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http://dx.doi.org/10.12717/DR.2022.26.3.117

Transforming Stimulated Clone 22 (TSC-22) Interacts Directly with Bromodomain-Containing Protein 7 (BRD7) to Enhance the Inhibition of Extracellular Signal-Regulate Kinase (ERK) Pathway in Ovarian Cancer  

Lee, Seung-Hoon (Department of Life Science, YongIn University)
Choi, Donchan (Department of Life Science, YongIn University)
Publication Information
Development and Reproduction / v.26, no.3, 2022 , pp. 117-126 More about this Journal
Abstract
Bromodomain-containing protein 7 (BRD7) participates in many cellular processes and embryo development. BRD7 is down-regulated in various cancers and evidence of its tumor suppressor function has been accumulating. Here, we identified transforming stimulated clone 22 (TSC-22) as a novel BRD7 interacting protein and show its novel function as a positive regulator of BRD7. We found that TSC-22 expression potentiated the inactivation of the extracellular signal-regulate kinase (ERK) pathway by BRD7. Our data establishes TSC-22 as a modulator of BRD7 and unravels the molecular mechanisms that drive the synergistic tumor-suppressing effects of TSC-22 and BRD7. Our findings may open new avenues for developing novel molecular therapies for tumors exhibiting down-regulated BRD7 and/or TSC-22.
Keywords
Transforming growth factor-${\beta}$-stimulated clone-22; Bromodomain-containing protein 7; ERK pathway; Ovarian cancer;
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