• 전자공학회논문지C
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• 제34C권6호
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• pp.37-43
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• 1997

In this paper, an analog-domain powr-reduction technique for a low-voltage CMOS operational amplifier and its application to clock-based VLSI systems are proposed. The proposed technique cuts off the bias current of the op amp during a half cycle of the clock in the sleeping mode and resumes the curent supply sequentially during the remaining cycle of the clock in the normal operating mode. The proposed sequential sbiasing technique reduces about 50% of the op amp power and improves the circuit performance through high phase margin and stable settling behavior of the output voltage. The power-reduction technique is applied to a sample-and-hold amplifier which is one of the critical circuit blocks used in the front-end stage of analog and/or digital integrated systems. The SHA was simulated and analyzed in a 0.8.mu.m n-well double-poly double-metal CMOS technology.

• 대한전자공학회논문지SD
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• 제39권7호
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• pp.74-80
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• 2002

SOC와 같은 VLSI 집적 회로는 기능적 이유 등으로 인해 다중 클락의 설계 기법을 필요로 한다. 테스트시 클락 오더링과 같은 문제의 효과적이지 못한 대응으로 인해 클락 도메인간의 전이에서 많은 오류들이 발생한다. 본 논문은 다중 클락 시스템에서의 새로운 자체 테스크 기법을 제시한다. 클락 스큐의 문제는 다중캡처의 동작으로 제거하며, 다른 클락 도메인간 혹은 같은 클락 도메인간의 테스트 모두를 동작속도에서 가능하게 한다.

• Molecules and Cells
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• 제39권1호
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• pp.6-19
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• 2016

Redox signalling comprises the biology of molecular signal transduction mediated by reactive oxygen (or nitrogen) species. By specific and reversible oxidation of redoxsensitive cysteines, many biological processes sense and respond to signals from the intracellular redox environment. Redox signals are therefore important regulators of cellular homeostasis. Recently, it has become apparent that the cellular redox state oscillates in vivo and in vitro, with a period of about one day (circadian). Circadian timekeeping allows cells and organisms to adapt their biology to resonate with the 24-hour cycle of day/night. The importance of this innate biological timekeeping is illustrated by the association of clock disruption with the early onset of several diseases (e.g. type II diabetes, stroke and several forms of cancer). Circadian regulation of cellular redox balance suggests potentially two distinct roles for redox signalling in relation to the cellular clock: one where it is regulated by the clock, and one where it regulates the clock. Here, we introduce the concepts of redox signalling and cellular timekeeping, and then critically appraise the evidence for the reciprocal regulation between cellular redox state and the circadian clock. We conclude there is a substantial body of evidence supporting circadian regulation of cellular redox state, but that it would be premature to conclude that the converse is also true. We therefore propose some approaches that might yield more insight into redox control of cellular timekeeping.

• 한국광과학회:학술대회논문집
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• 한국광과학회 2005년도 제12회 학술대회 논문초록
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• pp.19-19
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• 2005

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 II
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• pp.819-822
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• 2003

This paper defines an algorithmic description language in cycle-accurate level which can be used to design hardware components. The proposed language is less complex and more flexible than VHDL language. In that the language includes C-like control flow descriptions and brief timing information(i.e. clock cycle boundaries) indicated by 'wait_edge' statements. We generate RTL VHDL codes from the descriptions. The proposed language requires only 10～30% of the # of lines to describe the same functionality compared with RTL VHDL.

• Biomolecules & Therapeutics
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• 제26권4호
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• pp.358-367
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• 2018

Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the midbrain and forebrain. This indicates that Per2 may affect various neurobiological activities such as sleeping, depression, and addiction. In this review, we focus on the neurobiological functions of Per2, which could help to better understand its roles in the CNS.

• 한국항공우주학회지
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• 제33권12호
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• pp.61-67
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• 2005

본 논문에서는 GPS 신호가 자주 단절되는 환경하에서도 안정한 위치 해를 제공하는 반송파 DGPS 방법을 제안한다. 시계 바이어스 변화율을 이용하여 큰 오차가 포함된 측정치 채널을 제거함으로써 더욱 정확한 위치 해를 제공하는 알고리듬을 구현하였다. 가시위성의 앙각과 시계 바이어스 변화율의 관계를 살펴보고, 적절한 임계치를 제안하였으며, 구현된 알고리듬이 실데이터에서도 성능이 우수함을 상용프로그램과 비교하여 보였다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제12권1호
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• pp.10-17
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• 2012

This paper presents a clock regenerator using two $2^{nd}$ order ${\sum}-{\Delta}$ (sigma-delta) modulators for wide range of dividing ratio as defined in HDMI standard. The proposed circuit adopts a fractional-N frequency synthesis architecture for PLL-based clock regeneration. By converting the integer and decimal part of the N and CTS values in HDMI format and processing separately at two different ${\sum}-{\Delta}$ modulators, the proposed circuit covers a very wide range of the dividing ratio as HDMI standard. The circuit is fabricated using 0.18 ${\mu}m$ CMOS and shows 13 mW power consumption with an on-chip loop filter implementation.

• Molecules and Cells
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• 제22권3호
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• pp.285-290
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• 2006

The light sensing system in the eye directly affects the circadian oscillator in the mammalian suprachiasmatic nucleus (SCN). To investigate this relationship in the rat, we examined the circadian expression of clock genes in the SCN and eye tissue during a 24 h day/night cycle. In the SCN, rPer1 and rPer2 mRNAs were expressed in a clear circadian rhythm like rCry1 and rCry2 mRNAs, whereas the level of BMAL1 and CLOCK mRNAs decreased during the day and increased during the night with a relatively low amplitude. It seems that the clock genes of the SCN may function in response to a master clock oscillation in the rat. In the eye, the rCry1 and rCry2 were expressed in a circadian rhythm with an increase during subjective day and a decrease during subjective night. However, the expression of Opn4 mRNA did not exhibit a clear circadian pattern, although its expression was higher in daytime than at night. This suggests that cryptochromes located in the eye, rather than melanopsin, are the major photoreceptive system for synchronizing the circadian rhythm of the SCN in the rat.

• 수면정신생리
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• 제21권2호
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• pp.51-60
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• 2014

A 'circadian rhythm' is a self-sustained biological rhythm (cycle) that repeats itself approximately every 24 hours. Circadian rhythms are generated by an internal clock, or pacemaker, and persist even in the absence of environmental time cues, collectively termed 'zeitgebers.' Although organisms generate circadian rhythms internally, they are entrained by environmental stimuli, particularly the light-dark cycle. Measurement of the endogenous melatonin rhythm provides relatively reliable surrogate way of assessing the timing of the internal circadian clock. Also, core body temperature and cortisol can be used as markers of circadian rhythms. The sleep-wake cycle, body temperature, and melatonin rhythm have a stable internal phase relationship in humans and other diurnal species. They play an important role in controlling daily behavioral rhythms including task performance, blood pressure, and synthesis and secretion of several hormones. In this review, we address not only the properties, methods of measurement, and markers of circadian rhythms, but also the physiological and psychological importance of human circadian rhythms.