• 대한수학회논문집
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• 제33권4호
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• pp.1285-1301
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• 2018

This paper is devoted to the study of $Tur{\acute{a}}n$-type inequalities for some well-known special functions such as Gauss hypergeometric functions, generalized complete elliptic integrals and confluent hypergeometric functions which are derived by using a new form of the Cauchy-Bunyakovsky-Schwarz inequality. We also apply these inequalities for some sample of interest such as incomplete beta function, incomplete gamma function, elliptic integrals and modified Bessel functions to obtain their corresponding $Tur{\acute{a}}n$-type inequalities.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2002년도 제25회 KOSCI SYMPOSIUM 논문집
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• pp.11-17
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• 2002

The first-order conditional moment closure (CMC) model is applied to $CH_4$/Air turbulent jet diffusion flames(Sandia Flame D, E and F). The flow and mixing fields are calculated by fast chemistry assumption and a beta function pdf for mixture fraction. Reacting scalar fields are calculated by elliptic CMC formulation. The results for Flame D show reasonable agreement with the measured conditional mean temperature and mass fractions of major species, although with discrepancy on the fuel rich side. The discrepancy tends to increase as the level of local extinction increases. Second-order CMC may be needed for better prediction of these near-extinction flames.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.156-157
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• 1998

Taurine is synthesized in the body or uptaken from dietary and is distributed in the various organs. It differs from other amino acids by virtue of the fact that a sulfonic acid group replaces the carboxyl group of what would be ${\beta}$-alanine. In order to function within the cell it must be transported into the cells by taurine transporter that is spanned 12 transmembrane domains. The human taurine transporter has long cytoplasmic carboxy and amino termini that may function as regulatory attachment sites for other proteins. Six potential protein kinase C(PKC) phosphorylation sites have been reported in human taurine transporter.

• Computational Structural Engineering : An International Journal
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• 제2권1호
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• pp.43-50
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• 2002

This paper presents a method to predict dynamic responses of floating bodies in the time domain. Because of the frequency-dependence of the radiation wave forces, the memory effect must be taken into account when the responses are evaluated in the time domain. Although the formulations firstly developed by Cummins (1962) have been well-known for this purpose, the effective numerical procedure has not been established yet. This study employs FFT (Fast Fourier Transform) algorithm to evaluate the memory effect function, and the equations of motion of an integro-differential type are solved by Newmark-β method. Numerical examples for a truncated circular cylinder have indicated the effectiveness of the proposed numerical procedure.

• Kyungpook Mathematical Journal
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• 제57권1호
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• pp.109-124
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• 2017

In this article the Srivastava-Owa-Ruscheweyh fractional derivative operator $\mathcal{L}^{\alpha}_{a,{\lambda}}$ is applied for defining and studying some new subclasses of analytic functions in the unit disk E. Inclusion results, radius problem and other results related to Bernardi integral operator are also discussed. Some applications related to conic domains are given.

• 대한수학회논문집
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• 제33권1호
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• pp.179-196
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• 2018

In this paper we extend the two q-additions with powers in the umbrae, define a q-multinomial-coefficient, which implies a vector version of the q-binomial theorem, and an arbitrary complex power of a JHC power series is shown to be equivalent to a special case of the first q-Lauricella function. We then present several q-analogues of hypergeometric integral formulas from the two books by Exton and the paper by Choi and Rathie. We also find multiple q-analogues of hypergeometric integral formulas from the recent paper by Kim. Finally, we prove several multiple q-hypergeometric integral formulas emanating from a paper by Koschmieder, which are special cases of more general formulas by Exton.

• 한국발생생물학회지:발생과생식
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• 제26권3호
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• pp.117-126
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• 2022

Bromodomain-containing protein 7 (BRD7) participates in many cellular processes and embryo development. BRD7 is down-regulated in various cancers and evidence of its tumor suppressor function has been accumulating. Here, we identified transforming stimulated clone 22 (TSC-22) as a novel BRD7 interacting protein and show its novel function as a positive regulator of BRD7. We found that TSC-22 expression potentiated the inactivation of the extracellular signal-regulate kinase (ERK) pathway by BRD7. Our data establishes TSC-22 as a modulator of BRD7 and unravels the molecular mechanisms that drive the synergistic tumor-suppressing effects of TSC-22 and BRD7. Our findings may open new avenues for developing novel molecular therapies for tumors exhibiting down-regulated BRD7 and/or TSC-22.

