• Nuclear Engineering and Technology
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• v.55 no.3
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• pp.999-1008
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• 2023

Deformed fuel rods can cause a partial blockage of the flow area in a subchannel. Such flow blockage will influence the core coolant flow and further the core heat transfer during the reflooding phase and subsequent severe accidents. Nevertheless, most of the system analysis codes simulate the accident process based on the assumed flow blockage ratio, resulting in inconsistencies between simulated results and actual conditions. This paper aims to study the influence of flow blockage in severe accident scenario of the CAP1400 reactor. First, the flow blockage model of ISAA code is improved based on the FRTMB module. Then, the ISAA-FRTMB coupling system is adopted to model and calculate the QUENCH-LOCA-0 experiment. The correctness and validity of the flow blockage model are verified by comparing the peak cladding temperature. Finally, the DVI Line-SBLOCA accident is induced to analyze the influence of flow blockage on subsequent CAP1400 reactor core heat transfer and core degradation. From the results of the DVI Line-SBLOCA accident analysis, it can be concluded that the blockage ratio is in the range of 40%-60%, and the position of severe blockage is the same as that of cladding rupture. The blockage reduces the circulation area of the core coolant, which in turn impacts the heat exchange between the core and the coolant, leading to the early failure and collapse of some core assemblies and accelerating the core degradation process.

• IMMUNE NETWORK
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• v.22 no.6
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• pp.49.1-49.15
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• 2022

Exosomes derived from mesenchymal stem cells (MSCs) could protect against myocardial infarction (MI). TLR4 is reported to play an important role in MI, while microRNA-182-5p (miR-182-5p) negatively regulates TLR4 expression. Therefore, we hypothesize that MSCs-derived exosomes overexpressing miR-182-5p may have beneficial effects on MI. We generated bone marrow mesenchymal stem cells (BM-MSCs) and overexpressed miR-182-5p in these cells for exosome isolation. H₂O₂-stimulated neonatal mouse ventricle myocytes (NMVMs) and MI mouse model were employed, which were subjected to exosome treatment. The expression of inflammatory factors, heart function, and TLR4 signaling pathway activation were monitored. It was found that miR-182-5p decreased TLR4 expression in BM-MSCs and NMVMs. Administration of exosomes overexpressing miR-182-5p to H₂O₂-stimulated NMVMs enhanced cell viability and suppressed the expression of inflammatory cytokines. In addition, they promoted heart function, suppressed inflammatory responses, and de-activated TLR4/NF-κB signaling pathway in MI mice. In conclusion, miR-182-5p transferred by the exosomes derived from BM-MSCs protected against MI-induced impairments by targeting TLR4.

• Bulletin of the Korean Mathematical Society
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• v.28 no.2
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• pp.147-161
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• 1991

In this paper we define the conditional generalized Wiener measure and then express the conditional generalized Wiener integral over this new measure. In particular we consider a conditional expectation of functionals of the generalized Brownian paths under the condition that the paths pass through the given points .xi.$_{1}$, .xi.$_{2}$, .., .xi.$_{n}$ at times t$_{1}$, t$_{2}$, .., t$_{n}$, respectively.ely.

• Honam Mathematical Journal
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• v.41 no.3
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• pp.609-617
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• 2019

We characterize two-point homogeneous spaces M by means of the structural operator $h={\frac{1}{2}}{\mathcal{L}}_{\xi}{\phi}$ or the characteristic Jacobi operator ${\ell}=R({\cdot},{\xi}){\xi}$ on the unit tangent sphere bundles $T_1M$.

• Journal of the Chungcheong Mathematical Society
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• v.8 no.1
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• pp.19-27
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• 1995

In 1974 H.Herrlich invented nearness spaces, a very fruitful concept which enables one to unify topological aspects. In this paper, we introduce the Lindel$\ddot{o}$f nearness structure, countably bounded nearness structure and countably totally bounded nearness structure. And we show that (X, ${\xi}_L$) is concrete and complete if and only if ${\xi}_L={\xi}_t$ in a symmetric topological space (X, t). Also we show that the following are equivalent in a symmetric topological space (X, t): (1) (X, ${\xi}_L$) is countably totally bounded. (2) (X, ${\xi}_t$) is countably totally bounded. (3) (X, t) is countably compact.

