• Bulletin of the Korean Chemical Society
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• 제21권9호
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• pp.882-890
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• 2000

Ab initio calculations are carried out on protonation equilibria of 5-memberedheteroaromatic aldehydes (5MHAs;heteroatom Y = NH, O, PH,and S and substituentZ = NH2, OCH3, SCH3, CH3, H, Cl, CHO, CN,NO2) at the $MP2}6-31G*$ level. Naturalbond orbital (NBO) analyses show that the optimal localized natural Lewis structures of the protonated aldehydes,(P), are ortho (C3) protonated (for Y = O, PH and S) and N-pro-tonated (for Y = NH) forms in contrast to the standard structural Lewis formula for aldehydes, (R). The delo-calizability of ${\pilone}-pairon$ the heteroatom $(n{\pi}(Y))$ is in the order Y = NH > O > S > PH. The transmission efficiency of (Z) substituent effects to the carbonyl moiety run parallel to the delocalizability of $n{\pi}(Y)$ for R,but is dominantly influenced by the cationic charge on $C{\alpha}(C{\alpha}+)$ for P, which is in the reverse order of thede-localizability of $n{\pi}(Y).$ The Hammett ${\rho}values$ for variation of Z in the protonation are determined by the dif-ference in the transmission efficiencies between Pand R stateat simple interpretation of their magnitude is not warranted. However,the magnitude of the gas-phase ${\rho}z+$ values decreases as the level ofcomputation is raised from RHF/3-21G* to RHF/6-31G* and to $MP2}6-31G*$ but increases again at the MP4SDQ/6-31G* level. Further decrease occurs when solvent effect (water) is accounted for by the SCRF method. Comparison of the SCRF ${\rho}z+values$ with those determined in the aqueous acid solution for Y = S and CHCH shows inadequacy of accounting for the solvent effects on the ${\rho}values$ by a continuum model. It is noteworthy that semiempirical calculations, especially theAM1 method, give even lower magnitude of the gas-phase ${\rho}values.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1992년도 춘계학술대회
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• pp.85-91
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• 1992

In MRI, an image contrast can be developed as a result of the susceptibility effect if an object has paramagnetic substances. This is mainly due to the non-uniform phase distribution or linear gradient developed by the magnetic susceptibility within a voxel, which in turn reduces the signal intensity; e.g., spin phases are dephased and thereby cancel each other resulting in a reduced signal. In this paper, a new concept for manipulating the susceptibility effect through the use of tailored RF pulses is proposed. As potential applications of the method, two different types of tailored RF pulses are introduced: one for susceptibility artifact correction and the other for contrast enhancement. The latter, for example, can be applied to angiography utilizing the paramagnetic property of deoxygenated blood. Both a theoretical study of the method and experimental results are reported.

• 한국전자현미경학회:학술대회논문집
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• 한국현미경학회 2001년도 제32차 춘계학술대회
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• pp.41-42
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• 2001

• Investigative Magnetic Resonance Imaging
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• 제4권2호
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• pp.113-119
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• 2000

목적 : 산소호흡을 이용한 뇌의 관류 자기공명영상의 임상적용 가능성을 알고자 하였다. 대상 및 방법 정상 성인 지원자 2명과 3명의 환자, 각각 모야모야병 환자 1명, 뇌경색환자 1명, 뇌수막종 환자 1명을 대상으로 하였으며, 1.5 Tesla의 자기공명영상 장치를 이용하여 뇌의 자화율 대조 (susceptibility contrast) echo planar image (EPI) 방법으로 뇌영역을 10 slice씩 25회(검사시간은 검사당 1.6초) 영상을 얻었다. 검사자는 안면마스크를 착용한 상태로 스캔 시작 8초 후부터 35초가지 산소 15 liter/min를 실내 공기와 혼합되어 흡입되도록 하였다. 획득된 영상을 Magnetom Vision (Siemens Medical Systems, Erlangen, Germany)의 VB31C 프로그램을 이용하여 산소투여전(3골 번째 검사)과, 산소투여 후의 초기 (12-18 번째 검사)와 후기(19-25 번째 검사) 군으로 나누었다. 초기 및 후기 군과 산소투여전 군의 신호차이는 Z-score 0.7 내지 1.0으로 하여 여러번 영상후 처리를 반복하여 difference map을 얻어서, T1 강조영상에 중첩시켜 관류 영상을 얻었다. 모야모야병 환자는 추가로 Gd-DTPA를 0.1 mmol/kg급속주사 후 동일한 방법으로 관류 영상을 얻어 산소호흡에 의한 관류 영상과 비교하였다. 결과 : 산소 공급 후에 시행한 자화율 대조 EPI 방법으로 2명의 지원자와 각각 1예의 모야모야병, 뇌경색, 뇌수막종 증례에서 혈류 분포를 반영하는 관류 영상을 얻을 수 있었다. 모야모야병 1예의 산소 호흡에 의한 관류 영상은 Gd-DTPA투여후의 관류 영상과 유사한 양상을 보였다. 결론 : 산소호흡을 이용한 자화율 대조 EPI 방법은 향후 뇌의 관류 자기공명영상 방법으로 적용이 가능하리라고 생각된다.

