• Title/Summary/Keyword: Trial Functions

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Effects of Lipid Soluble Ginseng Extract on Immune Response (인삼의 지용성 추출물 투여가 면역기능에 미치는 영향)

  • Kim, Dong-Chung;Hwang, Woo-Ik;In, Man-Jin;Lee, Sung-Dong
    • Journal of Ginseng Research
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    • v.32 no.1
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    • pp.19-25
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    • 2008
  • Lipid soluble ginseng extract was administered by oral route in doses of 600 mg/patient daily in cancer patients over 2 months and 6 months. The administration of ginseng extract in cancer patients maintained the ratio of CD4/CD8 and number of the natural killer cell in the normal range during the administration period. Also its administration showed a positive effect on tumor values in 87.5% of patients in 2 month-group and in 50% of patients in 6 month-group, as determined by various cancer markers. Liver and kidney functions maintained normal condition during administration period of 6 months. Although there was no statistical significance, these data suggest that lipid soluble ginseng extract may be useful as an adjuvant therapeutic agent and nutritional supplement for the improvement of immune function and health in cancer patients. This study would provide the basis for the research in which the antitumor and immunopotential activity of lipid soluble ginseng extract for cancer patients are evaluated in formal clinical trial with statistically significant patient number.

Changes in the Sensory Function after Transcranial Direct Stimulation on Dorsolateral Prefrontal Cortex Area (배외측전전두엽피질 영역에 경두개직류전류자극이 감각기능에 미치는 영향)

  • Min, Dong-Ki
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.1
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    • pp.445-452
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    • 2015
  • Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers a low-intensity direct current to the cortical areas, thereby facilitating or inhibiting spontaneous neuronal activity. This study was designed to examine the changes in various sensory functions after tDCS. A single-center, single-blinded, randomized trial was conducted to determine the effect of a single session (August 4 to August 29) of tDCS with the current perception threshold (CPT) in 50 healthy volunteers. Nerve conduction studies (NCS) were performed in relation to the median sensory and motor nerves on the dominant hand to discriminate peripheral nerve lesions. The subjects received anodal tDCS with 1mA for 15 minutes under two different conditions, with 25 subjects in each group. The conditions were as follows: tDCS on the dorsolateral prefrontal cortex (DLPFC) and sham tDCS on DLPFC. The parameters of the CPT was recorded with a Neurometer$^{(R)}$ at frequencies of 2000, 250 and 5 Hz in the dominant index finger to assess the tactile sense, fast pain and slow pain, respectively. In the test to measure the CPT values of the DLPFC in the anodal tDCS group, the values increased significantly in all of 250 and 5 Hz. All CPT values decreased for the sham tDCS. These results showed that DLPFC anodal tDCS can modulate the sensory perception and pain thresholds in healthy adult volunteers. This study suggests that tDCS may be a useful strategy for treating central neurogenic pain in rehabilitation medicine.

The Development of Real-time Video Associated Data Service System for T-DMB (T-DMB 실시간 비디오 부가데이터 서비스 시스템 개발)

  • Kim Sang-Hun;Kwak Chun-Sub;Kim Man-Sik
    • Journal of Broadcast Engineering
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    • v.10 no.4 s.29
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    • pp.474-487
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    • 2005
  • T-DMB (Terrestrial-Digital Multimedia Broadcasting) adopted MPEG-4 BIFS (Binary Format for Scene) Core2D scene description profile and graphics profile as the standard of video associated data service. By using BIFS, we can support to overlay objects, i.e. text, stationary image, circle, polygon, etc., on the main display of receiving end according to the properties designated in broadcasting side and to make clickable buttons and website links on desired objects. Therefore, a variety of interactive data services can be served by BIFS. In this paper, we implement real-time video associated data service system far T-DMB. Our developing system places emphasis on real-time data service by user operation and on inter-working and stability with our previously developed video encoder. Our system consists of BIFS Real-time System, Automatic Stream Control System and Receiving Monitoring System. Basic functions of our system are designed to reflect T-DMB programs and characteristics of program production environment as a top priority. Our developed system was used in BIFS trial service via KBS T-DMB, it is supposed to be used in T-DMB main service after improvement process such as intensifying system stability.

