• The Korean Journal of Physiology
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• 제10권1호
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• pp.41-48
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• 1976

Tetrodotoxin (TTX) is the purified active principle responsible for tetrodon (Puffer-fish) poisoning which has long been known in the Orient. The pharmacological actions of TTX have been rather extensively investigated. Two of the most prominent effects of intravenousely administered TTX are severe hypotension and respiratory paralysis resulting from its depressant actions on tissues. This depressant actions of TTX in turn result from the selective inhibition of sodium-carrying mechanism which is essential to generation of the action potential. TTX differs from local anesthetics in that it does not affect potassium conductance. Although the mechanism of the hypotensive action of TTX remains a subject of controversy, most investigator agree that TTX-induced hypotension is caused by alteration in the blood vessels rather than the heart. Not only the study on the effects of TTX on cardiac function is meager but the results of reported works are often contradictory. The present study was undertaken to investigate the effect of TTX on the electrocardiogram of the rabbit and to compare them with well known electrocardiographical characteristics found in digitalis and quinidine intoxicated animals. The results obtained from the present study are summarized as follows. 1. No changes were found in P-R interval and QRS duration after i.v. administration of $1.0\;{\mu}g/kg\;to\;1.5\;{\mu}g/kg$ TTX to the animals. It is obvious that there were no conduction disturbance between atria and ventricles as well as in the ventricular tissue. 2. In $1.0\;{\mu}g/kg$ TTX group, S-T interval and T-P segment were not changed whereas marked changes were observed in $1.5\;{\mu}g/kg$ TTX group. 3. The first and second degree A-V blocks appeared in the $2.0\;{\mu}g/kg$ TTX group. 4. TTX differs from digitalis and quinidine in that it does not cause S-T interval depression and T-wave inversion. In contrast with digitalis, TTX caused Q-T interval prolongation.

• 한국발생생물학회지:발생과생식
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• 제22권4호
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• pp.309-318
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• 2018

The present study was conducted to investigate the regulatory mechanism of plasminogen activators (PAs) activation by $17{\beta}$-estradiol ($E_2$) and progesterone ($P_4$) in porcine uterine epithelial cells (pUECs). pUECs were collected from porcine uterine horn and cultured at 80% confluence. Then, 0.1% (v/v) DMSO, 20 ng/mL $E_2$, and $P_4$ with or without fetal bovine serum (FBS) treated to cultured cells for 24 hours. The supernatants were used for measurement of PAs activity and expression of urokinase-type PA (uPA), tissue-type PA (tPA), uPA specific receptor (uPAR), and type-1 PA inhibitor (PAI-1) mRNA were analyzed by real-time PCR. The expression of PAs-related genes was not affect by steroid hormones in both of serum treatment groups. However, PAs activity was increased by treatment of $E_2$ compared to 0.1% DMSO treatment in serum-free group (p<0.05). Then, $E_2$ and $P_4$ were diluted with 0.002% (v/v) DMSO for reduction of its effect and treated to cultured cells without FBS. Only tPA mRNA was significantly increased by $E_2$ treatment (p<0.05). PAs activity was enhanced in $E_2$ treated group compared to control groups (p<0.05). These results indicate that serum-free condition is more proper to evaluate effect of steroid hormones and activation of PAs in pUECs was mainly regulated by estrogen. These regulation of PAs activation may be associated with uterine remodeling during pre-ovulatory phase in pigs, however, further studies are needed to investigate precise regulatory mechanism.

• 조명전기설비학회논문지
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• 제14권1호
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• pp.22-29
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• 2000

본 논문은 가스절연개폐장치내에 바늘모양의 금속입자가 존재하는 경우 $\pm1.2/44[{\mu}s]$ 비진동성 임펄스와 $\pm0.4[{\mu}s]/1.14[MHz]$ 진동성 임펄스전압이 인가되었을 때 $SF_6$가스의 절연특성에 관한 것으로 절연파괴전압-시간 특성 (V-t 특성) 및 절연파괴전압-압력 특성(V-p 특성)을 측정하고 검토하였다. 실험은 길이 10[mml, 반경 0.5[mm]인 바늘모양의 돌기물에 의해 형성된 불평등 전계이며, 가스압력이 0.1~0.5[MPa]인 범위에서 수행하였다. 그 결과 절연 파괴는 정.부극성 모두 계단상 펄스에 의해 진전하는 리더메커니즘으로 발생하였다. 정극성의 진동성 임펼스전압이 인가되었을 때 절연파괴전압이 가장 낮았으며, 짧은 시간범위에서 V-t곡선의 감쇠가 현저하고 가스압력의 의존성이 적게 나타났다. 이에 반해 부극성의 경우 V-t 특성과 V-p 특성은 인가전압의 파형에 대한 의존성이 현저하였다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제14권2호
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• pp.139-145
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• 2014

Control of threshold voltage ($V_T$) by ground-plane (GP) technique for planar tunnel field-effect transistor (TFET) is studied for the first time using TCAD simulation method. Although GP technique appears to be similarly useful for the TFET as for the metal-oxide-semiconductor field-effect transistor (MOSFET), some unique behaviors such as the small controllability under weak ground doping and dependence on the dopant polarity are also observed. For $V_T$-modulation larger than 100 mV, heavy ground doping over $1{\times}10^{20}cm^{-3}$ or back biasing scheme is preferred in case of TFETs. Polarity dependence is explained with a mechanism similar to the punch-through of MOSFETs. In spite of some minor differences, this result shows that both MOSFETs and TFETs can share common $V_T$-control scheme when these devices are co-integrated.

