• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.373-380
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• 2019

Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors $S1P_1$ and $S1P_2$ on cell motility have been investigated. However, the function of $S1P_3$ has been poorly investigated. In this study, the roles of $S1P_3$ on inflammatory response were investigated in primary peritoneal macrophages. $S1P_3$ receptor was induced along with sphingosine kinase 1 by stimulation of lipopolysaccharide (LPS). LPS treatment induced inflammatory genes, such iNOS, COX-2, $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$. TY52156, an antagonist of $S1P_3$ suppressed the induction of inflammatory genes in a concentration dependent manner. Suppression of iNOS and COX-2 induction was further confirmed by western blotting and NO measurement. Suppression of $IL-1{\beta}$ induction was also confirmed by western blotting and ELISA. Caspase 1, which is responsible for $IL-1{\beta}$ production, was similarly induced by LPS and suppressed by TY52156. Therefore, we have shown $S1P_3$ induction in the inflammatory conditions and its pro-inflammatory roles. Targeting $S1P_3$ might be a strategy for regulating inflammatory diseases.

• Physical Therapy Rehabilitation Science
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• v.11 no.3
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• pp.296-303
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• 2022

Objective: In general, macular degeneration, cataracts and glaucoma generally cause visual injury in clinical settings. This study aimed to examine the effects of low visual acuity simulations on hand manual dexterity function and brainwaves in healthy young adults. Design: Cross-sectional study design Methods: This study was an observational, cross-sectional study. Seventy healthy young adults participated in this study. To evaluate the effects of low visual acuity simulations on hand function and brain waves, this study involved four different visual conditions including (1) normal vision, (2) simulated cataracts, (3) simulated glaucoma, and (4) simulated macular degeneration. The hand function was measured to use the Minnesota manual dexterity test (MMDT), and the brainwaves was also measured to use the electroencephalography. Results: In hand function, placing and turning performance on the MMDT in the normal visual condition was significantly different than that in the cataract and macular degeneration conditions (p<0.05), and the placing performance was significantly differred in the normal condition than that in the simulated glaucoma. However, turning was not significantly different in the normal condition than that in the simulated glaucoma. The alpha, beta, and gamma waves did not significantly differ among the four visual conditions (p>0.05). Conclusions: The results suggest that limited visual information negatively affects the ability to perform tasks requiring arm-hand dexterity and eye-hand coordination. However, the effectiveness of low visual acuity on the brainwaves should be further studied for rehabilitative evidence of visual impairment.

• The Korean Journal of Applied Statistics
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• v.29 no.3
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• pp.425-435
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• 2016

In this paper, we analyze the inverse statistics of rainfall for 12 regions from 1973 to 2014. We obtain a probability density function f(x) of daily rainfall x, and $f({\tau}_{\rho})$ of the first passage time ${\tau}_{\rho}$ for a given ${\rho}$. Lastly, we derive the relation between ${\rho}$ and ${\tau}_{mean}({\rho})$, i.e., the averaged value of ${\tau}_{\rho}$. The analyses result in the x and ${\tau}_{\rho}$ have stretched exponential distributions. Also, ${\tau}_{mean}({\rho})$ has the form of a stretched exponential function. We derive the shape parameter ${\beta}$ of the distribution, and analyze the characteristics of 12 regional rainfalls.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.6
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• pp.367-373
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• 2017

This study was performed using histochemical and immunohistochemical methods to investigate the effect of Gami-Shinkiwhan(GS) on reproductive function of male aged mice. 8-weeks-old ICR mice were used as control group, without any treatment, and 15-month-old ICR mice were used as aging elicited group(AE) and Gami-Shinkiwhan treatment group(GS). AE group didn't restrict diets and drinking for 6 months without any treatment. GS was administered 0.56g/kg/day for 6 months. Compared with AE group, the cell division of sertoli cells, spermatids, and spermatogonial cells was increased and the apoptosis of sertoli cells was decreased on GS group. Androgen receptor positive reaction and $17{\beta}$-HSD positive reaction were significantly increased in the GS group compared to AE group. In addition, the DJ-1 positive reaction was significantly increased and the HDAC3 positive response was significantly decreased in the GS group compared with AE group. Based on the above results, GS prevented the apoptosis of sertoli cells in the tubules, and increased the production of sertoli cells, spermatozoa and testosterone. Based on this, it is thought that it improves male reproductive dysfunction caused by late-onset hypogonadism.

