• Title/Summary/Keyword: cccA

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A Synthetic Exponentially Weighted Moving-average Chart for High-yield Processes

  • Kusukawa, Etsuko;Kotani, Takayuki;Ohta, Hiroshi
    • Industrial Engineering and Management Systems
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    • v.7 no.2
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    • pp.101-112
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    • 2008
  • As charts to monitor the process fraction defectives, P, in the high-yield processes, Mishima et al. (2002) discussed a synthetic chart, the Synthetic CS chart, which integrates the CS (Confirmation Sample)$_{CCC(\text{Cumulative Count of Conforming})-r}$ chart and the CCC-r chart. The Synthetic CS chart is designed to monitor quality characteristics in real-time. Recently, Kotani et al. (2005) presented the EWMA (Exponentially Weighted Moving-Average)$_{CCC-r}$ chart, which considers combining the quality characteristics monitored in the past with one monitored in real-time. In this paper, we present an alternative chart that is more superior to the $EWMA_{CCC-r}$ chart. It is an integration of the $EWMA_{CCC-r}$ chart and the CCC-r chart. In using the proposed chart, the quality characteristic is initially judged as either the in-control state or the out-of-control state, using the lower and upper control limits of the $EWMA_{CCC-r}$ chart. If the process is not judged as the in-control state by the $EWMA_{CCC-r}$ chart, the process is successively judged, using the $EWMA_{CCC-r}$ chart. We compare the ANOS (Average Number of Observations to Signal) of the proposed chart with those of the $EWMA_{CCC-r}$ chart and the Synthetic CS chart. From the numerical experiments, with the small size of inspection items, the proposed chart is the most sensitive to detect especially the small shifts in P among other charts.

Use of cccDNA Breakage Assay and Sulforhodamine B Assay for the Prescreening of Antitumor Agents from Microbial Sources (미생물 배양액으로부터 항암제의 예비선별을 위한 cccDNA Breakage 활성검정과 Assay Sulforhodamine B 활성검정의 이용)

  • Lee, Sang-Han;Lee, Dong-Sun;Kim, Jong-Guk;Hong, Soon-Duck
    • Journal of Life Science
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    • v.8 no.1
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    • pp.67-71
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    • 1998
  • In order to develop new antitumor agents from fermentation broths, we used cccDNA breakage assay abd sulforhodamine B assay for prescreening. As a result, it was shown that sample reach 3.3% when using cccDNA breakage assay. In sulforhodamine B assay, we obtained 4 acive fraction against A549 (a cell line of human lung carcinoma) and SK-OV-3 (a cell line of human adenocarcinoma). These results suggest that these assay would be a promising method for antitumor prescreening from microbial sources.

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The in-control performance of the CCC-r chart with estimated parameters (추정된 모수를 사용한 CCC-r 관리도에서 관리상태의 성능)

  • Kim, Jaeyeon;Kim, Minji;Lee, Jaeheon
    • The Korean Journal of Applied Statistics
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    • v.31 no.4
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    • pp.485-495
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    • 2018
  • The CCC-r chart is more effective than traditional attribute control charts for monitoring high-quality processes. In-control process parameters are typically unknown and should be estimated when implementing a CCC-r chart. Phase II control chart performance can deteriorate due to the effect of the estimation error. In this paper, we used the standard deviation of average run length (ARL) as well as the average of ARL to quantify the between-practitioner variability in the CCC-r chart performance. The results indicate that the CCC-r chart requires larger Phase I data than previously recommended in the literature in order to have consistent chart in-control performance among practitioners.

