• 동의생리병리학회지
• /
• 제33권2호
• /
• pp.109-115
• /
• 2019

Aster Yomena (AY) has been used in traditional medicine to treat diseases such as obesity, hyperlipidemia, atherosclerosis, diabetes and osteoarthritis. However, protective effect of AY on acute pancreatitis (AP) has not been reported. The present study examined the anti-inflammatory effects of an ethanol extract of AY on cerulein-induced AP. AP was induced in mice by intraperitoneally injecting cerulein ($50{\mu}g/kg$) hourly for 6 times. 70% ethanol extract of AY (0.1, 0.2, and 0.5 g/kg) was orally administered for 1 week before acute pancreatitis induction. The mouse was killed at 6 hours after the final cerulein injection. The pancreas and lung were rapidly removed for histological examination and myeloperoxidase (MPO) assay. Blood samples were taken to determine serum amylase and lipase activity. In addition real-time reverse transcription-polymerase chain reaction (RT-PCR) was also performed to investigate mRNA expression of proinflammatory cytokines such as $TNF-{\alpha}$. $IL-1{\beta}$, and IL-6. Administration of AY significantly ameliorated pancreatic weight to body weight ratio, histological damages and MPO activity during AP. In addition, AY inhibited the serum amylase and lipase activity during AP. Also, mRNA expression of $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 were inhibited by AY against AP. Our results revealed that pre-treatment of AY reduces the severity of cerulein-induced AP. Therefore, AY may have a protective effect drug against AP.

• 한국자원식물학회지
• /
• 제36권4호
• /
• pp.282-289
• /
• 2023

본 연구를 통해 국내 감초 신품종인 G. korshinskyi Grig.가 cerulein으로 유도한 생쥐의 급성 췌장염시 증가하는 염증성 세포의 유입과 혈청 소화효소(Amylase, Lipase) 수치를 유의하게 억제함으로써 급성 췌장염에 대한 보호 효과를 나타낸다는 것을 알 수 있었다. 이를 통해 급성 췌장염을 예방할 수 있는 의약품 소재로써 국내 감초 신품종의 가능성을 제기한다는 데 의의가 있지만, 치료 효과로써의 효능 및 억제 기전에 대한 보완연구가 뒷받침되어야 할 필요가 있다고 판단된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제8권2호
• /
• pp.275-278
• /
• 2005

소아에서 급성 췌장염은 드문 것으로 되어 있고 췌장염의 가장 흔한 원인은 둔상인 것으로 알려져 있다. 저자들은 복통은 호소하지 않으면서 심한 복부 팽만만을 주소로 내원하여 방사선학 검사 및 복수 천자 후 급성 췌장염으로 진단한 후 수술적 치료로 호전된 환아를 경험하였다.

• 동의생리병리학회지
• /
• 제34권6호
• /
• pp.334-340
• /
• 2020

Nypa fruticans Wurmb. (NF) has been used as a folk remedy to treat inflammatory diseases in Asia. In this study, we aimed to investigate the protective effect of NF water extract on cerulein-induced acute pancreatitis (AP). To measure the protective effects of NF on AP, AP was induced via intraperitoneal injection of cerulein (50 ㎍/kg) hourly for 6 h in mice. NF water extract (100, 250, or 500 mg/kg) or saline was administrated to intraperitoneal injection 1 h before the first injection of cerulein. The mice were sacrificed at 6 h after the final injection of the cerulein. Pancreas, and blood sample were taken for further analysis. Administration of NF water extract inhibited the pancreatic injury, the elevation of pancreatic weight/ body weight ratio, and the elevation of serum digestive enzymes such as amylase and lipase during cerulein-induced AP in mice. Also, pancreas MPO activity, which represents neutrophil infiltration, was inhibited by administration of NF water extract. Taken together, administration of NF water extract reduces the severity of cerulein-induced AP, which suggests a clinical basis that NF could be a potential agent to prevent AP.