• Journal of Korean Society of Forest Science
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• v.88 no.3
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• pp.320-326
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• 1999

In this study, 15 survival functions in integral and difference forms for forest plantation were derived based on assumptions for the number of surviving trees and the differential forms of the mortality rate model. Then, performance of the models was evaluated by fitting to remeasurement data of unthinned white pine(Pinus strobes) forest plantation. As a result, three equations associated with a power function of age, $t^{\beta}$, are somewhat more suitable for describing the effect of self-thinning over time. On the other hand, a general survival function for Japanese larch(Larix leptolepts) forest plantation was derived in order to exam the effect of site quality on self-thinning procedures. The results indicate that the $N_{min}$ is negatively correlated with site index and, even though the same initial stand density was assumed, the survival function curves differ in shapes associated with site index values.

• The Journal of the Convergence on Culture Technology
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• v.5 no.2
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• pp.397-404
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• 2019

This study was carried out to investigate the heat-treated broccoli extraction which have a beneficial effect on the human body and which can be used safely for a long period of time without adverse side effects and also have excellent effects of protecting liver and improving liver function. The heat-treated broccoli extract does not show cytotoxicity, and thus can be used safely. In an experiment performed on an animal model with liver injury induced by a drug (APAP), it could be seen that the heat-treated cabbage extract exhibited the effects of protecting liver and improving liver function by effectively reducing AST and ALT which are liver injury markers, indicating that the heat-treated brocoli extract is effective as a pharmaceutical extraction for preventing or treating liver disease. In particular, the heat-treated broccoli extract was effective in treating inflammation of the liver by reducing the expression of the inflammatory mediators iNOS and COX-2 and the proinflammatory cytokine $IL-1{\beta}$, which are involved in acute inflammatory reactions accompanying liver injury.

• East Asian mathematical journal
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• v.16 no.1
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• pp.61-69
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• 2000

We show that the intersection of two standard torus knots of type (${\lambda}_1$, ${\lambda}_2$) and (${\beta}_1$, ${\beta}_2$) induces an automorphism of the cyclic group ${\mathbb{Z}}_d$, where d is the intersection number of the two torus knots and give an elementary proof of the fact that all non-trivial torus knots are strongly invertiable knots. We also show that the intersection of two standard knots on the 3-torus $S^1{\times}S^1{\times}S^1$ induces an isomorphism of cyclic groups.

• Journal of the Chungcheong Mathematical Society
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• v.26 no.4
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• pp.757-767
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• 2013

We investigate the general solution of the following functional equation and the generalized Hyers-Ulam-Rassias stability problem in quasi ${\beta}$-normed spaces and then the stability by using alternative fixed point method for the following quintic function $f:X{\rightarrow}Y$ such that f(3x+y)+f(3x-y)+5[f(x+y)+f(x-y)]=4[f(2x+y)+f(2x-y)]+2f(3x)-246f(x), for all $x,y{\in}X$.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2287-2290
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• 2003

The electrical characteristics of power devices such as BJT (Bipolar Junction Transistor), and MOSFET (Metal Oxide Field Effect Transistor), etc, are altered due to impinging photon radiation and temperature in the nuclear or the space environment. In this paper, BJT and MOSFET are the two devices subjected to ${\gamma}$ radiation. In the case of BJT, the current gain (${\beta}$) and the collector to Emiter breakdown voltage ($V_{CEO}$) are the two main parameters considered. When it was subjected to ${\gamma}$ rays, the ${\beta}$ decreases as the dose level increases, whereas, $V_{CEO}$ gradually increases as the dose level increases. In the case of MOSFET, the threshold voltage is decreasing as the dose level increases. Here it has been observed the decent rate is an increasing function of the threshold voltage. The on-resistance does not change with respect to the dose. Both the devices recover back the original specification after the annealing is finished. No permanent damage has been occurred.

• Nuclear Engineering and Technology
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• v.49 no.7
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• pp.1483-1488
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• 2017

In order to predict and control the environmental and health impacts of ionizing radiation in environmental sources such as groundwater, it is necessary to identify the radionuclides present. Beta-emitting radionuclides are frequently identified by measuring their characteristic energy spectra. The present work shows that self-attenuation effects from volume sources result in a geometry-dependent shift in the characteristic spectra, which needs to be taken into account in order to correctly identify the radionuclides present. These effects are shown to be compounded due to the subsequent shift in the photon spectra produced by the detector, in this case an inorganic solid scintillator ($CaF_2:Eu$) monitored using a silicon photomultiplier. Using tritiated water as an environmentally relevant, and notoriously difficult to monitor case study, analytical predictions for the shift in the energy spectra as a function of depth of source have been derived. These predictions have been validated using Geant4 simulations and experimental results measured using bespoke instrumentation.