• Journal of Acupuncture Research
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• v.23 no.6
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• pp.145-152
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• 2006

Objectives : The aim of this study is to investigate the effect of Acupuncture and Bee-venom acupuncture for patients with chronic whiplash injury. Methods : Subjects were voluntarily recruited by newspapers and internet. Acupuncture(Eo-Hyeol Bang) and Bee-Venom Acupuncture were performed two times a week for 4 weeks. The patients' symptoms were assessed before, after 4 weeks of treatment by Visual Analogue Scale(VAS), Medical Outcome Study(MOS) 36-Item Short-Form Health Survey(SF-36) Results : VAS score was significantly improved after 4 weeks(p<0.05) compared to the pre-treatment. There were significant changes in physical functioning(PF), Social functioning(SF), role-physical(RP), role emotional(RE), mental health(MH), bodily pain(BP) score of SF-36 after 4 weeks(p<0.05), but there were no significant changes in vitality(VT), general health(GH) score of SF-36. Conclusion: This study suggests that Acupuncture(Eo-Hyeol Bang) and Bee-Venom Acupuncture can be applicable to improve symptoms in patients with chronic whiplash injury.

• Journal of Korean Medicine Rehabilitation
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• v.23 no.4
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• pp.251-259
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• 2013

The purpose of this study is to observe the effect of Korean medicine treatment in combination with intra-articular bee venom injection and needle-embedding therapy on recurrent patellar dislocation in patient. The Patient, diagnosed as recurrent patellar dislocation, was treated by Korean medicine treatment in combination with intra-articular bee venom injection and needle-embedding therapy. Visual analogue scale (VAS), knee flexion range of motion (ROM), Korean Western Ontario and Mcmaster Universities arthritis index (K-WOMAC) were used to measure changes during treatment. After treatment, VAS, knee flexion ROM, K-WOMAC were improved significantly. The Korean medicine treatment in combination with intra-articular bee venom injection and needle-embedding therapy was proved to be helpful to improve the symptoms of the recurrent patellar dislocation.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.698-708
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• 2017

Objectives: The aim of this study was to report the clinical effects of a combination of Gamiguibi-tang and sweet bee venom on a patient with Raynaud's disease. Methods: The patient with Raynaud's disease was treated with Gamiguibi-tang three times a day for 43 days and with sweet bee venom daily. The effects on Raynaud's disease were measured on both hands using a cold stress test and an infrared thermometer and by digital infrared thermographic imaging and a NRS (Numeric Rating Scale). We conducted the cold stress test at 6-8 day intervals from 2016.04.27 to 2016.06.08. Results: After treatment, the symptoms of pain were decreased in both hands and digital infrared thermographic imaging (DITI) confirmed a rise in the temperature of the fingers. The fingertip temperature increased from 29.6 to 30.4 degrees and the cooling/rewarming ratio (CRR) increased steadily. No adverse events were found at discharge. Conclusions: Gamiguibi-tang combined sweet bee venom may improve symptoms in patients with Raynaud's disease.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.618-622
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• 2005

Articular cartilage is an important target for studying the arthritic diseases. To verify the therapeutic effects of bee venom herb-acupuncture in vivo, 3${\mu}$l of diluted solution of bee venom for herb-acupuncture were injected into articular cavity once a day during 3 months after making full-thickness defects in rat articular cartilage. Histological examination and immunohistochemistry indicated that the chondrocyte-like tissue was formed during the repair process of cartilage injury, and the expression of a cartilage-specific protein, collagen type II, were significantly activated. It means that the expression of the gene encoding type I collagen was down-regulated, whereas those of collagen type II were up-regulated. Histological examination by hematoxylin-eosin staining indicated that the cells regained their original round morphology. In addition, a homogeneous distribution of articular cartilage extracellular matrices was detected around the cells. These results suggested that bee venom herb-acupuncture was very effective on the recovery of articular chondrocyte phenotype.

• Journal of Acupuncture Research
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• v.31 no.3
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• pp.91-102
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• 2014

Objectives : This study was done to determine the effect of Korean medical treatment to patient diagnosed as cauda equina syndrome(CES) suffering from both lower limb dysesthesia, saddle dysesthesia, buttock dysesthesia, dysuria, dyschezia and gait disturbance. Methods : A patient with CES was treated with acupuncture, sweet bee venom pharmacopuncture, herbal medicine from February 2 to April 9 at Department of Acupuncture & Moxibustion, Daejeon Korean Hospital of Daejeon University. Patient received acupuncture treatment($CV_1$, $CV_3$, $CV_4$, $CV_6$, $ST_{36}$, $BL_{31}$, $BL_{32}$, $BL_{33}$, $BL_{34}$) 12 times a week, bee-venom pharmacopuncture($BL_{23}$, $BL_{28}$) was conducted twice a week, herbal medicine(Samilsingihwan decoction) was applied to patient thrice a day for nine weeks. The following symptoms were observed saddle, and lower limb dysesthesia, dysuria, dyschezia and gait disturbance. Results : After treatment, dysesthesia, dysuria, dyschezia and gaiting developed good outcome. But anal reflex remained still. Conclusions : Acupuncture, bee-venom pharmacopuncture, herbal medicine combined treatment might be effective to patients with CES.

