• Korean Journal of Environmental Biology
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• v.22 no.4
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• pp.513-518
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• 2004

Pine needle oil and Korean medicinal herbs (KMH) are known as effective therapeutic agents on various blood vessel disease. We have already reported the ameliorative effect of complex of pine needle oil and Korean medicinal herbs against hyperlipidemia. But safety and non - toxicity of pine needle oil and Korean medicinal herbs to normal animal cells have not been studied clearly. In this study, we investigated whether pine needle oil and Korean medicinal herbs show side effects on rat or not. These materials were administered to rats, and subacute toxicity was examined by measuring the hematological values, CBC differentiation, biochemical levels of blood (TP, total protein; albumin; ALP, alkaline phosphotase; AST, aspatate aminotrans- ferase; ALT, alanine aminotransferase; T-Chol., total cholesterol; T-Bil., total bilirubin) and urine analysis, suggesting that the sample have no side effects and cytotoxicity. These results indicate that the complex of pine needle oil and Korean medicinal herbs may effective non- toxic, safety therapeutic agents on hepatocytes and hyperlipidemia.

• Korean Journal of Environmental Biology
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• v.21 no.4
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• pp.410-414
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• 2003

The effect of treatment with pine needle oil complex (complex of pine needle oil and Korean medicinal herbs) upon rat hepatocytes exposed to alcohol was investigated. We compared body weight gain and ratios of liver and kidney to body weight and the serum biochemistry of rats administered both alcohol and Pine needle oil complex to control rats treated with alcohol alone. Pine needle oil complex treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. These data suggest that Pine needle oil complex represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.9
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• pp.1764-1771
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• 2002

The latch needle cam system of circular knitting machines is analysed using multibody dynamics. A formulation is made to obtain the vertical stiffness between the needle and the cam. By implementing this formulation into the data of the multibody dynamics program, the motion of the needle is described and the forces and impulses between the needle and the cam are obtained.

• Design & Manufacturing
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• v.10 no.3
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• pp.25-29
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• 2016

Recently, a hyaluronic acid micro needle patch for therapeutic and cosmetic purposes has been used by attaching directly to the skin with a pattern having a micro needle shape of 1/3 thickness of hair. These products are attracting attention as an innovative product that maximizes the effect by activating the active ingredient in the skin in the deep skin without blocking the horny layer because the micro needle shape exists on the patch surface so that it can penetrate effectively to the skin. Currently, DAB (droplet air blowing) or MEMS technology is used to make pattern shapes for patches. Because of this technology, manufacturing time is long and manufacturing cost is high, so we tried to develop the mold technology to machine the microneedle shape directly to the metal. In this study, we first fabricated a needle pattern with a quadrangular pyramid shape and finally produced a conical needle pattern.

• The Journal of Korean Medicine
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• v.23 no.4
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• pp.27-31
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• 2002

Background and Purpose: There has been little study about the quality of acupuncture needle tips. In order to ensure safe acupuncture treatment, high quality of needle tips is essential. Therefore, we investigated the current condition of the tips of the acupuncture needles on the market. Methods: We selected needles made by 6 companies in Korea, one company each in Japan, the USA and China, and observed the tip of each needle using a scanning electron microscope. Results and Discussion: We found that needles had several defects such as scratch marks on the surface, metallic scuff, lumps and irregularities of the needle tips, stubbed or malformed tips, tips of point off-center, and peeled off coated tips. There were more faulty ones than good ones. Further, better-designed study with a bigger sample size is warranted.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.12
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• pp.2249-2254
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• 2008

A non-thermal micron size plasma needle is applicable for medical treatment because it includes radicals, charged particles, ultraviolet emission, and strong electric fields. The electric fields around the plasma needle device driven by a radio frequency wave are investigated in order to calculate the power delivered to the cell. A commercial multi-physics code, CFD-ACE, was utilized for the calculation of electric fields for the optimization of the needle structure. The electric field and energy absorption profiles are presented with the variation of the device structure and the distance between the needle and tissues. The living tissues effectively absorb the radio frequency power from the plasma needle device with the covered pyrex structure.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.05a
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• pp.234-238
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• 1999

The correlation between shape of electrical trees and partial discharge(PD) pulses in low density polyethylene(LDPE) were discussed. We observed growth feature of electrical tree by using optical microscope. On the basis of experimental results of measurements of trees occurring in the needle-plane arrangement with needle shape void and without needle shape void , statistical quantities are derived, which are relevant to PD pulse amplitude and phase. The PD quantities detected by partial discharge detector. we were analyzed q-n distribution pattern and $\psi$ -q-n distribution pattern. In this experiment, electrical trees in the needle-plane arrangement with needle shape void propagated branch type tree and in the needle-plane arrangement without needle shape void propagated bush type tree

