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Pharmacokinetic analysis for the development of new potent anti-HIV-1 agents, the KR-V series (새로운 항HIV-1제, KR-V series의 개발을 위한 약물동태연구)

  • Lee, Young-mi;Kim, Jin-suk;Han, Sang-seop;Shin, Ho-chul
    • Korean Journal of Veterinary Research
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    • v.40 no.3
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    • pp.471-478
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    • 2000
  • The pharmacokinetic properties of KR-V compounds, recently developed as new anti-HIV agents, were studied after i.v. and p.o. administration in rats. The concentrations of the KR-V series were determined in rat plasma using an high-performance liquid chromatography (HPLC)-UV detection system. Of the 19 KR-V compounds investigated in the present study, only KR-V 3, 10, 14, 16 and 18-1 showed oral bioavailability. The plasma concentration-time data could be adequately described by an one-compartment open model. In the i.v. kinetic study (10mg/kg), the CLt of KR-V 3, 10, 14 and 16 (>4L/hr/kg) were significantly higher than that of KR-V 18-1 (1.1 L/hr/kg). The AUC of KR-V 18-1 was greater ($8.97{\mu}g{\cdot}hr/ml$) than that of the other compounds, but the Vd (0.58 L/kg) was lower. In the p.o. kinetic study (50mg/kg), although the t-1/2 of KR-V 18-1 was shorter than that of the other compounds, the AUC ($3.659{\mu}g{\cdot}hr/ml)$ and $C_{max}(1.891{\mu}g/ml$) were markedly higher. In a seperated in vitro experiment, only KR-V 18-1, of the 5 compounds with bioavailibility, exhibits potent activity against HIV-1 mutant strains. Therefore, KR-V 18-1 is expected to become a new potent anti-AIDS drug candidate/lead compound.

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Effects of $v_2O_5$ Addition on the Magnetic Properties of Mn-Zn Ferrites (Mn-Zn Ferrites 의 자기적 성질에 미치는 $V_2O_5$의 첨가효과)

  • Jo, Deok-Ho
    • Journal of the Korean Magnetics Society
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    • v.2 no.3
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    • pp.222-227
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    • 1992
  • The effects of $V_2O_5$ addition as an additive on the densification, the microstructure and the magnetic properties of Mn-Zn ferrites were studied. The maximum density was observed at 0.1 wt% $V_2O_5$ content and it was recognized that a small content of $V_2O_5$ prohibited the discontinuous grain growth. The initial permeability showed maximum at 0.1 wt% $V_2O_5$ content and the power loss minimum at 0.03 wt% $V_2O_5$ content. It was found that a small content of $V_2O_5$ went into solid solution in the Mn-Zn ferrites, but above that extent $V_2O_5$ formed a second phase to be segregated at the grain boundaries.

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Separation Characteristics of Barium Ion in Water Using Capacitive Deionization (CDI) Process (축전식탈염(CDI) 공정을 이용한 수용액 중 바륨 이온 분리 특성 연구)

  • Nam, Dong Hyun;Rhim, Ji Won
    • Membrane Journal
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    • v.29 no.6
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    • pp.355-361
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    • 2019
  • We studied the removal of barium ions that may be contained in industrial wastewater using the existing capacitive deionization (CDI). The 30 mg/L BaCl2 (barium chloride dihydrate) solution was used as the feed solution, and the flow rate was set to 10 mL/min. The adsorption conditions were varied from 1.2 V to 3, 5 and 7 min, and the desorption conditions were -1, -1.5, -2 V and 1, 2 and 3 min, respectively, to select the most efficient conditions. As a result, barium ion removal efficiency of 64.4% was obtained under the adsorption conditions of adsorption of 1.2 V/7 min and the desorption -1 V/1 min. For the desorption voltages and time, under the same experimental conditions, the removal efficiency of CDI for 30 mg/L NaCl aqueous solution with the same concentration as barium showed 69.9% removal efficiency under the adsorption conditions of and the desorption conditions of 1.2 V/7 min desorption -1 V/1 min, respectively.

