대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제32권1호
  • /
  • Pages.11-18
  • /
  • 2018
  • /
  • 1226-8038(pISSN)
  • /
  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
권호 표지
DOI QR코드

DOI QR Code

자금정의 아토피피부염 치료 효과에 대한 환자군 연구

Case Series Study about the Effect of Jageum-Jung on Atopic Dermatitis

  • 박인우 (부산대학교 한의학전문대학원) ;
  • 김희연 (부산대학교한방병원 한방소아과) ;
  • 천진홍 (부산대학교 한의학전문대학원) ;
  • 사은호 (다나은 한방병원) ;
  • 사복석 (청신한약방) ;
  • 김기봉 (부산대학교 한의학전문대학원)
  • Park, In Woo (School of Korean Medicine, Pusan National University) ;
  • Kim, Hee Yun (Department of Korean Pediatrics, Pusan National University Korean Hospital) ;
  • Cheon, Jin Hong (School of Korean Medicine, Pusan National University) ;
  • Shih, Yin-hao (Danaeun Tradition Hospital) ;
  • Sah, Bok Seok (Chungsin Herbal Store) ;
  • Kim, Ki Bong (School of Korean Medicine, Pusan National University)
  • 투고 : 2018.01.15
  • 심사 : 2018.02.03
  • 발행 : 2018.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives The purpose of this study is to analyze the clinical data of atopic dermatitis patients and to report the therapeutic effect of Jageum-Jung. Methods We conducted a retrospective study on the effects of treatment on atopic dermatitis patients who took Jageum-Jung from August 1, 2017 to December 20, 2017. The patients visited three times during the treatment period. The SCORAD Index score was measured and analyzed. Results Atopic dermatitis patients were 2 adults and 5 children. Both 2 adults were male (100%). Among the children, 1 child was a male (20%) and 4 children were females (80%). For adults, average age was 29.5 years, average weight was 72.75 kg, average height was 1.76 m and average BMI was $23.49kg/m^2$. For children, average age was 6.2 years, average weight was 23.92 kg, average height was 1.2 m and average BMI was $16.08kg/m^2$. The atopic dermatitis patients' average SCORAD Index score was 18.04 at first visit, 11.46 at second visit, and 7.64 at third visit. The scores lowered significantly after every visit. Conclusions The SCORAD Index in atopic dermatitis patients who took Jageum-Jung significantly decreased and it is expected that Jageum-Jung will be clinically effective in the treatment of atopic dermatitis.

