• 대한한방소아과학회지
• /
• 제32권1호
• /
• pp.11-18
• /
• 2018

Objectives The purpose of this study is to analyze the clinical data of atopic dermatitis patients and to report the therapeutic effect of Jageum-Jung. Methods We conducted a retrospective study on the effects of treatment on atopic dermatitis patients who took Jageum-Jung from August 1, 2017 to December 20, 2017. The patients visited three times during the treatment period. The SCORAD Index score was measured and analyzed. Results Atopic dermatitis patients were 2 adults and 5 children. Both 2 adults were male (100%). Among the children, 1 child was a male (20%) and 4 children were females (80%). For adults, average age was 29.5 years, average weight was 72.75 kg, average height was 1.76 m and average BMI was $23.49kg/m^2$. For children, average age was 6.2 years, average weight was 23.92 kg, average height was 1.2 m and average BMI was $16.08kg/m^2$. The atopic dermatitis patients' average SCORAD Index score was 18.04 at first visit, 11.46 at second visit, and 7.64 at third visit. The scores lowered significantly after every visit. Conclusions The SCORAD Index in atopic dermatitis patients who took Jageum-Jung significantly decreased and it is expected that Jageum-Jung will be clinically effective in the treatment of atopic dermatitis.

• Clinical and Experimental Pediatrics
• /
• 제54권1호
• /
• pp.6-10
• /
• 2011

Many patients assume that allergic reactions against foods are responsible for triggering or worsening their allergic symptoms. Therefore, it is important to identify patients who would benefit from an elimination diet, while avoiding unnecessary dietary restrictions. The diagnosis of food allergy depends on the thorough review of the patients's medical history, results of supplemented trials of dietary elimination, and in vivo and in vitro tests for measuring specific IgE levels. However, in some cases the reliability of such procedures is suboptimal. Oral food challenges are procedures employed for making an accurate diagnosis of immediate and occasionally delayed adverse reactions to foods. The timing and type of the challenge, preparation of patients, foods to be tested, and dosing schedule should be determined on the basis of the patient's history, age, and experience. Although double-blind, placebo-controlled food challenges(DBPCFC) are used to establish definitively if a food is the cause of adverse reactions, they are time-consuming, expensive and troublesome for physician and patients. In practice, An open challenge controlled by trained personnel is sufficient especially in infants and young children. The interpretation of the results and follow-up after a challenge are also important. Since theses challenges are relatively safe and informative, controlled oral food challenges could become the measure of choice in children.

• Clinical and Experimental Pediatrics
• /
• 제63권7호
• /
• pp.278-283
• /
• 2020

Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea. Purpose: To identify the estimated recent prevalence and 10-year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017. Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008-2017) examined representative samples of the Korean population (n=85,006) including 2,131 infants, 4,352 preschool children, 12,919 school-age children, 44,200 adults, and 21,404 elderly adults. Results: In the 2016 to 2017 population, the estimated prevalence of asthma was 0.9% in infants, 2.3% in preschool children, 4.1% in school-age children, 2.3% in adults, and 4.1% in the elderly. The estimated prevalence of allergic rhinitis was 9.0%, 20.2%, 27.6%, 17.1%, and 6.9%, respectively. The estimated prevalence of atopic dermatitis was 5.9%, 11.3%, 14.6%, 3.9%, and 1.6%, respectively. Ten-year trends revealed a significant decrease in asthma prevalence in infants, preschool children, and the elderly. and in atopic dermatitis prevalence in infants and preschool children (P<0.05 for all trends). Furthermore, 10-year trends demonstrated a significant increase in allergic rhinitis prevalence in school-age children, adults, and the elderly, and in atopic dermatitis prevalence in school-age children and the elderly (P<0.05 for all trends). Conclusion: These results improve our understanding of the age-stratified epidemiology of allergic diseases in Korea and suggest the need for the development of tailored and precise strategies to prevent allergic diseases in different age groups.

