• 정보처리학회논문지A
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• 제8A권4호
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• pp.359-366
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• 2001

This paper overviews the design of SANique$^{TM}$ -a shred file system for Linux cluster based on SAN environment. SANique$^{TM}$ has the capability of transferring user data from network-attached SAN disks to client applcations directly without the control of centralized file server system. The paper also presents the characteristics of each SANique$^{TM}$ subsystem: CFM(Cluster File Manager), CVM(Cluster Volume Manager), CLM(Cluster Lock Manager), CBM(Cluster Buffer Manager) and CRM(Cluster Recovery Manager). Under the SANique$^{TM}$ design layout, then, the syndrome of '||'&'||'quot;split-brain'||'&'||'quot; in shared file system environments is described and defined. The work first generalizes and illustrates possible situations in each of which a shared file system environment may split into two or more pieces of separate brain. Finally, the work describes the SANique$^{TM}$ approach to the given "split-brain"problem using SAN disk named "split-brain" and develops the overall recovery procedure of shared file systems.

• 생물정신의학
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• 제22권3호
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• pp.101-108
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• 2015

Recent breakthroughs in functional neuroimaging techniques have launched the quest of mapping the connections of the human brain, otherwise known as the human connectome. Imaging connectomics is an umbrella term that refers to the neuroimaging techniques used to generate these maps, which recently has enabled comprehensive brain mapping of network connectivity combined with graph theoretic methods. In this review, we present an overview of the key concepts in functional connectomics. Furthermore, we discuss articles that applied task-based and/or resting-state functional magnetic resonance imaging to examine network deficits in post-traumatic stress disorder (PTSD). These studies have provided important insights regarding the etiology of PTSD, as well as the overall organization of the brain network. Advances in functional connectomics are expected to provide insight into the pathophysiology and the development of biomarkers for diagnosis and treatment of PTSD.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.10-26
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• 2019

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. High-intensity focused ultrasound can produce targeted lesions via thermal ablation of tissue. MRgFUS-mediated stereotactic ablation is non-invasive, incision-free, and confers immediate therapeutic effects. Since the US Food and Drug Administration approval of MRgFUS in 2016 for unilateral thalamotomy in medication-refractory essential tremor, studies on novel indications such as Parkinson's disease, psychiatric disease, and brain tumors are underway. MRgFUS is also used in the context of blood-brain barrier (BBB) opening at low intensities, in combination with intravenously-administered microbubbles. Preclinical studies show that MRgFUS-mediated BBB opening safely enhances the delivery of targeted chemotherapeutic agents to the brain and improves tumor control as well as survival. In addition, BBB opening has been shown to activate the innate immune system in animal models of Alzheimer's disease. Amyloid plaque clearance and promotion of neurogenesis in these studies suggest that MRgFUS-mediated BBB opening may be a new paradigm for neurodegenerative disease treatment in the future. Here, we review the current status of preclinical and clinical trials of MRgFUS-mediated thermal ablation and BBB opening, described their mechanisms of action, and discuss future prospects.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권3호
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• pp.962-975
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• 2020

The accurate segmentation of infant brain MR image into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is very important for early studying of brain growing patterns and morphological changes in neurodevelopmental disorders. Because of inherent myelination and maturation process, the WM and GM of babies (between 6 and 9 months of age) exhibit similar intensity levels in both T1-weighted (T1w) and T2-weighted (T2w) MR images in the isointense phase, which makes brain tissue segmentation very difficult. We propose a deep network architecture based on U-Net, called Triple Residual Multiscale Fully Convolutional Network (TRMFCN), whose structure exists three gates of input and inserts two blocks: residual multiscale block and concatenate block. We solved some difficulties and completed the segmentation task with the model. Our model outperforms the U-Net and some cutting-edge deep networks based on U-Net in evaluation of WM, GM and CSF. The data set we used for training and testing comes from iSeg-2017 challenge (http://iseg2017.web.unc.edu).

• Molecules and Cells
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• 제41권10호
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• pp.881-888
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• 2018

During the cortical development, cells in the brain acquire somatic mutations that can be implicated in various neurodevelopmental disorders. There is increasing evidence that brain somatic mutations lead to sporadic form of epileptic disorders with previously unknown etiology. In particular, malformation of cortical developments (MCD), ganglioglioma (GG) associated with intractable epilepsy and non-lesional focal epilepsy (NLFE) are known to be attributable to brain somatic mutations in mTOR pathway genes and others. In order to identify such somatic mutations presenting as low-level in epileptic brain tissues, the mutated cells should be enriched and sequenced with high-depth coverage. Nevertheless, there are a lot of technical limitations to accurately detect low-level of somatic mutations. Also, it is important to validate whether identified somatic mutations are truly causative for epileptic seizures or not. Furthermore, it will be necessary to understand the molecular mechanism of how brain somatic mutations disturb neuronal circuitry since epilepsy is a typical example of neural network disorder. In this review, we overview current genetic techniques and experimental tools in neuroscience that can address the existence and significance of brain somatic mutations in epileptic disorders as well as their effect on neuronal circuitry.

