Browse > Article

Study on the Subacute Toxicity of Complex of Pine Needle Oil and Korean Medicinal Herbs against Rats  

Park, Kap Joo (Department of Biological Sciences, Konkuk University)
Ahn, Ki Heung (Department of Biological Sciences, Konkuk University)
Lee, Hyung Hoan (Department of Biological Sciences, Konkuk University)
Publication Information
Korean Journal of Environmental Biology / v.22, no.4, 2004 , pp. 513-518 More about this Journal
Abstract
Pine needle oil and Korean medicinal herbs (KMH) are known as effective therapeutic agents on various blood vessel disease. We have already reported the ameliorative effect of complex of pine needle oil and Korean medicinal herbs against hyperlipidemia. But safety and non - toxicity of pine needle oil and Korean medicinal herbs to normal animal cells have not been studied clearly. In this study, we investigated whether pine needle oil and Korean medicinal herbs show side effects on rat or not. These materials were administered to rats, and subacute toxicity was examined by measuring the hematological values, CBC differentiation, biochemical levels of blood (TP, total protein; albumin; ALP, alkaline phosphotase; AST, aspatate aminotrans- ferase; ALT, alanine aminotransferase; T-Chol., total cholesterol; T-Bil., total bilirubin) and urine analysis, suggesting that the sample have no side effects and cytotoxicity. These results indicate that the complex of pine needle oil and Korean medicinal herbs may effective non- toxic, safety therapeutic agents on hepatocytes and hyperlipidemia.
Keywords
pine needle oil; Korean medicinal herb; subacute toxicity; animal cells;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Koelling MR. 1999. History and characteristics-scotch pine-pinus sylvestris L. DK Publishing Inc., New York. pp.114
2 Kana H, GE Arteel, I Rusyn, H Sies and RG Thurman. 2001. Ebselen prevents early alcohol-induced liver injury in rats. Free Radic. BioI. Med. 30:403-411   DOI   ScienceOn
3 Piola RC and CS Lieber. 1972. The energy cost of the metabolism of drugs, including ethanol. Phamacology. 7:185 -197
4 Nadkami KM. 1976. Indian materia medica. Popular prakashan Press, Bombay. pp.959
5 Park KJ, KS Kim, KH Abn and JS R. 2003. Pine needle oil and Korean medicinal herb complex protect hyperlipidemia and liver cell damage induced by alcohol. K. J. Environ. BioI. 21:410-414
6 Leung AY and S Foster. 1996. Encyclopedia of common natural ingredients used in food, drugs, and cosmetics. $2^{nd}$ ed. John Wiley & Sons Inc., New York
7 Krauze-Baranowska M, M Mardarowicz, M Wiwart, L Poblocka and M Dynowska. 2002. Antifungal activity of the essential oils from some species of the genus Pinus. Natur forsch. 57:478-482
8 Taber CWo 1962. Taber's cyclopedic medical dictionary. 9th ed. FA Davis Company, Philadelphia. pp.61
9 Karsentry BC, Chanussot F, Ulmer M and Debry G. 1985. Influence of chronic ethanol intake on obesity, liver steatosis and hyperlipidaemia in the Zucker fa/fa rat. Br. J. Nutr. 54:5-13   DOI   ScienceOn
10 Piola RC and CS Lieber. 1975. Energy wastage in rats given drugs that induce microsomal enzymes. J. Nutr. 105:1544-1548
11 But PPH. 1997. International collation of traditional and folk medicine. World Science Press, Singapore. pp.1516
12 Huh Joan. 1981. Young in bon-Dong eu bo gam. Han sung Book Press. Seoul
13 Bown D. 1995. Encyclopedia of herbs and their uses. DK Publishing Inc., New York. pp.329
14 Kono H, I Rusyn, T Uesugi, S Yamashina, HD Connor, A Dikalova, RP Mason and RG Thurman. 2001b. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 280:10051012
15 Schulz VR, VE Hansel, M Tyler. 1998. Rational phytotherapy: A physicians' guide to herbal medicine. Springer publishing Inc., New York