• 대한융합한의학회지
• /
• 제5권2호
• /
• pp.5-10
• /
• 2023

Objectives: Terminalia chebula Retzins (TC) has been used as a traditional remedy to treat gastrointestinal infectious and inflammatory diseases. However, the protective effect of TC on acute pancreatitis (AP) has not been studied. In this study, we tried to investigate the protective effect of TC water extract on cerulein-induced AP. Methods: To measure the protective effect of TC on AP, mice were injected with cerulein (50 ㎍/kg) hourly for 6 times. TC water extract (200 or 400 mg/kg) or saline was administered orally 1 h before the first injection of cerulein. The mice were sacrificed at 6 h after the last injection of cerulein. Pancreas tissues were taken for further analysis. Results: The administration of TC water extract showed an inhibitory effect on the increase of pancreas weight/body weight ratio and mitigated pancreatic damage in mice. Also, mRNA level of pro-inflammatory cytokines was inhibited by administration of TC water extract. Conclusion: Taken together, we found that administration of TC water extract ameliorates the severity of cerulein-induced AP, which suggests the potential to be an effective treatment on AP.

• Journal of Trauma and Injury
• /
• 제32권1호
• /
• pp.66-70
• /
• 2019

Traumatic diaphragmatic injuries (TDIs) are a rare complication in thoraco-abdominal trauma. The diagnosis is difficult and if left untreated, TDI can cause traumatic diaphragmatic hernia (TDH). Through an injured diaphragm, the liver, spleen, stomach, small intestine, and large intestine can be herniated to the thoracic cavity, but pancreatic herniation and pancreatitis are quite rare in TDH. This paper reports a case of pancreatitis developed by additional trauma in a patient with asymptomatic chronic TDH. A 58-year-old male visited the emergency department with a left abdominal injury after a fall 6 hours earlier. The vital signs were stable, but the amylase and lipase levels were elevated to 558 U/L and 1,664 U/L, respectively. Abdominal computed tomography (CT) revealed a left diaphragmatic hernia and an incarceration of the stomach, pancreatic ductal dilatation, and peripancreatic fatty infiltration. Additional history taking showed that he had suffered a fall approximately 20 years ago and had an accidentally diaphragmatic hernia through a chest CT 6 months earlier. A comparison with the previous CT revealed the pancreatitis to be caused by secondary pancreatic ductal obstruction due to the incarcerated stomach. For pancreatitis, gastrointestinal decompression was performed, and after 3 days, the pancreatic enzyme was normalized; hence, a thoracotomy was performed. A small ruptured diaphragm was found and reposition of the organs was performed. This paper reports the experience of successfully treating pancreatitis and pancreatic hernia developed after trauma without complications through a thoracotomy following gastrointestinal decompression.

• Tuberculosis and Respiratory Diseases
• /
• 제44권4호
• /
• pp.861-870
• /
• 1997

배 경 : 급성 췌장염의 사망률은 10~18%로 알려져 있으며 사망의 대부분은 급성 호흡 부전과 관련되어 있다. 급성 호흡 부전의 가장 심한 형태인 ARDS의 중요한 췌장염이 알려져 있으나 급성 췌장염 환자들 중 어떤 환자에서 ARDS가 더 잘 발생하는지는 확실히 밝혀져 있지 않다. 급성 췌장염 환자들의 입원 시점에서 ARDS의 발생과 연관된 인자들을 찾아보고자 본 연구를 시행하였다. 연구방법 : 1989년 5월부터 1995년 9월까지 아산 재단 서울 중앙 병원에 입원한 환자 86명 94예를 후향적으로 분석하였다. ARDS는 94예 중 13예(13.8%)에서 발생하였다. 통계 분석은 각 임상 지표들을 단변수 분석과 $x^2$-test를 이용하였다. 연구결과 : 내원 당시 흉부 단순 촬영상 이상 소견이 있는 경우 ARDS가 더 잘 발생하였으며(p<0.05)복부 컴퓨터 촬영 중증 지표가 높을 수록 ARDS가 더 잘 발생하였다(p<0.05). APACHE III score가 높을수록(p<0.01) Murray의 폐손상 점수가 1점 이상인 경우 0점인 경우보다 ARDS발생율이 더 높은 것으로 나타났다. 패혈증이 동반된 경우 그렇지 않은 경우보다 ARDS발생 위험도가 3.5 배 높았으며 (p<0.05) 다장기 부전이 3개 이상인 경우 다장기 부전이 없는 경우보다 ARDS 발생 위험도가 23.3 배 (p<0.01) 높은 것으로 나타났다. 결 론 : 급성 췌장염 환자 중 내원 당시 흉부 단순 촬영상 이상소견이 있거나 APACHE III score가 Murray의 폐손상 점수가 높을 수록 패혈증이 동반된 경우 다장기 부전이 3개 이상 동반된 경우에 ARDS가 더 잘 발생하는 것으로 나타났다.

