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http://dx.doi.org/10.15188/kjopp.2020.12.34.6.334

Protective Effect of Nypa fruticans Wurmb. Water Extract on Acute Pancreatitis  

Bae, Gi-Sang (Department of Pharmacology, School of Korean Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.34, no.6, 2020 , pp. 334-340 More about this Journal
Abstract
Nypa fruticans Wurmb. (NF) has been used as a folk remedy to treat inflammatory diseases in Asia. In this study, we aimed to investigate the protective effect of NF water extract on cerulein-induced acute pancreatitis (AP). To measure the protective effects of NF on AP, AP was induced via intraperitoneal injection of cerulein (50 ㎍/kg) hourly for 6 h in mice. NF water extract (100, 250, or 500 mg/kg) or saline was administrated to intraperitoneal injection 1 h before the first injection of cerulein. The mice were sacrificed at 6 h after the final injection of the cerulein. Pancreas, and blood sample were taken for further analysis. Administration of NF water extract inhibited the pancreatic injury, the elevation of pancreatic weight/ body weight ratio, and the elevation of serum digestive enzymes such as amylase and lipase during cerulein-induced AP in mice. Also, pancreas MPO activity, which represents neutrophil infiltration, was inhibited by administration of NF water extract. Taken together, administration of NF water extract reduces the severity of cerulein-induced AP, which suggests a clinical basis that NF could be a potential agent to prevent AP.
Keywords
Acute pancreatitis; Cerulein; Digestive enzymes; Nypa fruticans Wurmb. (NF);
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