• Asian-Australasian Journal of Animal Sciences
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• 제23권3호
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• pp.292-301
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• 2010

Follicle-stimulating hormone (FSH) is a pituitary glycoprotein hormone that is encoded by separate alpha- and betasubunit genes. It plays a key role in stimulating and regulating ovarian follicular development and egg production in chicken. FSH signal transduction is mediated by the FSH receptor (FSHR) that exclusively interacts with the beta-subunit of FSH, but characterization of prokaryotic expression of the FSHb gene and its effect on the expression of the FSHR gene in local chickens have received very little attention. In the current study, the cDNA fragment of the FSHb gene from Dagu chicken was amplified using reverse transcription polymerase chain reaction (RT-PCR), and inserted into the pET-28a (+) vector to construct the pET-28a-FSHb plasmid. After expression of the plasmid in E. coli BL21 (DE3) under inducing conditions, the recombination protein, $FSH{\beta}$ subunit, was purified and injected into the experimental hens and the effect on the mRNA expression levels of the FSHR gene was investigated. Sequence comparison showed that the coding region of the FSHb gene in the local chicken shared 99%-100% homology to published nucleotides in chickens; only one synonymous nucleotide substitution was detected in the region. The encoded amino acids were completely identical with the reported sequence, which confirmed that the sequences of the chicken FSHb gene and the peptides of the $FSH{\beta}$ subunit are highly conserved. This may be due to the critical role of the normal function of the FSHb gene in hormonal specificity and regulation of reproduction. The results of gene expression revealed that a recombinant protein with a molecular weight of about 19 kDa was efficiently expressed and it was identified by Western blotting analysis. After administration of the purified $FSH{\beta}$ protein, significantly higher expression levels were demonstrated in uterus, ovary and oviduct samples (p<0.05). These observations suggested that the expressed $FSH{\beta}$ protein possesses biological activity, and has a potential role in regulation of reproductive physiology in chickens.

• 한국산림과학회지
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• 제106권4호
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• pp.480-486
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• 2017

본 연구는 국내 소나무, 잣나무, 낙엽송을 대상으로 입목의 총재적 중 상부직경 혹은 상부수고까지의 재적을 예측하는 이용재적모델을 개발하고자 수행되었다. 모델개발을 위하여 사용된 자료는 강원 및 경북지역의 소나무림, 잣나무림, 낙엽송림에서 수집한 총 131본의 수간석해목이었으며, 이용재적비율, 단순비율형태, 지수비율형태의 6개 이용재적식을 검토하여 최종모델을 개발하였다. 본 연구의 분석결과, 상부직경까지의 이용재적예측은 지수비율형태인 $V_d=V_t\{{\exp}[{\alpha}_1(d^{{\alpha}_2}/D^{{\alpha}_3})]\}$ 이 상부수고까지의 이용재적예측은 단순비율형태인 $V_h=V_t\{1+{\beta}_1(P^{{\beta}_2}/H^{{\beta}_3})\}$이 최종모델로 선정되었다. 본 연구에서 선정된 2개의 최적모델식을 정리하여 내재간곡선식을 도출하였으며, 이를 활용해 상부직경에 따른 상부수고와 상부수고에 따른 상부직경 예측이 가능하였다. 본 연구결과에서 개발된 모델은 높은 정확도뿐만 아니라 임업현장에서 편리하게 사용할 수 있어 활용도가 높을 것으로 판단된다.

• 미생물학회지
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• 제40권2호
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• pp.87-93
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• 2004

세포질과 핵단백질의 serine과 threonine 잔기에 O-linked N-acetyl-$\beta$-glucosamine (O-GlcNAc)의 첨가는고등 진핵 세포에서 흔히 일어나는 번역 후 단백질의 변형 중 하나로서 단백질의 인산화와 유사한 세포 내 신호전달에 관여하는 것으로 보인다. O-GlcNAc의 첨가와 제거는 O-GlcNAc transferase (OGT)와 O-linked N-acetyl-$\beta$-D-glucos-aminidase (O-GlcNAcase) 효소에 의해 각각 촉매된다. 두가지 종류의 사람 유래 O-GlcNAcase 유전자(O-GlcNAcase, v-O-GlcNAcase)를cloning하고 세 가지의 융합단백질로 대장균에서 생산을 시도하였다. O-GlcNAcase의 기질 유사체 인 ${\rho}$-nitrophenyl-N-acetyl-$\beta$-D-g1ucosaminide (${\rho}$NP-$\beta$-D-GlcNAc)를 기질로 사용하여 효소활성을 측정 한 결과 v-O-GlcNAcase는 활성을 나타내지 않았다. 여러 종류의 amino sugar 기질 유사체를 사용하여 O-GlcNAcase의 활성을 측정하였으나 오직 ${\rho}$NP-$\beta$-D-GlcNAc만이 활성을 보였다. Blast검색으로 분석한 결과 아미노 말단의 hyaluronidase-like domain (hyaluronidase-유사 영역)과 카르복시 말단의 N-acetyltransferase 영역 두 곳의 conserved domains 존재하였다. 효소촉매에 중요한 영역을 밝히기 위해 여러 deletion mutants(결손 변이체)를 제작한 후 효소활성을 측정하고 Western blot으로 분석하였다. Hyaluronidas-유사 영역, 유전자 내부와 N-acetyltransferase 영역을 제거할 경우 효소활성이 사라졌으나 아미노 말단의 55개 아미노산과 카르복시 말단의 truncation은 활성을 일부분 유지하였다. 위의 사실에 기초하여 hyaluronidas-유사 영역은 효소활성에 중요하고 카르복시 말단의 N-acetyltransferase 영역은 조절기능으로 작용하는 것으로 추정된다.