NEARLY SIMULTANEOUS OBSERVATIONS OF SiO (v=0, 1, 2, J=3-2) EMISSION IN LATE-TYPE STARS

  • CHO SE-HYUNG;CHUNG HYUN-SOO;KIM HYO-RYOUNG;OH BOB-YOUNG
    • Journal of The Korean Astronomical Society
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    • v.29 no.spc1
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    • pp.261-262
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    • 1996
  • Nearly simultaneous observations for $^{28}SiO$ v=0, 1, 2, J =3-2 transitions in 39 late-type stars have been carried out in February 1995 and 1996 with the 14 m radio telescope at Taeduk Radio Astronomy Observatory (TRAO). Observations for $^{28}SiO$ v=0, 1, 2, J=2-1 lines in the same objects have been also carried out in March 1995 and March-April 1996. The detection rate of $^{28}SiO$ v=l, J=3-2 line for the $^{28}SiO$ v=l, J=2-1 sources was $59\%$. Seventeen new detections in the $^{28}SiO$ v=l, J=3-2 transition and 4 new detections in the $^{28}SiO$ v=2, J=3-2 transition have been reported including the intensity ratios within the vibrational ladders and rotational states.

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The Study on the Separation of the Subsidiary Elements in Iron and Steel by Using Ion Exchangers (II). The Separation of Anions (이온 교환수지에 의한 철 및 강의 분석에 관한 연구 (제2보). 음이온 성분의 분리)

  • Byoung-Cho Lee;Myon-Yong Park;Kee-Chae Park
    • Journal of the Korean Chemical Society
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    • v.17 no.6
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    • pp.428-433
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    • 1973
  • The quantitative separations of a mixture containing equal amount of each anion such as Si(IV), As(V), P(V), S(VI), W(VI) and Cr(VI) are carried out by the elution through 20${\times}3.14cm^2$ column of anion exchange resin, Dowex 1${\times}$8. The eluents are a mixture of 0.07 M hydrochloric acid and 0.03 M sodium chloride (pH = 1.30) for Si(IV), As(V) and P(V) species, a mixture of 0.6 M sodium chloride and 0.3 M sodium hydroxide for S(VI), W(VI) and Cr(VI) species, and 0.1 N sodium sulfite (pH = 3.48) for P(V) and As(V) species. The subsidiary anions in a standard mixture such as Si(IV), As(V), S(VI), P(V) and W(VI) are separated together from large amount of Fe(III) by the elution through 30cm${\times}3.14cm^2$ column of the resin, Dowex${\times}$50w${\times}$12, using a mixture of 0.1 M sodium nitrate and 2 percent dimethylsulfoxide aqueous solution as an eluent. Si(IV), As(V), S(VI), P(V) and W(VI) eluted together are separated quantitatively under the same conditions as in the separations of the anion mixture. By the conditions obtained in the separations of the standard mixture, Fe(III) and all of the subsidiary anions in steel are quantitatively separated.

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Electrical Properties of Ultra-shallow$p^+-n$ Junctions using $B_{10}H_{14}$ ion Implantation ($B_{10}H_{14}$ 이온 주입을 통한 ultra-shallow $p^+-n$ junction 형성 및 전기적 특성)

  • 송재훈;김지수;임성일;전기영;최덕균;최원국
    • Journal of the Korean Vacuum Society
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    • v.11 no.3
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    • pp.151-158
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    • 2002
  • Fabricated were ultra-shallow $p^+-n$ junctions on n-type Si(100) substrates using decaborane $(B_{10}H_{14})$ ion implantation. Decaborane ions were implanted at the acceleration voltages of 5 kV to 10 kV and at the dosages of $1\times10^{12}\textrm{cm}^2$.The implanted specimens were annealed at $800^{\circ}C$, $900^{\circ}C$ and $1000^{\circ}C$ for 10 s in $N_2$ atmosphere through a rapid thermal process. From the measurement of the implantation-induced damages through $2MeV^4 He^{2+}$ channeling spectra, the implanted specimen at the acceleration voltage of 15 kV showed higher backscattering yield than those of the bare n-type Si wafer and the implanted specimens at 5 kV and 10 kV. From the channeling spectra, the calculated thicknesses of amorphous layers induced by the ioin implantation at the acceleration voltages of 5 kV, 10 kV and 15 kV were 1.9 nm, 2.5 nm and 4.3 nm, respectively. After annealing at $800^{\circ}C$ for 10 s in $N_2$ atmosphere, most implantation-induced damages of the specimens implanted at the acceleration voltage of 10 kV were recovered and they exhibited the same channeling yield as the bare Si wafer. In this case, the calculated thickness of the amorphous layer was 0.98 nm. Hall measurements and sheet resistance measurements showed that the dopant activation increased with implantation energy, ion dosage and annealing temperature. From the current-voltage measurement, it is observed that leakage current density is decreased with the increase of annealing temperature and implantation energy.

