• Title/Summary/Keyword: aggressiveness

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Development of a Quantitative ELISA for Anti HER-2 Antibodies using Human HER-2 Recombinant Proteins (인간 HER-2 재조합 단백질을 사용한 항 HER-2 항체 단백질의 ELISA 정량 방법 개발)

  • Jung, Sun-Ki;Ryu, Chang-Seon;Choung, Kyu-Jin;Song, Gyu-Yong;Kim, Sang-Kyum
    • YAKHAK HOEJI
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    • v.55 no.1
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    • pp.16-21
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    • 2011
  • HER-2 (Human Epidermal Growth Factor Receptor-2) is a protein giving higher aggressiveness in human breast cancers. Trastuzumab is a monoclonal antibody that targets HER-2 and is known to extend survival across all stages of HER2-positive breast cancer. In this study, we attempted to development of a quantitative ELISA (Enzyme-Linked ImmunoSorbent Assay) for evaluating anti HER-2 antibodies using human HER-2 recombinant proteins to support antibody producing processes and pharmacokinetic studies. We established direct or indirect ELISA method for the trastuzumab-like protein combined human recombinant HER-2. The ELISA method will prove to be great value in quantitating anti-HER-2 antibodies levels for developing anticancer antibodies.

Effect of Tropical Atmosphere on Corrosion of Different Metals

  • Wijesinghe, Sudesh;Zixi, Tan
    • Corrosion Science and Technology
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    • v.16 no.6
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    • pp.273-277
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    • 2017
  • Atmospheric corrosion is clearly the most noticeable of all corrosion processes. A tremendous amount of economic losses are caused by atmospheric corrosion. Thus, it is imperative to know the level of atmosphere's aggressiveness or in other words "corrosivity", before designing or planning any corrosion prevention strategy. In Singapore, corrosivity values were not recorded earlier though the process of measurement and recording was prevalent in other countries. With an aim of filling this gap, three test sites were setup at three locations in Singapore to represent marine, industrial and urban atmospheres or their mixtures. Subsequently, corrosivity readings were measured and recorded according to ISO 9223:2012 for the first time in Singapore. Salient atmospheric constituents or parameters like time of wetness (TOW), $Cl^-$, $SO_2$, $NO_2$, $O_3$, and $HNO_3$ were measured at all sites over a period of time to categorize corrosivity of particular atmosphere. The effect of the atmosphere on corrosion of steel, Cu, Al, and Zn has also been investigated and quantified. "Estimated" and "determined" corrosivities were quantified and compared according to ISO 9223 standard. The study data along with final corrosivity measurements will be presented and discussed in the present work.

A Study on the Relationship among Family Functioning, Empathy, and Aggression by High School Students (일 지역 고등학생의 가족기능, 공감능력과 공격성간의 관계에 대한 연구)

  • Choi, Hee Jung;Lim, Eun Sun;Yoo, Jang Hak
    • Research in Community and Public Health Nursing
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    • v.24 no.4
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    • pp.480-487
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    • 2013
  • Purpose: The purpose of this study was to investigate the relationship among family functioning, empathy and aggression by high school students. Methods: This was a descriptive study. The survey participants were 467 high school students from M city. Data were collected from November 29 to December 7, 2012 and self-report questionnaires including a Family Adaptability Cohesion Evaluation Scale, Interpersonal Reactivity Indexes, and an Aggression Questionnaire. The collected data were analyzed by descriptive statistics, independent-samples t-test, ANOVA, stepwise multiple regression. Results: The majority of the subjects were 2nd graders (42.0%) and female (57.2%). 59.7% of the subjects had religion, 84.8% were living together with parents. The mean ages of their fathers and mothers were $49.90{\pm}0.20$ and $46.85{\pm}0.19$ respectively. Aggression was found to have a statistically negative correlation with family functioning and empathy. Stepwise multiple regression analysis revealed that the most powerful predictor of aggression was empathic concern. Empathic concern, family cohesiveness, perspective taking, personal distress and gender accounted for 16.7% of the variances. Conclusion: It is necessary to provide aggressiveness reduction programs for high school students that consider their family functioning and empathy.