• 정보관리연구
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• 제42권3호
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• pp.71-94
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• 2011

시각적 실례에 의한 질의는 내용기반 이미지 검색 환경에서 질의 표현을 위한 중요한 질의 패러다임이다. 이미지 및 스케치에 의한 질의는 질의표현을 가능하게 하는 방법으로서 오랫동안 알려졌다. 하지만 이 방법이 질의를 쉽게 작성하는 데 얼마나 도움을 주는지에 대한 효율성에 대한 실험적 입증은 아직 미미하다. 정보검색시스템에 표현하는 탐색자의 능력은 검색과정의 기본이다. 이 연구의 목적은 탐색자의 정보 문제와 효율적이고도 효과적인 시각적 질의 작성을 지원하기 위해 필요한 질의 방법들 간의 지식 격차의 원인이 되는 다양한 정보 요구를 지원하는 데 있어서 유용성 실험을 통해 이미지에 의한 질의와 스케치방법에 의한 질의 조사하기 위함이었다. 본 연구 결과는 이미지에 의한 질의가 시각적 질의 작성에 실행 가능한 접근방식임을 제시한다. 반면에, 본 연구결과를 통해 탐색자의 정보 문제와 시각적인 질의 작성에 도움을 주는 스케치 패러다임에 의한 질의표현 능력 간에 상당한 불일치가 있다는 것을 알 수 있다. 효율(시간)과 유효성(오류)에 초점을 둔 유용성 실험결과와 이용자의 만족도는 큰 차이점이 있다고 보여준다(p<0.001). 이는 다음 세 가지 측정(시간, 오류, 이용자의 만족도)에 대한 두 가지 질의 방식(이미지에 의한 질의, 스케치에 의한 질의) 사이에서 나타난 시간(Z=-3.597, p<0.001), 오류(Z=-3.317, p<0.001), 그리고 만족도(Z=-10.223, p<0.001)에서 드러난다. 본 연구결과는 또한 질의도구를 참가자가 인지하는 유용성에 큰 차이가 있다는 것을 보여준다(Z=-4.672, p<0.001).

• 한국재료학회지
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• 제25권1호
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• pp.1-8
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• 2015

This study suggested comprehensive structural characterization methods for the commercial blue light emitting diodes(LEDs). By using the Z-contrast intensity profile of Cs-corrected high-angle annular dark field scanning transmission electron microscope(HAADF-STEM) images from a commercial lateral GaN-based blue light emitting diode, we obtained important structural information on the epilayer structure of the LED, which would have been difficult to obtain by conventional analysis. This method was simple but very powerful to obtain structural and chemical information on epi-structures in a nanometer-scale resolution. One of the examples was that we could determine whether the barrier in the multi-quantum well(MQW) was GaN or InGaN. Plan-view TEM observations were performed from the commercial blue LED to characterize the threading dislocations(TDs) and the related V-pit defects. Each TD observed in the region with the total LED epilayer structure including the MQW showed V-pit defects for almost of TDs independent of the TD types: edge-, screw-, mixed TDs. The total TD density from the region with the total LED epilayer structure including the MQW was about $3.6{\times}10^8cm^{-2}$ with a relative ratio of Edge- : Screw- :Mixed-TD portion as 80%: 7%: 13%. However, in the mesa-etched region without the MQW total TD density was about $2.5{\times}10^8cm^{-2}$ with a relative ratio of Edge- : Screw- :Mixed-TD portion of 86%: 5%: 9 %. The higher TD density in the total LED epilayer structure implied new generation of TDs mostly from the MQW region.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3253-3257
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• 2012

