• International Journal of Industrial Entomology and Biomaterials
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• v.1 no.2
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• pp.115-122
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• 2000

A Bacillus thuringiensis designated NT0423, belonging to B. thuringiensis subsp. aizawai (H 7), was isolated from samples of dust and soil of sericultural farms. B. thuringiensis NT0423 having dualspecificity against Lepidoptera and Diptera produced bipyramidal inclusions consisting of two major polypeptides of approximately 130- and 70-kDa. Proteolytic processing by trypsin and gut juice of Bombyx mori yielded predominant proteins with molecular masses of about 66-kDa. The whole crystal protein of B. thuringiensis NT0423 immunologically was related to that of B. thuringiensis subsp. aizawai. PCR analysis showed that B. thuringiensis NT0423 has at least five crystal protein genes including cryIA(a), cryIA(b), cryIC, cryID and cryIIA, and southern blot was determined the location of each gene on intact and enzyme-digested plasmid DNA fragments. Except for cryIA(a) gene on the high molecular weight plasmid of 165-kb, all of four genes were located on the plasmid of 66-kb. The production of $\beta$-exotoxin from B. thuringiensis NT0423 was identified by the HPLC analysis. In addition, the $\beta$-exotoxin showed its ability to prevent pupation of treated larvae of house flies (Musca domestica) from developing into normal adults.

• IMMUNE NETWORK
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• v.11 no.1
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• pp.59-67
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• 2011

Background: Insulin resistance is an integral feature of metabolic syndromes, including obesity, hyperglycemia, and hyperlipidemia. In this study, we evaluated whether the aloe component could reduce obesity-induced inflammation and the occurrence of metabolic disorders such as blood glucose and insulin resistance. Methods: Male C57BL/6 obese mice fed a high-fat diet for 54 days received a supplement of aloe formula (PAG, ALS, Aloe QDM, and Aloe QDM complex) or pioglitazone (PGZ) and were compared with unsupplemented controls (high-fat diet; HFD) or mice fed a regular diet (RD). RT-PCR and western blot analysis were used to quantify the expression of obesity-induced inflammation. Results: Aloe QDM lowered fasting blood glucose and plasma insulin compared with HFD. Obesity-induced inflammatory cytokine (IL-$1{\beta}$, -6, -12, TNF-${\alpha}$) and chemokine (CX3CL1, CCL5) mRNA and protein were decreased markedly, as was macrophage infiltration and hepatic triglycerides by Aloe QDM. At the same time, Aloe QDM decreased the mRNA and protein of $PPAR{\gamma}/LXR{\alpha}$ and $11{\beta}$-HSD1 both in the liver and WAT. Conclusion: Dietary aloe formula reduces obesity-induced glucose tolerance not only by suppressing inflammatory responses but also by inducing anti-inflammatory cytokines in the WAT and liver, both of which are important peripheral tissues affecting insulin resistance. The effect of Aloe QDM complex in the WAT and liver are related to its dual action on $PPAR{\gamma}$ and $11{\beta}$-HSD1 ression and its use as a nutritional intervention against T2D and obesity-related inflammation is suggested.

• Journal of the Korean Electrochemical Society
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• v.25 no.4
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• pp.191-200
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• 2022

Na-β"-Al₂O₃ has been widely employed as a solid electrolyte for high-temperature sodium (Na) beta-alumina batteries (NBBs) thanks to its superb thermal stability and high ionic conductivity. Recently, a vapor phase conversion (VPC) method has been newly introduced to fabricate thin Na-β"-Al₂O₃ electrolytes by converting α-Al₂O₃ into β"-Al₂O₃ in α-Al₂O₃/yttria-stabilized zirconia (YSZ) composites under Na⁺ and O^2- dual percolation environments. One of the main challenges that need to be figured out is lowered conductivity due to the large volume fraction of the non-Na⁺-conducting YSZ. In this study, the effect of lithia addition in the β"-Al₂O₃ phase on the grain size and ionic conductivity of Na-β"-Al₂O₃/YSZ solid electrolytes have been investigated in order to enhance the conductivity of the electrolyte. The amount of pre-added lithia (Li₂O) precursor as a phase stabilizer was varied at 0, 1, 2, 3, and 4 mol% against that of Al₂O₃. It turns out that ionic conductivity increases even with 1 mol% lithia addition and reaches 67 mS cm^-1 at 350 ℃ of its maximum with 3 mol%, which is two times higher than that of the undoped composite.

