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http://dx.doi.org/10.14478/ace.2019.1004

Adsorption and Release Characteristics of Sulindac on Chitosan-based Molecularly Imprinted Functional Polymer Films  

Yoon, Yeon-Hum (Department of Energy and Resources Engineering, Chonnam National University)
Yoon, Soon-Do (Department of Chemical and Biomolecular Engineering, Chonnam National University)
Nah, Jae Woon (Department of Polymer Science and Engineering, Sunchon National University)
Shim, Wang Geun (Department of Polymer Science and Engineering, Sunchon National University)
Publication Information
Applied Chemistry for Engineering / v.30, no.2, 2019 , pp. 233-240 More about this Journal
Abstract
Molecular recognition technology has attracted considerable attention for improving the selectivity of a specific molecule by imprinting it on a polymer matrix. In this study, adsorption and release characteristics of chitosan based drug delivery films imprinted with sulindac (SLD) were investigated in terms of the plasticizer, temperature and pH and the results were also interpreted by the related mathematical models. The adsorption characteristics of target molecules on SLD-imprinted polymer films were better explained by the Freundlich and Sips equation than that of the Langmuir equation. The binding site energy distribution function was also useful for understanding the adsorption relationship between target molecules and polymer films. The drug release of SLD-imprinted polymer films followed the Fickian diffusion mechanism, whereas the drug release using artificial skin followed the non-Fickian diffusion behavior.
Keywords
Adsorption; Modelling; Molecularly imprinted polymer; Release; Sulindac;
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