• Title/Summary/Keyword: association mapping

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Evaluation of Cofactor Markers for Controlling Genetic Background Noise in QTL Mapping

  • Lee, Chaeyoung;Wu, Xiaolin
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.4
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    • pp.473-480
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    • 2003
  • In order to control the genetic background noise in QTL mapping, cofactor markers were incorporated in single marker analysis (SMACO) and interval mapping (CIM). A simulation was performed to see how effective the cofactors were by the number of QTL, the number and the type of markers, and the marker spacing. The results of QTL mapping for the simulated data showed that the use of cofactors was slightly effective when detecting a single QTL. On the other hand, a considerable improvement was observed when dealing with more than one QTL. Genetic background noise was efficiently absorbed with linked markers rather than unlinked markers. Furthermore, the efficiency was different in QTL mapping depending on the type of linked markers. Well-chosen markers in both SMACO and CIM made the range of linkage position for a significant QTL narrow and the estimates of QTL effects accurate. Generally, 3 to 5 cofactors offered accurate results. Over-fitting was a problem with many regressor variables when the heritability was small. Various marker spacing from 4 to 20 cM did not change greatly the detection of multiple QTLs, but they were less efficient when the marker spacing exceeded 30 cM. Likelihood ratio increased with a large heritability, and the threshold heritability for QTL detection was between 0.30 and 0.05.

Intervention Development Stages in Health Promotion Planning Models: PRECEDE-PROCEED and Intervention Mapping (건강증진 기획모형의 중재기획 단계 비교: PRECEDE-PROCEED와 Intervention Mapping)

  • Yoo, Seung-Hyun;Kim, Hye-Kyeong
    • Korean Journal of Health Education and Promotion
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    • v.27 no.2
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    • pp.141-149
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    • 2010
  • Objectives: This paper aims to compare the intervention development steps of the revised PRECEDE-PROCEED model and the Intervention Mapping model. Methods: Concepts and structure of the intervention development step of each model are reviewed with examples. Results: The revised PRECEDE-PROCEED model and the Intervention Mapping model share characteristics in intervention development in employing PRECEDE assessments, applying a social ecological framework and behavior theories for intervention building, emphasizing multi-interventions at multiple levels, and involving stakeholders and existing resources in intervention development. A detailed explanation of the intervention alignment and matrix building is provided with illustration of examples. Conclusion: Intervention development should not be done compartmentally but in line with other steps in a planning model to sustain the program logic. For successful application of planning models for intervention development, solid understanding of the models and behavior theories are required. Multisectoral collaboration is also critical for the successful application.

Development of the Process Mapping for the Radiation Safety Management (방사선안전관리를 위한 Process Mapping 개발)

  • Lee, Yong Sik;Lee, Jin Woo;Lee, Yun Jong
    • Journal of Radiation Protection and Research
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    • v.38 no.3
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    • pp.149-156
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    • 2013
  • Recent domestic use of radiations has increased in the number of institutions and companies as well as operating as an investment, a variety of facilities and safety management are becoming increasingly complex. Despite the increase of radiation workers and facilities, the number of RSOs (Radiation Safety Officers) has not increased with a growing domestic radiation industry. The radiation safety management work (radiation workers management, radiation sources management, facilities management etc.) has been managed by insufficient number of the RSOs. These problems could be directly or indirectly related to causes of the radiation accidents. In this paper, we designed the Process Mapping of radiation safety management work for an efficient safety management of the radiation facilities and protection of radiation accidents. To develop the Process Mapping, we analyzed the radiation safety requirements of management issues and the individual procedures. Based on the Process Mapping, the work procedures for an appropriate radiation safety management of each institution can be configured clearly. Through this procedures, the safety risk factors in radiation facilities can be reduced, and the radiation safety management system will be improved. Depending on your needs, the Process Mapping could be modified and could be used for an efficient radiation safety management.

Modern Control of Space and the British Empire's Management of Irish Territory (공간의 근대적 규율과 영국 제국의 아일랜드 영토 경영)

  • Lee, Sungbum
    • Journal of English Language & Literature
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    • v.57 no.4
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    • pp.553-580
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    • 2011
  • This article addresses how the British Empire administered the discipline of space in nineteenth century Ireland. Space control is a part of modern disciplinary practices. I approach this issue in light of the two modern mapping of space: the geometric mapping of space and the Romantic mapping of space. The former, as seen in map-making, is characterized by imposing a standardized, stratified grid on space by eliminating local characteristics of nature. On the other hand, the latter, as shown in picturesque landscaping, aims to balance a close-up observation of nature and a far-sighted view of it, with the result of creating an ironic tension of local diversity and perspectival totality. These modern disciplinary projects of space repeat themselves in the British management of the colonized Irish territory. As the British conquer other lands, they put to good use both geometric and Romantic disciplinary methods of space. Supervising the Ordnance Survey of Ireland from 1824 to 1846, Thomas Frederick Colby, British Director of Ordnance Survey, made a mathematically strict and scientific mapping of Ireland as a scale of six inches to one mile. Parallelled to this geometric colonization of space, the Romantic colonization of space is efficiently used for the Empire's management of Ireland as well. British tourists and pro-unionist Anglo-Irish landed gentries transform it into the nature of picturesque beauty; Ireland's wild boglands turn aesthetically into desolate but beautiful scenery. Picturesque landscape in England is reborn as an aesthetics of desolation in Ireland.

