• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.8
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• pp.1377-1384
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• 2003

This study investigated the effects of different types of dietary fats and fibers on the concentrations of serum and liver lipids and biochemical index in male Sprague-Dawley rats for 6 weeks. The experimental groups were divided into three groups; 5% corn oil +5% cellulose (CO group),10% corn oil +10% psyllium husk (CO +PH group) and 10% lard +10% psyllium husk (LA+ PH group). Body weight gain and FER (food efficiency ratio%) decreased significantly in the LA+PH group and decreased slightly in the CO+PH group compared with the CO group. Food intake and tissue weights were not significantly different among the dietary groups. Concentrations of serum total cholesterol decreased significantly in the CO + PH group compared with the CO group, but no significant different in the LA + PH group. Concentrations of serum triglyceride and phospholipid decreased significantly in the CO+PH and the LA+PH groups compared with the CO group. Liver cholesterol concentration was significantly decreased in the LA+PH group compared with the CO and the CO+PH groups. Glutamic pyruvic transaminase activity was significantly increased in the LA + PH group compared with the CO and the CO + PH groups. However, lactate dehydrogenase and blood urea nitrogen was significantly decreased in the LA+ PH group compared with the CO and the CO +PH groups. The others biochemical parameters, total protein, albumin, glucose, glutamic oxaloacetic transaminase, alkaline phosphatase were not significantly different among the dietary groups. These results showed that the lowering effect of dietary psyllium husk on serum lipid concentrations was more pronounced in the corn oil -feeding group than in the lard-feeding group as dietary fat source.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.11
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• pp.1629-1636
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• 2015

The edible mushroom Agaricus blazei Murill is known to have many physiological functions, including antitumor, antiviral, and anti-inflammatory effects. Aqueous extracts were obtained by extracting A. blazei in water at $90^{\circ}C$ for 15 h, followed by spray-drying with dextran at a 70:30 ratio. In this study, we examined the immunomodulatory effect of A. blazei Murill water extract (ABM) in BALB/c mice. Mice were administered orally with 4, 20, and 100 mg/kg of ABM for 21 days. ABM-treated mice did not show significant differences in body and organ weights compare to saline-treated control mice. Splenocytes isolated from ABM-administered mice revealed similar levels of cellularity and proliferation compared to control mice, whereas they showed increased natural killer (NK) cell activity and decreased IL-4 and IL-12 production. Different from in vivo results, splenocytes isolated from normal mice showed increased proliferation and $INF-{\gamma}$ production following ABM treatment in vitro. In addition, ABM treatment enhanced macrophage proliferation and nitric oxide (NO) production in a dose-dependent manner. However, ABM had no effect on LPS-induced NO production. These results suggest that A. blazei modulates immune function by increasing NK cell activity and macrophage function.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.8
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• pp.975-982
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• 2007

The purpose of this study was to investigate repeated-dose toxicity in male and female rats orally administered with Pediococcus pentosaceus MD1, an anti-Helicobacter pyroli producing lactic acid bacteria isolated from kimchi. Sprague-Dawley rats were divided into 4 groups, 10 animals in each group. The test article was administered once daily by gavage to rats at dose levels of 0, 500, 1,000 and 2,000 mg/kg for 4 weeks. No test article-related deaths and clinical findings in both sexes of rats during the study period were resulted. In addition, no differences were found between control and treated groups in body weight changes, food intake consumption and water consumptions. Hematological parameters, serum biochemical analysis and any other findings did not also show any significant or dose-dependent alterations. There were no alterations in absolute and relative organ weights by the administration of Pediococcus pentosaceus MD1. These results suggest that no-observed-adverse-effect level (NOAEL) of Pediococcus pentosaceus MD1 is considered to be more than 2 g/kg in male and female rats.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.8
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• pp.1037-1041
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• 2009

The effect of dietary zinc levels on macro mineral contents was investigated in rats. Rats were divided into three groups by zinc levels, such as low (50% of requirement, Zn/L), adequate (100%, Zn/A) and high (200%, Zn/H) levels of dietary zinc. The calcium, magnesium, sodium and potassium contents in serum and organs were measured. The food intake was significantly higher in Zn/L group compared to that of Zn/H group. The body weight gain in Zn/H group was significantly lower than that of other two groups. There were no significant differences in liver, kidney and spleen weights. Also, serum calcium, magnesium, sodium and potassium concentrations were not significantly changed by the zinc diet at any level. In the low zinc diet group, liver calcium content was significantly lower, but the magnesium and potassium contents in spleen were significantly higher than that in other groups. The calcium, magnesium, sodium and potassium contents of kidney were not significantly different for any level of zinc. In conclusion, the macro mineral contents of liver and spleen in the normal rats were changed by zinc levels. Based on this study, the interaction between micro and macro minerals remains to be further studied.