키워드

참고문헌

  1. Park ID, Son CG, Cho CK. A literal study of anti-tumor effects of Jakeumjung. J Haehwa Med. 2002;10(2):73-81.
  2. Ren M, Chen M, Xie Y, Zhao G, Ren P. The observation of the efficacy of using purple tablets on the patients with subcutaneous ecchymosis at the puncture site after coronary angiography or percutaneous coronary intervention. J Guangzhou Med. 2012;43(4):65-7.
  3. Xie X, Pang S, Wang H, Mai M. Application research of topical drugs in combination with hirudoid in hemodialysis puncture hematoma. China Med Herald. 2016;40(6):493-4.
  4. Cho YK, Jeon JY, Shin YJ, Seol JK, Rhee JH, Won JH, Moon G. Induction of apoptosis and cell cycle arrest by Jageum-Jung in HepG2 hepatoma cells. Korean J Orient Int Med. 2007;28(4):694-708.
  5. Lee MS, Ahn KS, Moon JJ. A literature review on the detoxifying effect of Jakeumjung. J East-West Med. 1979;4(3):34-7.
  6. Engel-Yeger B, Mimouni D, Rozenman D, Shani-Adir A. Sensory processing patterns of adults with atopic dermatitis. J Eur Acad Dermatol Venereol. 2011;25(2):152-6. https://doi.org/10.1111/j.1468-3083.2010.03729.x
  7. Jin QY, Lee JY. Research trends of the traditional Korean medicine treatment for atopic dermatitis objectives. J Pediatr Korean Med. 2017;31(1):25-42. https://doi.org/10.7778/jpkm.2017.31.1.025
  8. Kim JS, Choi JH, Kim JH, Jeong MY, Park SY. Effects of SaengRyo-SaMul-tang on atopic dermatitis induced by DNCB in mice. J Korean Med Ophthalmol Otolaryngol Dermatol. 2017;30(1):87-105. https://doi.org/10.6114/jkood.2017.30.1.087
  9. Park Y. Status of clinical practice on diagnosis and management of atopic dermatitis in Korea: a questionnaire survey of physicians. Allergy Asthma Respir Dis. 2013;1(3):257-65. https://doi.org/10.4168/aard.2013.1.3.257
  10. Cho AR, Han SR, Park G, Seo S. Retrospective study about the effectiveness of Korean medicine treatment on 89 severe atopic dermatitis patients. J Korean Med Ophthalmol Otolaryngol Dermatol. 2016;29(2):161-79. https://doi.org/10.6114/jkood.2016.29.2.161
  11. Schmitt J, Langan S, Deckert S, Svensson A, von Kobyletzki L, Thomas K, Spuls P. Assessment of clinical signs of atopic dermatitis: a systematic review and recommendation. J Allergy Clin Immunol. 2013;132(6):1337-47. https://doi.org/10.1016/j.jaci.2013.07.008
  12. Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI. Global variations in prevalence of eczema symptoms in children from ISAAC phase three. J Allergy Clin Immunol. 2009;124(6):1251-8. https://doi.org/10.1016/j.jaci.2009.10.009
  13. Guttman-Yassky E, Nograles KE, Krueger JG. Contrasting pathogenesis of atopic dermatitis and psoriasis-part I: clinical and pathologic concepts. J Allergy Clin Immunol. 2011;127(5):1110-8. https://doi.org/10.1016/j.jaci.2011.01.053
  14. Boguniewicz M, Leung DY. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev. 2011;242(1):233-46. https://doi.org/10.1111/j.1600-065X.2011.01027.x
  15. Seo JH, Jung CH, Park SJ, Lim SY, Han SR. 6 cases of atopic dermatitis diagnosed as the febrile tendency treated with Gagamchengyoung-tang. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):191-204. https://doi.org/10.6114/jkood.2014.27.3.191
  16. Ki HP, Jang SI, Yun YG. Ameliorative effects of Hwangnyeonhaedok-tang on atopic dermatitis. J Herb Formula Sci. 2013;21(1):80-90. https://doi.org/10.14374/HFS.2013.21.1.080
  17. Wei X, Lin L. A study on the antibacterial effect of external application Jageum-Jung. J Chin Med Mater. 2004;27(10):761-2.
  18. Lee HJ, Cho SH. Therapeutic effects of Korean red ginseng extract in a murine model of atopic dermatitis: anti-pruritic and anti-inflammatory mechanism. J Korean Med Sci. 2017;32(4):679-87. https://doi.org/10.3346/jkms.2017.32.4.679
