有关购买的产品服务进行了广泛的信息搜索, 因此更详细, 长期理性的广告信息可以内化这些消费者的思想过程. 本文的结果有几个原因应慎重解释. 这项研究采用了数量较少的便利样本, 而且只调查了两个维度的行为. 为此, 今后的研究应包括更多样化特点和衡量行为的不同方面的样本. 未来的研究还应该调查与情感作用理论密切相关的个性特征. 在以后的研究中, 特征变量会是很另人感兴趣的领域, 如感觉的好奇, 人际敏感性的好奇心, 和气氛反应.

• 성인간호학회지
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• 제14권1호
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• pp.125-134
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• 2002

Purpose: The objectives for this study were to identify the factors that correlate with appraisal of illness and to explore what variables are predictive of cancer patients primary caregivers' cognitive appraisal for stress. Method: The subjects were selected by convenient sampling and 130 caregivers who completed a questionnaire. Measures used in this study included the Family Inventory of Resources for Management, Social Support Index, Family Crisis Oriented Personal Evaluation Scales and Family Coping Coherence Index. Pearson correlation was used to identify the relationship among factors and multiple regression was used to determine the individual and cumulative effect of potential predictors on the caregivers' appraisal. Results: Patient's level of activity, severity of the disease, quality of relation between patient and caregiver, caregiver's subjective health status, economic status, family resources and coping were significantly correlated. Among the variables, coping, family resources, economic status and quality of relation between caregiver and patient predicted 49.2 percent of the variance in appraisal of caregivers' stress condition. Conclusion: These findings suggest that coping mechanisms and family resources are important for positive appraisal. Nurses should provide adequate nursing care for the primary caregiver about professional care information and supportive counseling.

• 아동학회지
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• 제37권4호
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• pp.57-67
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• 2016

Objective: This study examined the relations between maternal meta-emotion philosophy, child interpersonal problem solving, and peer competence among children aged 4-5 and their mothers and teachers. Methods: A total of 54 children from 24 kindergartens were assessed on their interpersonal problem solving and peer competence. Their mothers reported on meta-emotion philosophy. Their teachers were assessed on child peer competence. Results: The major findings of this study were as follows. First, maternal meta-emotion philosophy, child interpersonal problem solving, and child peer competence showed positive correlation patterns. Second, child interpersonal problem solving and peer competence was found to be influenced by maternal child-directed meta-emotion philosophy but not by maternal self-directed meta-emotion philosophy. Conclusion: Findings highlight the importance of maternal meta-emotion philosophy and that their emotion socialization play a significant role in identifying the mechanisms leading to child social cognitive ability and social adjustment. Furthermore, these results could lead to important basic studies in developing parent/teacher education programs.

• 대한간호학회지
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• 제43권5호
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• pp.579-586
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• 2013

Purpose: This article provides an update and overview of a nursing research program focused on understanding the pathophysiology and management of irritable bowel syndrome (IBS). Methods: This review includes English language papers from the United States, Europe, and Asia (e.g., South Korea) from 1999 to 2013. We addressed IBS as a health problem, emerging etiologies, diagnostic and treatment approaches and the importance of a biopsychosocial model. Results: IBS is a chronic, functional gastrointestinal disorder characterized by recurrent episodes of abdominal pain and alterations in bowel habit (diarrhea, constipation, mixed). It is a condition for which adults, particularly women ages 20-45, seek health care services in both the United States and South Korea. Clinically, nurses play key roles in symptom prevention and management including designing and implementing approaches to enhance the patients' self-management strategies. Multiple mechanisms are believed to participate in the development and maintenance of IBS symptoms including autonomic nervous system dysregulation, intestinal inflammation, intestinal dysbiosis, dietary intolerances, alterations in emotion regulation, heightened visceral pain sensitivity, hypothalamic-pituitary-adrenal dysregulation, and dysmotility. Because IBS tends to occur in families, genetic factors may also contribute to the pathophysiology. Patients with IBS often report a number of co-morbid disorders and/or symptoms including poor sleep. Conclusion: The key to planning effective management strategies is to understand the heterogeneity of this disorder. Interventions for IBS include non-pharmacological strategies such as cognitive behavior therapy, relaxation strategies, and exclusion diets.

