• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2009.10a
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• pp.136-137
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• 2009

Japanese waterfront project consisted actively from an early stage in 1980's, and the project which activated an area in a destination in a various part of Japan was implemented. For a study to however conscious whether the user in water front be of the waterside space in such waterfront project paper its number is very small. A questionnaire survey was put into effect targeted for 17 points of Japanese typical waterfront project paper completed in about 1990 by this research. With the foundation of this, a member item mean, it was possible to classify development paper of 17 results factor analysis is by 4 kind type of the aquarium type, the natural type, the middle type and the artificial type. And it was possible to classify the motive item conscious of the waterside space by 7 kinds, a view, smell, hearing, sense of touch, the taste, existence of facilities and activity behavior. When seeing the motive item in the center, sight was highest by 57% and about 8%, sense of touch, hearing and olfactory three senses had the lowest taste by 1%. "With aquarium" existence of facilities including etc was about 12 %, and activity behavior including Hitoshi who" can clear a quay" was about 6 %, and it appeared.

• Journal of Korea Technology Innovation Society
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• v.11 no.2
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• pp.264-286
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• 2008

In 2006, the share of energy in Korea amounted to 28% from the total import, 97% from overseas dependency, and 83% for the national Greenhouse Gas (GHG) emission in 2004. Thus, from the aspects of economical and environmental policies, an energy analysis is very important, for the industry to cope with the imminent pressure for climate change. However, the estimation of GHG gas emissions due to an energy use is still done in a primitive way, whereby each industry's usage is multiplied by coefficients recommended from international organizations in Korea. At this level, it is impossible to formulate the prevailing logic and policies in face of a new paradigm that seeks to force participation of developing countries through so called post-Kyoto Protocol. In this study, a hybrid energy input-output (E-IO) analysis is conducted on the basis of the input-output(IO) table of 2000 issued by the Bank of Korea in 2003. Furthermore, according to economic sectors, emission of the GHG relative to an energy use is characterized. The analysis is accomplished from four points of view as follows: 1) estimating the GHG emission intensity by 96 sectors, 2) measuring the contribution ratio to GHG emissions by 14 energy sources, 3) calculating the emission factor of 3 GHG compounds, and 4) estimating the total amount of national GHG emission. The total amount estimated in this study is compared with a national official statistical number. The approach could be an appropriate model for the recently spreading concept of a Life Cycle Analysis as it analyzes not only a direct GHG emission from a direct energy use but also an associated emission from an indirect use. We expect this model can provide a form for the basis of a future GHG reduction policy making.

• Journal of Ginseng Research
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• v.37 no.4
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• pp.425-434
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• 2013

UV irradiation is the main factor contributing to skin damages that are associated with an excessive production of matrix-degrading metalloproteinase (MMP)-1 and a deficient expression of collagens. To date, red ginseng has been revealed to possess many biomedical effects, such as anti-aging, anti-oxidation, and anti-inflammatory. In this study, we prepared the Korean Red Ginseng extracts treated with enzyme (KRGE) and investigated the effects of dietary KRGE on the formation of wrinkles generated by UVB irradiation in hairless mice. It was found that KRGE inhibited the UVB-induced formation of wrinkles, epidermal thickness, and skin dryness in hairless mice. Further results also showed that KRGE attenuated UVB-induced MMP-${\beta}$1 level, while accelerated procollagen type I, transforming growth factor-${\beta}$1 secretion. Interestingly, the expression of profilaggrin and filaggrin in both the epidermis and dermis were decreased due to UVB exposure and reversed by KRGE. The KRGE 0.06% was prior to KRGE 0.24%. In view of these results, which indicated that KRGE protected skin from UVB-induced photodamages, which may not only mediated by regulating of MMP-1 and procollagen type I, but also by increasing the production of profilaggrin and filaggrin. In conclusion, our results suggest that KRGE may be a promising agent for the treatment of skin photodamages. The challenge of KRGE will be expected as cosmeceuticals and nutraceuticals in order to intervene in aging-related degenerative skin changes.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.584-589
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• 2001

