• Title/Summary/Keyword: UFT

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Impact of Postoperative Oral Administration of UFT for Completely Resected pT2N0 Non-Small Cell Lung Cancer (완전 절제된 비소세포폐암 병기 IB (pT2N0) 환자에서 수술 후 UFT의 효과)

  • Lee, Jin-Gu;Park, In-Kyu;Kim, Dae-Joon;Kim, Kil-Dong;Cho, Sang-Ho;Chung, Kyung-Young
    • Journal of Chest Surgery
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    • v.40 no.6 s.275
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    • pp.428-434
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    • 2007
  • Background: Recent studies have suggested that UFT may be an effective adjuvant therapy for completely resected IB (pT2N0) non-small cell lung cancer (NSCLC). We designed this study to clarify the feasibility of performing adjuvant chemotherapy with UFT for completely resected IB nor-small cell lung cancer, Material and Method: We randomly assigned patients suffering with completely resected IB non-small cell lung cancer to receive either UFT 3g for 2 year or they received no treatment. All patients had to be followed until death or the cut-off date (December 31 2006). Result: From June 2002 through December 2004, 64 patients were enrolled. Thirty five patients were assigned to receive UFT (the UFT group) and 29 patients were assigned to observation (the control group). A follow-up surrey on the 3 year survival rate was successfully completed for all the patients. The median follow-up time for all the patients was 32.8 months. In the UFT group, the median time of administration was 98 weeks (range: $2{\sim}129$ weeks). The rate of compliance was 88.2% at 6 months, 87.5% at 12 months, 80.6% at 18 month and 66.7% at 24 months. Seven recurrences (24.1%) occurred in the control group and six (17.1%) occurred in the UFT group (p=0,489). The three-year disease free survival rate was 71.3% for the control group and 82.0% for the UFT group (p=0.331). On the subgroup analysis, the three-year disease free survival rate for the patients with adenocacinoma was 45.0% for the control group and 75.2% for the UFT group (p=0.121). The three-year disease free survival rate for the patients with non-adenocarcinoma was 88.1% for the control group and 88.9% for the UFT group (p=0.964), Conclusion: Postoperative oral administration of UFT was well-tolerated. Adjuvant chemotherapy with UFT for completely resected pT2N0 adenocarcinoma of the lung could be expected to improve the disease free survival, but this failed to achieve statistical significance. A prospective randomized study for a large number of patients will be necessary.

THE EXISTENCE AND UNIQUENESS OF E(*κ)-CONNECTION IN n-*g-UFT

  • Lee, Jong Woo
    • Korean Journal of Mathematics
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    • v.13 no.1
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    • pp.1-11
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    • 2005
  • The purpose of the present paper is to introduce a new concept of the E($^*{\kappa}$)-connection ${\Gamma}^{\nu}_{{\lambda}{\mu}}$, which is both Einstein and ($^*{\kappa}$)-connection, and to obtain a necessary and sufficient condition for the existence of the unique E($^*{\kappa}$)-connection in $n-^*g$-UFT. Next, under this condition, we shall obtain a surveyable tensorial representation of the unique E($^*{\kappa}$)-connection in $n-^*g$-UFT.

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Early Experiences with Ultra-Fast-Track Extubation after Surgery for Congenital Heart Disease at a Single Center