• Journal of the Korean Mathematical Society
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• v.45 no.3
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• pp.859-870
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• 2008

In the present paper, we investigate the geometric structures of the Dirichlet manifold composed of the Dirichlet distribution. We show that the Dirichlet distribution is an exponential family distribution. We consider its dual structures and give its geometric metrics, and obtain the geometric structures of the lower dimension cases of the Dirichlet manifold. In particularly, the Beta distribution is a 2-dimensional Dirich-let distribution. Also, we construct an affine immersion of the Dirichlet manifold. At last, we give the e-flat hierarchical structures and the orthogonal foliations of the Dirichlet manifold. All these work will enrich the theoretical work of the Dirichlet distribution and will be great help for its further applications.

• Kyungpook Mathematical Journal
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• v.48 no.4
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• pp.559-575
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• 2008

A commutative hypercomplex system $L_1$(Q,m) is, roughly speaking, a space which is defined by a structure measure (c(A,B, r), (A,$B{\in}{\beta}$(Q)). Such space has bee studied by Berezanskii and Krein. Our main purpose is to establish a generalization of convolution semigroups and to discuss the role of the L$\'{e}$vy measure in the L$\'{e}$vy-Khinchin representation in terms of continuous negative definite functions on the dual hypercomplex system.

• Animal cells and systems
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• v.12 no.3
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• pp.127-136
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• 2008

Caspase-11 has been known as a dual regulator of cytokine maturation and apoptosis. Although the role of caspase-11 under pathological conditions has been well documented, its physiological role has not been studied much. In the present study, we investigated a possible physiological function of caspase-11 during immune response. In the absence of caspase-11, immunized spleen displayed increased cellularity and abnormal germinal center structure with disrupted microarchitecture. The rate of cell proliferation and apoptosis in the immunized spleen was not changed in the caspase-11-deficient mice. Furthermore, the caspase-11-deficient peritoneal macrophages showed normal phagocytotic activity. However, caspase-11-/-splenocytes and macrophages showed defective migrating capacity. The dysregulation of cell migration did not seem to be mediated by caspase-3, interleukin-$1{\alpha}$ or interleukin-$1{\beta}$ which acts downstream of caspase-11. These results suggest that a direct regulation of immune cell migration by caspase-11 is critical for the formation of germinal center microarchitecture during immune response. However, humoral immunity in the caspase-11-deficient mice was normal, suggesting the formation of germinal center structure is not essential for the affinity maturation of the antibodies.

• Kyungpook Mathematical Journal
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• v.56 no.3
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• pp.793-806
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• 2016

G-vector-valued sequence space frames and g-Banach frames for Banach spaces are introduced and studied in this paper. Also, the concepts of duality mapping and ${\beta}$-dual of a BK-space are used to define frame mapping and synthesis operator of these frames, respectively. Finally, some results regarding the existence of g-vector-valued sequence space frames and g-Banach frames are obtained. In particular, it is proved that if X is a separable Banach space and Y is a Banach space with a Schauder basis, then there exist a Y-valued sequence space $Y_v$ and a g-Banach frame for X with respect to Y and $Y_v$.

• Journal of the Chungcheong Mathematical Society
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• v.24 no.2
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• pp.247-252
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• 2011

We study some properties of the Riemann-Stieltjes integrals with respect to the Riesz-$N\acute{a}gy$-$Tak\acute{a}cs$ distribution $H_{a,p}$ and its inverse $H_{p,a}$ on the unit interval satisfying the equation 1 - a = $a^2$ and p = 1 - a. Using the properties of the dual distributions $H_{a,p}$ and $H_{p,a}$, we compare the Riemann-Stieltjes integrals of $H_{a,p}$ over some essential intervals with that of its inverse $H_{p,a}$ over the related intervals.

• Steel and Composite Structures
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• v.30 no.6
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• pp.577-589
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• 2019

In this study, on-site testing was carried out to investigate the vibration performance of a composite steel-bar truss slab with steel girder system. Ambient vibration was performed to capture the primary vibration parameters (natural frequencies, damping ratios, and mode shapes). The composite floor possesses low frequency (< 10 Hz) and damping (< 2%). Based on experimental, theoretical, and numerical analyses on natural frequencies and mode shapes, the boundary condition of SCSC (i.e., two opposite edges simply-supported and the other two edges clamped) is deemed more reasonable for the composite floor. Walking excitations by one person (single excitation), two persons (dual excitation), and three persons (triple excitation) were considered to evaluate the vibration serviceability of the composite floor. The measured acceleration results show a satisfactory vibration perceptibility. For design convenience and safety, a crest factor ${\beta}_{rp}$ describing the ratio of peak acceleration to root-mean-square acceleration induced from the walking excitations is proposed. The comparisons of the modal parameters determined by ambient vibration and walking tests reveal the interaction effect between the human excitation and the composite floor.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.