• 약학회지
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• 제50권5호
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• pp.326-331
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• 2006

We designed and synthesized new benzylpiperidinyl ether derivatives as beta-amyloid aggregation inhibitors for the development of novel anti-Alzheimer's disease agents. As starting material, 4-hydroxypiperidine was used. For protection of the amine group in piperidine (2), di-tert-butyl dicarbonate was reacted with 4-hydroxypiperidine in the presence of triethylamine. For introduction of benzyl group, benzylbromide was treated with compound 2 in dioxane. After deprotection of Boc group on amine in compound 3, ester (5) was synthesized by addition of ethyl-4-chlorobutyrate. The alcohol 6 was synthesized by hydride reduction of 5 using $LiAlH_4$. To obtain final products (7-14), the alcohol 6 was condensed with each of substituted benzoic acids. To screen beta-amyloid aggregation inhibition of the products, thioflavinT assay was performed using $A{\beta}1-42\;at\;37^{\circ}C$ for 26 h incubation, in vitro. From the result of screening, compound 8, 9, 11 and 12 showed effective activity about $65{\sim}85\;{\mu}M\;as\;IC_{50}$ value. Among the prepared compounds, 4-[4-(benzyloxy)piperidino]butyl-4-chlorobenzoate (8) was the most effective inhibitor having $IC_{50}\;of\;65.4{\mu}M$.

• Applied Biological Chemistry
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• 제31권3호
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• pp.298-307
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• 1988

토마토 과실의 저장 중 향기물질은 호흡 Climaceteric peak 시기와 함께 그 종류가 증가하였고 SAP-L이 NAP-N보다 향기성분 함량의 증가폭이 완만하였다. 향기성분 중 함량이 많은, 2-hexanone, n-propanol, n-pentanol 및 ethanol은 저장초기에 감소한 후 증가하였고, n-octanol과 furfural은 저장 전반에 걸쳐 증가한 반면 n-butanol, cyclohexanone 및 phenylacetaldehyde 등은 감소하였으며 trans, trans-2,4-decadienal, bensyl alcohol 및 2-heptanone 등은 거의 변화가 없었다.

• 대한화학회지
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• 제38권3호
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• pp.194-199
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• 1994

Sodium dodecylsulfate(SDS) 0.2M수용액 미셀내에 몇 가지 페닐 알카놀$[C_6H_5(CH_2)_nOH;$ 페놀(n=1), 벤질 알코올(n=1), 펜에틸 알코올(n=2), 3-페닐-1-프로판올(n=3)]이 가용화(solubilization)될 때 이들의 가용화 위치를 이차원 이핵 상관 NMR분광법(Two dimensional heteronuclear correlation spectroscopy (2D C-H COSY)으로 조사하였다. 실험 결과 $^1H$-NMR 신호의 적분에 의하여 조사한 이전의 연구결과보다 훨씬 정량적이며 정확한 가용화 위치를 알 수 있었다. 이들이 SDS 미셀 중심의 중간부 메틸렌기에 침투하는 깊이는 ${\alpha}$메틸렌기로부터 6.5~7.0 단위까지 임을 알았다.

• 한국임상수의학회지
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• 제16권1호
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• pp.193-198
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• 1999

Ketoprofen has been used as nonsteroidal anti-inflammatory (NSAI) agent for analgesia in surgical patients and increasing numbers of surgical patients are chronically take some forms of NSAI drugs. The purpose of this study was to investigate the therapeutic effects of ketoprofen on the healing of a closed linear surgical wound and on the contraction of an opened surgical wound in rats. The experimental groups were divided into two groups and ten rats were allocated in each group. In ketoprofen-treated group, the rats were given 2.5 mg/mg/day of ketoprofen by s.c. for ten days. In control group, the rats were given 1ml of benzyl alcohol and distilled water by s.c. for ten days. After time period, all rats were sacrificed, and the breaking strength and the collagen concentrations, at the wound site, were measured. In ketoprofen-treated group, the mean breaking strength and the mean collagen concentration were significantly decreased when compared with those of controls. The ketoprofen-treated group had shown a mean rate of wound contraction less than that of the control, although not statistically significant. These results suggested that ketoprofen impaired wound healing.

• 동력기계공학회지
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• 제11권2호
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• pp.64-71
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• 2007

The main purpose of this study is to analyze the characteristics of toluene removal by plasma, photocatalyst, and plasma/photocatalyst system with the major parameters such as flow rate, inlet toluene concentration and applied voltage, etc., experimentally. In the combined plasma/photocatalyst process, rates of toluene conversion are represented as 99% at flow rate 250, 500 mL/min while, below 97% at flow rate 1000 mL/min due to the low residence time(reaction time) at the same applied voltage 4173 voltage and toluene inlet concentration 50 ppm. The intermediate products are detected by GC/MS analysis showing the small amounts of benzoic acid, benzyl alcohol and residual ozone concentration $0.04{\sim}0.05$ ppm generated by plasma process in the present system.

