• BMB Reports
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• 제47권9호
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• pp.475-482
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• 2014

Ubiquitin (Ub) is a versatile signaling molecule that plays important roles in a variety of cellular processes. Cellular Ub pools, which are composed of free Ub and Ub conjugates, are in dynamic equilibrium inside cells. In particular, increasing evidence suggests that Ub homeostasis, or the maintenance of free Ub above certain threshold levels, is important for cellular function and survival under normal or stress conditions. Accurate determination of various Ub species, including levels of free Ub and specific Ub chain linkages, have become possible in biological specimens as a result of the introduction of the proteomic approach using mass spectrometry. This technology has facilitated research on dynamic properties of cellular Ub pools and has provided tools for in-depth investigation of Ub homeostasis. In this review, we have also discussed the consequences of the disruption of Ub pool dynamics and homeostasis via deletion of polyubiquitin genes or mutations of deubiquitinating enzymes. The common consequence was a reduced availability of free Ub and a significant impact on the function and viability of cells. These observations further indicate that the levels of free Ub are important determinants for cellular protection.

• 약학회지
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• 제46권1호
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• pp.52-57
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• 2002

Effects of the butanl fraction of Astragali Radix (BFAR) on the cellular and nonspecific immune responses were investigated in ICR mice. Mice were divided into 4 groups and BFAR at doses of 5, 25 and 125 mg/kg u ere administered orally to mice daily for 3 weeks, and the normal animals were given vehicle. The results of this study are summarized as follows; the relative weight of thymus was greatly increased by BFAR treatment, compared with that in mormal mice. However, the body weight gain was not affected. Delayed-type hypersensitivity (DTH) reaction to sheep red blood cells (SRBC) for cellular immunity was significantly enhanced by BFAR treatment, compared with those in normal mice. In these mice, BFAR also dose-dependently increased activities of phagocyte and natural killer (NK) cells as well as the number of leukocyte resulted from nonspecific immunity Thus, these results demonstrate that BFAF treatment results in a significant increase in both cellular and nonspecific immune responses to antigen in concentrations that enhance humoral immune function.

• 한국컴퓨터정보학회논문지
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• 제24권7호
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• pp.79-85
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• 2019

We investigate the D2D utility maximization in the cellular system. We focus on the non cooperative game theoretic approach to maximize the individual utility. Cellular system's perspective, interference from the D2D links must be limited to protect the cellular users. To accommodate this interference issue, utility function is first defined to control the individual D2D user's transmit power. More specifically, utility function includes the pricing which limits the individual D2D user's transmit power. Then, non cooperative power game is formulated to maximize the individual utility. Distributed algorithm is proposed to maximize the individual utility, while limiting the interference. Convergence of the proposed distributed algorithm is verified through computer simulation. Also the effect of pricing factor to SIR and interference is provided to show the performance of the proposed distributed algorithm.

• 한국컴퓨터산업학회논문지
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• 제9권1호
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• pp.29-38
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• 2008

본 논문은 Cellular Automata의 이론적 원리를 체계적으로 분석하였다. 특히 Cellular Automata는 transition rule를 이용하여 다양한 형태의 기능을 처리할 수 있다는 것을 암시하고 있다. Cellular Automata는 State, Neighborhood, Program Rules이라는 단순한 특징을 가지고 다양하고 복잡한 원리를 구현할 수 있다. 특히 영상 처리 분야에서 뛰어난 인식력을 가지고 있다. 따라서 본 논문에서는 이러한 Cellular Automata를 이용하여 영상처리에서 중요한 Edge Detection을 시도하여 그 능력이 뛰어남을 규명하였다.

• Molecules and Cells
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• 제43권4호
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• pp.397-407
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• 2020

DNAJB9 is known to be a member of the molecular chaperone gene family, whose cellular function has not yet been fully characterized. Here, we investigated the cellular function of DNAJB9 under strong mitogenic signals. We found that DNAJB9 inhibits p53-dependent oncogene-induced senescence (OIS) and induces neoplastic transformation under oncogenic RAS activation in mouse primary fibroblasts. In addition, we observed that DNAJB9 interacts physically with p53 under oncogenic RAS activation and that the p53-interacting region of DNAJB9 is critical for the inhibition of p53-dependent OIS and induction of neoplastic transformation by DNAJB9. These results suggest that DNAJB9 induces cell transformation under strong mitogenic signals, which is attributable to the inhibition of p53-dependent OIS by physical interactions with p53. This study might contribute to our understanding of the cellular function of DNAJB9 and the molecular basis of cell transformation.

