Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Functional Effects of $\beta4$-Subunit on Rat $BK_{Ca}$ Channel $\alpha$-Subunit, rSlo

  • Ha, Tal-Soo (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST)) ;
  • Heo, Moon-Sun (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST) ;
  • Park, Chul-Seung (Laboratory of Molecular Neurobiology, Department of Life Science, Kwangju Institute of Science and Technology (K-JIST))
  • Published : 2002.06.01
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Abstract

To understand the functional roles of the neuron-specific $\beta$-subunit of large-conductance calcium-activated potassium ($BK_{Ca}$) channel, we isolate the full-length complementary DNA of $\beta$4-subunit from rat brain library and investigated its effects on the function of $\alpha$-subunit (Slo). The deduced amino acid sequence of rat $\beta$4 (r$\beta$4), 210 amino acids in length, was closely related to those of $\beta$4 subunits in other mammalian species but showed only a limited sequence homology to the other $\beta$-subunits, $\beta$1 to $\beta$3.(omitted)d)

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