  19. Totté J, de Wit J, Pardo L, Schuren F, van Doorn M, Pasmans S. Targeted anti-staphylococcal therapy with endolysins in atopic dermatitis and the effect on steroid use, disease severity and the microbiome. Trials. 2017;18(1):404. https://doi.org/10.1186/s13063-017-2118-x
  20. Mendonca P, Taka E, Bauer D, Cobourne-Duval M, Soliman KF. The attenuating effects of 1,2,3,4,6-Penta-O-galloyl-$\beta$-D-glucose on inflammatory cytokines release from activated BV-2 microglial cells. J Neuroimmunol. 2017;305:9-15. https://doi.org/10.1016/j.jneuroim.2017.01.011
  21. Doh ES, Yoo JH. Antibacterial activity of bio-fermented Galla Rhios extract, department of herbal pharmaceutical science. Kor J Herbol. 2014;29(4):21-7. https://doi.org/10.6116/KJH.2014.29.4.21
  22. Cho HS, Kang SW, Kim JH, Choi MJ, Yu HW, Park ET, Chun HS. Antioxidant and antimicrobial activities of combined extracts of Galla Rhois, Achyranthes Japonica Nakai, Terminalia Chebula Retz and Glycyrrhiza Uralensis. KSBB J. 2014;29(1):29-35. https://doi.org/10.7841/ksbbj.2014.29.1.29
  23. Yoo JG, Choi KH, Kim YK, Kang SK, Jung SY, Jung JH, Seo HS. The study on the anti-inflammatory effects of Phellodendri Cortex, Indigo Naturalis, Alumen, and Chinensis Galla, most frequently used for the external therapy of Gu-Chang. J Korean Med Ophthalmol Otolaryngol Dermatol. 2005;18(1):183-98.
  24. Liu L, Li J, Zeng KW, Jiang Y, Tu PF. Five new biphenanthrenes from Cremastra Appendiculata. Molecules. 2016;21(8):1089. https://doi.org/10.3390/molecules21081089
  25. Kong LY, Li Y, Wu XL, Min ZD. Cytotoxic diterpenoids from Euphorbia Pekinensis. Planta Med. 2002;68(3):249-52. https://doi.org/10.1055/s-2002-23132
  26. Jo YR, Kang SM. Lactococcus Lactis culture methods for the enhanced depression of inducers in atopic diseases. Korean J Microbiol Biotechnol. 2012;40(4):310-8. https://doi.org/10.4014/kjmb.1205.05025
  27. Kim CT, Jung MH, Kim HS, Kim HJ, Kang SJ, Kang SH. Inhibitors of melanogenesis from Euphorbiae Lathyridis Semen. J Kor Pharmacogn. 2000;31(2):168-73.
  28. Suh KS, Baek JW, Kim TK, Lee JW, Roh JW, Jeon JW, Kim ST. The inhibitory effect of phytoclear-EL1 on melanogenesis. Ann Dermatol. 2009;21(4):369-75. https://doi.org/10.5021/ad.2009.21.4.369
  29. Liang QQ, Zhang M, Zhou Q, Shi Q, Wang YJ. Muscone protects vertebral end-plate degeneration by antiinflammatory property. Clin Orthop Relat Res. 2010;468(6):1600-10. https://doi.org/10.1007/s11999-009-1079-0
  30. Inoue E, Shimizu Y, Masui R, Tsubonoya T, Hayakawa T, Sudoh K. Agarwood inhibits histamine release from rat mast cells and reduces scratching behavior in mice. J Pharmacopuncture. 2016;19(3):239-45. https://doi.org/10.3831/KPI.2016.19.025
  31. Kim MS, Hwang HI, Lee YR, Kim HW, Park JK. The effects of Lentinula Edodes and Aquilariae Agallocha extracts combination on the repair of UVA-damaged DNA and DNCB-induced allergic dermatitis. Korean J Food Nutr. 2015;28(5):759-65. https://doi.org/10.9799/ksfan.2015.28.5.759
  32. Canli K, Yetgin A, Akata I, Altuner EM. In vitro antimicrobial screening of Aquilaria Agallocha roots. Afr J Tradit Complement Altern Med. 2016;13(5):178-81.
  33. Lim HJ, Yu DS, Kim JW. A diagnostic questionnaire for the epidemiologic studies of childhood and adult atopic dermatitis in Korea. Kor J Dermatol. 2008;46(11):1495-9.
  34. Peters AS, Kellberger J, Vogelberg C, Dressel H, Windstetter D, Weinmayr G. Prediction of the incidence, recurrence, and persistence of atopic dermatitis in adolescence: a prospective cohort study. J Allergy Clin Immunol. 2010;126(3):590-5. https://doi.org/10.1016/j.jaci.2010.06.020