• Journal of Digital Convergence
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• v.14 no.9
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• pp.471-478
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• 2016

The purpose of this study to examine the effect of 12 hours fasting resistance exercise on metabolic efficiency and fatigue of middle-aged female for 8 weeks. 50 middle-aged female target group pre-test exercise group(EX) and the control over the homogeneity in the control group(CON) were selected for this purpose divided into two groups. Exercise group(EX) is maintained after 8 weeks four times weeks 12 hours fasting resistance was performed for 60 minutes, the control group(CON) were compared to a normal life with the group of the exercise group(EX). Resistance applied to the exercise group(EX) were using free weights and a fixed mechanism applied around the upper and lower body exercise program for heart muscle, exercise intensity based on the 70% 1RM until 4 weeks, 5-8, which was performed by the aid program set to 80%. Through this procedure were as follows. First, 12 hours fasting resistance exercise showed the significance of the interaction effect in metabolic efficiency, blood pressure(SBP, DBP), fat, fasting glucose, fasting insulin(p<.01). Second, 12 hours fasting resistance exercise showed the significance of the interaction effect in the treatment program in which lactic acid, uric acid(p<.01).

• Journal of the East Asian Society of Dietary Life
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• v.24 no.3
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• pp.325-334
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• 2014

The effects of aloe on liver function and lipid metabolic disorders induced by alcohol consumption were studied in rats using aloe power (0.25%, 0.5%, 1%) and 10% ethanol. 35 Sprague-Dawley (male, 4 weeks old) rats were divided into five groups and fed experimental diets for six weeks. Body weights of rats tended to be lower in all alcohol supplemented groups than in the control. Food intakes and dry feces per day were significantly lower in all alcohol supplemented groups than in the control. Atherogenic indices (AI) were highest in the alcohol group and decreased in proportion with aloe amount. Serum triglyceride level was significantly higher in the alcohol group than in the control, but tended to be lower in the aloe supplemented groups. In relation to liver function, glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), and alkaline phosphatase (ALP) activities tended to be higher in the alcohol groups than in the control, but lower in the aloe groups, especially in the alcohol+0.5% AO group. The levels of liver cholesterol were significantly lower in the alcohol group than in the control and aloe supplemented groups. In the histochemical evaluation, fat droplets appeared extensively on the liver-lobule in the alcohol group, whereas they decreased slightly in the alcohol+0.25% AO group and apparently disappeared in the alcohol +0.5% AO. On the other hand, fat droplets appeared again on the liver-lobule in the alcohol+1% AO group, but were reduced compared with the alcohol group. Regarding the fatty acid composition of adipose tissue triglycerides, the level of linoleic acid (18:2) was significantly higher in the aloe supplemented group. Regarding the fatty acid composition of liver phosphatidylcholine (PC), the level of linoleic acid was higher in the alcohol group and alcohol+1% AO group than the other groups. In contrast, the level of arachidonic acid was significantly lower in the alcohol group. As a result, arachidonic / linoleic acid ratios were significantly lower in the alcohol group compared to the control group, whereas the ratios of the aloe supplemented groups were similar to that of the control group. Therefore, aloe had some beneficial effects on lipid metabolic disorders induced by alcohol and affected desaturation of fatty acids.

• Korean Journal of Veterinary Service
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• v.37 no.1
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• pp.51-58
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• 2014

The aim of the study was to investigate the anti-obesity effect of Coprinus comatus (CC) in high-fat diet-fed Zucker rat (fa/fa). Obesity was induced by feeding on high-fat diet (HFD) containing 60% kcal fat for 10 weeks, in which CC extracts were administrated through the gastrointestinal tract at a concentration of 200 mg/kg BW/day for 10 weeks. The total polyphenol and flavonoid contents of CC extracts were found to be $18.5{\pm}1.1mg$ of catechin equivalent/g, and $5.24{\pm}0.54mg$ of quercetin equivalent/g extract, respectively. The DPPH, ABTS, and hydroxyl radical scavenging activities of CC extracts were 15.34 %, 17.25%, and 16.18%, respectively. In animal study, CC administration significantly reduced the body weight, while there were no significant differences in the daily food intake between the HFD-fed Zucker rats and HFD plus CC-fed rats. CC treatment decreased epididymal and perirenal fat weights in HFD-fed Zucker rats. Significant decreases in the levels of triglyceride and total cholesterol in the serum and liver were observed in the CC-treated group compared with HFD-fed Zucker rats. Serum HDL-cholesterol levels in the CC-treated group were increased compared with the HFD-fed groups. Serum AST and ALT activities in the CC group were significantly lower than those of the HFD-fed group. Taken together, these data demonstrated that CC has potential in preventing high-fat diet induced obesity and is a good candidate for an anti-obesity agent.

