• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.37 no.1
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• pp.17-28
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• 2024

Objectives : This study was conducted to reveal the scientific mechanism of the anti-skin aging activity of Kyung-Ok-Ko(KOK), which is highly useful as a Korean traditional medicine and functional food. Methods : The skin wrinkle and aging inhibitory activity of KOK was confirmed through in vitro experiments of human dermal fibroblast neonatal cell(HDFn) and in vivo of C. elegans, and hairless mouse(SKH-1). Results : The amount of the C-terminus of the collagen precursor in the HDFn cell culture medium treated with KOK using an enzymes-linked immunoassay kit. The group treated with KOK 200㎍/㎖ was a 28.3% increase of collagen precursor compared to the control group. KOK showed inhibitory activity of MMP-1 compared to the control group at a concentration of 200㎍/㎖. In addition, KOK 200㎍/㎖ showed significant inhibitory activity of thermal stress and an oxidative stress compared to the control group in C. elegans. Furthermore, KOK showed a concentration-dependent(100mg/kg and 500mg/kg) anti-wrinkle formation effect in UV-irradiated hairless mouse(SKH-1). Additionally, when KOK was administered to UV-irradiated hairless mice, an increase in procollagen -1 and -3 genes expression was observed, and mmp-1 and mmp-9 genes, which increase collagen decomposition, decreased with the administration of KOK. Conclusions : The skin aging inhibition mechanism of Kyung-Ok-Ko(KOK) is presumed to be achieved through suppressing thermal stress and oxidative stress, suppressing mmp-1 and mmp-9 genes, and increasing procollagen-1 and procollagen-3.

• Journal of the Korea Concrete Institute
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• v.12 no.3
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• pp.67-75
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• 2000

It was well recognized that the damages associated mainly with the aging of civil infrastructures were one of very serious problems for assurance of safety and reliability. Recently carbon fiber sheet(CFS) has been widely used for reinforcement and rehabilitation of damaged concrete beam. However, the fundamental mechanism of load transfer and its load-resistant for carbon fiber sheet reinforced concrete are not fully understood. In this study, three point bending test has been carried out to understand the damage progress and the micro-failure mechanism of CFS reinforced mortars. For this purpose, four different types of specimens are used, that is, mortar, steel bar reinforced mortar, CFS reinforced mortar, and steel bar and CFS reinforced morter. Acoustic Emission(AE) technique was used to evaluate the characteristics of damage progress and the failure mechanism of specimens. in addition, two-dimensional AE source location was also performed to monitor crack initiation and propagation processes for these specimens.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.07a
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• pp.129-130
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• 2005

The electrical stress has a major effect on the long-term reliability of the thyristor. Therefore, it is needed to analyze the relationship between reliability and stress. In this paper, we investigate the device failure mechanism which induced by the stress. And also investigate the effect of the thermal stress on the device failure and relationship between electrical and thermal stress. Two-dimensional process simulator ATHENA and device simulator ATLAS are used to analyze the failure mechanism of the device.

• Biomedical Science Letters
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• v.29 no.3
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• pp.103-108
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• 2023

Enhancers are cis-elements to regulate transcription of cell/tissue-specific genes in multicellular organisms. These elements locate in upstream or downstream regions of target genes and are found in a long distance up to 100 Kb in some cases. Transcription factors and coactivators bind to enhancers in a chromatin environment. Enhancers appear to facilitate the transcription of target genes by communicating with promoters and activating them. As transcription activation mechanism of enhancers, chromatin looping between enhancers and promoters, tracking of enhancer activity to promoters along the intervening regions, and movement of enhancers and promoters into transcription condensates have been suggested based on various molecular and cellular biology studies. These mechanisms are likely to act together rather than exclusive each other for gene transcription. Understanding of enhancer action mechanism may provide a way to regulate the transcription of cell/tissue-specific genes relating with aging or various diseases.

• Korean Journal of Metals and Materials
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• v.48 no.10
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• pp.957-963
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• 2010

The aging behavior of aluminum borate whisker ($Al_{18}B_4O_{33}$) reinforced AS52+Sr magnesium matrix composites was investigated with Vickers hardness measurements, bending tests, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Experimental results showed that aging is accelerated in the $AS52+Sr/Al_{18}B_4O_{33}$ composite compared with an unreinforced AS52+Sr alloy. The hardness of the alloy and composite increases monotonically as a function of the aging time before reaching its peak hardness and then gradually decreases. The composite reaches its peak hardness in 10 h, whereas the matrix alloy requires 30h, indicating accelerated age-hardening in the $AS52+Sr/Al_{18}B_4O_{33}$ composite compared with the unreinforced AS52+Sr alloy at $170^{\circ}C$. The interfacial reaction of $AS52+Sr/Al_{18}B_4O_{33}$ magnesium matrix composite is considered to play a dominant role in the strengthening mechanism, ultimately affecting the mechanical properties of the composite.