Application Analysis of Vitex rotundifolia by Difference of the Shallow-Extensive Green Roof System (저관리 옥상녹화의 식재기반 시스템 차이에 따른 순비기나무의 활용성 평가)

  • Park, Jun-Suk;Ju, Jin-Hee;Kim, Won-Tae;Yoon, Young-Han
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.13 no.4
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    • pp.10-17
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    • 2010
  • The objectives of this study were to compare the growth of Vitex rotundifolia as affected by the difference of soil depth and mixture ratio in a shallow-extensive green roof module system, and to identify the level of soil thickness and mixture ratio as suitable growing condition to achieve the desired plant growth in green roof. Different soil thickness levels were achieved under 7cm, 15cm and 25cm of shallow-extensive green roof module systems made by woody frame of $500{\times}500{\times}300mm$. Soil mixture ratio were eight types for perlite : peatmoss : leafmold = 7 : 1 : 2 (v/v/v, $P_7P_1L_2$), perlite : peatmoss : leafmold = 6 : 2 : 2 (v/v/v, $P_6P_2L_2$), perlite : peatmoss : leafmold = 5 : 3 : 2 (v/v/v, $P_5P_3L_2$), perlite : peatmoss : leafmold = 4 : 4 : 2 (v/v/v, $P_4P_4L_2$), only sand ($S_{10}$), sand : leafmold = 7 : 3 (v/v, $S_7L_3$), sand : leafmold = 5 : 5 (v/v, $S_5L_5$) and only leafmold ($L_{10}$). The growth response of Vitex rotundifolia had fine and sustain condition in $P_6P_2L_2$, $P_5P_3L_2$ and $P_4P_4L_2$., Especially, in case of $P_6P_2L_2$, growth response appeared to be good even in soil thickness 7cm, which showed low survival rates of Vitex rotundifolia in other soil mixtures. Tree height, root diameter, photosynthesis and chlorophyll contents tended to increase with increased soil thickness.

Studies on electrocardiogram of the normal Korean native cattle I. Standard limb leads (정상적(正常的)인 한우(韓牛)의 심전도(心電圖)에 관(關)한 연구(硏究) I. 표준지유도(標準肢誘導))

  • Choi, In-hyuk;Jung, In-sung;Kim, Nam-soo;Suh, Doo-seok
    • Korean Journal of Veterinary Research
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    • v.33 no.4
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    • pp.719-734
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    • 1993
  • The electrocardiographic(ECG) parameters on the standard limb leads in the normal Korean native cattle have been measured with a 3 channel Electrocardiograph built in a computed analysis. The study was conducted on the animals 98 heads of mean age of 17.7 months. Conduction parameters, waves, intervals and segments have been recorded. The recordings were analyzed as to shape and amplitude of the P and T waves and the components of the QRS complex. Heart rate was recorded by the Electrocardiogram which were a mean of $80.4{\pm}11.6beats/min$. And the younger had a higher heart rate than the older one. Average conduction times in the RP, the QRS complex and the QTc interval recorded $166.7{\pm}23.1msec.$, $79.7{\pm}8.8msec.$ and $395.5{\pm}30.4msec.$, in the P and T wave duration recorded $70.1{\pm}13.5msec.$ and $97.6{\pm}16.9msec.$, and in the PR and ST segment duration recorded $97.9{\pm}23.5msec.$ and $173.9{\pm}40.3msec.$, respectively. The wave forms in each lead observed various types. The amplitudes of wave type showed the highest frequency in each lead that were analyzed as follow : 1. In P wave, amplitudes of the positive type showed the frequency of 65.3%, 82.7% and 52.0% in leads I, II and III that were $103.1{\pm}47.8{\mu}V$, $115.2{\pm}37.3{\mu}V$ and $67.4{\pm}26.9{\mu}V$, and it showed the frequency of 54.1% and 85.7% in the leads aVL and aVF that were $63.7{\pm}23.0{\mu}V$, $88.0{\pm}83.6{\mu}V$, respectively. Average amplitude of the negative type showed the frequency of 78.6% in lead aVR which was $99.3{\pm}38.0{\mu}V$. 2. Average amplitude of the QRS complex were from $362.8{\pm}177.7{\mu}V$ to $532.8{\pm}253.9{\mu}V$(mean of $449.1{\pm}57.2{\mu}V$) that in all leads except lead I were manifested the Low-Voltage QRS complex(below 0.5mV). Average amplitudes of each wave type in the QRS complex aere $-50.2.4{\pm}258.2{\mu}V$ and $-428.6{\pm}195.1{\mu}V$ in the QS groups type that showed a frequency of 66.3%, 70.4% in the leads I and aVL, were $451.1{\pm}20.4.0{\mu}V$, $387.6{\pm}175.8{\mu}V$ and $299.3{\pm}146.5{\mu}V$ in the R groups type that showed a frequency of 48.0%, 53.1% and 34.7% in the leads III, aVR and aVF, and were $-307.5{\pm}180.3{\mu}V$, $201.4{\pm}77.2{\mu}V$ in the QR wave type which showed a frequency of 39.8% in lead II, respectively. 3. In T wave, amplitude of the positive type showed the frequency of 50.0%, 82.7%, 51.0% and 57.1% in leads II, III aVR and aVF which were $214.9{\pm}115.6{\mu}V$, $188.5{\pm}119.3{\mu}V$, $191.0{\pm}93.7{\mu}V$ and $165.7{\pm}91.9{\mu}V$, and the negative type showed a frequecny of 66.3% and 72.5% in leads I and aVL. that were $221.3{\pm}112.5{\mu}V$, $-173.6{\pm}86.7{\mu}V$, respectively. 4. Amplitude of ST segment in leads I, II and III were a mean of $-12.2{\pm}37.2{\mu}V$, $17.5{\pm}42.6{\mu}V$ and $28.3{\pm}40.4{\mu}V$, in leads aVR, aVL and aVF were $-3.9{\pm}32.5{\mu}V$, $-15.9{\pm}35.6{\mu}V$ and $26.2{\pm}37.5{\mu}V$, respectively.