• 대한한의학회지
• /
• 제34권1호
• /
• pp.146-159
• /
• 2013

Objectives: The purpose of this study was to evaluate the effects and develop the role and contents of the atopic dermatitis care program with Korean medicine in a public health center. Methods: The data were collected from 180 parents and 43 kindergarten teachers who participated in a child care program with Korean medicine. The program ran from April to October of 2012. The atopic dermatitis conditions of children were reported by SCORAD index; the questionnaires to measure effect and satisfaction of the program were composed of demographic items, children's life habit change checklist, etc. The questionnaires were executed before and after the program. Results: The SCORAD index total scores decreased (1.3908) after the program, especially itching scores (1.1) and sleep disorder scores (0.5693) significantly. The satisfaction with the program was 88% and 77% of parents and teachers groups, respectively. Making food and treatment were mentioned as the best program. The Children's food preference for junk food, irritability, and anger also decreased after the program. Conclusions: From this study, the atopic dermatitis care program with Korean medicine is worthwhile for treating atopic dermatitis.

• Biomolecules & Therapeutics
• /
• 제18권3호
• /
• pp.246-256
• /
• 2010

Atopic dermatitis is a common skin disease affecting up to 10% of children and approximately 2% of adults. Atopic dermatitis exhibits four major symptoms, including intense itching, dry skin, redness and exudation. The "itch-scratch-itch" cycle is one of the major features in atopic dermatitis. The pathophysiology and neurobiology of pruritus is unclear. Currently there are no single and universally effective pharmacological antipruritic drugs for treatment of atopic dermatitis. Thus, controlling of itch is a very important unmet need in patients suffering from atopic dermatitis. This article will update progress during the past 10 years of research in the field of pruritus of atopic dermatitis, focusing on aspects of pruritogens (including inflammatory lipids, histamine, serotonin, proteinases, proteinase-activating receptors, neurotransmitters, neuropeptides, and opioid peptides), antipruritic therapies, and emerging new targets. Based on recent progress, researchers expect to identify exciting possibilities for improved treatments and to develop new antipruritic drugs acting through novel targets, such as histamine H4 receptor, gastrin-releasing peptide receptor, MrgprA3, thromboxane A2 receptor and the putative SPC receptor.

• 대한한방소아과학회지
• /
• 제15권2호
• /
• pp.177-188
• /
• 2001

Background : Atopic Dermatitis is thought to be a common and chronic relapsing inflammatory skin disease that probably results from allergic reaction. Because it make some serious problems in children, it is needed to treat and at least subside symptoms. Objective : The aim of this study was to evaluate the efficacy of GamiYeoldahansotang(加味熱多寒少湯) for treating Atopic Dermatitis and survey the general characteristics in children with Atopic Dermatitis. Method : Atopic Dermatitis with typical clinical symptoms were included in this study. Forty two patients were treated with hot water extract of GamiYeoldahansotang(加味熱多寒少湯) for four weeks. Clinical evaluation were made by Jacob T scoring system before and after treatment. Total Serum IgE, Eosinophil count were also conducted. Results : Reduction in body surface area was not observed. But significant reductions of severity scores before and after adminstration of GamiYeoldahansotang(加味熱多寒少湯) were observed in all of three groups: mind, moderate, severe. specially severe intensity group was very statistically significant.(p<0.05) Conclusion : We speculate that GamiYeoldahansotang(加味熱多寒少湯) has some therapeutic effects in mitigating the symptoms of Atopic Dermatitis.

• 대한한방소아과학회지
• /
• 제20권3호
• /
• pp.129-141
• /
• 2006

Objectives : The purpose of this study is to determine clinical efficacy of herbal medicine by evaluating SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis Methods : Subjects are divided into two groups : Group 1(non-differentiation children treated with Saenghyeoryunbueom) and group 2(differentiation children treated with either pyungwisan, onchungum or gamitongsungsan). We determine SCORAD Index and total level of ceramaides in the skin of 13 children with atopic dermatitis before and after taking each of herbal treatment for 12 weeks. Results : After herbal prescription for 12 weeks, A SCORAD index of both group 1 and group 2 was decreased. However, the total level of ceramides in group 1 and group 2 was not altered after 12 weeks. When the correlation between the alteration of SCORAD index and ceramides levels was determined, the SCORAD index in group 1 was inversely correlated with the total level of ceramides(r=-0.994, p=0.006) In contrast, the alteration of SCORAD index in group 2 was not correlated with ceramide levels. Conclusions : The clinical efficacy of Saenghyeoryunbueom for non-differentiation children with atopic dermatitis is paralleled with the increased level of ceramides in skin. The clinical efficacy of pyungwisan, onchungum or gamitongsungsan for differentiation children with atopic dermatitis is not correlated with ceramide level in skin.