• Journal of Acupuncture Research
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• v.19 no.1
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• pp.54-64
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• 2002

Objective : The one of the main cause in back pain & sciatica is HNP of L-spine. This study is for taking data for the clinical application of Bee-Venom Acupuncture on HNP of L-spine. Methods : This clinical study was carried out 24 patients with HNP of L-spine, who had been admitted from March, 2001 to November, 2001. We devided the patients into two groups; One was an experimental group, treated by 2 methods-common acupuncture therapy and Bee-Venom Acupuncture. The other was an control group, treated only by common acupuncture therapy. Results and Conclusion : In an experimental group, there were 4 excellent cases (33.33%) and 5 good cases(41.67%). In an control group, there were 2 excellent cases (16.67%) and 5 good cases (41.67%). We thought that it needed to prove effects of Bee- Venom Acupuncture for efficient application by more clinical data from now.

• Journal of Pharmacopuncture
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• v.3 no.2
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• pp.245-255
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• 2000

After observing a patient diagnosed with Systemic Lupus Erythematosus from the September 21, 2000 to the January 13, 2001, the following results are obtained. Method and Result: We treated one case of Systemic Lupus Erythematosus with the Korean Bee Venom Therapy and the other Oriental Medical treatments. In acupuncture therapy, Korean Bee-venom Therapy is believed to be outstanding way to treat Systemic Lupus Erythematosus. Korean Bee Venom Therapy is treated on the following acupuncture points: ST36(B23(Shinsu:腎兪), BL26(Guanyuanshu:關元兪), ST36(Chok-Samni:足三里), LI4(Hapkok:合谷), LV3(Taechung), SP10(Hyolhae:血海) SP6 (Samumgyo;三陰交). In addition, CFC(Carthami Flos;紅花 and Cervi Pantotrichum Cornu;) Herbal-Acupuncture was applied on the acupucture points of GB20(Pungji: 風池), GB21(Kyonjong:), as well as BUM(It was made of Boviscalculus(牛黃), Moschus and Fel ursi Herbal-Acupuncture was given on CV17(Chonjung). In herbal medication, based on the Sasang Constitution, Taeyumin Chungsimyunja-Tang was given to the patient. As the results of these treatments, general conditions of this patient improved drastically. Conclusion: Based on the clinical results, traditional Korean Medical treatment is believed to be effective for treating Systemic Lupus Erythematosus, and futher studies should be carried out to provide more valuable information.

• Journal of Pharmacopuncture
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• v.14 no.1
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• pp.5-24
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• 2011

Objective: This study was performed to analyse four weeks repeated -dose toxicity of Sweet Bee Venom (SBV-pure melittin, the major component of honey bee venom) in rats. Methods: All experiments were conducted under the regulations of Good Laboratory Practice (GLP) at Biotoxtech Company, a non-clinical study authorized institution. Male and female rats of 5 weeks old were chosen for the pilot study of four weeks repeated-dose toxicity and was injected at the level of 0.56 mg/kg body weight (eighty times higher than the clinical application dosage as the high dosage), followed by 0.28 and 0.14 mg/kg as midium and low dosage, respectively. Equal amount of normal saline was injected as the control group every day for four weeks. Results: 1. No mortality was witnessed in all of the experiment groups. 2. All experiment groups appealed pain sense in the treating time compared to the control group, and side effects such as hyperemia and movement disorder were observed around the area of injection in all experiment groups, and the higher dosage in treatment, the higher occurrence in side effects. 3. Concerning weight measurement, neither male nor female groups showed significant changes compared to the control group. 4. Concerning to the CBC and biochemistry, all experiment groups didn't show any significant changes compared to the control group. 5. Concerning weight measurement of organs, experiment groups didn't show any significant changes compared to the control group. 6. To verify abnormalities of organs and tissues, those such as cerebellum, cerebrum, liver, lung, kidney, and spinal cords were removed and we conducted histologocal observation with H-E staining. Concerning the histologocal observation of liver tissues, some fatty changes were observed around portal vein in 0.56 mg/kg experiment group. But another organs were not detected in any abnormalities. 7. The proper high dosage of SBV for the thirteen weeks repeated test in rats may be 0.28 mg/kg in one time. Conclusion: Above findings suggest that SBV is relatively safe treatment medium. Further studies on the subject should be conducted to yield more concrete evidences.

• Journal of Veterinary Clinics
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• v.30 no.2
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• pp.107-110
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• 2013

A 6-year-old, castrated male Shih-tzu dog was presented due to left side facial paralysis with head tilt. Neurological examination revealed absence of facial sensation, menance response, and palpebral reflex on the left side. On magnetic resonance imaging (MRI), intracranial intra-arachnoid cyst (IIAC) was noted. The dog was poor response to steroid and dieuretic therapy. Based on characteristic historical and clinical findings, and excluding of other causes of acute facial nerve dysfunction, the dog was tentatively diagnosed as idiopathic facial paralysis. The clinical signs were improved gradually after acupuncture therapy with bee venom. Eight weeks after initial acupuncture with bee venom, the patient recovered sensory and neurological facial signs. This case report demonstrates that bee venom acupuncture for an idiopathic facial paralysis could be useful in a dog.

• The Journal of Internal Korean Medicine
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• v.42 no.5
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• pp.958-966
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• 2021

Objective: This study investigated the effectiveness of bee venom acupuncture for a diabetic neuropathy patient. Methods: A diabetic neuropathy patient received twenty-one bee venom acupuncture treatments for a total of 99 days. The Neuropathy Pain Scale (NPS) was used to evaluate the weekly peak pain during the treatment period. Results: After the treatments, the NPS scores improved, and the frequencies of peak pain decreased. Conclusions: This clinical case indicates that bee venom acupuncture combined with Korean medicine may be effective for treating diabetic neuropathy patients.