• Korean Journal of Veterinary Service
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• v.34 no.3
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• pp.235-243
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• 2011

Probiotics have many effects such as antihypertensive, prevention of cancer, antioxidation, reduction of dermatitis symptoms, improvement of mineral absorption, reduction of allergic symptoms, and decrease of cholesterol, However, the main role of probiotics is that they balance intestinal microbials proportion. L. acidophilus is one of probiotics and microflora in intestine. It has an acidification activity, aroma production, texture formation and probiotics properties. We studied on the roles of L. acidophilus in mice. In this study, body weights of mice were decreased when administration of L. acidophilus ($1{\times}10^{10}$ CFU) and swimming ability has been raised than a normal group after feeding on L. acidophilus ($1{\times}10^{10}$ CFU). After taking L. acidophilus ($1{\times}10^{10}$ CFU), total white cells were increased than a normal group; hemoglobin and thrombocytes were increased. The level of cholesterol and triglyceride were decreased in blood analysis. We knew L. acidophilus is related to innate immune system. We found out the secretion of cationic peptide was increased in the Lysoplate assays as a result of L. acidophilus ($1{\times}10^{10}$ CFU) administration. Appearance rate of lysozyme was also increased than the normal group on an immunohistochemistry stain. We confirmed L. acidophilus contributes to host health through innate immune system stimulation. L. acidophilus more than $1{\times}10^{10}$ CFU are thought to be beneficial for the host health and prevention of intestinal diseases in field condition.

• Korean Journal of Community Nutrition
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• v.7 no.2
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• pp.232-244
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• 2002

This study investigated the correlation between health-related habits and the biochemical characteristics of the blood of Korean bus drivers. A total of 178 bus drivers working in the Masan area participated in this study. The general characteristics and health-related habits of the subjects were surveyed using a serf-administered questionnaire. The biochemical date were collected from regular health check-ups done through their workshop health insurance company in lune, 1999. The results were as follows : The average age of the subjects was 38 years, and 44.2% had a driving career of between 10 and 19 years. About 90% of the subjects ate irregularly, and 36% ate. health floods. Their rates of drinking, smoking and exercise were 74.6%, 83.6% and 70.8%, respectively. Their frequency of drinking was significantly increased as the length of their driving career increased (p < 0.001). Their levels of total serum cholesterol, in relation to the length of their driving career was significantly higher in the over 20 year group than in the below 10 year group (p < 0.05). Their systolic blood pressures, according to age, were significantly higher in the 51 to 60 age group than in the other groups (p < 0.05). Their total um cholesterol levels signiscantly increased with increasing age (p < 0.001). Their diastolic blood pressures (p < 0.001) and blood glucose levels (p < 0.05) were significantly higher among the subjects who drinking alcohol almost everyday, than among other subjects. Their systolic blood pressures who significantly increased with increasing frequency of their drinking (p < 0.001). The systolic blood pressure and diastolic blood pressure were positively related to age, the amount of drinking, the frequency of drinking and the obesity index, and negatively related to exercise and the duration of exercise. The hemoglobin was positively related to age, preference for a meat diet and the obesity index. The blood glucose was positively related to the amount of drinking, and the total serum cholesterol was positively related to age, length of driving career, period of smoking and the obesity index. The results of this study indicated that bus drivers need regular exercise, moderation of their drinking and smoking, and control of their body weights so as to prevent chronic diseases.

• Korean Journal of Agricultural Science
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• v.28 no.2
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• pp.70-77
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• 2001

A preliminary experiment was conducted to produce fowl-typhoid resistant egg type breeds, using three brown egg layer breeders (ISA, Hyline, and Lohman) and two white egg layer breeders (ISA and Lohman). Various economic parameters were measured from day-old to mature stages using parent stocks of each breed. No significant difference in viabilities of mature hens from 34 to 66 wk of ages was found between brown(93.3%) and white(93.5%) egg layer breeders (P>0.05). Also, there was no difference in viabilities of mature cockerels. Although not significant, the mature body weights of brown egg layer breeders tended to be heavier than those of the white egg layer breeders both in hens and cockerels. No difference in feed intakes of mature brown and white hens were detected. Ages of sexual maturity of white and brown egg layer hens were 147.7 and 140.5 d, respectively (P<0.05). Egg production of white egg layer hens during 23-66 weeks age was significantly higher than their counterpart (81.4% vs. 75.0%). Comparisons of Haugh Unit, egg shape index, yolk color, and egg weight between brown and white eggs were not significantly different; however, the brown eggshells were thicker and stronger than those of white eggs (P<0.05).