Second-order rate constants for the reactions of phenyl Y-substituted-phenyl carbonates 5a-g with Z-substituted-phenoxides ($k_{Z-PhO^-}$) have been measured spectrophotometrically in 80 mol % $H_2O$/20 mol % DMSO at $25.0{\pm}0.1^{\circ}C$. 4-Nitrophenyl phenyl carbonate (5e) is up to 235 times more reactive than 4-nitrophenyl benzoate (4e). The Br$\o$nsted-type plot for the reactions of 5e with Z-substituted-phenoxides is linear with ${\beta}_{nuc}=0.54$, which is typical for reactions reported previously to proceed through a concerted mechanism. Hammett plots correlated with ${\sigma}^o$ and ${\sigma}^-$ constants for the reactions of 5a-f with 4-chlorophenoxide exhibit highly scattered points. In contrast, the Yukawa-Tsuno plot results in an excellent linear correlation with ${\rho}_Y=1.51$ and r = 0.52, indicating that the leaving-group departure occurs at the rate-determining step (RDS). A stepwise mechanism, in which leaving-group departure occurs at RDS, has been excluded since the incoming 4-$ClPhO^-$ is more basic and a poorer nucleofuge than the leaving Y-substituted-phenoxides. Thus, the reaction has been concluded to proceed through a concerted mechanism. Our study has shown that the modification of the nonleaving group from benzoyl to phenyloxycarbonyl causes a change in the reaction mechanism (i.e., from a stepwise mechanism to a concerted pathway) as well as an increase in the reactivity.

• 한국환경복원기술학회지
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• 제4권1호
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• pp.1-15
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• 2001

The purpose of this study is to evaluate the creation techniques of eco-pond, one of biotopes to promote biodiversity in urban residence area. Investigation were classified out plant, mammals, amphibia, reptiles, birds, fishes and insects. The results were summarized as follows: Around the eco-pond shows simple vegetation structurs, consisted of Pinus densoflora S et Z. and Robinia pseudoacacia under competition. In case of shrub, consisted of 4 species but plant growing appearence diversely by seasons. The evaluation of vegetation of eco-pond, there are found 4 species of aquatic plants. Inside the revetment of pond, Echinochloa crus-galli, Persicaria hydropiper, Digiaria sanguinalis, Cyperus microiria and Bidens frondosa L. are mainly distributed. Near the revetment, Trifolium repens L. and Digiaria sanguinalis are prevailed. And in its background, Erigeron canadensis, Erigeron annuus and vines are begins to make their appearances. When evaluation animals in eco-pond and contrast plot, it show simple species and numbers of mammals. It seemed to be resulted from its isolation and outside intervention by users In eco-pond, Pica pica and Streptopelia orientalis are mainly found and in contrast plot of Columba livia, which are so strong adaptation to city life environment. In case of amphibia and reptiles, none is observed in contrast plot, but in ecological pond, Rana nigromaculata and Hyla japonica are constantly observed. In case of insects, more species are found in eco-pond than contrast plot. And in eco-pond, more dragonflies are visibly increased one year after its construction. In floral zone inside of pond revetment, grasshopper and Locusta migratoria are frequently observed. In case of butterflies, they are mainly found in log fence and willow(salix) around eco-pond. In case of fishes inside of eco-pond, the species and its density are remarkable increased one year after the construction. With above evaluation results, we have identify the increase effect of biodiversity after construction of the eco-pond.

• BMB Reports
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• 제43권7호
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• pp.468-473
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• 2010

Previously, various inhibitors of cell wall synthesis induced the drp35 gene of Staphylococcus aureus efficiently. To determine whether drp35 could be exploited in antistaphylococcal drug discovery, we cloned the promoter of drp35 ($P_d$) and developed different biological assay systems using an engineered S. aureus strain that harbors a chromosomally-integrated $P_d$ - lacZ transcriptional fusion. An agarose-based assay showed that $P_d$ is induced not only by the cell wall-affecting antibiotics but also by rifampicin and ciprofloxacin. In contrast, a liquid medium-based assay revealed the induction of $P_d$ specifically by the cell wall-affecting antibiotics. Induction of $P_d$ by sublethal concentrations of cell wall-affecting antibiotics was even assessable in a microtiter plate assay format, indicating that this assay system could be potentially used for high-throughput screening of new cell wall-inhibiting compounds.

• 대한본초학회지
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• 제22권3호
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• pp.1-7
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• 2007

Objectives : This research was observed by examining the external and internal parts and the quantity of the surface components of the wild type and cultivar of Angelica tenuissima in korea. Methods : The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by the microscope and examined the quantity of the surface components. Results : 1. The cultivar has comparatively many thick roots while the wild type has many radicles, with its root and stem constituting the major part, and the size of its root is small. 2. In case of ferulic acid, the wild type contains 0.066% of it, while the cultivar, 0.031%, The wild type contains 4.258% of z-ligustilide and the cultivar, 1.956%. Conclusions : It was thought that there might be also some differences in their genetic characteristics, etc. On this, however, further in-depth study is needed.