• Biomolecules & Therapeutics
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• 제26권4호
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• pp.368-373
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• 2018

Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia, has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations. In the present study, we examined whether linalool elicited an anti-stress effect, reversing the behavioral alterations observed following REM-sleep deprivation in mice. Furthermore, we investigated the underlying mechanism of the effect of linalool. Spatial memory and learning memory were assessed through Y maze and passive avoidance tests, respectively, and the forced swimming test was used to evaluate anti-stress activity. The mechanisms through which linalool improves memory loss and behavioral alterations in sleep-deprived mice appeared to be through an increase in the serotonin levels. Linalool significantly ameliorated the spatial and learning memory deficits, and stress activity observed in sleep-deprived animals. Moreover, linalool led to serotonin release, and cortisol level reduction. Our findings suggest that linalool has beneficial effects on the memory loss and behavioral alterations induced by REM-sleep deprivation through the regulation of serotonin levels.

• 한국시뮬레이션학회논문지
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• 제27권2호
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• pp.101-114
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• 2018

무인 비행체의 실시간 경로계획 생성 시 최적의 경로를 찾기 위한 다양한 연구가 진행되어 왔다. 본 논문에서는 진화알고리즘을 통한 무인비행체의 경로계획 생성을 수행하고, 이를 에이전트 기반 시뮬레이션 환경에서 구현 및 테스트가 가능함을 검증하였다. 이를 위해, Repast toolkit에 JGAP 패키지를 탑재하여 Java 기반의 유전 알고리즘 프로그래밍을 통한 무인 비행체의 경로 계획을 생성하였고, 해당 결과를 에이전트 기반으로 시뮬레이션을 수행하였다. 본 논문에서는 에이전트 기반 시뮬레이션 소프트웨어를 소프트웨어 공학 개발 생명주기에 맞춰 문서화하여 설계 및 구현되었으며, 에이전트 모델링 설계는 자동화, 적응성 및 에이전트 간의 상호 작용에 초점을 맞추었다. 또한, 시뮬레이션을 통해 에이전트 기반 환경에서 설계한 모델 및 시나리오를 검증하여 다수의 비행 에이전트에 내재된 동적 경로계획 알고리즘이 실시간으로 자율적인 경로 생성이 가능함을 증명하였다.

• 대한가정학회지
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• 제49권3호
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• pp.99-111
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• 2011

Relations between mother-infant interactive behaviors and parenting-related variables were analyzed in a sample of 72 infants (35 boys and 37 girls, average age=31 mo.) and their mothers in Ulsan, Korea. Parents' views on children, parenting stress, fathers' participation in parenting and social support were measured using questionnaires and mother-infant interactive behaviors were observed using the 3-bags test. Among the parenting-related variables, parents' views on children were related significantly with mothers' emotional expressions & infant's participation with mothers. Social support was correlated with mother's behaviors, including positive rewards and emotional expressions. Mother-infant interactive behaviors were closely correlated with one another: Mothers' positive behaviors such as overall reactivity and cognitive stimulation were correlated positively with infants' positive behaviors, including sustained attention and positive affect. Future studies will provide us with greater insights into the mechanisms underlying the effects of these parenting-related variables on infant behavior and development.

• Biomolecules & Therapeutics
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• 제21권3호
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• pp.229-233
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• 2013

This study was aimed at investigating the possible effects of phytoceramide (Pcer) on learning and memory and their underlying mechanisms. Phytoceramide was orally administered to ICR mice for 7 days. Memory performances were assessed using the passive avoidance test and Y-maze task. The expressions of phosphorylated cAMP response element binding protein (pCREB), brain-derived neurotrophic factor (BDNF) were measured with immunoblot. The incorporation of 5-bromo-2-deoxyuridine (BrdU) in hippocampal regions was investigated by using immunohistochemical methods. Treatment of Pcer enhanced cognitive performances in the passive avoidance test and Y-maze task. Immunoblotting studies revealed that the phosphorylated CREB and BDNF were significantly increased on hippocampus in the Pcer-treated mice. Immunohistochemical studies showed that the number of immunopositive cells to BrdU was significantly increased in the hippocampal dentate gyrus regions after Pcer-treatment for 7 days. These results suggest that Pcer contribute to enhancing memory and BDNF expression and it could be secondary to the elevation of neurogenesis.