한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제26권3호
  • /
  • Pages.263-268
  • /
  • 2009
  • /
  • 1225-9098(pISSN)
  • /
  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
권호 표지
DOI QR코드

DOI QR Code

글리콜키토산을 이용한 초다공성 하이드로젤의 제조 및 팽윤거동

Preparation and Swelling Property of Superporous Hydrogels using Glycol Chitosan

  • 광가 (충남대학교 고분자공학과) ;
  • 이정정 (충남대학교 고분자공학과) ;
  • 윤취임 (충남대학교 고분자공학과) ;
  • 육군영 (충남대학교 고분자공학과) ;
  • 허강무 (충남대학교 고분자공학과)
  • Kuang, Jia (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Li, Zheng-Zheng (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Yun, Chwi-Im (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Yuk, Kun-Young (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Huh, Kang-Moo (Department of Polymer Science and Engineering, Chungnam National University)
  • 발행 : 2009.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Superporous Hydrogels (SPHs) have been extensively investigated for various biomedical applications due to their fast swelling and superabsorbent properties. In this study, glycol chitosan that is one of most abundant natural polymers was used as a cross-linking agent instead of bisacrylamide (BIS), which is a broadly used crosslinking agent for preparation of SPHs. Glycol chitosan was modified to have reactive vinyl groups by chemical conjugation with glycidyl methacrylate (GMA). The vinyl group-containing glycol chitosan (GC-GMA) was characterized by FT-IR and $^1H$-NMR measurements. SPHs have been prepared in various synthetic conditions to establish the optimum synthetic process for making superporous structure, where the inner pores are interconnected to each other to form a open channel structure. Various SPHs with different GC-GMA contents have been successfully prepared and have been observed to show faster swelling properties than other conventional SPHs. From the study on the swelling behavior of SPHs, the GC-GMA content is considered to be an important factor for controlling their swelling properties.

키워드

참고문헌

  1. K. Park, W. S. W. Shalaby, and H. Park, "Biodegradable hydrogels for drug delivery". p. 2, Technomic Publishing Co., Lancaster, 1993
  2. A. S. Hoffman, Hydrogels for biomedical application, Adv. Drug Del. Rev., 43, 3 (2002) https://doi.org/10.1016/S0169-409X(01)00239-3
  3. H. Omidian, J. G. Rocca, and K. Park, Advances in superporous hydrogels, I Control. Release, 102, 3 (2005) https://doi.org/10.1016/j.jconrel.2004.09.028
  4. K. M. Huh, N. Baek, and K. Park, Enhanced swelling rate of poly (ethylene glycol)-grafted superporous hydrogels, I Biooctive Compatible Polymers, 20, 231 (2005) https://doi.org/10.1177/0883911505053378
  5. K. Kabiri, H. Omidian, S. A. Hashemi, and M. J. Zohuriaan-Mehr, Eur. Polym I, 39, 1341 (2003) https://doi.org/10.1016/S0014-3057(02)00391-9
  6. J. S. Hwang, K. Y. Yuk, and K. M. Huh, Research and development of superporous hydrogels with fast swelling and superabsorbent properties, I Tissue Eng. Regen Med, 5(2), 147 (2008)
  7. S. J. Park and C. H. Kim, Chitosan for tissue engineering, I Tissue Eng. Regen Med, 4(4), 471 (2007)
  8. S. Y. Cha, J. K. Lee, B. S. Lim, T. S. Lee, and W. H. Park, Conjugated vinyl derivatives of chitooligosaccharide: Synthesis and characterization I Polym Sci. Pol. Chem, 39, 880 (2001) https://doi.org/10.1002/1099-0518(20010315)39:6<880::AID-POLA1062>3.0.CO;2-K
  9. B. Karagoz and N. Bicak, Novel photocurable polyethers with methacrylate pendant groups, Eur. Poiym J, 44, 106 (2008) https://doi.org/10.1016/j.eurpolymj.2007.10.005