• Bulletin of the Korean Chemical Society
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• 제26권11호
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• pp.1761-1766
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• 2005

Solvolysis rates of isopropenyl chloroformate (3) in water, $D_2O$, $CH_3OD$ and in aqueous methanol, ethanol, 2,2,2-trifluoroethanol (TFE), acetone, 1,4-dioxane as well as TFE-ethanol at 10 ${^{\circ}C}$ are reported. Additional kinetic data for pure water, pure ethanol and 80%(w/w) 2,2,2-trifuoroethanol (T)-water (W) at various temperatures are also reported. These rates show the phenomena of maximum rates in specific solvents (30% (v/v) methanol-water and 20% (v/v) ethanol-water) and, variations in relative rates are small in aqueous alcohols. The kinetic data are analyzed in terms of GW correlations, steric effect, kinetic solvent isotope effects (KSIE), and a third order model based on general base catalysis (GBC). Solvolyses based on predominately stoichiometric solvation effect relative to medium solvation are proceeding in 3 and the results are remarkably similar to those for p-nitrobenzoyl chloride (4) in mechanism and reactivity.

• 한국자동차공학회논문집
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• 제13권1호
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• pp.19-27
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• 2005

The spray characteristics of DISI injector has a great role in engine efficiency and emission. Thus, many researchers have been studied to investigate the spray characteristics of hollow cone type and slit type injector which are used in DISI engine. In this study, we tried to provide spray parameters which effect on the spray characteristics such as injection pressure, ambient pressure and ambient temperature. In addition, we calculated $t_b\;and\;t_c$ to investigate the break up mechanism of test injectors and also obtained $C_v$ to evaluate the spray characteristics. From this study, As the ambient pressure increases in case of slit injector, $C_v$ decreases.

• E2M - 전기 전자와 첨단 소재
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• 제9권4호
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• pp.385-395
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• 1996

이 논문은 금속성 돌기물에 의한 불평등전계중에서의 비진동성과 진동성 임펄스전압에 의한 SF$_{6}$ 가스의 절연파괴 특성에 대해 기술하였다. 절연파괴전압-시간특성을 가스압 0.1-0.5MPa의 범위에서 정.부 극성의 전압을 인가하여 측정하였으며, 그리고 50.ohm.분류기를 통해서 전구방전 전류를 관측하였다. 가스압력에 의한 리이더 진전시간의 의존성도 측정하였다. 스트리머 코로나에 의해 발생하는 공간전하에 의한 국부전계강화는 시험갭의 전기적 절연파괴에 영향을 미치는 것으로 판명되었다. 절연파괴는 초기 스트리머 코로나로부터 발단되어, 국부전계강화에 의한 리이더진전으로 이루어진다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1223-1227
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• 2005

Fine microgroove is the key component to fabricate micro-grating, micro-grating lens and so on. Conventional groove fabrication methods such as etching and lithography have some problems in efficiency and surface integrity. This study deals with the creation of ultra-precision micro grooves using non-rotational diamond tool and CNC machining center. The shaping type machining method proposed in the study allows to produce V-shaped grooves of $40\mu{m}$ in depth with enough dimensional accuracy and surface. For the analysis of machining characteristics in micro V-grooving, three components of cutting forces and AE signal are measured and processed. Experimental results showed that large amplitude of cutting forces and AE appeared at the beginning of every cutting path, and cutting forces had a linear relation with the cross-sectional area of uncut chip thickness. From the results of this study, proposed micro V-grooving technique could be successfully applied to forming the precise optical parts like prism patterns on light guide panel of TFT-LCD.

• 한국재료학회지
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• 제15권5호
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• pp.348-352
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• 2005

Gallium oxyhydroxide (GaOOH) powders were heat-treated in a flowing ammonia gas to form GaN, and the reaction kinetics of the oxide to nitride was quantitatively determined by X-ray diffraction analysis. GaOOH turned into intermediate mixed phases of $\alpha-\;and\;\beta-Ga_2O_3$, and then single phase of GaN. The reaction time for full conversion $(t_c)$ decreased as the temperature increased. There were two-types of rapid reaction processes with the reaction temperature in the initial stage of nitridation at below $t_c$, and a relatively slow processes followed over $t_c$ does not depends on temperatures. The nitridation process was found to be limited by the rate of an interfacial reaction with the reaction order n value of 1 at $800^{\circ}C$ and by the diffusion-limited reaction with the n of 2 at above $1000^{\circ}C$, respectively, at below $t_c$. The activation energy for the reaction was calculated to be 1.84 eV in the temperature of below $830^{\circ}C$, and decreased to 0.38 eV above $830^{\circ}C$. From the comparative analysis of data, it strongly suggest the rate-controlling step changed from chemical reaction to mass transport above $830^{\circ}C$.

• 천문학회지
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• 제37권1호
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• pp.55-59
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• 2004

We have developed a two fluid solar wind model from the Sun to 1 AU. Its basic equations are mass, momentum and energy conservations. In these equations, we include a wave mechanism of heating the corona and accelerating the wind. The two fluid model takes into account the power spectrum of Alfvenic wave fluctuation. Model computations have been made to fit observational constraints such as electron($T_e$) and proton($T_p$) temperatures and solar wind speed(V) at 1 AU. As a result, we obtained physical quantities of solar wind as follows: $T_e$ is $7.4{\times}10^5$ K and density(n) is $1.7 {\times}10^7\;cm^{-3}$ in the corona. At 1 AU $T_e$ is $2.1 {\times} 10^5$ K and n is $0.3 cm^{-3}$, and V is $511 km\;s^{-1}$. Our model well explains the heating of protons in the corona and the acceleration of the solar wind.