Application of Concept Mapping in Program Planning for the Mental Disorders: Can be Achieved Consensus Expected Outcomes of the Mental Disorders and Community Psychiatric Rehabilitation Center Employees through Client Participation? (정신장애인을 위한 프로그램 기획에의 컨셉트 맵핑(concept mapping) 적용 : 클라이언트 참여를 통해 사회복귀시설 종사자와 정신장애인의 기대성과 합의를 이룰 수 있는가?)

  • Kwon, Sunae;Kim, Sunjoo
    • The Journal of the Korea Contents Association
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    • v.15 no.1
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    • pp.140-151
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    • 2015
  • This study apply concept mapping to realize of client participation and self-determination in social welfare program for the mental disorders. They are relatively easily marginalized in decision-making process of their program. But realization of client participation and self-determination is directly connected with effect of service. For this reason, we confirmed the applicability of concept mapping in program planning that support client participation. Case of this study is social welfare program of B community psychiatric rehabilitation center located in the A city. This program is community interchange service for the mental disorders. Interchange type is to have a food with the mental disorder and the solitary elderly. We took advantage of the concept mapping to derive the outcomes that are expecting the mental disorders and mental health social workers. Concept mapping was proceeding in six steps; preparation stage ${\rightarrow}$ idea collection stage ${\rightarrow}$ structuralization stage ${\rightarrow}$ analysis stage ${\rightarrow}$ interpretation stage ${\rightarrow}$ application stage. Participants were a total of 25 people including the mental disorders and community psychiatric rehabilitation center employees. The participants produced 42 statements. Sorting results, the mental disorders produced 6 clusters; community psychiatric rehabilitation center employees produced 3 clusters. The mental disorders classified better detail than community psychiatric rehabilitation center employees. Two group were found gap of expected outcomes each other, went narrowed it. They agreed 3 expected outcomes finally. We identified empirically the usefulness of concept mapping to realize self-determination and program participation.

Characteristics, Mapping Understanding, Mapping Errors, and Perceptions of Student-Generated Analogies by Elementary School Students' Approaches to Learning (초등학생의 학습접근양식에 따른 비유 만들기 특성, 대응 관계 이해도, 대응 오류, 비유 만들기에 대한 인식)

  • Kang, Hun-Sik;Cheon, Ji-Hyun
    • Journal of The Korean Association For Science Education
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    • v.30 no.5
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    • pp.668-680
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    • 2010
  • In this study, we investigated the characteristics, the mapping understanding, the mapping errors, and the perceptions of student-generated analogies on the separation of mixtures using the sizes of particles by elementary school students' approaches to learning. Fourth graders (N=92) were selected and administered with the tests on the approaches to learning, self-generating analogies, and perception of self-generating analogies. The results revealed that the meaningful learners made more analogies, especially structural/functional, enriched, and higher systematic ones than the rote learners. However, there were little difference in students' approaches to learning in the subcategories of representation (verbal, pictorial, and verbal/pictorial), artificiality (artificial and everyday), and abstraction (abstract and concrete). The meaningful learners had deeper understanding of the analogy and fewer mapping errors than the rote learners. In addition, the numbers of the shared attributes included in student-generated analogies and the scores of the mapping understanding of the meaningful learners were significantly higher than those of the rote learners. Many students, regardless of students' approaches to learning, had positive perceptions of the self-generating analogies in various cognitive and motivational aspects. However, they also point out the various difficulties in the self-generating analogies as their disadvantages. Educational implications of these findings are discussed.

Development of "Drink Smart" Alcohol Education Program for University Students: Application of the Intervention Mapping and Transtheoretical Model (대학생 절주교육 프로그램(과음없는 캠퍼스 만들기) 개발: Intervention Mapping과 Transtheoretical Model의 적용)

