• The Korean Journal of Pharmacology
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• v.26 no.1
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• pp.91-100
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• 1990

The benzylacycoluridines (BAU and BBAU) are potent and specific inhibitors of uridine phosphorylase (UrdPase). In contrast to the report that benzylacyclouridines potentiated 5-fluoro-2'-deoxyuridine (FdUrd) cytotoxicity against human solid tumor cells (Cancer Res., 44:1852, 1984), continuous exposure of mouse lymphoma L5178Y cells, to FdURd, 5-fluorouridine (FUrd), 5'-deoxy-5-fluorouridine (5'-dFUrd), or 5-fluorouracil (FUra) showed no potentiation of cytotoxicity by benzylacyclouridines. In fact, under the conditions employed, benzylacycoluridines protected the cells from the cytotoxicity of FdUrd, FUrd, or 5'-dFUrd, but not FUra in a dose dependent manner. Intraperitoneal coadministration of BAU or BBAU and a 5-fluorinated pyrimidine (i.e., FdUrd, FUrd, or FUra), to mice bearing L5178Y cells also did not significantly increase the life span compared to those treated with the antimetabolites alone. Anabolism of these nucleosides through the sequential action of UrdPase and orotate phosphoribosyltransferase (OPRTase), inhibition of nucleoside transport by benzylacyclouridines, or both could be responsible for the ineffectiveness of UrdPase inhibitors to potentiate the antineoplastic activity of fluoropvrimidines in L5178Y cells.

• Korean Journal of Food Science and Technology
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• v.40 no.1
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• pp.111-114
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• 2008

Adsorption isotherm with the most fundamental information related to chromatography process is obtained experimentally. The adsorption isotherm of 2-deoxyuridine (dUrd) and 2-deoxycytidine (dCyd) with ${\mu}$-Bondapak $C_{18}$, static method was adopted in RP-HPLC. The concentrations of mobile and stationary phases were measured with different initial concentrations of dUrd and dCyd, 1, 3, 5, 7, 10 mg/mL, respectively. The adsorption isotherm data were applied by Freundlich, Langmuir, Sips, and Radke-Prausnitz model equations. As a result of the regression analysis, standard error between adsorption isotherm of dUrd and Radke-Prausnitz equation was very low, and adsorption isotherm of dCyd was in an agreement with Sips equation very well.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07a
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• pp.244-247
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• 2002

In order to evaluate the water ingress to URD power cables with the jacketing materials and the cable structures, water vapor transmission (WVT) tests were carried out by the ASTM and the TEPCO's specification. All polyolefin compounds showed the superior water suppression to conventional PVC. Especially, linear polyethylenes have very low WVT. In case of cable structures, Allaminate cables showed the significant water suppression due to the watertight structure. Accordingly, it can be concluded that jacketing material and cable structure play an important role in the water suppression of URD power cables.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.05c
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• pp.7-10
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• 2002

In this study, polyolefin compounds were developed and evaluated for replacing a jacket material of URD power cables. The characteristics of compounds were investigated by water vapor transmission (WVT) test and mechanical test. In WVT test, all polyolefin compounds showed the superior water resistance to conventional PVC. The molecular structure and density of polyolefin play an important role in WVT. Also, polyolefin compounds showed the suitable characteristics in mechanical test. Especially, polyolefin compounds having linear molecules showed the superior characteristics to LDPE ones. From this study, it can be considered that polyolefin compounds may be suitable to jacket material for URD power cables.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.15 no.8
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• pp.687-694
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• 2002

In order to replace the jacket material for URD power cables, the 6 kinds of polyethylene compounds were manufactured and evaluated. The characteristics of the compounds were investigated by water vapor transmission (WVT) test, thermal and mechanical test. In WVT test, all the polyethylene compounds showed the superior water resistance to conventional PVC. The molecular structure and density of polyethylene play an important role in WVT. Also, the polyethylene compounds showed the suitable characteristics in thermal and mechanical test. Especially, the linear polyethylene compounds showed the superior characteristics to LDPE ones. Due to the fillers in compounds, the abrasion resistance was decreased and the cut-through resistance was increased. From this study, it can be considered that the polyethylene compounds may be suitable to jacket material for URD power cables.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.15 no.7
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• pp.609-614
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• 2002

In this study, we investigated the effects of hot water on the aging of URD power cables due to the hot water ingress to power distribution lines. Hot water contacted and non-contacted cables extracted from 2 distribution lines were characterized by the measurement of oxidation induction time(OIT) and chemical structure. In OIT measurement, hot water contacted cables showed the shorter OIT than non-contacted ones. Especially, hot water contacted insulation layer near insulation shield showed the shortest OIT. In chemical structure analysis, the antioxidant content was decreased and the acid concentration was increased by hot water ingress. From this results, it can be concluded that the hot water ingress to power cable may be accelerate the aging by means of antioxidant consumption.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.11a
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• pp.484-487
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• 2000

This study is for assessing a reliability of diagnostic device through comparing diagnostic results to ACDB strength. The dielectric diagnosis using IRC (isothermal relaxation current) measurement was carried on service-aged cables. From this study, there was little correlation between dielectric diagnosis and ACBD strength in long distance cables. But the correlation between them showed in short distance below 200 m. Therefore, it is desirable to diagnose the URD cables in short distance.

• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.11-16
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• 1988

Various Benzylacyclouridine (BAU, HM-BAU, suc-BAU, BBAU, HMBBAU, suc-BBAU, and BBBAU) developed as specifc inhibitors of uridine phosphorylase (UrdPase), inhibit transport (zero-trans influx) of ridine (Urd) in human erythrocytes. The inhibition pattern of these compounds is competitive, though suc-BBAU and BBBAU show a slight noncompetivieness. The order of potency as an inhibitor of the nucleoside transport system is BBAU ${\sim}$ HM-BBAU ${\sim}$ suc-BBAU > BBBAU > BAU ${\sim}$ suc-BAU ${\sim}$ HM-BAU ($K_1$ values of 19, 23, 38, 112, 124, 174 and 176 ${\mu}M$, respectively). These data indicate that there is a differnece in potency of Urd transport inhibition between the analogs of BAU and BBAU. Further, the potency correlates with the hydrophobicity of the compound, but it has a limit in the size of $C_5$ substitution. Abbreviation: BAU (5-benzylacyclouridine), 5-benzyl-1-(2'-hydroxyethoxymethyl) uracil; HM-BAU (3'-hydroxymethyl-BAU), 5-benzyl-1- [(1',3'-dihydroxy-2-propoxy) methyl]uracil; suc-BAU, 3'-succinyl-BAU; BBAU (benzyloxybenzylacyclouridine), 5-( m-benzyloxybenByl)-1-(2'-hydroxyethoxymethyl)uracil; HM-BBAU (3'-hydroxymethyl-BBAU), 5-(m-benzyloxybenzyl)-1- [(1'3'-dihyd.oxy-2-p.epoxy)methyll u.acil; suc-BAU, 3'-succinyl-BBAU; BBBAU, 5- f 3-(4-benzyloxyben-Eyl)benzyll -1-(2'-hydroxyethoxymethyl)uracil; Urdpase, uridine phosphorylase; Urd, Uridine; Fd-Urd, 5-fluoro-2'-deoxyuridine; AcThd, aoyclothyrnidine; AcUrd, acyclouridine; dThd, thymidine; NBMPR, nitrobenzylthioisone; FUra, 5-fluorouracil.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.21 no.5
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• pp.90-98
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• 2007

The objective of this investigation was to reveal the cause of the faulted cable(LV URD(low voltage underground) cable). For the analysis, various types or equipments such as external pattern, thermal pattern, surface structure, thermal analysis, and property distribution were deployed. The international standards and the specification provided by the manufacturer of faulted cable were examined whether it fit the standards. The summary is as follows. (1) Discovered as a factor lowering insulation performance of the faulted cable: minimum thickness of the insulation layer specified by IEC 60502-1 and IEC 60811-1-1 was not fit. (2) Infrared absorption peaks measured by FT-IR spectrometer revealed that the measurements made for the same material did not conform and it is an important basis for proving heterogeneous composition of the insulation material. (3) It was found that PVC bedding was thermally fragile and therefore long term exposure at the site could cause similar fault pattern.

• Korean Chemical Engineering Research
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• v.43 no.2
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• pp.230-235
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• 2005

Reversed-phase high-performance liquid chromatography (RP-HPLC) was used to determine the equilibrium isotherm of single and multi-components of dUrd(2'-deoxyuridine), dGuo(2'-deoxyguanosine), and dAdo(2'-deoxyadenosine) of 2'-deoxyribonucleosides by dynamic method. The composition of mobile phase was 90/10 vol.% (water/MeOH). With an increase in the injection volumes, the retention times were shorter and the peak shapes were triangle-shaped, so Langmuir-type isotherm was assumed. The Langmuir adsorption parameters were estimated by PIM (pulsed-input method), and the competitive Langmuir adsorption isotherm was further utilized. For the sample of the dUrd and dGuo whose retention times were relatively short, the agreement of between the calculated value and experimental data was fairly good in both single and multi-components, but for the dAdo, the last eluting component, some deviations were caused by non-linear and non-ideal properties.