• Science of Emotion and Sensibility
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• 제21권4호
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• pp.77-90
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• 2018

Behavioral studies of emotion recognition in autism spectrum disorders (ASD) have yielded mixed results. Most of the studies focused on emotion recognition abilities with regard to ASD using stimuli with unisensory modality, making it difficult to determine difficulties in real life emotion perception in ASD. Herein, we review the recent behavioral and cognitive neuroscience studies on emotion recognition functions in ASD, including both unisensory and multisensory emotional information, to elucidate the possible difficulties in emotion recognition in ASD. In our study, we discovered that people with ASD have problems in the process of integrating emotional information during emotion recognition tasks. The following four points are discussed: (1) The restrictions of previous studies, (2) deficits in emotion recognition in ASD especially in recognizing multisensory information, (3) possible compensation mechanisms for emotion recognition in ASD, and (4) the possible roles of attention and language functions in emotion recognition in ASD. The compensatory mechanisms proposed herein for ASD with regard to emotion recognition abilities could contribute to a therapeutic approach for improving emotion recognition functions in ASD.

• Applied Chemistry for Engineering
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• 제30권2호
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• pp.233-240
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• 2019

Molecular recognition technology has attracted considerable attention for improving the selectivity of a specific molecule by imprinting it on a polymer matrix. In this study, adsorption and release characteristics of chitosan based drug delivery films imprinted with sulindac (SLD) were investigated in terms of the plasticizer, temperature and pH and the results were also interpreted by the related mathematical models. The adsorption characteristics of target molecules on SLD-imprinted polymer films were better explained by the Freundlich and Sips equation than that of the Langmuir equation. The binding site energy distribution function was also useful for understanding the adsorption relationship between target molecules and polymer films. The drug release of SLD-imprinted polymer films followed the Fickian diffusion mechanism, whereas the drug release using artificial skin followed the non-Fickian diffusion behavior.

• Journal of Astronomy and Space Sciences
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• 제39권4호
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• pp.145-158
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• 2022

The dynamics of the outer zone radiation belt has received a lot of attention mainly due to the correlation between the occurrence of enhancing relativistic electron flux and spacecraft operation anomalies or even failures (e.g., Baker et al. 1994). Relativistic electron events are often observed during great storms associated with ultra low frequency (ULF) waves. For example, a large buildup of relativistic electrons was observed during the great storm of March 24, 1991 (e.g., Li et al. 1993; Hudson et al. 1995; Mann et al. 2013). However, the dominant processes which accelerate magnetospheric radiation belt electrons to MeV energies are not well understood. In this paper, we present observations of Pc5 ULF waves in the recovery phase of the Bastille day storm of July 16, 2000 and electron and proton flux simultaneously oscillating with the same frequencies as the waves. The mechanism for the observed electron and proton flux modulations is examined using ground-based and satellite observations. During this storm time, multiple packets of discrete frequency Pc5 ULF waves appeared associated with energetic particle flux oscillations. We model the drift paths of electrons and protons to determine if the particles drift through the ULF wave to understand why some particle fluxes are modulated by the ULF waves and others are not. We also analyze the flux oscillations of electrons and protons as a function of energy to determine if the particle modulations are caused by a ULF wave drift resonance or advection of a particle density gradient. We suggest that the energetic electron and proton modulations by Pc5 ULF waves provide further evidence in support of the important role that ULF waves play in outer radiation belt dyanamics during storm times.

• BMB Reports
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• 제54권1호
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• pp.44-58
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• 2021

Natural killer (NK) cells, key antitumor effectors of the innate immune system, are endowed with the unique ability to spontaneously eliminate cells undergoing a neoplastic transformation. Given their broad reactivity against diverse types of cancer and close association with cancer prognosis, NK cells have gained considerable attention as a promising therapeutic target for cancer immunotherapy. NK cell-based therapies have demonstrated favorable clinical efficacies in several hematological malignancies but limited success in solid tumors, thus highlighting the need to develop new therapeutic strategies to restore and optimize anti-tumor activity while preventing tumor immune escape. The current therapeutic modalities yielding encouraging results in clinical trials include the blockade of immune checkpoint receptors to overcome the immune-evasion mechanism used by tumors and the incorporation of tumor-directed chimeric antigen receptors to enhance NK cell anti-tumor specificity and activity. These observations, together with recent advances in the understanding of NK cell activation within the tumor microenvironment, will facilitate the optimal design of NK cell-based therapy against a broad range of cancers and, more desirably, refractory cancers.

• Journal of the Korea Institute of Information Security & Cryptology
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• 제22권6호
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• pp.1271-1282
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• 2012

Recently, security incidents occur continuously, resulting in the leakages of a large amount of the company's confidential and private information. For these reasons, the security technologies such as the authentication and the access control in order to prevent the information leakage are attracting attention. In particular, location-based authentication that utilizes the user's current location information which is used an authentication factor. And it provides more powerful authentication by controlling the users who attempt to access and blocks internal information leakage path. However, location information must be handled safely since it is the personal information. The location based authentication scheme proposed in this paper enhances the stability of the process location information compared with existing relevant location-based authentication protocol. Also it strengthens the end-user authentication by using one-time password. In addition, the proposed scheme provides authentication to prevent information leakage and employs the concept of the user's physical access control. Resultingly, the proposed scheme can provide higher security than the previous studies, while guarantee to low communication cost.