• Journal of Communications and Networks
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• 제18권6호
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• pp.926-937
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• 2016

In this paper, we study the feasibility of receiver diversity for application to downlink cellular networks, where low-energy devices are equipped with information decoding and energy harvesting receivers for simultaneous wireless information and power transfer. We compare several options that are based on selection combining and maximum ratio combining, which provide different implementation complexities. By capitalizing on the Frechet inequality, we shed light on the advantages and limitations of each scheme as a function of the transmission rate and harvested power that need to be fulfilled at the low-energy devices. Our analysis shows that no scheme outperforms the others for every system setup. It suggests, on the other hand, that the low-energy devices need to operate in an adaptive fashion, by choosing the receiver diversity scheme as a function of the imposed requirements. With the aid of stochastic geometry, we introduce mathematical frameworks for system-level analysis. We show that they constitute an important tool for system-level optimization and, in particular, for identifying the diversity scheme that optimizes wireless information and power transmission as a function of a sensible set of parameters. Monte Carlo simulations are used to validate our findings and to illustrate the trade-off that emerge in cellular networks with simultaneous wireless information and power transfer.

• Journal of applied mathematics & informatics
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• 제28권3_4호
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• pp.583-596
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• 2010

In this paper, the problem of delay-dependent stability analysis for cellular neural networks systems with time-varying delays was considered. By using a new Lyapunov-Krasovskii function, delay-dependant stability conditions of the delayed cellular neural networks systems are proposed in terms of linear matrix inequalities (LMIs). Examples are provided to demonstrate the reduced conservatism of the proposed stability results.

• 한국통신학회논문지
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• 제16권6호
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• pp.517-532
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• 1991

This paper shows performance analysis for FH/MF나 systems over the cellular mobile communication channel. The Channel capacity over FH/MF나 system is represented as a function of deletion probalblity (Po) and insertion probalbility(Pt). The spectral efficiency of the system serves as a per formance of cellular system is inferior to that of non cellular system. In the case of frequency reuse, we get the best performance when the reuse pattern(N) is 3.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3587-3592
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• 2013

Aims: To study the CIK cell treatment effects on regulation of cellular immune function disorders in patients with lung cancer, and to analyze the time characteristics. Methods: Cellular immune function was assessed by FCM, and patients with functional disorders were randomly divided into two groups, one given CIK cell therapy within 18 months (5 courses) and the other the controls, which were followed up for 1 year with cellular immune functions tested once a month. Results: There were 5 types of cellular immunity, 4 of which are disorders; after CIK treatment, the improvement rate of the 4 groups were 79.1%, 70.8%, 76.0% and 70.0%, intergroup differences not being statistically significant (P=0.675), all significantly higher than in the control group (P=0.000). The median maintenance times for the 4 groups were 10.4 months (9.76-11.04), 8.4 months (7.86-8.94), 9.8 months (9.20-10.4) and 7.9 months (6.25-9.55), respectively. Conclusions: CIK cells were able to improve the immune functions of patients with lung cancer, the rate of improvement and maintenance time being related to the immune function before the treatment and CIK-cell-therapy courses.

• Journal of Microbiology and Biotechnology
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• 제14권2호
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• pp.390-394
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• 2004

The genetically modified glyphosate-tolerant soybean contains the following introduced DNA sequences: the EPSPS (5-enol-pyruvylshikimate-3-phosphate synthase) gene from Agrobacterium sp. strain CP4, the 35S promoter from the cauliflower mosaic virus, and the NOS terminator from Agrobacterium tumefaciens. In the present study, detection of these introduced DNAs was performed by amplification using the polymerase chain reaction (PCR). A multiplex PCR method was also applied to prevent false positive results. When primers for 35S promoter, nos3', CTP(chloroplast transit peptide), and CP4 EPSPS (EPSPS from Agrobacterium sp. CP4) were used, positive results were obtained in PCR reactions using DNA from genetically modified glyphosate-tolerant soybeans. There were no false positive results when using DNA from non-genetically modified soybeans. The CP4 EPSPS gene was detected when less than 125 pg glyphosate-tolerant soybean DNA was amplified. Lectin Lel and psb A were amplified from both non-genetically modified and genetically modified glyphosate-tolerant soybean DNA. Multiplex PCR was performed using different primer sets for actin Sacl, 35S promoter and CP4 EPSPS. The actin gene was detectable in both non-genetically modified and glyphosate-tolerant soybeans as a constant endogenous gene. Target DNAs for the 35S promoter, and CP4 EPSPS were detected in samples containing 0.01-0.1% glyphosate-tolerant soybean, although there were variations depending on primers by multiplex PCR. Soybean seeds from five plants of non-genetically modified soybean were co-cultivated for six months with those of genetically modified soybean, and they were analyzed by PCR. As a result, they were not positive for 35S promoter, nos3' or CP4 EPSPS. Therefore, these results suggest there was no natural crossing of genes between glyphosate-tolerant and non-genetically modified soybean during co-cultivation, which indicates that gene transfer between these plants is unlikely to occur in nature.