Differences of Interactive Peer Play According to the Problem Behaviors Types (아동의 문제행동 유형에 따른 또래 놀이행동)

  • Shin, Hae-Young;Choi, Hye-Yeong
    • Journal of Families and Better Life
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    • v.29 no.4
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    • pp.175-186
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    • 2011
  • The purpose of this study was to explore the differences in interactive peer play according to the type of problem behavior. The subjects were 112(67 boys, 45 girls) S-year-old children at 25 daycare centers in Seoul, Gyeonggi, and Gyeongsang areas. Instruments included the Preschool Behavior Questionnaire(PBQ; Behar & Stringfield, 1974) and the Penn Interactive Peer Play Scale(PIPPS) in both the teacher version(Choi & Shin, 2008) and the parent version(Fantuzzo, Mendez, & Tighe, 1998). The data were analyzed with descriptive statistics, cluster analysis, t-test, and one-way ANOVA using the SPSS 18.0 software program. The results showed that the clusters of problem behaviors on the PBQ could be grouped into four categories; 'hostility-aggressiveness', 'hyperactivity- distractibility', 'anxiety-fear', and 'combined'. In addition, group differences among the problem behaviors were significantly found in 'play disruption' and 'play disconnection' but not in 'play interaction' of the PIPPS on teachers' and parents' ratings. Specifically, group differences were not found in the parental reports, while significant group differences were noted in the 'play disconnection on PIPPS component of the teachers' reports.

BENIGN AND MALIGNANT MYOEPITHELIOMAS IN SALIVARY GLAND: CASES REPORT AND IMMUNOHISTOCHEMICAL STUDY (양성 및 악성 타액선 근상피종: 증례보고 및 면역조직화학적 연구)

  • Byun, June-Ho;Lee, Jong-Sil;Kim, Jong-Ryoul;Park, Bong-Wook
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.31 no.1
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    • pp.71-76
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    • 2009
  • Benign myoepithelioma (BME) and malignant myoepithelioma (MME) of the salivary gland are very rare and its biologic behavior has not been clarified fully. Although, cases reports for BME and MME were increased in recent, their diagnostic criteria were not completely established. We describe herein a case of BME of the parotid gland and a case of MME of the palatal minor gland, respectively. Histologically, multinodular growth pattern, infiltration to adjacent tissues, and hyalinized and myxoid matrix were observed in MME, that were different histologic features compared with BME. Strong immunoreactivities for the S-100 protein and vimentin were detected in the tumor cells of BME and MME. In specimen of MME, moderately expressed p53 and strongly expressed p63 were detected. However, in specimen of BME, p53 was negatively and p63 was weakly expressed, respectively. In conclusion, the expression patterns of p53 and p63 as well as histologic aggressiveness might be used to diagnose the MME.

A study on the Depression of the Middle aged Woman (중년기 여성의 우울증에 관한 연구)

  • 장하경;서병숙
    • Journal of Families and Better Life
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    • v.10 no.2
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    • pp.263-276
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    • 1992
  • The middle aged woman today have met discord of unbalance in gender role identity due to change in cultual situation and view of value of our country since 1960. Under the promise that there is a relationship between depression which is a psychological characteristic and gender role traits of middle aged woman, and in consideration that the depression of middle-aged woman may be differentiated depend upon the expressive manner of gender role, this research was trying to find out the relationship between the gender role traits and the depression of middle aged women. The purpose of his research is to provide data to be helpful for marital hygirne of middle-aged women by presenting a plan to reduce depression of middle-aged woman by the desirable gender role. In order for such studying purpose, the gender role, physical symptom and socio-demographic feature were researched using the scale which was by this researcher. The questionnaire sheets of 327 use form middle-aged woman of 39 years to 59 years old in full with their last child is 10 years or order. The summerized results of study are as follows. In consolidation of the foregoing it have known that the socio-economic position and recognition of physical symptom and the masculinity feature has shown less depression as she feels less physical symptom due to there is relationship between recondition of physical symptom and he masculity feature, and also, it has known that the depression of middle-aged women may be reduced when such extroversive and expressional gender role features are developed as 'aggressiveness and ' fraternity, and the depression may be prompted due to such introvert and easy to be impacted by grudge as 'impression'

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The Congestion Control using Multiple Time Scale under Self-Similar Traffic of TCP (TCP의 자기 유사성 트래픽 조건하에서 다중 시간 간격을 이용한 혼잡 제어)