Isopropryl 2-(1-3-dithiethane-2-ylidene)-2 [N-(4-methyl-thiazole-2-yl) carbamoyl] acetate (YH439) is currently under phase ll clinical trials by the Yuhan Research Center for use as a hepatoprotective agent. Unfortunately, the oral bioavailbility of YH439, which is sparingly soluble in water (i.e., $0.3{\;}\mu\textrm{g}/ml{\;}or{\;}0.91{$\mu}M$ at room temperature), reportedly, is negligibleregardless of the dose administered to rats in the 10-300 mg/kg range. The bioavailability of the compound increased up to 24%, when administered in the form of a micellar solution ($700{\;}\mu\textrm{g}/ml$or 2.1 mM for YH439) at a dose of 10 mg/kg, suggesting that its limited solubility is associated with its negligible bioavailability. In order to obtain additional informmation concerning the bioavailability of YH439, the mechanism(s) involved in gastrointestinal (Gl) absorption were investigated in the present study. For this purpose, the transport of YH430 across a Caco-2 cell monolayer was measured in a $Transwell^{\circledR}$. A permeability of $4.07{\times}10^{-5}{\;}cm/s$ was obtained for the absorptive (i.e., apical to basolateral direction) transport of $0.42{\mu}M$ YH439, implicating that the in vivo Cl absorption is nearly complete. The absorptive transport exhibited a slight concentration-dependency with an intrinsic clearance ($CL_{i}$) of $0.38{\mu}L/{\textrm{cm}^2}/sec$, which accounted for 28.1% of the total intrinsic clearance (i.e., $CL_i$ plus the intrinsic clearance for the linear component) of the transport. Thus, saturation of the absorption process appears to be a minor factor in limiting the bioavailability of the compound. The apparent permeability of YH439 from the basolateral to the apical direction (i.e., efflux, $6.67{\times}10^{-5}{\;}cm/s$) was comparable to that for absorptive transport, but, interestingly, a more distinct concentration-dependency was observed for this transport. However, the efflux does not appear to influence the bioavailability of the compound, as evidenced by the sufficiently high permeability in the absorption direction. Rather, a reportedly extensive first-pass hepatic metabolism appears to be a principal factor in limiting the bioavailability. In this respect, reducing the first-pass metabolism by some means would lead to a higher bioavailability of the compound. Thus, elevation of the absorption rate of YH439 becomes a necessity. From a practical point of view, increasing the concentration of YH439 in the Cl fluid appears to be a feasible way to increase the absorption rate, because the compound is primarily absorbed via a linear mechanism. In summary, the solubilization of YH439, as previously demonstrated for a micellar solution of the compound, appears to be a practical way to increase the oral bioavailability of YH439.

• Journal of the Korean Applied Science and Technology
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• v.36 no.2
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• pp.609-622
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• 2019

When the surfactant is dissolved in an aqueous solution, it forms aggregate called micelles (<20 nm) in the solution, and micelles can form the solubilized formulation by supporting the active ingredient therein. Swollen micelles are formulations capable of carrying larger amounts of active ingredient than conventional solubilized formulations at 50~100 nm. Unlike liposomes or nanoemulsions, which require a separate process such as high pressure emulsification, Swollen micelle is a more efficient method of solubilization and particle formation from a productive point of view. In this study, stabilization experiments on swollen micelle formulations were carried out using poloxamer 407, and then optimized formulation experiments for tocopheryl acetate components were performed using Response Surface Methodology (RSM). Tocopheryl acetate, a surfactant that affects solubilization and an active substance, were set as a factor and the correlation between them was confirmed. As the evaluation method, stability and particle size distribution and size were confirmed by temperature and time, and the structure and shape of the swollen micelle carrying the active ingredient were confirmed by FIB. These results show that poloxamer 407 0.500%, octyldodeceth-16 0.387% and tocopheryl acetate 0.945% are the most optimized prescriptions for swollen micelle stabilized with tocopheryl acetate.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.259-267
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• 2019

The purpose of this study is to examine the inner side of those who raise the children, that is, the mothers, through the satisfaction with the parental roles and the child-rearing stress of them, with a view to emphasize the importance of an alternative for the mothers to cope with child-rearing stress and enhancing their satisfaction level with their role as a parent as well as the importance of social support in order to enhance the quality of rearing. For this purpose, the researcher conducted a survey with 312 mothers with preschool children of age 4 to 7 in Seoul and Gyeonggi Area from October 1, 2018 to October 15, 2018. To analyze the data, the researcher conducted frequency analysis, exploratory factor analysis, confirmatory factor analysis, confidence analysis, correlation analysis, structural equation model, and Sobet-test, using SPSS 22.0 and AMOS 22.0. The results of the analyses showed that social support and satisfaction with the parental role were significantly influenced by child-rearing stress, while social support influenced the satisfaction with the parental role significantly. Also, it turned out to have a mediating effect in the relationship between the mother's child-rearing stress and the satisfaction with the parental role. Based on these findings, the study highlights that the social network that is connected with the mothers may function to reduce the negative influence of child-rearing stress on the satisfaction with the parental role when the social network channels appropriate support, tangible assistance, appealing of difficulties, and encouragement.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.214-221
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• 2019