• Korean Journal of Acupuncture
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• v.34 no.3
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• pp.109-115
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• 2017

Objectives : Many researches have studied warm needling technique to standardize its treatment by temperature measurement and material differences in the effectiveness. The purpose of this study is to compare the temperature changes of the acupuncture needle shaft during the combustion process of the moxa stick to determine the heat transfer pattern of the warn needling. Methods : A moxa stick($7{\times}8mm$) was connected to one side of the needle shaft using a stainless steel needle(ø 0.3 mm, ø 0.5 mm, ø 0.8 mm, shaft length 40 mm) with the needle handle removed. During the warm needling, temperature changes of the needle shaft were observed with an infrared camera(Flir E30) and an infrared thermometer(TESTO 845). Results : In the normal condition, heat transmit of needle shaft increased at spots 10 mm and 25 mm below the moxa stick. The amount of heat transmit increased with the diameter of needle shaft. However, when the heat shield was installed to exclude radiant heat from the moxa stick, heat transfer was less at 10 mm below the moxa stick and no temperature change was observed at 25 mm below the moxa stick. Heat transfer by warm needling does not reach the end of needle shaft even in ø 0.8 mm needle. Conclusions : It is suggested that the radiant heat of moxa stick results in the heat transmit of acupuncture needle shaft. Thus, radiant heat transmit must be considered as one of the heat transfer characteristics of the warm needling.

• Journal of Acupuncture Research
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• v.28 no.5
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• pp.65-76
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• 2011

Objectives : Study about needle retaining time. Methods : We reviewed the ancient and the present text of China with using the China academic journal(CAJ) of China national knowledge infrastructure(CNKI) Results & Conclusions : 1. Needle retaining time is important in acupuncture, because the therapy effect is influenced by it. 2. The time of needle retaining is up to those conditions like different disease, viscera and bowels(臟腑), meridian and collateral(經絡), obtaining Qi(得氣), seasons, constitution of the patients and acupuncture tools. In ${\ll}$Hwangdineijing(黃帝內經) ${\gg}$, needle retaining time is called by 'Zhiruzhichu(直入直出)', 'Jichu(疾出)', 'Liu(留)', 'Buliu(不留)', 'Jiuliu(久留)' and 'Liu ${\bigcirc}$ hu(留${\bigcirc}$呼)', and the time was shorter than nowadays. 3. The respiration number was counted to check needle retaining time but we can't find out any evidence. Recently in China, 'obtaining Qi(得氣)' and 'Qi arrival(氣至)' is used to check it. 4. Looking into clinical researches, different diseases need different needle retaining time. For example, 20~30min is appropriate time for musculoskeletal system. 60min is for circulatory system, 10~20min is for peripheral facial nerve paralysis. Insomnia and some stubborn diseases need longer time. Cold and heat(寒熱), deficiency and excess(虛實) are always influences the needle retaining as well. 5. It is important to figure out the most effective needle retaining time for different disease with the base of connection between needle retaining time and effect.

• Korean Journal of Head & Neck Oncology
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• v.14 no.1
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• pp.81-87
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• 1998

Fine needle aspiration cytology was used widely to select thyroid nodules for surgery. The result could be highly reliable for most malignancies and for benign nodules. The purpose of this study was to determine the value of frozen biopsy by directly comparing the results of preoperative fine needle aspiration cytology to frozen biopsy examination. In our university hospital, 103 patients with thyroid nodule were operated during the years 1996 through 1997. A comparison of accuracy of the fine needle aspiration cytology with frozen biopsy was made for 85 patients who underwent both procedures. The 85 patients were separated into two groups. The group I included 65 patients, whose preoperative fine needle aspiration cytology results were reported as benign or malignant lesion definitely. The group II included 85 patients, the patients whose reported fine needle aspiration cytologic result was suspicious for malignancy were regarded .as malignant lesion and results for follicular neoplasm were regarded as benign lesion. The accuracy of both procedures was compared on two group also. The sensitivity, specificity, and accuracy of frozen biopsy were 76.7%, 93.5%, and 85.2% in group I and 75.6%, 95.5%, and 85.9% in group II, respectively, compared with 63.3%, 87.1%, and 75.4% in group I and 65.4%, 81.8%, and 72.9% in group II for fine needle aspiration cytology. On benign lesion, the accuracy was 95.5% in frozen biopsy and 68.2% in fine needle aspiration cytology, 75.6% in frozen biopsy and 53.7% in fine needle aspiration cytology on malignant lesion. We conclude that although fine needle aspiration cytology is the reliable diagnostic test in the evaluation of thyroid nodule, frozen biopsy should be performed intraoperatively, because fine needle aspiration cytology is insufficiently sensitive for reliable surgical planning.