• 한국화재소방학회논문지
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• 제20권4호
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• pp.1-12
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• 2006

경사계단통로의 천장 아래로 확산되는 연기의 냉각 및 일시 차단을 위해 설치된 2개의 스프링클러헤드와 깊이가 0.54m인 제연커텐의 통합작동시 그 제연성능을 조사하기 위해 제연구역의 크기가 $17.92m{\times}4.00m{\times}6.12m$인 단일계단통로의 화재모형에 대해 FDS로 화재모의실험을 수행하였다. 스프링클러헤드 반응시간은 화재크기가 증가할수록 감소하며, 제연커텐이 있는 경우가 없는 경우보다 1.1초 증가하고, 화원에서 경사통로출구까지 연기전파시간은 화재크기가 증가할수록 상당히 감소하며, 연기전파지연효과는 스프링클러의 작동여부와는 관계가 없음을 확인할 수 있었다. 스프링클러와 제연커텐의 통합작동은 연기냉각측면에서는 효과가 큰 반면 연기전파지연측면에서는 작지만 효과가 있는 것을 확인할 수 있었다. 살수냉각효과에 의해 경사통로에는 고온연기층의 복사열유속의 화상위험은 감소되나, 헤드살수의 하향끌림과 연기와 공기의 혼합 난류 현상에 의해 경사통로 입구부 주변에는 짙은 연기층이 형성되어 시계약화 및 연기질식 위험은 증가하여 피난에 어려움이 가중될 것으로 사료된다.

• Archives of Pharmacal Research
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• 제26권7호
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• pp.559-563
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• 2003

Cytokines produced by immune cells infiltrating pancreatic islets have been incriminated as important mediators of $\beta$-cell destruction in insulin-dependent diabetes mellitus. In non insulin-dependent diabetes, cytokines are also associated with impaired $\beta$-cell function in high glucose condition. By the screening of various natural products blocking $\beta$-cell destruction, we have recently found that epigallocatechin gallate (EGCG) can prevent the in vitro destruction of RINm5F cell, an insulinoma cell line, that is induced by cytokines. In that study we suggested that EGCG could prevent cytokine-induced $\beta$-cell destruction by down-regulation of nitric oxide synthase (NOS) through inhibition of NF-kB activation. Here, to verify the in vivo antidiabetogenic effect of EGCG, we examined the possibility that EGCG could also prevent the experimental autoimmune diabetes induced by the treatment of multiple low doses of streptozotocin (MLD-STZ), which is recognized as an inducer of type I autoimmune diabetes. Administration of EGCG (100 mg/day/kg for 10 days) during the MLD-STZ induction of diabetes reduced the increase of blood glucose levels caused by MLD-STZ. Ex vivo analysis of $\beta$-islets showed that EGCG downregulates the MLD-STZ-induced expression of inducible NOS (iNOS). In addition, morphological examination showed that EGCG treatment ameliorated the decrease of islet mass induced by MLD-STZ. In combination these results suggest that EGCG could prevent the onset of MLD-STZ-induced diabetes by protecting pancreatic islets. Our results therefore revealed the possible therapeutic value of EGCG for the prevention of diabetes mellitus progression.

• 동의생리병리학회지
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• 제23권1호
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• pp.104-112
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• 2009

The purpose of this study was to investigate the anti-inflammatory effects of extract from GuBoEum(GBE) on the peritoneal macrophage. To evaluate anti-inflammatory effects of GBE. I measured cytokines (interleukin-6; IL-6, interleukin-12; IL-12, tumor necrosis factor-$\alpha$; TNF-$\alpha$) and nitric oxide (NO) production in lipopolysacchride (LPS)-induced macrophages. Furthermore, I examined molecular mechanism using western blot and also LPS-induced endotoxin shock. Extract from GBE does not have any cytotoxic effect in the peritoneal macrophages. Extract from GBE reduced LPS-induced IL-6, TNF-$\alpha$, IL-12 and NO production in peritoneal macrophages. GBE inhibited the activation of extracelluar signal-regulated kinase (ERK), C-Jun $NH_2$-terminal kinase (JNK) but not of p38, degradation of $I{\kappa}B-{\alpha}$ in the LPS-stimulated peritoneal macrophages. GBE inhibited the production of TNF-$\alpha$, IL-6 and IL-12 in serum after LPS injection. These results suggest that GBE may inhibit the production of TNF-$\alpha$, IL-6, and IL-12 through inhibition of ERK and JNK activation, and that GBE may be beneficial oriental medicine for inflammatory diseases.

