• Biomolecules & Therapeutics
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• 제20권5호
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• pp.433-445
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• 2012

During the course of evolution, animals encountered the harmful effects of fungi, which are strong pathogens. Therefore, they have developed powerful mechanisms to protect themselves against these fungal invaders. ${\beta}$-Glucans are glucose polymers of a linear ${\beta}$(1,3)-glucan backbone with ${\beta}$(1,6)-linked side chains. The immunostimulatory and antitumor activities of ${\beta}$-glucans have been reported; however, their mechanisms have only begun to be elucidated. Fungal and particulate ${\beta}$-glucans, despite their large size, can be taken up by the M cells of Peyer's patches, and interact with macrophages or dendritic cells (DCs) and activate systemic immune responses to overcome the fungal infection. The sampled ${\beta}$-glucans function as pathogen-associated molecular patterns (PAMPs) and are recognized by pattern recognition receptors (PRRs) on innate immune cells. Dectin-1 receptor systems have been incorporated as the PRRs of ${\beta}$-glucans in the innate immune cells of higher animal systems, which function on the front line against fungal infection, and have been exploited in cancer treatments to enhance systemic immune function. Dectin-1 on macrophages and DCs performs dual functions: internalization of ${\beta}$-glucan-containing particles and transmittance of its signals into the nucleus. This review will depict in detail how the physicochemical nature of ${\beta}$-glucan contributes to its immunostimulating effect in hosts and the potential uses of ${\beta}$-glucan by elucidating the dectin-1 signal transduction pathway. The elucidation of ${\beta}$-glucan and its signaling pathway will undoubtedly open a new research area on its potential therapeutic applications, including as immunostimulants for antifungal and anti-cancer regimens.

• 대한간호학회지
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• 제23권4호
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• pp.678-693
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• 1993

The purposes of this study were to describe the level of vision and hearing impairments, depression and functional capacity, among Korean institutionalized elderly and to examine the relation-ship between sensory impairments, depression, and functional capacity in these people. The final pupose was to test the cognitive function path model using sensory competencies as predictors. A convenience sample of thirty nine male and 90 female subjects with a mean age of 80.5 were the subjects of this study. The subjects were tested for cognitive function, and vision and hearing impairments. Physical function and social function were measured by observation of designated task performance by the subjects. Their level of de-pression was measured using a Geriatric Depression Scale administered through an interview. Individual subjective ratings of hearing and vision were marked by the subjects, on a ladder scale. The results of the study showed that 48.8% of the subjects had a hearing impairment, 63.5% had a vision impairement, and 36.4% had both a vision and hearing impairement. The four sensory groups (no sensory impairement, hearing impairement, vision impairement, hearing and vision impairement) were tested for differences in depression, physical function, social behavior and cognitive function. The only significant difference that was found was in cognitive function, between the no sensory impairement group and the hearing and vision impairement group(F=3.25, P<.05), Subjective ratings of hearing showed a significant correlation with cognitive function(r=.34, p<.001) and with social behavior(r=.31, p<.001). There was no correlation between subjective vision ratings and cognitive function or social behavior. However there was a significant correlation between vision and hearing(r=.49, p<.001). There was also a significant negative correlation between age and vision(r=-.21, p<.01) and between age and hear-ing(r=-.34, p<.001). There was a significant correlation between depression and physical function (r=-.32, p<.001) but there was no correlation between depression and cognitive function or social behavior. Based on the literature review and the result, this study, a path model of sensory competence-> cognitive function- >social behavior was developed and tested : Perceived vision and perceived hearing were the exogenous variahles and cognitive function and social behavior were the endogeneous variables in the model. The path analysis result demonstrated an accept-able fit (GFI=.997, AGFI=.972, X$^2$=.72 (p=.396), RMSR=.019) between the data and the model. There was a significant direct effect($\beta$=.38) of perceived hearing on cognitive function. There was a significant direct effect ($\beta$=.32) of cognitive function on social behavior. The total effect of hearing on social behavior was $\beta$=.32 including the indirect effect ($\beta$=.12) . However perceived vsion had little effect ($\beta$=-.08) on cognitive function. The result of path analysis confirms that hearing levels influence cognitive function, and both hearing and cognitive function levels influence social behavior. However, vision has little effect on cognitive function or on social behavior. For the next study, a combined model of the pre viously developed environment - >depression- > physical and social function model, and the present cognitive function model, should be tested to further refine the functional capacity model. There also a need for longitudinal study of functional capacity and sencory competence in order to better understand how declining sensory competence influences functional capacity and how it effects in-creasing dependency and nursing needs in the elderly.

