• The Journal of Internal Korean Medicine
• /
• v.35 no.4
• /
• pp.519-531
• /
• 2014

Objectives: Diabetic nephropathy is the most common cause of end stage renal disease. Transforming growth factor (TGF)-${\beta}1$, type IV collagen, advanced glycation end-products (AGEs), and angiotensin II type 1 receptor (AT1) are the main factors of diabetic nephropathy. We investigated the effects of Prunus on renal function and histopathological changes of diabetic nephropathy rat model induced by unilateral nephrectomy and streptozotocin. Methods: Diabetes was induced in male Sprague-Dawley rats ($290{\pm}10g$) by injecting streptozotocin (55 mg/kg) into the tail vein after unilateral nephrectomy. Rats were divided into 3 groups (n=6): normal, control, and Prunus. After 8 weeks of oral administration of Prunus extract on the Prunus group from 3 days after streptozotocin injection, we checked weight, 24 hrs urine, blood biochemistry and renal tissue to evaluate renal function and histopathological changes by examining parameters including albuminuria, BUN, creatinine, cholesterol, low density lipoprotein (LDL), triglyceride, TGF-${\beta}1$, type IV collagen, AGEs, and AT1. We also measured mRNA expression of TGF-${\beta}1$, type IV collagen, AGEs, and AT1 by Real Time polymerase chain reaction (RT-PCR). Results: Prunus decreased the amount of 24 hrs proteinuria, and inhibited histopathological changes of diabetic nephropathy including the expression and accumulation of TGF-${\beta}1$, type IV collagen and AGEs which could promote development of diabetic nephropathy. Prunus also inhibited mRNA expression of TGF-${\beta}1$, type IV collagen. Conclusions: These findings suggest that Prunus might protect the renal function and inhibit the development of renal injury by regulating factors including TGF-${\beta}1$, type IV collagen, AGEs, except AT1, so Prunus can be used for diabetic patients to prevent the progression of diabetic nephropathy.

• The Journal of the Korea Contents Association
• /
• v.17 no.9
• /
• pp.426-436
• /
• 2017

The purpose of this study was to analyze factors affecting malnutritional status of elders with dementia in facilities. The subjects were 140 elders with dementia residing in three nursing facilities in Chungnam, South Korea. Data were collected from May 30 to September 30 in 2016, using questionnaires. The collected data were tested by t-test, ANOVA, correlation, regression analysis. The malnutritional status of elders with dementia in facilities was high in the high-risk group (84, 60.0%), and the nutritional status was appeared to be related to sex, long-term care grade, Korean version-Activities of Daily Living and feeding difficulty and cognitive function. As a result of multiple regression analysis, significant influence variables on malnutritional status were Activities of Daily Living(${\beta}=0.379$, p=.001), feeding difficulty(${\beta}=0.264$, p=.001), cognitive function(${\beta}=-0.187$, p=.014) and these variables showed an explanatory power of 35.9% on malnutritional status. The results of this study are expected to be used as basic data for the development of malnutritional status improvement program for elders in facilities with dementia.

• Proceedings of the Korean Biophysical Society Conference
• /
• 2002.06b
• /
• pp.32-32
• /
• 2002

To understand the functional roles of the neuron-specific $\beta$-subunit of large-conductance calcium-activated potassium ($BK_{Ca}$) channel, we isolate the full-length complementary DNA of $\beta$4-subunit from rat brain library and investigated its effects on the function of $\alpha$-subunit (Slo). The deduced amino acid sequence of rat $\beta$4 (r$\beta$4), 210 amino acids in length, was closely related to those of $\beta$4 subunits in other mammalian species but showed only a limited sequence homology to the other $\beta$-subunits, $\beta$1 to $\beta$3.(omitted)d)

• Journal of Korean Academy of Nursing
• /
• v.45 no.5
• /
• pp.733-741
• /
• 2015

Purpose: This study was a descriptive survey research to identify the impact of bowel function, anxiety and depression on quality of life in patients with rectal cancer who had a sphincter-preserving resection. Methods: Participants were 100 patients who had rectal cancer surgery at W hospital in Korea. Bowel function, anxiety & depression, and quality of life were measured using the BFI (Bowel Function Instrument), HADS (Hospital Anxiety-Depression Scale) and the FACT-C (Functional Assessment of Cancer Therapy-Colorectal). Results: The mean scores were $39.81{\pm}5.16$ for bowel function, $6.15{\pm}3.25$ for anxiety, $7.24{\pm}3.13$ for depression, and $72.50{\pm}13.27$ for quality of life. There were significant negative correlations between quality of life and anxiety (r= -.59, p <.001) and between quality of life and depression (r= -.53, p <.001). But the correlation between quality of life and bowel function was significantly positive (r=.22, p =.025). The influence of the independent variables on the total quality of life was examined using multiple regression analysis. Anxiety (${\beta}$= -.38, p =.002), bowel function (${\beta}$= -.25, p =.028) and occupation (${\beta}$=.16, p =.048) were identified as factors affecting quality of life. The explanation power of this regression model was 44% and it was statistically significant (F=16.53, p <.001). Conclusion: The results of this study indicate that in order to improve the bowel function of patients after sphincter-preserving resection for rectal cancer, effective nursing interventions should be developed. As psychological problem such as anxiety and depression can relate to quality of life for these patients, nurses should work on improving the situation by providing continuous emotional nursing.