  • Kim, Kang Min;Kwak, Jae Gun;Shin, Beatrice Chia-Hui;Kim, Eung Re;Lee, Ji-Hyun;Kim, Eun Hee;Kim, Jin Tae;Kim, Woong-Han
    • Journal of Chest Surgery
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    • v.51 no.4
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    • pp.247-253
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    • 2018
  • Background: Early extubation after cardiovascular surgery has some clinical advantages, including reduced hospitalization costs. Herein, we review the results of ultra-fast-track (UFT) extubation, which refers to extubation performed on the operating table just after the operation, or within 1-2 hours after surgery, in patients with congenital cardiac disease. Methods: We performed UFT extubation in patients (n=72) with a relatively simple congenital cardiac defect or who underwent a simple operation starting in September 2016. To evaluate the feasibility and effectiveness of our recently introduced UFT extubation strategy, we retrospectively reviewed 195 patients who underwent similar operations for similar diseases from September 2015 to September 2017, including the 1-year periods immediately before and after the introduction of the UFT extubation protocol. Propensity scores were used to assess the effects of UFT extubation on length of stay (LOS) in the intensive care unit (ICU), hospital LOS, and medical costs. Results: After propensity-score matching using logistic regression analysis, 47 patients were matched in each group. The mean ICU LOS ($16.3{\pm}28.6$ [UFT] vs. $28.0{\pm}16.8$ [non-UFT] hours, p=0.018) was significantly shorter in the UFT group. The total medical costs ($182.6{\pm}3.5$ [UFT] vs. $187.1{\pm}55.6$ [non-UFT] ${\times}100,000$ Korean won [KRW], p=0.639) and hospital stay expenses ($48.3{\pm}13.6$ [UFT] vs. $54.8{\pm}29.0$ [non-UFT] ${\times}100,000KRW$, p=0.164) did not significantly differ between the groups. Conclusion: UFT extubation decreased the ICU LOS and mechanical ventilation time, but was not associated with postoperative hospital LOS or medical expenses in patients with simple congenital cardiac disease.

A Phase n Study on UFT Therapy for Head and Neck Squamous Cell Carcinoma (두경부 편평세포암종에 대한 UFT 투여 후 항종양효과에 관한 제2상 임상 연구)

  • Choi Jong-Ouck;Choi Geon;Jung Kwang-Yoon
    • Korean Journal of Head & Neck Oncology
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    • v.10 no.1
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    • pp.74-79
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    • 1994
  • A Phase II study of UFT which is a mixture of Tegafur and Uracil was conducted in two institutions during past two years. Ninty-four patients of head and neck squamous cell carcinoma entered this trial, of which sixty-eight were evaluated. Among those, thirty-six cases were previously untreated and thirty-two cases were recurrent UFT was administrated orally at a daily dose of $400mg/m^2$ for eight weeks. The results were as following: 1) Overall response was 30.88%, but for 38.36% for 36 cases of the untreated cases, 21.88% for 32 cases of recurrent cases. 2) UFT was more effective in early stage and well differentiated squamous cell carcinoma and UFT tended to reduce the tumor size maximally at fourth or fifth week 3) There was no serious side effects except mild gastrointestinal disturbances such as nausea and vomiting, which were recovered immediately after stop or reducing a daily dose. Therefore, UFT therapy is clinically effective for head and neck squamous cell carcinoma and also may be useful for combination or palliative chemotherapy because of mild side effects.

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EIGHT-DIMENSIONAL EINSTEIN'S CONNECTION FOR THE FIRST CLASS II. THE EINSTEIN'S CONNECTION IN 8-g-UFT

  • Hwang, In-Ho;Han, Soo-Kyung;Chung, Kyung-Tae
    • Honam Mathematical Journal
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    • v.30 no.1
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    • pp.53-64
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    • 2008
  • Lower dimensional cases of Einstein's connection were already investigated by many authors for n = 2, 3, 4, 5, 6. In the following series of two papers, we present a surveyable tensorial representation of 8-dimensional Einstein's connection in terms of the unified field tensor: I. The recurrence relations in 8-g-UFT II. The Einstein 's connection in 8-g-UFT In our previous paper [1], we investigated some algebraic structure in Einstein's 8-dimensional unified field theory (i.e., 8-g-UFT), with emphasis on the derivation of the recurrence relations of the third kind which hold in 8-g-UFT. This paper is a direct continuation of [1]. The purpose of the present paper is to prove a necessary and sufficient condition for a unique Einstein's connection to exist in 8-g-UFT and to display a surveyable tensorial representation of 8-dimensional Einstein's connection in terms of the unified field tensor, employing the powerful recurrence relations of the third kind obtained in the first paper [1]. All considerations in this paper are restricted to the first class only of the generalized 8-dimensional Riemannian manifold $X_8$, since the cases of the second class are done in [2], [3] and the case of the third class, the simplest case, was already studied by many authors.