  • Kim, Hye-Kyeong;Kim, Myung;Lee, Eun-Hee;Kwon, Eun-Joo;Cho, Han-Ik
    • Korean Journal of Health Education and Promotion
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    • v.28 no.5
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    • pp.145-160
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    • 2011
  • Objectives: This study attempted to apply the Intervention mapping and Transtheoretical models to develop a program to promote moderate alcohol drinking in university students. Methods: Surveyed data from 1,137 university students were analyzed to identify personal and environmental determinants for alcohol drinking. Based on these determinants, program objectives were established. Crossing the objectives with related important determinants resulted in matrices of learning objectives for which educational strategies were developed. Subsequently, an intervention program were designed to achieve those objectives. Results: Identified personal determinants included awareness, attitudes, self-efficacy and behavioral skills. Environmental determinants were binge drinking behaviors of family members and peers, and social pressure for drinking. Program, impact and learning objectives were developed to change the identified determinants. Program activities included provision of information on positive and negative consequences of binge drinking, opportunities for assessing one's drinking pattern, increasing outcome expectancies of and skill building for monitoring drinking, resisting peer pressure and managing stress. To facilitate adoption and maintenance of the program, an intervention diffusion plan was suggested. An evaluation plan was developed by utilizing RE-AIM framework. Conclusions: In order to expand evidence bases for effective theory-based programs, the developed program should be tested in diverse university settings.

A tunnel back analysis using artificial neural network technique and face mapping data (인공신경망 기법과 굴진면 관찰자료를 활용한 터널 역해석 연구)

  • You, Kwang-Ho;Kim, Kyoung-Seok
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.14 no.4
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    • pp.357-374
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    • 2012
  • Considerable uncertainties are included in ground properties used for tunnel designs due to the limited investigation and tests. In this study, a back analysis was performed to find optimal ground properties based on artificial neural network using both face mapping data and convergence measurement data. First of all, the rock class of a study tunnel is determined from face mapping data. Then the possible ranges of ground properties were selected for each rock class through a literature review on the previous studies and utilized to establish more precise learning data. To find an optimal training model, a sensitivity analysis was also conducted by varying the number of hidden layers and the number of nodes more minutely than the previous study. As a result of this study, more accurate ground properties could be obtained. Therefore it was confirmed that the accuracy of the results could be increased by making use of not only convergence measurement data but also face mapping data in tunnel back analyses using artificial neural network. In future, it is expected that the methodology suggested in this study can be used to estimate ground properties more precisely.

Development and Application of the SWAT HRU Mapping Module for Accurate Estimation of Groundwater Recharge and $NO_3$-N of Each HRU in the SWAT Model (SWAT HRU 단위 지하수 함양량 및 질산성 질소의 정확한 산정을 위한 SWAT HRU Mapping module 개발 및 적용)

  • Ryu, Ji-Chul;Mun, Yu-Ri;Kim, Ik-Jae;Lim, Kyung-Jea
    • Proceedings of the Korea Water Resources Association Conference
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    • 2010.05a
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    • pp.2011-2015
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    • 2010
  • 비점오염원에 의한 수질오염은 지표수 오염과 지하수 오염으로 분리될 수 있는데 보통 지하수는 지표수에 비하여 수질이 양호 하다고 여겨지만 오염된 하천 주위의 지하수 오염이 심각할 수 있다. 이러한 지하수에 의한 오염원을 산정하고 분석하기 위해 여러 가지 수문관련 공식이나, HSPF, MODFLOW, SWAT 모형 등이 사용되고 있는데 이 중, SWAT 모형은 다양한 작물 및 재배방법이 지표수 및 지하수 수질에 미치는 영향을 유역단위로 평가가 가능하여 국내 외 에서 널리 활용되고 있다. SWAT 모형은 소유역별 수문학적 반응단위인 HRU를 이용하여 유역 내 수문 및 수질을 평가하는데 소유역내 HRU의 공간적인 정보를 고려하지 않는 준 분포형 모형으로 다양한 영농방법이 지표수 및 지하수에 미치는 영향을 공간적으로 분석 하는데는 한계가 있다. 따라서 본 연구에서는 이러한 SWAT 모형의 단점을 개선하여 공간적으로 분석할 수 있는 SWAT HRU Mapping module을 개발하였고 강원도 평창군 대관령면 횡계2리 지역에 적용하여 지하수 함양량 및 대수층 유입 $NO_3$-N 부하량 및 농도를 분석하였다. 적용결과, 횡계2리 유역의 2006년 대수층 유입 $NO_3$-N 부하량 및 농도를 비교하면 일반적으로 농경지에서의 대수층 유입 $NO_3$-N 부하량이 큰 것으로 나타났고, 대부분 농경지에서 대수층으로 유입되는 $NO_3$-N의 농도가 산림에 비해서 상당히 높은 것으로 분석되었으며 2007년의 결과도 비슷한 경향이 나타났다. 본 연구의 결과에서와 같이 같은 밭이라 하더라도 재배되는 작물의 종류 및 시비량 등에 따라 대수층으로 유입되는 오염부하에는 상당한 영향이 있을 수 있으며, 또한 재배 작물과 토양 특성에 따라 $NO_3$-N이 대수층으로 유입될 것으로 판단된다. 따라서 본 연구에서 개발된 HRU Mapping Module은 유역에서의 수질 개선시기저유출을 통한 오염원의 시공간적 분석을 하는데 매우 유용하게 활용될 수 있으리라 판단된다.

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