• 한국통신학회논문지
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• 제30권7B호
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• pp.433-439
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• 2005

본 논문에서는 무선 통신시스템에서 클래스간 비례지연 서비스를 위한 Flow Based Waiting Time Priority (FB-WTP) 스케쥴러를 제안한다. 기존의 스케쥴러는 클래스 단위로 동작하는 유선망의 구조를 그대로 사용하나, 제안된 FB-WTP 스제쥴러는 이와 달리 플로우 단위로 동작을 하며, 네트웍크 운영자가 입력한 클래스간 목표 큐잉 지연 비율은 기존 알고리즘과 같이 거의 동일하게 만족 시키면서도 클래스별 평균 큐잉 지연 성능은 월등히 향상 되었다. 이것은 각 플로우의 채널 환경이 동적으로 변화는 무선 환경에서 FB-WTP는 다중 플로우 다이버시티 효과를 최대한 이용 하기 때문이다. 또한 기존 알고리즘들에서 발생 할 수 있는 HOL 패킷 블록킹 문제가 발생하지 않는다. 성능평가를 위한 모의 실험에서 다중 채널 상태를 고려한 Look-ahead Waiting Time Priority (LWTP) 스케줄링 알고리즘과의 비교 분석으로 제안한 FB-WTP가 클래스간 목표 큐잉 지연 비율을 만족 시킬뿐만 아니라 LWTP에 비해 클래스별 평균 큐잉 지연 특성이 향상됨을 보였다.

• 생명과학회지
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• 제19권4호
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• pp.514-519
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• 2009

혈관벽에 단핵구, 대식세포 등의 세포와 지질 등의 축적은 중요한 동맥경화 발병 요인이다. 이들 세포의 혈관벽으로의 이동에 있어서 chemokine인 MCP1이 중요한 역할을 한다는 것이 많이 알려져 있다. 본 연구에서는 사람 평활근세포에서 $IL-1{\beta}$의 처리에 의하여 MCP1의 발현이 증가되는 기전을 알아보고자 실험을 진행하였다. $IL-1{\beta}$의 처리는 전사인자 $NF-{\kappa}B$의 활성화를 통해 MCP1 발현을 전사단계에서 증가시켰다. 이러한 $IL-1{\beta}$에 의해 증가된 MCP1 발현을 억제하는 물질을 찾기 위해 여러 항염증작용을 하는 물질들을 전처리하여 확인해 본 결과 luteolin이 선택적으로 $IL-1{\beta}$에 의해 증가된 MCP1의 발현을 전사단계에서 저해하는 것을 확인하였고 이는 전사인자 $NF-{\kappa}B$가 핵으로 이동하는 것을 감소시킴으로써 나타나는 현상임을 확인하였다. Luteolin이 염증작용을 조절하는데 있어서 중요한 전사인자인 $NF-{\kappa}B$의 활성을 조절한다는 것을 본 실험을 통해 알 수 있었고 이는 식용식물에서 일반적으로 발견되는 luteolin이 어떠한 기전으로 항 염증작용을 하는지에 대한 이해를 높여줄 것이다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제37권7호
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• pp.573-577
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• 2010

영상 해상도 개선은 영상 복원이나 확대 같은 응용 분야에서 널리 사용되는 기술로서, 결과 영상에서의 블록 현상이나 인공물 발생과 같은 화질 열화를 제거하는 것이 중요하다. 본 논문에서는 영상의 손실 정보를 이용하는 영상 해상도 개선 방법을 제안한다. 제안하는 방법은 획득 저해상도를 하위 레벨 보간을 통해서 손실 정보를 계산 및 추정하고 이를 보간된 고해상도 영상에 적용함으로서 1차적인 보간을 수행하고 획득 저해상도 영상과의 에러를 계산한 후 다시 보간된 영상에 적용하는 과정을 반복하여 최종적인 보간 영상을 생성한다. 동일한 영상을 이용한 시험을 통해서 비교 방법들보다 평균 PSNR에서 3.2㏈ 이상 향상된 것을 확인하였고, 주관적 화질도 개선된 것을 알 수 있었다. 또한 계산복잡도를 85% 이상 감소시킬 수 있었다. 제안한 해상도 개선 방법은 영상 처리의 다양한 분야에서 기반 기술로 사용될 수 있다.

• 동의생리병리학회지
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• 제16권5호
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• pp.928-931
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• 2002

To elucidate the toxic effect of oxygen free radicals on cultured mouse cerebral neurons damaged by hydrogen peroxide(H₂O₂)-induced neurotoxicity, we examined the neurotoxicity induced by oxygen radicals by NR assay when cultured cerebral neurons were grown in the media containing various concentrations of H202 for 6 hours. In addition, neuroprotective effects of herb extracts such Rhizoma Gastrodiae(RG) on H202-induced neurotoxicity in cultured cerebral neurons were evaluated after cultured cerebral neurons were preincubated with various concentrations of herb extract, RG for 2 hours before 50uM H₂O₂ for 6 hours. H₂O₂ decreased remarkably cell viability in dose-and time-dependent manner in these cultures, and also herb exract, RG decreased LDH activity of cerebral neurons damaged by H₂O₂. From the above results, it is suggested that H₂O₂ was toxic in cultured cerebral neurons from mouse, and RG was effective in blocking the neurotoxicity induced by oxygen radicals in these cultures.