• BMB Reports
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• v.52 no.4
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• pp.259-264
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• 2019

Social requirements are needed for living in an aging society and individual longevity. Among them, improved health and medical cares, appropriate for an aging society are strongly demanded. Human cord blood-derived plasma (hUCP) has recently emerged for its unique anti-aging effects. In this study, we investigated brain rejuvenation, particularly olfactory function, that could be achieved by a systemic administration of young blood and its underlying mechanisms. Older than 24-month-old mice were used as an aged group and administered with intravenous injection of hUCP repetitively, eight times. Anti-aging effect of hUCP on olfactory function was evaluated by buried food finding test. To investigate the mode of action of hUCP, brain, serum and spleen of mice were collected for further ex vivo analyses. Systemic injection of hUCP improved aging-associated olfactory deficits, reducing time for finding food. In the brain, although an infiltration of activated microglia and its expression of cathepsin S remarkably decreased, significant changes of proinflammatory factors were not detected. Conversely, peripheral immune balance distinctly switched from predominance of Type 1 helper T (Th1) cells to alternative regulatory T cells (Tregs). These findings indicate that systemic administration of hUCP attenuates age-related neuroinflammation and subsequent olfactory dysfunction by modulating peripheral immune balance toward Treg cells, suggesting another therapeutic function and mechanism of hUCP administration.

• Korean Journal of Metals and Materials
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• v.47 no.3
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• pp.202-208
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• 2009

The effects of aging time on the microstructure and shear strength of the Low Temperature Co-fired Ceramic (LTCC)/Ag pad/Electroless Nickel Immersion Gold (ENIG)/BGA solder joints were investigated through isothermal aging at $150^{\circ}C$ for 1000 h with conventional Sn-37Pb and Sn-3Ag-0.5Cu. $Ni_3Sn_4$ intermetallic compound (IMC) layers was formed at the interface between Sn-37Pb solder and LTCC substrate as-reflowed state, while $(Ni,Cu)_3Sn_4$ IMC layer was formed between Sn-3Ag-0.5Cu solder and LTCC substrate. Additional $(Cu,Ni)_6Sn_5$ layer was found at the interface between the $(Ni,Cu)_3Sn_4$ layer and Sn-3Ag-0.5Cu solder after aging at $150^{\circ}C$ for 500 h. Thickness of the IMC layers increased and coarsened with increasing aging time. Shear strength of both solder joints increased with increasing aging time. Failure mode of BGA solder joints with LTCC substrate after shear testing revealed that shear strength of the joints depended on the adhesion between Ag metallization and LTCC. Fracture mechanism of Sn-37Pb solder joint was a mixture of ductile and pad lift, while that of Sn-3Ag-0.5Cu solder joint was a mixture of ductile and brittle $(Ni,Cu)_3Sn_4$ IMC fracture morphology. Failure mechanisms of LTCC/Ag pad/ENIG/BGA solder joints were also interpreted by finite element analyses.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.3
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• pp.149-158
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• 2022

As a bridge ages, its mechanical properties and structural performance deteriorate, degrading its seismic performance during a strong earthquake. In this study, the aging of piers and bridge bearings was quantified in several stages and reflected in the analysis model, enabling the evaluation of the member-level seismic fragility of these bearings. Moreover, by assuming that the failure mechanism of a bridge system is a series system, a method for evaluating the system-level seismic fragility based on the member-level seismic fragility analysis result is formulated and proposed. For piers with rubber and lead-rubber bearings (members vulnerable to aging effects), five quantitative degrees of aging (0, 5, 10, 25, and 40%) are assumed to evaluate the member-level seismic fragility. Then, based on the result, the system-level seismic fragility evaluation was implemented. The pier rather than the bridge bearing is observed to have a dominant effect on the system-level seismic fragility. This means that the seismic fragility of more vulnerable structural members has a dominant influence on the seismic fragility of the entire bridge system.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4111-4124
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• 2022

The control rod drive system is critical to the reactor's reliable operation. The performance of its control system and mechanical system will gradually deteriorate because of operational and environmental stresses, thus increasing the reactor's operational risk. Currently there are few researches on the aging-related degradation of the entire control rod drive system. Because it is difficult to quantify the effect of various environmental stresses and establish an accurate physical model when multiple mechanisms superimposed in the degradation process. Therefore, this paper investigates the aging-related degradation of a control rod drive system by integrating Dynamic Object-Oriented Bayesian Network and Hidden Markov Model. Uncertainties in the degradation of the control system and mechanical system are addressed by using fuzzy theory and the Hidden Markov Model respectively. A system which consists of eight control rod drive mechanisms divided into two groups is used to demonstrate the method. The aging-related degradation of the control rod drive system is analyzed by the Bayesian inference algorithm based on the accelerated life test data, and the impact of different operating schemes on the system performance is also investigated. Meanwhile, the components or units that have major impact on the system's performance are identified at different operational phases. Finally, several essential safety measures are suggested to mitigate the risk caused by the system degradation.

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.1909-1911
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• 2004

It is caused that insulation paper, which had got a lot of thermal stress by over-load after installation, should have been deteriorated in electrical and mechanical characteristics. Beside, insulation material is decreased the insulating property and accelerated aging of them in case of dielectric loss when transformers are manufactured with some moisture or transformers would have been them because of moisture-permeation, Therefore, in this study we experienced the influence of moisture content in case of the thermal aged insulation paper. we have measured tan ${\delta}$ and breakdown voltage in the ratio of paper' moisture content before the aging and then taken the same tests again after insulation paper thermally accelerating-aged. There is a purpose to gain data for a life-design and to establish aging mechanism in order to continuously study life expectancy of the insulation paper.