  • 김광준;윤찬호;김천석
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.8 no.2
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    • pp.310-323
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    • 2004
  • In this paper, we extend the multiple time scale control framework to window-based congestion control, in particular, TCP This is performed by interfacing TCP with a large tine scale control nodule which adjusts the aggressiveness of bandwidth consumption behavior exhibited by TCP as a function of "large time scale" network state. i.e., conformation that exceeds the horizon of the feedback loop as determined by RTT Our contribution is threefold. First, we define a modular extension of TCP-a function call with a simple interface-that applies to various flavors of TCP-e.g., Tahoe, Reno, Vegas and show that it significantly improves performance. Second, we show that multiple time scale TCP endows the underlying feedback control with preactivity by bridging the uncertainty gap associated with reactive controls which is exacerbated by the high delay-bandwidth product in broadband wide area networks. Third, we investigate the influence of three traffic control dimensions-tracking ability, connection duration, and fairness-on performance. Performance evaluation of multiple time scale TCP is facilitated by a simulation bench-mark environment which is based on physical modeling of self-similar traffic.

Effect of surgical castration treatments on blood parameters and behavioral characteristics in Korean native cattle (Hanwoo)

  • Kim, Byeong-Soo
    • Korean Journal of Veterinary Service
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    • v.39 no.4
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    • pp.221-226
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    • 2016
  • The animal welfare issues in cattle breeding include breeding environment, elimination, and castration. Among these, castration is unavoidable because it decreases cattle aggressiveness, improves meat quality, and enhances feed efficiency. In this study, the degree of stress associated with various methods of castration treatment was investigated for animal welfare in Hanwoo breeding. Cortisol levels dramatically increased right after castration in both the SoF and SoV groups. However, the increase in the SoF group was significantly (P<0.05) higher than that in the SoV group, and the range of decrease was also smaller. Among the behavioral characteristics, standing was significantly (P<0.05) higher in the SoV ($374.93{\pm}21.51$) and SoF ($379.93{\pm}21.30$) groups based on the behavioral time (min/12 hours) compared to that in the NC group ($359.37{\pm}19.69$). The SoF and SoV groups did not show any significant (P<0.05) difference. In terms of behavioral frequency, the NC group demonstrated a significantly (P<0.05) high frequency of drinking, self-grooming, scratching, and rubbing, and a significantly (P<0.05) less frequency of fighting behavior. The feeding time significantly (P<0.05) decreased in the SoV and SoF groups, and their frequencies of pairwise grooming were significantly (P<0.05) less. Based on the results, the cattle experienced less stress during castration by a veterinarian than during treatment using a move-stop.

Three Cases of Intracranial Clear Cell Meningioma

  • Kim, Yeon-Seong;Kim, In-Young;Jung, Shin;Lee, Min-Cheol
    • Journal of Korean Neurosurgical Society
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    • v.38 no.1
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    • pp.54-60
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    • 2005
  • The clear cell meningioma[CCM] is a rare and recently described as a histologic variant of meningioma. It has been identified and included in new World Health Organization[WHO] classification of the Central Nervous System[CNS] tumors recently. The CCMs are histologically characterized by sheets of spindled to polygonal cells with clear cytoplasm, which is the expression of high glycogen concentration. The CCMs occur in younger patients and usually are located in the spinal canal and posterior fossa. The most interesting aspect of CCM is the high recurrence rate and aggressiveness. Poor outcome has been shown in intracranial and spinal tumor location, but the indicators that predict outcome have not been established. Until now 22 intracranial CCM cases had been reported in English literature and 3 cases in Korean. The authors report two cases of CCM located at cerebral convexity and one at cavernous sinus those were totally removed [Simpson Grade $I{\sim}II$] by subfrontal, frontal and orbitocranial approaches. The clinical, radiological, histopathological, and neurosurgical features of these cases are discussed with the relevant literatures.

A Case Study on Startup Practice of Entrepreneurship Education at a University in Anhui Province, China (중국 안휘성 소속 대학교 창업교육의 창업 실천 사례연구)

  • Wang, Jinling;Fu, Ting;Yang, Man
    • Journal of the International Relations & Interdisciplinary Education
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    • v.1 no.2
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    • pp.91-101
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    • 2021
  • With the rapid development of the Chinese economy, it is particularly important to strengthen the development of start-up innovation among Chinese university students, that is, public innovation is no longer a slogan.College student start-ups can promote the constant development of society, provide more jobs to society, diversify college students' experiences, and help college students gain experience.However, currently, there are problems such as an imbalance in economic and educational development in China, which affects the aggressiveness of college student start-ups. This study aims to contribute to the development of innovative start-ups in Chinese university students by analyzing the influencing factors of innovative start-ups for college students and presenting solutions.