• Toxicological Research
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• 제21권2호
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• pp.99-105
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• 2005

Photo-mutagenic compounds have been known to alter skin cancer rates by acting as initiators or by affecting subsequent steps in carcinogenesis. The objectives of this study are to investigate the utility of photo-chromosomal aberration (photo-CA) assay for detecting photo-clastogens, and to evaluate its ability to predict rodent photocarcinogenicity. Photo-CA assay was performed with five test substances that demonstrated positive results in photo-carcinogenicity tests: 8-Methoxypsoralen (photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation), chlorpromazine (an aliphatic phenothiazine an alpha-adrenergic blocking agent), lomefloxacin (an antibiotic in a class of drugs called fluoroquinolones), anthracene (a tricyclic aromatic hydrocarbon a basic substance for production of anthraquinone, dyes, pigments, insecticides, wood preservatives and coating materials) and Retinoic acid (a retinoid compound closely related to vitamin A). For the best discrimination between the test substance-mediated genotoxicity and the undesirable genotoxicity caused by direct DNA absorption, a UV dose-response of the cells in the absence of the test substances was firstly analyzed. All 5 test substances showed a positive outcome in photo-CA assay, indicating that the photo-CA test is very sensitive to the photo-genotoxic effect of UV irradiation. With this limited data-set, an investigation into the predictive value of this photo-CA test for determining the photo-carcinogenicity showed that photo-CA assay has the high ability of a test to predict carcinogenicity. Therefore, the photo-CA test using mammalian cells seems to be a sensitive method to evaluate the photo-carcinogenic potential of new compounds.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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• pp.250-250
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• 2012

Organic light-emitting diodes (OLED) and polymer light emitting diodes (PLED) have been regarded as the candidate for the next generation light source and flat panel display. Currently, the most common OLED industrial fabrication technology used in producing real products utilizes a fine shadow mask during the thermal evaporation of small molecule materials. However, due to high potential including low cost, easy process and scalability, various researches about solution process are progressed. Since polymer has some disadvantages such as short lifetime and difficulty of purifying, small molecule OLED (SMOLED) can be a good alternative. In this work, we have demonstrated high efficient solution-processed OLED with small molecule. We use CBP (4,4'-N,N'-dicarbazolebiphenyl) as a host doped with green dye (Ir(ppy)3 (fac-tris(2-phenyl pyridine) iridium)). PBD (2-(4-biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole) and TPD (N,N'diphenyl-N,N'-Bis (3-methylphenyl)-[1,1-biphenyl]-4,4'-diamine) are employed as an electron transport material and a hole transport material. And TPBi (2,2',2''-(1,3,5-phenylene) tris (1-phenyl-1H-benzimidazole)) is used as an hole blocking layer for proper hole and electron balance. With adding evaporated TPBi layer, the current efficiency was very improved. Among various parameters, we observed the property of OLED device by changing the thickness of hole transporting layer and solvent which can dissolve organic material. We could make small molecule OLED device with finding proper conditions.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 추계학술대회 초록집
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• pp.39.2-39.2
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• 2010

In this work we have investigated electrical and optical properties of interface for ITO/Si with shallow doped emitter. The ITO is prepared by DC magnetron sputter on p-type monocrystalline silicon substrate. As an experimental result, The transmittance at 640nm spectra is obtained an average transmittance over 85% in the visible range of the optical spectrum. The energy bandgap of ITO at oxygen flow from 0% to 4% obtained between 3.57eV and 3.68eV (ITO : 3.75eV). The energy bandgap of ITO is depending on the thickness, sturcture and doping concentration. Because the bandgap and position of absorption edge for degenerated semiconductor oxide are determined by two competing mechanism; i) bandgap narrowing due to electron-electron and electron-impurity effects on the valance and conduction bands (> 3.38eV), ii) bandgap widening by the Burstein-Moss effect, a blocking of the lowest states of the conduction band by excess electrons( < 4.15eV). The resistivity of ITO layer obtained about $6{\times}10^{-4}{\Omega}cm$ at 4% of oxygen flow. In case of decrease resistivity of ITO, the carrier concentration and carrier mobility of ITO film will be increased. The contact resistance of ITO/Si with shallow doped emitter was measured by the transmission line method(TLM). As an experimental result, the contact resistance was obtained $0.0705{\Omega}cm^2$ at 2% oxygen flow. It is formed ohmic-contact of interface ITO/Si substrate. The emitter series resistance of ITO/Si with shallow doped emitter was obtained $0.1821{\Omega}cm^2$. Therefore, As an PC1D simulation result, the fill factor of EWT solar cell obtained above 80%. The details will be presented in conference.