YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of the Butanol Fraction of Astragali Radix on the Cellular Immune Function in Mice

황기 부탄올 분획물이 생쥐의 세포성 면역기능에 미치는 영향

  • 김정훈 (원광대학교 한의학전문대학원) ;
  • 문연자 (원광대학교 한의학전문대학원) ;
  • 이성원 (원광대학교 한의학전문대학원) ;
  • 이승연 (원광대학교 한의학전문대학원) ;
  • 우원홍 (원광대학교 한의학전문대학원) ;
  • 박정숙 (원광대학교 대학원 약학과)
  • Published : 2002.02.01
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Abstract

Effects of the butanl fraction of Astragali Radix (BFAR) on the cellular and nonspecific immune responses were investigated in ICR mice. Mice were divided into 4 groups and BFAR at doses of 5, 25 and 125 mg/kg u ere administered orally to mice daily for 3 weeks, and the normal animals were given vehicle. The results of this study are summarized as follows; the relative weight of thymus was greatly increased by BFAR treatment, compared with that in mormal mice. However, the body weight gain was not affected. Delayed-type hypersensitivity (DTH) reaction to sheep red blood cells (SRBC) for cellular immunity was significantly enhanced by BFAR treatment, compared with those in normal mice. In these mice, BFAR also dose-dependently increased activities of phagocyte and natural killer (NK) cells as well as the number of leukocyte resulted from nonspecific immunity Thus, these results demonstrate that BFAF treatment results in a significant increase in both cellular and nonspecific immune responses to antigen in concentrations that enhance humoral immune function.

Keywords

References

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