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http://dx.doi.org/10.5352/JLS.2009.19.4.514

Effects of Luteolin on IL-1β-Induced MCP1 Protein Expression  

Lim, Jun-Hee (Department of Immunology, School of Medicine, Keimyung University)
Kwon, Taeg-Kyu (Department of Immunology, School of Medicine, Keimyung University)
Publication Information
Journal of Life Science / v.19, no.4, 2009 , pp. 514-519 More about this Journal
Abstract
Monocyte chemoattractant protein 1 (MCP1) plays a key role in monocyte /macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined $interleukin-1{\bate}$ ($IL-1{\beta}$) induced MCP1 expressions via activation of transcription factor $NF-{\kappa}B$ in primary human aorta smooth muscle cells. We determined the effect of several anti-inflammatory agents on $IL-1{\beta}-induced$ MCP1 expression. The pretreatment of luteolin significantly suppressed $IL-1{\beta}-induced$ MCP1 expressions through blocking activation and translocation of $NF-{\kappa}B$ to the nucleus.
Keywords
Luteolin; monocyte chemoattractant protein 1 (MCP1); $interleukin-1{\beta}$ ($IL-1{\beta}$); nuclear $factor-{\kappa}B\; (NF-{\kappa}B)$;
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