• 응용통계연구
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• 제35권1호
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• pp.161-175
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• 2022

뇌활동으로 발생하는 전기신호는 다시 자기신호로 유도되는데 센서로 측정한 것을 뇌자도(magnetoencephalography, MEG)라고 한다. MEG 기술은 비접촉, 비침습적인 측정방법이고 시간분해능과 공간분해능력이이 우수하기 때문에 뇌의 기능적인 정보를 얻는데 유용하게 사용될 수 있다. 또한 MEG 신호를 측정하고 분석하여 뇌신경전류의 활동을 이해할 수 있고 나아가 정밀한 뇌기능 연구가 가능하다. 본 연구에서는 뇌 활동(brain activity) 현상에 관한 궁극적 정보를 얻기위해 MEG 데이터의 특성을 설명하고 통계적 문제를 다루어 앞으로 뇌연구에 통계학의 필요성과 뇌정보학의 중요성을 강조하고자 한다.

• 한국전자통신학회논문지
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• 제19권1호
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• pp.137-142
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• 2024

최근, 의료 데이터 표현 분야에서 딥러닝 방법들이 사실상의 표준으로 자리잡고 있다. 하지만, 딥러닝 기술은 내재적으로 많은 양의 학습 데이터를 필요로 하므로 대규모의 데이터를 확보하기 쉽지 않은 의료 분야에서는 직접적인 적용이 어려운 실정이다. 특히 뇌신호 모달리티의 경우, 변동성이 크기 때문에 여전히 데이터 부족 문제를 가진다. 이에, 최근 연구에서는 뇌신호의 시간-공간-주파수 특징을 적절하게 추출할 수 있는 딥 뉴럴 네트워크 구조를 설계하거나, 혹은 자가-지도 학습 방법을 도입하여 뇌신호의 신경생리학적 특징을 미리 학습하도록 한다. 본 논문에서는, 최근 각광받는 기술인 뇌-컴퓨터 인터페이스 및 피험자 상태 예측 등의 관점에서 소규모데이터를 다루기 위해 적용되는 방법론에 대한 분석 및 향후 기술 방향성을 제시한다. 먼저 현재 제안되고 있는 뇌신호 표현을 위한 딥 뉴럴 네트워크 구조에 대해 분석한다. 또한 뇌신호의 특성을 잘 학습하기 위한 자가-지도 학습 방법론을 분석한다. 끝으로, 딥러닝 기반 뇌신호 분석을 위한 중요 시사점 및 방향성에 관하여 논한다.

• Investigative Magnetic Resonance Imaging
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• 제15권2호
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• pp.110-122
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• 2011

목적 : 본 연구의 목적은 확산텐서영상에 기반하여 한국 아동 집단의 해부학적 뇌연결성 지도를 확립하고 뇌신경망의 효율성을 평가하는 기법을 개발하는 것이다. 대상 및 방법 : 건강한 아동 12명에서 얻은 확산텐서영상과 뇌구획영상을 바탕으로 구조 연결 행렬을 구하여 집단의 구조 연결성을 평가하였다. 일표본 t-검정을 시행하여 평균적인 구조 연결성을 파악하였고 이 때 얻은 각 피험자의 백질 다발을 표준공간으로 정규화하여 집단의 해부학적 뇌연결망 지도를 확립했다. 뇌신경망의 군집정도(clustering coefficient), 평균이동거리(characteristic path length), 전체/부분 연결망 효율성(global/local efficiency) 등 연결망 속성을 계산한 후 시각화 하였다. 결과 : 연결망 측면에서 한국 아동 집단의 뇌연결성이 작은세상속성을 가짐을 밝혔다. 또한 해부학적 뇌연결망 지도를 얻었는데 대뇌 반구 내의 연결성이 높게 나타남과 뇌간과 운동/감각 영역간에 많은 신경 연결이 집중되어 있음을 확인하였다. 결론 : 한국 아동 집단의 해부학적 뇌연결망 지도를 작성하는 방법론을 제시하여 뇌를 연결성 측면에서 이해하고 발달 장애와 성인 뇌신경망의 효율성을 평가할 수 있는 기본 도구를 확립하게되었다.

• Applied Microscopy
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• 제46권2호
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• pp.100-104
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• 2016

Electron microscopy is currently the only available technique with a spatial resolution sufficient to identify fine neuronal processes and synaptic structures in densely packed neuropil. For large-scale volume reconstruction of neuronal connectivity, serial block-face scanning electron microscopy allows us to acquire thousands of serial images in an automated fashion and reconstruct neural circuits faster by reducing the alignment task. Here we introduce the whole reconstruction procedure of synaptic network in the rat hippocampal CA1 area and discuss technical issues to be resolved for improving image quality and segmentation. Compared to the serial section transmission electron microscopy, serial block-face scanning electron microscopy produced much reliable three-dimensional data sets and accelerated reconstruction by reducing the need of alignment and distortion adjustment. This approach will generate invaluable information on organizational features of our connectomes as well as diverse neurological disorders caused by synaptic impairments.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제16권1호
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• pp.59-63
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• 2016

Secondary damage to the user is a problem in biometrics. A brain-wave has no shape and a malicious user may not cause secondary damage to a user. However, if user sends brain-wave signals to an authentication system using a network, a malicious user could easily capture the brain-wave signals. Then, the malicious user could access the authentication system using the captured brain-wave signals. In addition, the dataset containing the brain-wave signals is large and the transfer time is long. However, user authentication requires a real-time processing, and an encryption scheme on brain-wave signals is necessary. In this paper, we propose an efficient encryption scheme using a chaos map and adaptive junk data on the brain-wave signals for user authentication. As a result, the encrypted brain-wave signals are produced and the processing time for authentication is reasonable in real-time.