• 디지털융복합연구
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• 제13권8호
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• pp.401-408
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• 2015

본 연구의 목적은 인지기능, 우울, 불안의 관계를 파악하고, 노인의 인지기능과 우울이 불안에 미치는 영향을 파악하고자 함이다. 자료수집은 2014년 6월 1일 부터 8월 30일까지였고, 연구대상은 65세 이상 노인 363명이었으며 연구도구는 MMSE-DS, 우울, 불안이었다. 자료분석은 SPSS/WIN 18.0 프로그램을 이용하여 기술통계, t-test, ANOVA, Pearson's correlation 상관분석, 다중회귀분석을 실시하였다. 연구결과로 불안에 영향을 미치는 요인은 수면시간(${\beta}=-.249$, p<.001), 우울(${\beta}=.218$, p<.001), 인지기능(${\beta}=-.209$, p<.001), 직업(${\beta}=-.133$, p=.006) 순이었다. 결론적으로, 적절한 수면유지와 인지기능 저하를 예방하고, 우울수준을 낮출 수 있는 융복합적인 프로그램을 개발하는 것이 필요할 것이다.

• 한국컴퓨터정보학회논문지
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• 제16권10호
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• pp.101-109
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• 2011

리만의 제타함수 $\zeta(s)$는 주어진 수 x보다 작은 소수의 개수 $\pi$(x)를 구하는 해답으로 알려져 있으며, 소수정리에서 지금까지 리만의 제타 함수 이외에 $\frac{x}{lnx}$,Li(x)와 R(x)의 근사치 함수가 제안되었다. 여기서 $\pi$(x)와의 오차는 R(x) < Li(x) < $\frac{x}{lnx}$이다. 로그적분함수 Li(x) = $\int_{2}^{x}\frac{1}{lnt}dt$, ~ $\frac{x}{lnx}\sum\limits_{k=0}^{\infty}\frac{k!}{(lnx)^k}=\frac{x}{lnx}(1+\frac{1!}{(lnx)^1}+\frac{2!}{(lnx)^2}+\cdots)$ 이다. 본 논문은 $\pi$(x)는 유한급수��Li(x)로 표현됨을 보이며, 일반화된 $\sqrt{ax}{\pm}{\beta}$의 소수계량함수를 제안한다. 첫 번째로, $\pi$(x)는 $0{\leq}t{\leq}2k$의 유한급수인 $Li_3(x)=\frac{x}{lnx}(\sum\limits_{t=0}^{{\alpha}}\frac{k!}{(lnx)^k}{\pm}{\beta})$와 $Li_4(x)=\lfloor\frac{x}{lnx}(1+{\alpha}\frac{k!}{(lnx)^k}{\pm}{\beta})\rfloor$, $k\geq2$ 함수로 표현됨을 보였다. $Li_3$(x)는 $\pi(x){\simeq}Li_3(x)$가 되도록 ${\alpha}$ 값을 구하고 오차를 보정하는 ${\beta}$ 값을 갖도록 조정하였다. 이 결과 $x=10^k$에 대해 $Li_3(x)=Li_4(x)=\pi(x)$를 얻었다. 일반화된 함수로 $\pi(x)=\sqrt{{\alpha}x}{\pm}{\beta}$를 제안하였다. 제안된 $\pi(x)=\sqrt{{\alpha}x}{\pm}{\beta}$ 함수는 리만의 제타함수에 비해 소수를 월등히 계량할 수 있었다.

• 대한예방한의학회지
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• 제4권2호
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• pp.214-234
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• 2000

This study was carried to identify whether acupuncture of several acupuncture points can affect the brain and to observe which aspects appear in EEG mapping, using electroencephalography. Those results are as follows ; 1. The pattern of resting computerized EEG map in intact human is appered normal 2. Each Acupuncture in Kwan Weon or Jog Sam Ri meridian points bring about the increase in $\theta,\;\alpha-wave$ activity and at various area of the cerebrium and the decrease in $\delta,\;\beta-wave$ activity. It strands to reason that brain function is elevated On the other hand , synchronous acupuncture bring about the decrease of brain function in view of the decrease of $\delta,\;\theta-wave$ activity at frontal area, and the unstable brain state in view of the increase of $\beta-wave$ activity. 3. Acupuncture in Hyeon Jong meridian point bring about the increase of $\delta,\;\theta-wave$ activity at frontal area and $\beta-wave$ activity at temporal area. From these we deduce that brain function is declined and brain is unstable. Synchronous acupuncture with other meridian points reversly showed that brain function is elevated. 4. Synchronous acupuncture in Kwan Weon , Jog Sam Ri, Hyeon Jong bring about the decrease of the brain function and the unstable brain state, showing the pattern of increased $\delta,\;\theta-wave$ activity at frontal, parietal area, and increased $\beta-wave$ activity at temporal area.

