• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2329-2334
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• 2014

Curcumin can inhibit proliferation of liver cancer cells by inducing apoptosis, but the specific signaling pathways involved are not completely clear. Here, we report that curcumin inhibited proliferation of MHCC97H liver cancer cells by induction of apoptosis in a concentration dependent manner via stimulating intracellular reactive oxygen species (ROS) generation. Also, we showed that increased intracellular ROS formation activated the TLR-4/MyD-88 signaling pathway, resulting in activation of caspase-8 and caspase-3, which eventually led to apoptosis in MHCC97H cells. These results showed that as an prooxidant, curcumin exerts anti-cancer effects by inducing apoptosis via the TLR-4/MyD-88 signaling pathway.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1169-1173
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• 2015

Background: Paris polyphylla (Chinese name: Chonglou) had been traditionally used for a long time and shown anti-cancer action. Based on the previous study that paris polyphylla steroidal saponins (PPSS) induced cytotoxic effect in human lung cancer A549 cells, this study was designed to further illustrate the mechanisms underlying. Materials and Methods: The mechanisms involved in PPSS-induced A549 cell death were investigated by phase contrast microscopy and fluorescence microscopy, flow cytometry and western blot analysis, respectively. Results: PPSS decreased the proportion of viable A549 cells, and exposure of A549 cells to PPSS led to both apoptosis and autophagy. Apoptosis was due to activations of caspase-8, caspase-3, as well as cleavage of PARP, and autophagy was confirmed by up-regulation of Beclin 1 and the conversion from LC3 I to LC3 II. Conclusions: PPSS was able to induce lung cancer A549 cell apoptosis and autophagy in vitro, the results underlining the possibility that PPSS would be a potential candidate for intervention against lung cancer.

• Journal of the Korean Applied Science and Technology
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• v.26 no.3
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• pp.263-268
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• 2009

Superporous Hydrogels (SPHs) have been extensively investigated for various biomedical applications due to their fast swelling and superabsorbent properties. In this study, glycol chitosan that is one of most abundant natural polymers was used as a cross-linking agent instead of bisacrylamide (BIS), which is a broadly used crosslinking agent for preparation of SPHs. Glycol chitosan was modified to have reactive vinyl groups by chemical conjugation with glycidyl methacrylate (GMA). The vinyl group-containing glycol chitosan (GC-GMA) was characterized by FT-IR and $^1H$-NMR measurements. SPHs have been prepared in various synthetic conditions to establish the optimum synthetic process for making superporous structure, where the inner pores are interconnected to each other to form a open channel structure. Various SPHs with different GC-GMA contents have been successfully prepared and have been observed to show faster swelling properties than other conventional SPHs. From the study on the swelling behavior of SPHs, the GC-GMA content is considered to be an important factor for controlling their swelling properties.

• Journal of Acupuncture Research
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• v.20 no.1
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• pp.61-73
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• 2003

Objective: The purpose of this study is to compare Sa-Am's Ohaeng-acupuncture(舍巖五行鍼法) with Linqi-aupuncture(六氣鍼法)-the transforms of Sa-Am's Ohaeng-acupuncture. Methods : Zheng Ge(正格), Sheng(勝格), Han Ge(寒格), Re Ge(熱格) of Sa-Am's Ohaeng-acupuncture compared with Liuqi-acupuncture(六氣鍼法)-therapy form invigoration and purgation of five zang-fu's wind. heat, dapness, dryness and cold(風熱濕燥寒). Results: 1. Liuqi-acupuncture used five-su points(五兪穴) and Zi-Ta Jing Bu Xie(自他經補瀉). 2. Liuqi-acupuncture is reinforced or reduced itself-point of itself-meridian(自經自穴) in therapy for invigoration and purgation. 3. Liuqi-acupuncture is therapy for invigoration and purgation of five zang-fu's wind, hear, dampness, dryness and cold(風熱濕燥寒). 4. Zheng Ge is similar to Bu-fa, Sheng Ge is similar to Xie-fa in Qu-xue of Ta-jing. The Qu-xue of interrestraining relations is the same, but that of interdependent relation is the difference in Qu-xure of Zi-jing. 5. Han Ge and Re Ge is similar to Re Bu Xie fa in Qu-xue fo Zi-jing but is different to in Ta-zing. For example, Han Ge is Shaofu(Bu), Yingu(Xie) but Re Ge is Shaofu(Xie), Yingu(Bu).