• East Asian mathematical journal
• /
• v.5 no.2
• /
• pp.135-150
• /
• 1989

In this paper, we define new classes $S*({\alpha},{\beta},{\gamma})$ and $C*({\alpha},{\beta},{\gamma})$ of T, the class of analytic and univalent functions with negative coefficients. We have sharp results concerning coefficients, distortion of functions belonging to these classes along with a. representation formular for the function in $S*({\alpha},{\beta},{\gamma})$ and $C*({\alpha},{\beta},{\gamma})$. Furthermore, we improve the results of Libera for the class of starlike functions having negative coefficients.

• Journal of the military operations research society of Korea
• /
• v.9 no.1
• /
• pp.69-74
• /
• 1983

This article presents a deterministic inventory model for situations in which, during the stockout period, a fraction ${\beta}$ of the demand is backordered and the remaining fraction $1-{\beta}$ is lost. By defining a time proportional backorder cost and a fixed penalty cost per unit lost, a convex objective function representing the average annual cost of operating the inventory system is obtained. The optimal operating policy variables are calculated directly. At the extremes ${\beta}\;=\;1$ and ${\beta}\;=\;0$ the model presented reduces to the usual backorders and lost sales case, respectively.

• Bulletin of the Korean Mathematical Society
• /
• v.55 no.5
• /
• pp.1563-1575
• /
• 2018

In this paper, our central focus is upon gamma and beta q-distributions from a probabilistic viewpoint. The gamma and the beta q-distributions are characterized by investing the nature of the joint q-probability density function through the q-independence property and the q-Laplace transform.

• Nuclear Engineering and Technology
• /
• v.26 no.3
• /
• pp.381-388
• /
• 1994

Recently, the American National Standards Institute (ANSI) had made some changes in the radiation sources specified from those in the original performance test criteria ANSI N13. 11-1983. In case or beta category, in addition to the high-energy $^{90}$ Sr/$^{90}$ Y beta source, the $^{204}$ Tl source was added because many workplaces have significant levels of lower energy betas. In this study, the performance or the Teledyne PB-3 personnel dosimetry system in the fields of $^{204}$ Tl and $^{90}$ Sr/ $^{90}$ Y beta was investigated using the PTB beta secondary standard sources. The new beta correction function of PB-3 personnel dosimetry system for $^{204}$ Tl beta was also developed in this response experiment. The results show that the Teledyne PB-3 personnel dosimetry system is very effective for $^{90}$ Sr/ $^{90}$ Y beta dose assessment. In case of $^{204}$ Tl beta radiation, however, the results of simple performance test indicated that the use of beta correction factor(=2.088) which was recommanded by manufacturer may result in unexpectable overestimation of delivered dose by about 60%, while the use of developed beta correction function could measure the delivered doses in errors of 15%.

• Preventive Nutrition and Food Science
• /
• v.14 no.2
• /
• pp.102-108
• /
• 2009

The comparative immunomodulatory effects of ${\beta}$-glucans isolated from mushroom fungi (Coriolus versicol), yeast (Saccharomyces cerevisiae) and bacteria (Agrobacterium) on the major functions of macrophages were evaluated. As parameters of macrophage functions, we examined tumoricidal activity, phagocytosis, nitric oxide (NO) production, and the induction of inducible NO synthetase (iNOS) in RAW264.7 cells, following treatments with ${\beta}$-glucans from the three different sources. The results indicated that all ${\beta}$-glucan treatments significantly induced tumoricidal activity in the RAW264.7 cells, with a remarkable effect shown by the beta-glucan from Agrobacterium at a concentration of $10{\mu}g/mL$. There was also a significant increase in iNOS-NO system activity in macrophages treated with ${\beta}$-glucans extracted from yeast; however, iNOS-NO system activity was not markedly changed by the treatment of ${\beta}$-glucans from C. versicolor mushroom fungi or Agrobacterium. Furthermore, the ${\beta}$-glucans from C. versicolor had a significant phagocytotic effect at concentrations of 1, 10, and $100{\mu}g/mL$. Taken together, the present data suggest that these ${\beta}$-glucans, isolated from three different sources, have different effects on macrophage function, and therefore, may have different clinical uses in different for various types of diseases.

• BMB Reports
• /
• v.46 no.1
• /
• pp.47-52
• /
• 2013

Intestinal epithelial cell (IEC) apoptosis induced by hypoxia compromise intestinal epithelium barrier function. Both Akt and Hsp90 have cytoprotective function. However, the specific role of Akt and $Hsp90{\beta}$ in IEC apoptosis induced by hypoxia has not been explored. We confirmed that hypoxia-induced apoptosis was reduced by $Hsp90{\beta}$ overexpression but enhanced by decreasing $Hsp90{\beta}$ expression. $Hsp90{\beta}$ overexpression enhanced BAD phosphorylation and thus reduced mitochondrial release of cytochrome C. Reducing $Hsp90{\beta}$ expression had opposite effects. The protective effect of $Hsp90{\beta}$ against apoptosis was negated by LY294002, an Akt inhibitor. Further study showed that Akt phosphorylation was enhanced by $Hsp90{\beta}$, which was not due to the activation of upstream PI3K and PDK1 but because of stabilization of pAkt via direct interaction between $Hsp90{\beta}$ and pAkt. These results demonstrate that $Hsp90{\beta}$ may play a significant role in protecting IECs from hypoxia-induced apoptosis via stabilizing pAkt to phosphorylate BAD and reduce cytochrome C release.