Exponentially Weighted Moving Average Chart for High-Yield Processes

  • Kotani, Takayuki;Kusukawa, Etsuko;Ohta, Hiroshi
    • Industrial Engineering and Management Systems
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    • v.4 no.1
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    • pp.75-81
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    • 2005
  • Borror et al. discussed the EWMA(Exponentially Weighted Moving Average) chart to monitor the count of defects which follows the Poisson distribution, referred to the $EWMA_c$ chart, as an alternative Shewhart c chart. In the $EWMA_c$ chart, the Markov chain approach is used to calculate the ARL (Average Run Length). On the other hand, in order to monitor the process fraction defectives P in high-yield processes, Xie et al. presented the CCC(Cumulative Count of Conforming)-r chart of which quality characteristic is the cumulative count of conforming item inspected until observing $r({\geq}2)$ nonconforming items. Furthermore, Ohta and Kusukawa presented the $CS(Confirmation Sample)_{CCC-r}$ chart as an alternative of the CCC-r chart. As a more superior chart in high-yield processes, in this paper we present an $EWMA_{CCC-r}$ chart to detect more sensitively small or moderate shifts in P than the $CS_{CCC-r}$ chart. The proposed $EWMA_{CCC-r}$ chart can be constructed by applying the designing method of the $EWMA_C$ chart to the CCC-r chart. ANOS(Average Number of Observations to Signal) of the proposed chart is compared with that of the $CS_{CCC-r}$ chart through computer simulation. It is demonstrated from numerical examples that the performance of proposed chart is more superior to the $CS_{CCC-r}$ chart.

Performance of CCC-r charts with bootstrap adjusted control limits (붓스트랩에 기초하여 조정한 관리한계를 사용하는 CCC-r 관리도의 성능)

  • Kim, Minji;Lee, Jaeheon
    • The Korean Journal of Applied Statistics
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    • v.33 no.4
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    • pp.451-466
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    • 2020
  • CCC-r chart is effective for high-quality processes with a very low fraction nonconforming. The values of process parameters should be estimated from the Phase I sample since they are often not known. However, if the Phase I sample size is not sufficiently large, an estimation error may occur when the parameter is estimated and the practitioner may not achieve the desired in-control performance. Therefore, we adjust the control limits of CCC-r charts using the bootstrap algorithm to improve the in-control performance of charts with smaller sample sizes. The simulation results show that the adjustment with the bootstrap algorithm improves the in-control performance of CCC-r charts by controlling the probability that the in-control average number of observations to signal (ANOS) has a value greater than the desired one.

Implementation of Wireless Network Planning System for HSPA + and CCC (HSPA+와 CCC를 위한 무선망 설계 시스템의 구현)

  • Bae, Young-Ho;Kim, Byung-Woo;Lee, Seong-Choon
    • Journal of The Institute of Information and Telecommunication Facilities Engineering
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    • v.9 no.4
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    • pp.158-163
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    • 2010
  • KT will deploy HSPA+/CCC network in this year to handle data explosion. CCC is an evolutionary wireless network architecture which divides a node B into baseband and radio part. By collecting baseband units in a digital unit central station and installing only remote units on desired sites, the operator can reduce the total cost of ownership and $CO_2$ emission. In this paper, we describe some expected problems in deploying HSPA+/CCC network, and how to implement the wireless network planning system to solve them effectively.

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Cross-coupled Control with a New Contour Error Model (새로운 윤곽 오차 모델을 이용한 상호 결합 제어)

  • 이명훈;손희수;양승한
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 1997.10a
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    • pp.341-344
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    • 1997
  • The higher precision in manufacturing field is demanded, the more accurate servo controller is needed. To achieve the high precision, Koren proposed the cross-coupled control (CCC) method. The objective of the CCC is reducing the contour error rather than decreasing the individual axial error. The performance of CCC depends on the contour error model. In this paper we propose a new contour error model which utilizes contour error vector based on parametric curve interpolator. The experimental results show that the new CCC is more accurate than the variable-gain CCC during free-form curve motion.