• Journal of Photoscience
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• 제10권1호
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• pp.1-7
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• 2003

The results of recent work on the dye-sensitized photooxygenation of sulfides is discussed. In the case of dialkyl sulfides, the weakly bonded adduct initially formed with singlet oxygen (the persulfoxide) decays unproductively unless protonation by an acid (an alcohol or a carboxylic acid) facilitates its conversion to the sulfoxide. The effect is proportional to the strength of the acid (eg., less than 0.1 % chloroacetic acid in benzene is sufficient for maximal efficiency) and corresponds to general acid catalysis, suggesting that protonation of the persulfoxide occurs. On the other hand, with sulfides possessing an activated hydrogen in ${\alpha}$ position (eg., benzyl and allyl sulfides), hydrogen transfer becomes an efficient process in aprotic media and yields a S-hydroperoxysulfoniumm ylide, possibly arising from a conformation of the persulfoxide that is different from the one protonated in the presence of acids. Calculations on some substituted sulfides support this hypothesis. This process, which leads to C-S bond fragmentation with formation of an aldehyde, may be viewed as a general method for the preparation of aryl and heteroaryl aldehydes. In this effort, mechanistic studies offered new hints on the structure of the intermediate persulfoxide.

• 한국의류학회지
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• 제10권2호
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• pp.79-84
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• 1986

Methacrylic acid was graft polymerized with benzoyl peroxide in itiator onto the commercial PET film. Graft polymerization was carried out in emulsion, which consisted of BPO (1), chlorobenzene(8) as swelling agent, tween 80(1) and sodium lauryl sulfate(1) as emulsifier and water(1,000). Original PET film has poor reactivities and, so the film preswdled with benzyl alcohol($150^{\circ}C$, 1hr) was also examined. The graft yield of PET film was increased with reaction temperature and monomer concentration. The graft yield of preswelled PET film was higher than that of no-treated PET film. Moisture regain was linearly increased with graft yield. DSC thermodiagram showed the Tm of grafted PET film was same as that of original PET film. Grafted PET film was dyed with methylene blue solution. The photograph of the cross section showed that grafting was occured not at the center but near surfaces.

• 한국연초학회지
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• 제11권2호
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• pp.143-148
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• 1989

Field experiment was conducted to find out the chemical characteristics of 12 Korean local varities, Local varities were compared with oriental, flue-cured and burley tobacco. Among tested varities, Hyangcho and Matskawa were desirable in respect of flavor, leaf color and texture. Hyangcho and Matskawa were higher in the content of nicotine and petroleum ether extract. Gajacho, Byeolcho and Kukjuo were higher in the content of reducing sugar, but lower nicotine, total nitrogen and petroleum ether extract. The nicotine and total nitrogen content of Kwangcho, Daruma and Catterton were lower than that of Br. 21. In the content of volatile organic acid which were major characteristic component of oriental tobacco, the Korean local varities were lower in the content of 3-methyl butanoic and 3-methyl pentanoic acid, but hirities, Hyangcho, Matskawa and Daruma were higher in the content of volatile organic acid. Korean local varities, especially small leaf group, were higher in the content of benzyl alcohol and furfural than any other type tobacco.

• 생약학회지
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• 제39권2호
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• pp.91-94
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• 2008

Column chromatographic separation of the MeOH extract from the aerial parts of Paris verticillata led to the isolation of three phenolics, two terpene glucosides and two pyrrolidine alkaloids. Their structures were characterized to be methyl caffeate (1), 5-hydroxy pyrrolidin-2-one (2), vanillic acid (3), benzyl alcohol glucopyranoside (4), (6S, 9R)-roseoside (5), staphylionoside H (6) and 5-methoxy pyrrolidin-2-one (7) by spectroscopic means. The isolated compounds (1-7) were for the first time reported from this source. The isolated compounds were tested for their cytotoxicity against four human tumor cell lines by SRB method in vitro.

• 한국연초학회지
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• 제8권2호
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• pp.51-66
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• 1986

Volatile aroma components, non-volatile organic acids in lamina and stems of flue-cured(NC 2326) and burley ( Burley 21) were analyzed by gas chromatography and mass spectrometry, respectively. Then compositional differences of these components between lamina and stems were discussed. The contents of volatile components were higher in flue-cured than in burley tobacco, and it was also higher in lamina then in stem. The major aroma components in lamina were neophytadiene , nicotine, solanone and benzyl alcohol but those in stems were palmitic acid, neophytadiene, nicotine, solanone and phenyl ethyl acetate. On the other hand, the contents of non-volatile organic acids were higher in burley than in flue-cured tobacco, and these values of burley tobacco were higher in lamina than in stem but flue-cured tobacco were higher in stem than in lamina. The major acids in all the above four tabacco samples were malic, citric, oxalic and linolenic acid.