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Development of environmentally friendly inorganic fluorescent pigments, A3V5O14 (A = K and Rb) and Cs2V4O11: Crystal structure, optical and color properties (친환경 무기 형광 안료 A3V5O14 (A = K and Rb) and Cs2V4O11 개발: 결정구조, 광학적 특성 및 착색 특성)

  • Jeong, Gyu Jin;Kim, Jin Ho;Lee, Younki;Hwang, Jonghee;Toda, Kenji;Bae, Byoungseo;Kim, Sun Woog
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.30 no.2
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    • pp.47-54
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    • 2020
  • To develop the bright-vivid red- and yellow-inorganic fluorescent pigments with high luminescence properties, A3V5O14 (A = K and Rb) and Cs2V4O11 inorganic pigments were synthesized by a water assisted solid state reaction (WASSR) method and a conventional solid state reaction method. Although impurity peaks corresponding to the AVO3 and AV3O8 (A = K, Rb, and Cs) were observed in all samples prepared, the trigonal structure A3V5O14 (A = K and Rb) and orthorhombic structure Cs2V4O11 were successfully obtained as a main phase. These inorganic pigments showed the broad absorption band (under 550 nm) originated from CT transitions of VO4 polyhedron, and the strong broad red- and green-emission bands due to 3T21A1 and 3T11A1 transitions of the [VO4]3- group. The A3V5O14 (A = K and Rb) and Cs2V4O11 pigments showed a bright-vivid red- and yellow-body color, where the a* values of the A3V5O14 (A = K and Rb) were +35.5 and +45.9, respectively, and b* value of Cs2V4O11 pigments was +50.3. The L* values of the A3V5O14 (A = K and Rb) and Cs2V4O11 inorganic pigments were over +45. These results indicate that the A3V5O14 (A = K and Rb) and Cs2V4O11 inorganic pigments could be an attractive candidate as a bright-vivid red- and yellow inorganic pigments.

Design of 2-Ch DC-DC Converter with Wide-Input Voltage Range of 2.9V~5.6 V for Wearable AMOLED Display (2.9V~5.6V의 넓은 입력 전압 범위를 가지는 웨어러블 AMOLED용 2-채널 DC-DC 변환기 설계)

  • Lee, Hui-Jin;Kim, Hak-Yun;Choi, Ho-Yong
    • Journal of IKEEE
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    • v.24 no.3
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    • pp.859-866
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    • 2020
  • This paper proposes a 2-ch DC-DC converter with a wide-input voltage range from 2.9V~5.6V for wearable AMOLED displays. For positive voltage VPOS, a boost converter is designed using an over-charged voltage permissible circuit (OPC) which generates a normal output voltage even if over-input voltage is applied, and a SPWM-PWM dual mode with 3-segmented power transistors to improve efficiency at light load. For negative voltage VNEG, a 0.5x regulated inverting charge pump is designed to increase power efficiency. The proposed DC-DC converter was designed using a 0.18-㎛ BCDMOS process. Simulation results show that the proposed DC-DC converter generates VPOS voltages of 4.6 V and VNEG voltage of -0.6V~-2.3V for input voltage of 2.9V to 5.6V. In addition, it has power efficiency of 49%~92%, output ripple voltage has less than 20 mV for load current range of 1 mA~70 mA.