Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
권호 표지

Effects of Aloe on Liver Function and Lipid Metabolism in Alcohol-Consuming Rats

Aloe가 알코올을 섭취한 흰쥐의 간 기능 및 지질대사에 미치는 영향

  • Choi, Hye-Gyoung (Dept. of Home Economics Education, Graduate School of Education, Chungnam National University) ;
  • Lee, Joon-Ho (Dept. of Consumers' Life Information, Chungnam National University)
  • 최혜경 (충남대학교 교육대학원 가정교육전공) ;
  • 이준호 (충남대학교 생활과학대학 소비자생활정보학과)
  • Received : 2014.04.09
  • Accepted : 2014.06.14
  • Published : 2014.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of aloe on liver function and lipid metabolic disorders induced by alcohol consumption were studied in rats using aloe power (0.25%, 0.5%, 1%) and 10% ethanol. 35 Sprague-Dawley (male, 4 weeks old) rats were divided into five groups and fed experimental diets for six weeks. Body weights of rats tended to be lower in all alcohol supplemented groups than in the control. Food intakes and dry feces per day were significantly lower in all alcohol supplemented groups than in the control. Atherogenic indices (AI) were highest in the alcohol group and decreased in proportion with aloe amount. Serum triglyceride level was significantly higher in the alcohol group than in the control, but tended to be lower in the aloe supplemented groups. In relation to liver function, glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), and alkaline phosphatase (ALP) activities tended to be higher in the alcohol groups than in the control, but lower in the aloe groups, especially in the alcohol+0.5% AO group. The levels of liver cholesterol were significantly lower in the alcohol group than in the control and aloe supplemented groups. In the histochemical evaluation, fat droplets appeared extensively on the liver-lobule in the alcohol group, whereas they decreased slightly in the alcohol+0.25% AO group and apparently disappeared in the alcohol +0.5% AO. On the other hand, fat droplets appeared again on the liver-lobule in the alcohol+1% AO group, but were reduced compared with the alcohol group. Regarding the fatty acid composition of adipose tissue triglycerides, the level of linoleic acid (18:2) was significantly higher in the aloe supplemented group. Regarding the fatty acid composition of liver phosphatidylcholine (PC), the level of linoleic acid was higher in the alcohol group and alcohol+1% AO group than the other groups. In contrast, the level of arachidonic acid was significantly lower in the alcohol group. As a result, arachidonic / linoleic acid ratios were significantly lower in the alcohol group compared to the control group, whereas the ratios of the aloe supplemented groups were similar to that of the control group. Therefore, aloe had some beneficial effects on lipid metabolic disorders induced by alcohol and affected desaturation of fatty acids.

Keywords

References

  1. Oh YJ, Park WY, Kim KH, Hong JT, Yoon YP (1991) Effect of using Aloe vera linne together with Aloe arborescens miller on hepatitis and cirrhotic liver patients. A summary of the International symposium of natural pharmacology, pp 105-113.
  2. Kim JM, Chang SH (1992) Mysterious medical plant, aloe. Garinae, pp 94-174.
  3. Heo SH, Yang JH, Ha HJ, Kang EJ, Chang MJ (2009) Functional sitology. Hyoil, p 434.
  4. American Institute of Nutrition (1977) Report of AIN Ad. Hoc committee on standards for nutrition studies. J Nutr 107: 1340-1348.
  5. Choi YS, Chung KH, Cho SH, Choi KH (1990) Effects of ethanol consumption and fat content in diet on biochemical indices of blood and liver in the rat. Korean Soc. Food Nutr. 19(1): 1-12
  6. Chung KH, Cho Lee SH, Sin EN, Choi KH, Son Choi YS (1988) Effects of alcohol consumption and fat content in diet on chemical composition and morphology of liver in rat. Korean J Nutrition 21(31): 154-163.
  7. Gallagher J, Gray M (2003) Is aloe vera effective for healing chronic wounds? J WOCN 30(2): 68-71.
  8. Kim JH (1991) Effect of chronic alcohol feeding and 2-acetylaminofluorene treatment on serum and liver lipid metabolism in rats. MS Thesis Seoul Woman University, Seoul. pp 18-27.
  9. Kim MH, Sung CJ (1991) The effect of the levels of dietary zinc and alcohol consumption on lipid metabolism in the rats. Korean J Nutrition 24(2): 87-96.
  10. Kim SN, Kim MS, Park HS (2007) Effects of dietary conjugated linoleic acid(CLA) on antioxidant system in the liver of chronically ethanol-treated rats. Korean J Nutrition 40 (2): 118-129.
  11. Lee CH, Jung YJ, Park DK, Kim CW, Han YB, Lee WC, Kim JB (1993) Effects of ascorbate and $\alpha$-tocopherol administration on liver function in chronically ethanol-treated rats. J. Korean Soc Food Nurt 22(2): 132-137.
  12. Lee CW, Kang DY (1991) The effect of acute ethanol intoxication on the acute hepatotoxicity induced by chloroform. Chungnam Medical Journal 18(1): 37-49.
  13. Lee JH, Kim HS (2001) Effects of dietary docosahexaenoic acid levels on the brain phospholipids and serum and liver lipid compositions in rats. Korean J Nutrition 34(2): 132-140.
  14. Lee JH, Park KS (1999) Effect of Ganoderma lucidum on the liver function and lipid metabolism in alcohol-consuming rats. Korean J Nutrition 32(5): 519-525.
  15. Numa S (1984) Fatty acid metabolism and its regulation, elsevier Science Publishers, B. V., 85-112.
  16. Purohit V, Brenner DA (2006) Mechanism of alcohol-induced hepatic fibrosis: a summary of the Rom Thurman Symposium. Hepatology 43(4): 872-878. https://doi.org/10.1002/hep.21107
  17. Sakai K, Saitoh Y, Ikawa C, Nishihata T (1989) Effect of water extracts of aloe ansome herbs in decreasing blood ethanol concentration in rats. II. Chemical & Pharmaceutical Bulletin, 37: 155-159, 1989. https://doi.org/10.1248/cpb.37.155
  18. Sheo HJ (1995) The physiological efficacy of aloe gel. J Korean Soc Food Nutr 24(6): 1026-1038.
  19. Sohn HS, Jung BM, Cha YS (2001) Effects of Ixeris sonchifolia H. Fiet on lipid metabolism and liver function of rats administered with ethanol. Korean J Nutrition 34(5): 493-498.
  20. Suh KH (1991) Effects of alcohol and tocopherol on lipid composition and peroxidation in the rat liver. MS Thesis Hyosung Woman University, Daegu, pp 12-15.
  21. Tusuda H, Matsumoto K, Ito M. Kawai K, Beppu H, Nagao M. Fujjta K (1991) Suppressing effects of Aole arborescens mill var. natalensis berger (Kidachi aloe) on inducing preneoplastic focal lesions in rats' liver. A summary of the International symposium of natural pharmacology, pp 185-198.
  22. Um YS, Chung EJ, Oh JY, Park TS (2000) Effects of chronic ethanol consumption and taurine supplementation on hepatic total and phospholipid fatty acid compositions in rats. Korean J Nutrition 33(2): 124-133.