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Game-Theoretic Optimization of Common Control Channel Establishment for Spectrum Efficiency in Cognitive Small Cell Network

  • Jiao Yan
    • International journal of advanced smart convergence
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    • v.13 no.1
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    • pp.1-11
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    • 2024
  • Cognitive small cell networks, consisting of macro-cells and small cells, are foreseen as a promising candidate solution to address 5G spectrum scarcity. Recently, many technological issues (such as spectrum sensing, spectrum sharing) related to cognitive small cell networks have been studied, but the common control channel (CCC) establishment problem has been ignored. CCC is an indispensable medium for control message exchange that could have a huge significant on transmitter-receiver handshake, channel access negotiation, topology change, and routing information updates, etc. Therefore, establishing CCC in cognitive small cell networks is a challenging problem. In this paper, we propose a potential game theory-based approach for CCC establishment in cognitive radio networks. We design a utility function and demonstrate that it is an exact potential game with a pure Nash equilibrium. To maintain the common control channel list (CCL), we develop a CCC update algorithm. The simulation results demonstrate that the proposed approach has good convergence. On the other hand, it exhibits good delay and overhead of all networks.

Cytochrome $C_{550}$ is Related to Initiation of Sporulation in Bacillus subtilis

  • Shin Inji;Ryu Han-Bong;Yim Hyung-Soon;Kang Sa-Ouk
    • Journal of Microbiology
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    • v.43 no.3
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    • pp.244-250
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    • 2005
  • The effect of cytochrome $c_{550}$ encoded by cccA in Bacillus subtilis during the event of sporulation was investigated. The sporulation of cccA-overexpressing mutant was significantly accelerated, while disruptant strain showed delayed sporulation in spite of the same growth rate. Activity of sporulation stage-0-specific enzyme, extracellular $\alpha-amylase$ of mutant strains was similar to that of the control strain, but cccA-overexpressing mutant exhibited higher activity of stage-II-specific alkaline phosphatase and stage-III-specific glucose dehydrogenase when compared to deletion mutant and control strain. Northern blot analysis also revealed that cccA-overexpressing mutant showed high level of spo0A transcripts, while the disruptant rarely expressed spo0A. These results suggested that although cytochrome $c_{550}$ is dispensable for growth and sporulation, expression of cccA may play an important role for initiation of sporulation through regulation of spo0A expression.

Microtuberization and Morphological Development by Culture Condition In Vitro Node Culture of Potato (감자절간 기내배양에서 소괴경의 형성과 형태적 발달)

  • Hwang, Hye-Yeon;Lee, Young-Bok
    • Journal of Plant Biotechnology
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    • v.34 no.4
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    • pp.331-338
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    • 2007
  • One-node stem pieces ca. 1 cm in length containing a axillary bud and a fully expanded leaf were obtained from it in vitro plants of potato (Solanum tuberosum L.). Leaves were removed and the nodes were cultured on the MS medium to investigate the effects of temperature, day length, sucrose, and CCC in microtuber formation and development. The fresh weight of microtubers after 80 days increased significantly at 8% sucrose and $20^{\circ}C$ compared with $28^{\circ}C$. The tuberization and development were reduced at $28^{\circ}C$ except short-day treatment of 8 hours at 8% sucrose. The fresh weight and diameter were increased on the culture medium added CCC 500 mg/L. The potato tuberization was promoted under short daylength, and it showed great effect by treatment with the CCC. Though the tuberization was promoted at low temperature of $20^{\circ}C$ in a histologic change of an axillary bud part cell of a potato, the cells were able to observe the swelling growth. Swelling growth of tissue was stimulated in the darkness and was more remarkable by addition of CCC. In particular, in the visual ratio of cell division for each position in the tissue, the cortex part showed larger ratio of cell expansion than that of the pith part. The effect of CCC was identified at 8% sucrose in the darkness. The effect of CCC was not showed in sucrose 3% under long daylength of 16 hours. As a result, the fact of a substance with AGPase important for starch composition was certified by the result with the inclose of AGPase activity on high concentration of sucrose, CCC, and dark treatment by which tuber formation and development are promoted.