Visual perception information acquired through human eyes contains much information on how to view visual stimuli using eye tracking technology, it is possible to acquire and analyze consumer visual information as quantitative data. These measurements can be used to measure emotions that customers feel unconsciously, and they can be directly collected by numerically quantifying the character's search response through eye tracking. In this study, we traced the character's area of interest (AOI) and found that the average of fixation duration, count, average of visit duration, count, and finally the time to first fixation was analyzed. As a result of analysis, it was found that there were many cognitive processing processes on the face than the character's body, and the visual attention was high. The visual attention of attraction factor has also been able to verify that attraction is being presented as an important factor in determining preferences for characters. Based on the results of this study, further studies of more characters will be conducted and quantitative interpretation methods can be used as basic data for character development and factors to be considered in determining character design.

• Journal of the Microelectronics and Packaging Society
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• v.26 no.1
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• pp.29-33
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• 2019

With shrinking form factor and improving performance of electronic packages, high input/output (I/O) density is considered as an important factor. Fan out wafer-level packaging (FO-WLP) has been paid great attention as an alternative. However, FO-WLP is vulnerable to warpage during its manufacturing process. Minimizing warpage is essential for controlling production yield, and in turn, package reliability. While many studies investigated the effect of process and design parameters on warpage using finite element analysis, they did not take uncertainty into consideration. As parameters, including material properties, chip positions, have uncertainty from the point of manufacturing view, the uncertainty should be considered to reduce the gap between the results from the field and the finite element analysis. This paper focuses on the effect of uncertainty of Young's modulus of chip on fan-out wafer level packaging warpage using finite element analysis. It is assumed that Young's modulus of each chip follows the normal distribution. Simulation results show that the uncertainty of Young's modulus affects the maximum von Mises stress. As a result, it is necessary to control the uncertainty of Young's modulus of silicon chip since the maximum von Mises stress is a parameter related to the package reliability.

• Journal of the Society of Disaster Information
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• v.17 no.2
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• pp.289-305
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• 2021

Purpose: The purpose of this study is to check the importance of higher level, sub higher level and lower alternative factor and the factor for relieved life and also check the comprehensive priority in executed "Safety and relieved life level improvement of apartment house residents by AHP analysis". Method: The safety management evaluation elements and alternatives have been arranged as hierarchical structure based on the preceding studies and the advice of experts for the maintenance and system of apartment house in this study. Study model is used for the survey of pair wise comparison composition targeting experts and AHP analysis method is used for alternative plan ranking, etc. Result: The response result of survey secured the consistency and it is confirmed that safety inspection for apartment house electricity facility is most important for higher level, safety inspection, detailed inspection and diagnosis evaluation are most important for sub higher level and plumbing equipments is most important for alternatives based on the analysis result of relative weight comparison for sub higher level and alternatives for final goal attainment of the study. Conclusion: Plumbing equipments, crime prevention safety and electrical safety are shown as top priority alternatives when observe it with expert manager's point of view for apartment house. It shows that securing the importance of living safety accident and deciding the level of relieved life can be improved are the alternatives of pre-prevention and management strengthening.

• Journal of Digital Convergence
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• v.20 no.5
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• pp.569-584
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• 2022

This study can be helpful in establishing and establishing company-wide marketing strategies from the supplier's point of view by analyzing the effects of rental service users' risk perception and service quality on customers' re-use intentions, and revealing differences according to demographic characteristics. It was intended to provide valid results. A total of 218 data were used as analysis data. Frequency, factor, mean, reliability and regression analysis, ANOVA, and t-test were performed through SPSS program (statistics). As a result of the study, first, as a result of analyzing the effect of risk perception on rental service quality, functional and psychological risks have a negative (-) effect on service quality. Second, in the relationship between service quality and re-use intention, the empathy factor has a high positive (+) effect, and as a result of analyzing the effect of risk perception on re-use intention, functional and psychological risk have the greatest influence, and financial Risk perception was also highly influential. In conclusion, the research results suggest that increasing the concentration of marketing strategies by reducing the negative (-) effect related to risk perception for short-term customers and housewives and enhancing the reliability and empathy for service quality can maximize the sales of suppliers.