EIGHT-DIMENSIONAL EINSTEIN'S CONNECTION FOR THE SECOND CLASS II. THE EINSTEIN'S CONNECTION IN 8-g-UFT

  • HAN, SOO KYUNG;HWANG, IN HO;CHUNG, KYUNG TAE
    • Honam Mathematical Journal
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    • v.27 no.1
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    • pp.131-140
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    • 2005
  • Lower dimensional cases of Einstein's connection were already investigated by many authors for n = 2, 3, 4, 5, 6, 7. In the following series of two papers, we present a surveyable tensorial representation of 8-dimensional Einstein's connection in terms of the unified field tensor: I. The recurrence relations in 8-g-UFT II. The Einstein's connection in 8-g-UFT In our previous paper [1], we investigated some algebraic structure in Einstein's 8-dimensional unified field theory (i.e., 8-g-UFT), with emphasis on the derivation of the recurrence relations of the third kind which hold in 8-g-UFT. This paper is a direct continuation of [1]. The purpose of the present paper is to prove a necessary and sufficient condition for a unique Einstein's connection to exist in 8-g-UFT and to display a surveyable tensorial representation of 8-dimensional Einstein's connection in terms of the unified field tensor, employing the powerful recurrence relations of the third kind obtained in the first paper [1]. All considerations in this paper are restricted to the second class only of the generalized 8-dimensional Riemannian manifold $X_8$, since the case of the first class are done in [2], [3] and the case of the third class, the simplest case, was already studied by many authors.

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SOME RECIPROCAL RELATIONS BETWEEN THE g-UNIFIED AND *g-UNIFIED FIELD TENSORS

  • Lee, Jong-Woo
    • Communications of the Korean Mathematical Society
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    • v.23 no.2
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    • pp.229-239
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    • 2008
  • In n-dimensional unified field theory(n-UFT), the reciprocal representations between the g-unified field tensor $g{\lambda}{\nu}$ and $^*g$-unified field tensor $^*g^{{\lambda}{\nu}}$ play essential role in the study of n-UFT. The purpose of the present paper is to obtain some reciprocal relations between g-unified field tensor and $^*g$-unified field tensor.

A PARTICULAR SOLUTION OF THE EINSTEIN'S EQUATION IN EVEN-DIMENSIONAL UFT Xn

  • Lee, Jong Woo
    • Journal of the Chungcheong Mathematical Society
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    • v.23 no.2
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    • pp.185-195
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    • 2010
  • In the unified field theory(UFT), in order to find a solution of the Einstein's equation it is necessary and sufficient to study the torsion tensor. The main goal in the present paper is to obtain, using a given torsion tensor (3.1), the complete representation of a particular solution of the Einstein's equation in terms of the basic tensor $g_{{\lambda}{\nu}}$ in even-dimensional UFT $X_n$.

SOME GEOMETRIC RESULTS ON A PARTICULAR SOLUTION OF EINSTEIN'S EQUATION

  • Lee, Jong Woo
    • Korean Journal of Mathematics
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    • v.18 no.1
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    • pp.21-28
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    • 2010
  • In the unified field theory(UFT), many works on the solutions of Einstein's equation have been published. The main goal in the present paper is to obtain some geometric results on a particular solution of Einstein's equation under some condition in even-dimensional UFT $X_n$.

EIGHT-DIMENSIONAL EINSTEIN'S CONNECTION FOR THE FIRST CLASS I. THE RECURRENCE RELATIONS IN 8-g-UFT

  • HWANG, IN HO;CHUNG, KYUNG TAE;HAN, SOO KYUNG
    • Honam Mathematical Journal
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    • v.28 no.4
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    • pp.605-639
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    • 2006
  • Lower dimensional cases of Einstein's connection were already investigated by many authors for n = 2,3,4,5,6,7. This paper is the first part of the following series of two papers, in which we obtain a surveyable tensorial representation of 8-dimensional Einstein's connection in terms of the unified field tensor, with main emphasis on the derivation of powerful and useful recurrence relations which hold in 8-dimensional Einstein's unified field theory(i.e., 8-g-UFT): I. The recurrence relations in 8-g-UFT II. The Einstein's connection in 8-g-UFT All considerations in these papers are restricted to the first class only of the generalized 8-dimensional Riemannian manifold $X_8$.

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