• 대한임상독성학회지
• /
• 제6권2호
• /
• pp.138-141
• /
• 2008

A 47-year-old woman ingested about 12 mg of colchicine with suicidal intent. Colchicine, a highly poisonous alkaloid, is a commonly used treatment for gout, Bechet's disease, and familial Mediterranean fever. Despite the knowledge of its side effects, the risk of a significant overdose is under-appreciated. She suffered from acute multisystem toxicity, including gastrointestinal disorders, bone marrow suppression, alopecia, and probable pancreatitis, but she ultimately recovered with supportive therapy. We report a case of acute colchicine toxicity from a single overdose with a review of the literature.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제24권2호
• /
• pp.164-172
• /
• 2021

Purpose: The use of Endoscopic ultrasonography (EUS) in pediatric patients is not as common as in adults. The aim of this study is to evaluate the role of EUS in the diagnosis of pancreatobiliary disease in childhood. Methods: Between December 2016 and January 2018, the findings of patients who underwent EUS were evaluated retrospectively. Results: Of the 41 patients included in the study 25 were girls (61.0%), mean age was 12.2±4.2 years. EUS was performed for biliary colic in 21 (51.2%), for recurrent pancreatitis in 12 (29.2%), for cholecystitis/cholangitis in 5 (12.2%), and for acute pancreatitis in 3 (7.4%) patients. EUS had a significant clinical effect in the decision of treatment and follow-up of 6/21 biliary colic cases, in diagnosis and follow-up of 6/12 recurrent pancreatitis cases, in decision-making and monitoring of invasive procedures (ERCP/surgery) of 3/5 acute cholecystitis/cholangitis and 2/3 of acute pancreatitis cases as well as in follow-up of the other cases. The effectiveness of EUS in determining direct treatment and invasive intervention was 43.9%. None of the patients had complications related to the EUS procedure. Conclusion: Although current guidelines show that EUS can be used in pediatric patients, this is limited to a few published studies. In this study, it is shown that EUS is a safe method for the diagnosis, follow-up and treatment of common pancreatobiliary pathologies in childhood.

• 한국임상수의학회지
• /
• 제20권3호
• /
• pp.274-277
• /
• 2003

임상적으로 건강한 비글견 17두와 췌장염으로 진단된 5두(요크셔테리어 3두, 토이푸들 2두)의 견에서, 화학보정 없이 전방 십이지장동맥(cranial pancreaticodudenal artery: cPDA) 혈관저항지수(resitive index: RI)를 측정하고 이를 비교 평가하였다. RI 측정을 위해 이중 펄스 색도플러 초음파와 11-MHz 선형 위상차 배열 탐촉자를 이용하였다. 췌장염견(0.75$\pm$0.04)견의 평균 RI는 정상견(0.63$\pm$0.04)과 비교하여 유의성(t = 5.79, p = 0.001)있게 증가된 소견을 보였다. 췌장염에 이환 또는 의증 환축에서는 cPDA의 RI 평가 또한 보조적 진단 가치가 있음을 확인하였다.