• 여성건강간호학회지
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• 제25권1호
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• pp.73-85
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• 2019

Purpose: To determine whether maternal attitude toward sex during pregnancy and health-related quality of life could influence sexual function of pregnant women. Methods: In this study, 138 second and third trimester pregnant women completed self-report questionnaires during their visits to women's hospitals or community health centers to assess their general characteristics, attitude toward sex during pregnancy (PIES-M), health-related quality of life (EQ-5D), and sexual function (FSFI-6K). Multiple regression analysis was performed to test the research model with SPSS version 23. Results: Pregnant women who had discontinued their sexual life after recognizing their pregnancy accounted for 27.5% of women questioned. The average sexual function score of pregnant women was higher in the second trimester than the third trimester. Attitude toward sex during pregnancy (${\beta}=-.38$, p<.001), maintaining sexual life (${\beta}=.20$, p=.028), health-related quality of life (${\beta}=.18$, p=.030), and adverse symptoms during sex (${\beta}=.18$, p=.042) were determinants of sexual function during pregnancy. Conclusion: Nurses in antenatal care units need to help pregnant women maintain a positive attitude toward sexual activity during pregnancy and manage their health-related quality of life to maintain their sexual life during pregnancy.

• 디지털융복합연구
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• 제16권12호
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• pp.417-425
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• 2018

본 연구의 목적은 뇌졸중 환자의 상지기능, 일상생활활동, 치료적 몰입과 삶의 질 간의 상관관계를 알아보고, 삶의 질에 영향을 미치는 요인을 파악하기 위함이다. 총 13개 병원에서 입원중인 뇌졸중 환자 249명을 대상으로 상지기능, 일상생활활동, 치료적 몰입과 삶의 질을 치료사와 연구자가 평가하였다. 그 결과, 뇌졸중 환자의 상지기능(r=.312, p<.001), 일상생활활동(r=.605, p<.001), 치료적 몰입(r=.525, p<.001)이 양의 상관관계를 나타내었다. 그리고 뇌졸중 환자의 삶의 질에 영향을 미치는 요인을 분석한 결과, 치료적 몰입(${\beta}=.344$, p<.001), 일상생활활동(${\beta}=.293$, p<.001), 발병기간(${\beta}=.145$, p<.05)은 뇌졸중 환자의 삶의 질에 유의한 영향을 미치는 변수로 확인되었으며, 이들 요인은 삶의 질을 35.9% 설명하는 것으로 나타났다(F=35.736, p<.001). 이를 통하여 치료적 몰입은 삶의 질에 영향을 미치는 중요한 요인임을 확인할 수 있었으며, 향후 치료적 몰입에 대한 계속적인 연구가 요구된다.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1984년도 추계학술발표회 논문집
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• pp.100-106
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• 1984

Traditional methods for estimating the location of underwater target, i.e. the triangulation method and the wavefront curvature method, have been utilized. The location of a target is defined by the range and the bearing, which estimates can be obtained by evaluating the time delay between neighboring sensors. Many components of error occur in estimating the target range, among which the error due to the fluctuation of heading angle is outstanding. In this paper, the wavefront curvature method was used. We considered the error due to the heading fluctuation as the $\beta$-density process, from which we analized the range estimates with $\beta$-density function exist in some finite limits, and its mean value and variation are depicted as a function of true range and heading fluctuation. Given heading angles and sensor separation, maximum estimated heading errors are presented as a function of true range.

• Korean Journal of Mathematics
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• 제29권4호
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• pp.715-723
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• 2021

In this paper we wish to introduce the concept of generalized relative index-pair (𝛼, 𝛽) of a p-adic entire function with respect to another p-adic entire function and then prove some results relating to the growth rates of composition of two p-adic entire functions with their corresponding left and right factors.

• Journal of Mechanical Science and Technology
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• 제16권1호
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• pp.60-74
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• 2002

In this study, normal, log-normal, triangular, uniform. Weibull, Erlang and unit beta probability density functions are tried to represent the behaviour of frequency distributions of workpiece dimensions collected from various manufacturing firms. Among the distribution functions, the unit beta distribution function is found to be the best fit using the chi-square test of fit. An attempt is made for the adoption of the unit beta model to x-bar charts of quality control in manufacturing. In this direction, upper and lower control limits (UCL and LCL) of x-bar control charts of dimension measurements are estimated for the beta model, and the observed differences between the beta and normal model control limits are discussed for the measurement sets.