• Korean Journal of Mathematics
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• v.15 no.2
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• pp.149-165
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• 2007

We investigate the existence of multiple nontrivial solutions $u(x,t)$ for a perturbation $b[({\xi}-{\eta}+2)^+-2]$ of the hyperbolic system with Dirichlet boundary condition $$(0.1)\;L{\xi}={\mu}[({\xi}-{\eta}+2)^+-2]\;in\;({-{\frac{{\pi}}{2}}},{\frac{{\pi}}{2}}){\times}\mathbb{R},\\L{\eta}={\nu}[({\xi}-{\eta}+2)^+-2]\;in\;({-{\frac{{\pi}}{2}}},{\frac{{\pi}}{2}}){\times}\mathbb{R},$$, where $u^+$=max{u,o}, ${\mu}$, ${\nu}$ are nonzero constants. Here L is the wave operator in $\mathbb{R}^2$ and the nonlinearity $({\mu}-{\nu})[({\xi}-{\eta}+2)^+-2]$ crosses the eigenvalues of the wave operator.

• Korean Journal of Mathematics
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• v.18 no.4
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• pp.473-487
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• 2010

We investigate the existence of multiple nontrivial solutions (${\xi}$, ${\eta}$) for perturbations $g_1$, $g_2$ of the harmonic system with Dirichlet boundary condition $${\Delta}^2{\xi}+c{\Delta}{\xi}=g_1(2{\xi}+3{\eta})\;in\;{\Omega}\\{\Delta}^2{\eta}+c{\Delta}{\eta}=g_2(2{\xi}+3{\eta})\;in\;{\Omega}$$ where we assume that ${\lambda}_1$ < $c$ < ${\lambda}_2$, $g^{\prime}_1({\infty})$, $g^{\prime}_2({\infty})$ are finite. We prove that the system has at least three solutions under some condition on $g$.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.10b
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• pp.67-72
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• 2003

The cold precision forging of spur gears has been researched, and the effects of relief-hole shape and forging process on the spur gears forming has been analyzed. The results present that the forging load decreases when a suitability diameter of relief-hole is chosen, but the function is not obvious. The spur gears precision forging method with an adjustable movement of concave mould can benefit both the top and the bottom comers forming of the spur gears, full fill the tooth cavity, and decrease the forging load.

• Honam Mathematical Journal
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• v.29 no.4
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• pp.723-732
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• 2007

We investigate the existence of solutions u(x, t) for a perturbation b[$(\xi+\eta+1)^+-1$] of the hyperbolic system with Dirichlet boundary condition (0.1) = $L\xi-{\mu}[(\xi+\eta+1)^+-1]+f$ in $(-\frac{\pi}{2},\frac{\pi}{2}\;{\times})\;\mathbb{R}$, $L\eta={\nu}[(\xi+\eta+1)^+-1]+f$ in $(-\frac{\pi}{2},\frac{\pi}{2}\;{\times})\;\mathbb{R}$ where $u^+$ = max{u,0}, ${\mu},\nu$ are nonzero constants. Here $\xi,\eta$ are periodic functions.

• Honam Mathematical Journal
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• v.30 no.4
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• pp.703-711
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• 2008

Let ${{\xi}_k,k{\in}{\mathbb{Z}}}$ be an associated H-valued random variables with $E{\xi}_k$ = 0, $E{\parallel}{\xi}_k{\parallel}$ < ${\infty}$ and $E{\parallel}{\xi}_k{\parallel}^2$ < ${\infty}$ and {$a_k,k{\in}{\mathbb{Z}}$} a sequence of bounded linear operators such that ${\sum}^{\infty}_{j=0}j{\parallel}a_j{\parallel}_{L(H)}$ < ${\infty}$. We define the sationary Hilbert space process $X_k={\sum}^{\infty}_{j=0}a_j{\xi}_{k-j}$ and prove that $n^{-1}{\sum}^n_{k=1}X_k$ converges to zero.