• Applied Chemistry for Engineering
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• 제32권3호
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• pp.243-252
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• 2021

With increasingly strict requirements for advanced energy storage devices in electric vehicles (EVs) and stationary energy storage systems (EES), the development of lithium-ion batteries (LIBs) with high power density and safety has become an urgent task. Because the performance of LIBs is determined primarily by the physicochemical characteristics of its electrode material, TiO₂, owing to its excellent stability, high safety levels, and environmentally friendly properties, has received significant attention as an alternative material for the replacement of commercial carbon-based anode materials. In particular, self-organized TiO₂ micro and nanostructures prepared by anodization have been intensively investigated as promising anode materials. In this review, the mechanism for the formation of anodic TiO₂ nanotubes and microcones and the parameters that influence their morphology are described. Furthermore, recent developments in anodic TiO₂-based composites as anode electrodes for LIBs to overcome the limitations of low conductivity and specific capacity are summarized.

• Applied Chemistry for Engineering
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• 제32권3호
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• pp.229-236
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• 2021

During the last two decades, metal-organic frameworks (MOFs) have been drawn attention due to their high specific surface area, porosity, and catalytic activities that allow to use in many applications such as sensor, catalysis, energy storage, etc. To synthesize MOFs hydrothermal or solvothermal method were generally used. However, these methods require high-cost equipment and long time-spend for the synthesis with multi-step process. In contrast, electrochemical synthesis has been considered as a simple and easy process under the ambient conditions. In this review, we described the mechanism of electrochemical MOFs synthesis by the number of configured electrodes system, with the recent reports of various applications.

• Journal of Microbiology and Biotechnology
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• 제31권11호
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• pp.1533-1544
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• 2021

n-Caproic acid (CA) is gaining increased attention due to its high value as a chemical feedstock. Ruminococcaceae bacterium strain CPB6 is an anaerobic mesophilic bacterium that is highly prolific in its ability to perform chain elongation of lactate to CA. However, little is known about the genome-wide transcriptional analysis of strain CPB6 for CA production triggered by the supplementation of exogenous lactate. In this study, cultivation of strain CPB6 was carried out in the absence and presence of lactate. Transcriptional profiles were analyzed using RNA-seq, and differentially expressed genes (DEGs) between the lactate-supplemented cells and control cells without lactate were analyzed. The results showed that lactate supplementation led to earlier CA p,roduction, and higher final CA titer and productivity. 295 genes were substrate and/or growth dependent, and these genes cover crucial functional categories. Specifically, 5 genes responsible for the reverse β-oxidation pathway, 11 genes encoding ATP-binding cassette (ABC) transporters, 6 genes encoding substrate-binding protein (SBP), and 4 genes encoding phosphotransferase system (PTS) transporters were strikingly upregulated in response to the addition of lactate. These genes would be candidates for future studies aiming at understanding the regulatory mechanism of lactate conversion into CA, as well as for the improvement of CA production in strain CPB6. The findings presented herein reveal unique insights into the biomolecular effect of lactate on CA production at the transcriptional level.

• Journal of Digital Convergence
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• 제20권2호
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• pp.21-35
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• 2022

In this paper, government R&D supported 310 small and medium enterprises in three main sectors were surveyed and examined the relationship between major factors related to social return using the structural equation model. The main results show that although the level of public awareness of social return and willingness of government R&D supported SMEs are established to some extent, the internal culture and system of SMEs for social return implementation are insufficient, and therefore policy aiming should be placed on establishing internal system of SMEs. In addition, this study suggests that the government policy delivery mechanism should be supplemented to positively increase willingness of SMEs and it is important to pay attention to the growth of SMEs must precede for activation of social return.

• The Journal of Information Systems
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• 제31권2호
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• pp.263-288
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• 2022

Purpose Recently, the tours and activities (TAA) market provided by online travel agencies (OTA) has grown rapidly and has become the third-largest in the travel industry. However, compared to its practical proliferation, TAA has not yet received much academic attention. This study aims to discuss the effect of the four domains (e.g., educational, entertainment, escapist, and esthetic experiences) of the experience economy on users' memorable tourism experiences (MTE), satisfaction, and loyalty in the context of TAA. Moreover, the study investigates how this mechanism varies depending on the tour guides' professional competency. Design/methodology/approach This study developed a research model based on the S-O-R framework. Using the survey method, data were collected from consumers who had experienced TAA offered by OTA more than once within one year. A total of 307 respondents (consumers) were used for the final analysis, and developed hypotheses were tested using a structural equation model technique. Findings The results of this study are as follows. First, educational, entertainment, and escapism experiences in the experience economy positively affect MTE. Second, within the experience economy, entertainment and esthetic experiences have a positive effect on satisfaction. Third, MTE positively influences satisfaction, repurchase intention, and recommendation intention. Fourth, satisfaction has a positive impact on repurchase and recommendation intentions. Finally, according to the level of tour guides' professional competency, there is a significant difference in the effect of escapism experience on MTE/satisfaction.