• 대한한방소아과학회지
• /
• 제25권2호
• /
• pp.8-14
• /
• 2011

Objectives: This study is performed to investigate the use of oriental medicine on pediatric outpatients with atopic dermatitis(AD). Methods: The study was carried out with 267 AD outpatients who visited the Department of Pediatrics, Oriental Medical Hospital from January 2010 to May 2011 and was completed by reviewing patients' chart. Results: The relative frequency of AD on the oriental pediatrics hospital was 6.8%. In a sexual distribution, the male children were more frequent than the females. In an age distribution, atopic dermatitis children visited the hospital were the most frequent in the age from 3 to 10. The highest frequency that started the oriental therapy after the outbreak of AD was from 1 month to 1 year. Approximately, 49.4% of the children who visited hospital relied on western medicine in treating their atopic dermatitis. The therapeutic effect of the oriental medicine was found to be excellent in 47.9%, no change was seen in 16.9%, and aggravation was seen in 3.4% of the patients. Less than a month of oriental treatment was the most common. The improvement depending on the length of the treatment was found to be 91.8% in more than 3 months, and 21.8% in less than 1 month. The use of the herbal medicine and herbal external treatment was seen in 67.4% and the therapeutic effect was improved in 63.3% of the patients. Conclusions: Considering the results, we can improve accommodation of oriental therapies for the pediatric outpatients with atopic dermatitis, and enhance the doctor-patient relationship to help the children with atopic dermatitis.

• 부모자녀건강학회지
• /
• 제9권1호
• /
• pp.17-32
• /
• 2006

The purpose of this study was to understand mother's experience of caring child with a severe atopic dermatitis. Twelve participants were selected and collected on their caring difficulties using in-depth interview. Data were analyzed according to the method of Colaizzi. Significant statements were extracted from the data. From the significant statement, 18 clusters of themes and 7 categories were emerged. Eighteen cluster of themes formed 7 categories : Thinking of atopic dermatitis during 24 hour, Mom would cure you, You are atopic, I'm depressive, I need 12 or more bodies to take care of him/her, Great conversion of daily life, From a bitterness to a frailness, In peace with an atopic dermatitis. In this study, it was implicated that mothers were suffered from caring children with an atopic dermatitis and nurses need to have more interests in the maternal stress and their quality of life as well as provision of information.

• Child Health Nursing Research
• /
• 제29권4호
• /
• pp.300-312
• /
• 2023

Purpose: This study investigated knowledge of atopic dermatitis and food allergies, as well as health information literacy, among North Korean refugee mothers with preschool-age children and explored how these variables were related to participants' characteristics. Methods: A descriptive study design was used. Data from 130 North Korean refugee mothers were collected between January and March 2023. Results: The mean scores were 14.48 of 30 for atopic dermatitis knowledge; 2.77 of 10 for food allergy knowledge, and 56.95 of 80 for health information literacy. Significant differences were observed in knowledge of atopic dermatitis based on breastfeeding duration (F=4.12, p=.009), and in knowledge of food allergies based on mixed feeding (F=3.11, p=.049). Health information literacy showed significant relationships with education level (F=3.76, p=.026), occupation (F=3.99, p=.021), checking nutritional information (t=2.91, p=.004), mixed feeding (F=4.50, p=.014), and atopic dermatitis diagnosis (t=6.86, p=.001). Significant positive correlations were observed between atopic dermatitis knowledge, food allergy knowledge, and health information literacy. Conclusion: Personalized educational programs should be implemented to improve awareness of allergies and health information literacy among North Korean refugee mothers, which would help them find, evaluate, and understand health-related information. These programs should focus on providing nutrition and dietary education to promote healthy growth in children and prevent diseases.