• Health Policy and Management
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• v.19 no.4
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• pp.98-120
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• 2009

The purpose of this study is to elicit preference for drug listing decision criteria and to estimate the ICER threshold in South Korea using the discrete choice experiment (DCE) method. To collect the data, a DCE survey was administered to a subject sample either educated in the principle concepts of pharmacoeconomics or were decision makers within that field. Subjects chose between alternative drug profiles differing in four attributes: ICER, uncertainty, budget impact and severity of disease. The orthogonal and balanced designs were determined through computer algorithm to take the optimal set of drug profiles. The survey employed 15 hypothetical choice sets. A random effect probit model was used to analyze the relative importance of attributes and the probabilities of a recommendation response. Parameter estimates from the models indicated that three attributes (ICER, Impact, Severity of disease) influenced respondents' choice significantly(p${\pm}$0.001). In addition, each parameter displayed an expected sign. The Lower the ICER, the higher the probability of choosing that alternative. Respondents also preferred low levels of uncertainty and smaller impact on health service budget. They were also more likely to choose drugs for serious diseases rather than mild or moderate ones. Uncertainty however is not statistically significant. The ICER threshold, at which the probability of a recommendation was 0.5, was 29,000,000 KW/QALY in expert group and 46,500,000 KW/QALY in industry group. We also found that those in our sample were willing to accept high ICER to get medication for severe diseases. This study demonstrates that the cost-effectiveness, budget impact and severity of disease are the main reimbursement decision criteria in South Korea, and that DCE can be a useful tool in analyzing the decision making process where a variety of factors are considered and prioritized.

• Journal of Science and Technology Studies
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• v.15 no.1
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• pp.281-325
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• 2015

In this paper, we continue our previous study on the differences, similarities and interfaces between the various models of scientific governance discussed in STS and those in risk governance developed by risk studies. In the previous paper we illuminated that theoretical differences among STS scholars on scientific governance and public participation goes back to the 1970s and 1980s, during which they first laid down the conceptual basis of STS. In this paper we investigate how these divergent positions among STS scholars influenced their evaluations of precautionary principle and the framework of risk analysis (especially the separation between risk assessment and risk management), which are the two main paradigms in the area of risk regulation. By doing that, this paper will show divergent positions of STS scholars on risk analysis and precautionary principle. Further, we will suggest some theoretical and practical interfaces between STS and risk governance models.

• Journal of the Korean Institute of Telematics and Electronics
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• v.17 no.1
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• pp.1-9
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• 1980

In this paper several basic techniques for signal processing and analysis are surveyed. Firstly by the intervention of the uncertainty principle, an equality sign may have different degree of precision if non commutable operators are applied. Seconds y maximum entropy estimate and randam process based viewpoint must be enhanced to get rid of the well established and reigning deterministic image of science. Thirdly techniques for the analysis of a signal namely detection. ess]motion and modulation are explained as well as the positive definiteness of a covariance function, Karhunen-Loeve expansion and SVD of an image.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10b
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• pp.179-184
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• 1993

In this paper, an optimal motion control scheme is proposed for robot manipulators. A simple explicit solution to the Hamilton-Jacobi equation is presented. The optimization of motion control is based on the mininization of the torque term affecting the kinetic energy and the augmented error which has the first-order stable dynamics for the position and velocity tracking error. In the presence of parametric uncertainty, an adaptive control scheme using the optimal principle is proposed. The global stability of the closed-loop system is guaranteed by the Lyapunov stability approach, The effectiveness and feasibility of the proposed control schemes are shown by simulation results.

• Journal of the Korean Institute of Intelligent Systems
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• v.11 no.6
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• pp.528-531
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• 2001

Finding a shortest path on a graph is a fundamental problem in the area of graph theory. In an application where we cannot exactly determine the weights of edges fuzzy weights can be used instead of crisp weights. and Type-2 fuzzy weight will be more suitable of this uncertainty varies under some conditions. In this paper, shortest path problem in type-1 fuzzy weighted graphs is extended for type 2 fuzzy weighted graphes. A solution is also given based on possibility theory and extension principle.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2001.12a
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• pp.314-318
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• 2001

Constructing a shortest path on a graph is a fundamental problem in the area of graph theory. In an application where we cannot exactly determine the weights of edges, fuzzy weights can be used instead of crisp weights, and Type-2 fuzzy weights will be more suitable if this uncertainty varies under some conditions. In this paper, shortest path problem in type-1 fuzzy weighted graphs is extended for type-2 fuzzy weighted graphes. A solution is also given based on possibility theory and extension principle.

• Journal of Electrical Engineering and Technology
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• v.10 no.6
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• pp.2427-2433
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• 2015

This paper presents an observer-based robust controller for constant reference tracking of linear time invariant systems with polytopic model uncertainties. To this end, this paper not only designs a robust integral controller gain but also suggests how to determine the robust observer gain and the observer model used in the observer. Since the observer model selection is not obvious due to the polytopic uncertainties, particular attention needs to be paid to that. This paper computes the robust controller and observer gains first. Then, the observer model is selected in a way that the whole closedloop is stable and LMIs are used in the middle of choosing the gains and observer model. Simulation examples show that the proposed observer-based feedback control successfully achieves robust reference tracking.

• Journal of Satellite, Information and Communications
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• v.11 no.3
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• pp.1-5
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• 2016

The continuous variable quantum key distribution has been considered to have practical solution to provide high key rate. This paper explains the difference between DV-QKD and CV-QKD schemes. It describes CV-QKD as a theory that satisfies the uncertainty principle using continuous variable and homodyne detector. We shows varying length of secret key in QKD systems and amount of the exposed information to amplify privacy.

• Journal of the Korean Magnetic Resonance Society
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• v.15 no.2
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• pp.157-174
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• 2011

Although the use of apodization functions in connection with postprocessing of a 2D NMR spectrum proves improved spectral quality, there is usually a trade-off between resolution enhancement and noise suppression due to a classical "uncertainty principle." In this study, therefore, a mathematical deconvolution technique called "Maximum Likelihood Deconvolution (MLD)" was adopted to achieve the spectral resolution and sensitivity enhancement simultaneously. The MLD technique greatly facilitates visualization and restoration of the genuine spectral information from complex 2D NMR spectra that would be problematic with the conventional apodization/FT processing. In particular, application of the MLD to the 2D-NOE spectrum would be very useful to derive the important proton connectivities, which are essential to achieve elucidating the 3D molecular structure.

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.8
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• pp.822-827
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• 2014

This paper presents a robust observer-based output feedback control for stabilization of linear time invariant systems with polytopic uncertainties. To this end, this paper not only finds a robust observer gain but also suggests how to determine the model used in the observer, which is not obvious due to model uncertainties in the conventional observer design method. The robust observer gain and the observer model are selected in a way that the whole closed-loop is stable by solving LMIs and BMIs (Linear Matrix Inequalities and Bilinear Matrix Inequalities). A simulation example shows that the proposed robust observer-based output feedback control successfully leads to closed-loop stability.