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.3
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• pp.576-599
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• 2013

Protocol reverse engineering is useful for many security applications, including intelligent fuzzing, intrusion detection and fingerprint generation. Since manual reverse engineering is a time-consuming and tedious process, a number of automatic techniques have been proposed. However, the accuracy of these techniques is limited due to the complexity of binary instructions, and the derived formats have missed constraints that are critical for security applications. In this paper, we propose a new approach for protocol format extraction. Our approach reasons about only the evaluation behavior of a program on the input message from concolic execution, and enables field identification and constraint inference with high accuracy. Moreover, it performs binary analysis with low complexity by reducing modern instruction sets to BIL, a small, well-specified and architecture-independent language. We have implemented our approach into a system called Icefex and evaluated it over real-world implementations of DNS, eDonkey, FTP, HTTP and McAfee ePO protocols. Experimental results show that our approach is more accurate and effective at extracting protocol formats than other approaches.

• Journal of the Korea Society of Computer and Information
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• v.11 no.2 s.40
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• pp.239-251
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• 2006

Zheng's signcryption scheme is a new encryptical scheme of which can save more expense than those of the current signature encryption by using digital signature and symmetric key encryption logically. The current signcryption schemes have a problem that is to be exposed the secret key of the receiver in the case of checking repudiation of origin by the third party. To solve this problem, a solution suggested in this paper is to use multi-purpose ID-based signcryption scheme with anonymity and unlinkability. This solution is safe and more efficient than current signcryption schemes because the suggested scheme keeps the security of the random oracle model as using Weil-pairing in encryption. and follows a formal proof of semantic security of the decisional Diffie-Hellman problem.

• Molecules and Cells
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• v.37 no.5
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• pp.418-425
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• 2014

Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF-${\alpha}$ or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.

• Journal of Korean Medical classics
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• v.32 no.1
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• pp.75-93
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• 2019

Objectives : This study is to reveal the origin of Mingtangyangfutu in "YiXueRenMen". Methods : This study compares and analyzes it with MingTang diagrams in reference books of "YiXueRenMen", MingTang diagrams and diagrams of bronze statues for acu-moxibustion in those days. Results : The origins of Mingtangyangfutu cannot be found in the citations. The argument that it is copied and simplified from MingTang diagrams in "JinLanXunJing(金蘭循經)" lacks its grounds. As MingTang diagrams in "TongRenShuXueZhengJiuTuJing" and "ZhenJiuJuYing" have less information than it, they were nothing more than references when it drew. Apparel of man, the first acupoint, the last acupoint and orders of acupoints of their meridians in it are different from ones in MingTang diagrams and diagrams of bronze statues for acu-moxibustion. Conclusions : Mingtangyangfutu is not a copied and simplified version of MingTang diagrams in "JinLanXunJing", but is one to add new information for MingTang diagrams in "TongRenShuXueZhengJiuTuJing", "ZhenJiuJuYing", or has a separate rationale (Gajeongdongin(嘉靖銅人) related to at the time.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.16 no.4
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• pp.139-146
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• 2006

A Signcryption proposed by Yuliang Zheng in 1997 is a hybrid public key primitive that combines a digital signature and a encryption. It provides more efficient method than a straightforward composition of an signature scheme with a encryption scheme. In a mobile communication environment, the authenticated key agreement protocol should be designed to have lower computational complexity and memory requirements. The password-based authenticated key exchange protocol is to authenticate a client and a server using an easily memorable password. This paper proposes an secure Authenticated Key Exchange protocol using Signcryption scheme. In Addition we also show that it is secure and a more efficient that other exiting authenticated key exchange protocol.

• ETRI Journal
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• v.43 no.1
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• pp.120-132
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• 2021

A frequency diverse array (FDA) multiple-input multiple-output (MIMO) radar employs a small frequency increment across transmit elements to produce an angle-range-dependent beampattern for target angle and range detection. The joint angle and range estimation problem is a trilinear model. The traditional trilinear alternating least square (TALS) algorithm involves high computational load due to excessive iterations. We propose a fast-convergence trilinear decomposition (FC-TD) algorithm to jointly estimate FDA-MIMO radar target angle and range. We first use a propagator method to obtain coarse angle and range estimates in the data domain. Next, the coarse estimates are used as initialized parameters instead of the traditional TALS algorithm random initialization to reduce iterations and accelerate convergence. Finally, fine angle and range estimates are derived and automatically paired. Compared to the traditional TALS algorithm, the proposed FC-TD algorithm has lower computational complexity with no estimation performance degradation. Moreover, Cramer-Rao bounds are presented and simulation results are provided to validate the proposed FC-TD algorithm effectiveness.