A Study on the Interference of Harmonic Frequency during the Change of Urban Transit's Signalling Systems (도시철도 신호시스템의 절체에 따른 주파수 간섭 연구)

  • Jeong, Rag-Gyo;Kim, Beak-Hyun;Joung, Eui-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.2
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    • pp.469-475
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    • 2010
  • The railway signalling system plays an essential role in the safe and efficient train operation as serving control functions of train operation intervals and train routes. The reliability and safety of the system are very important because the failure of the railway signalling system can lead to train collision or derailment as well as train operation stop. Until now, in railway signalling system the conventional wayside signal mode has been used generally. There are, however, the risk of accidents such as human mistakes caused by that the driver identifies the signal lamp status and controls train speed with the naked eye. It is also necessary to refurbish the obsolete system. Thereby, It is being effective that the onboard signal mode has been recently introduced and applied in order to transmit the speed control information to train by using the computer and communication equipment. It is necessary to switch over the system in a way while providing passengers with an operation service to replace the obsolete signal system. In this paper, we verify the cases through trial assessment which are solved by the way of adding specific functionalities in the problems of interference among the procedure of switch-over processes and a serial of processes for system verification while a train is operated in the new system in parallel to the existing system.

Daily Feed Intake, Energy Intake, Growth Rate and Measures of Dietary Energy Efficiency of Pigs from Four Sire Lines Fed Diets with High or Low Metabolizable and Net Energy Concentrations

  • Schinckel, A.P.;Einstein, M.E.;Jungst, S.;Matthews, J.O.;Booher, C.;Dreadin, T.;Fralick, C.;Wilson, E.;Boyd, R.D.
    • Asian-Australasian Journal of Animal Sciences
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    • v.25 no.3
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    • pp.410-420
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    • 2012
  • A trial was conducted to: i) evaluate the BW growth, energy intakes and energetic efficiency of pigs fed high and low density diets from 27 to 141 kg BW, ii) evaluate sire line and sex differences when fed both diets, and iii) to compare ME to NE as predictor of pig performance. The experiment had a replicated factorial arrangement of treatments including four sire lines, two sexes (2,192 barrows and 2,280 gilts), two dietary energy densities and a light or heavy target BW, 118 and 131.5 kg in replicates 1 to 6 and 127 and 140.6 kg in replicates 7 to 10. Pigs were allocated to a series of low energy (LE, 3.27 Mcal ME/kg) corn-soybean meal based diets with 16% wheat midds or high energy diets (HE, 3.53 to 3.55 Mcal ME/kg) with 4.5 to 4.95% choice white grease. All diets contained 6% DDGS. The HE and LE diets of each of the four phases were formulated to have equal lysine:Mcal ME ratios. Pigs were weighed and pen feed intake (11 or 12 pigs/pen) recorded at 28-d intervals. The barrow and gilt daily feed (DFI), ME (MEI) and NE (NEI) intake data were fitted to a Bridges function of BW. The BW data of each sex were fitted to a generalized Michaelis-Menten function of days of age. ME and NE required for maintenance (Mcal/d) were predicted using functions of BW (0.255 and 0.179 BW^0.60 respectively). Pigs fed LE diets had decreased ADG (915 vs. 945 g/d, p<0.001) than pigs fed HE diets. Overall, DFI was greater (p<0.001) for pigs fed the LE diets (2.62 vs. 2.45 kg/d). However, no diet differences were observed for MEI (8.76 vs. 8.78 Mcal/d, p = 0.49) or NEI (6.39 vs. 6.44 Mcal/d, p = 0.13), thereby indicating that the pigs compensated for the decreased energy content of the diet. Overall ADG:DFI (0.362 vs. 0.377) and ADG:Mcal MEI (0.109 vs. 0.113) was less (p<0.001) for pigs fed LE compared to HE diets. Pigs fed HE diets had 3.6% greater ADG:Mcal MEI above maintenance and only 1.3% greater ADG:Mcal NEI (0.152 versus 0.150), therefore NEI is a more accurate predictor of growth and G:F than MEI.Pigs fed HE diets had 3.4% greater ADG:Mcal MEI and 0.11% greater ADG:NEI above maintenance than pigs fed LE diets, again demonstrating that NEI is a better predictor of pig performance than MEI. Pigs fed LE diets had similar daily NEI and MEI but grew slower and less efficiently on both ME and NE basis than pigs fed HE diets. The data suggest that the midds NE value (2.132 Mcal/kg) was too high for this source or that maintenance was increased for pigs fed LE diets.

A Study on the Need of Specialized Institution for Post-Evaluation of Construction Projects (건설공사 사후평가 전문기관 설치 필요성 연구)

  • Lee, Du-Heon;Park, Hee-Sung
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.36 no.2
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    • pp.285-295
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    • 2016
  • The post-evaluation system after construction projects can evaluate estimates of use demand, project cost, and project schedule estimated in the planning phase of construction projects in public sector. Thus, it was introduced in 2000 for the purpose of reduction in future errors during similar constructions by project orderer by referring the post-evaluation results. However, many barriers to the post-evaluation system after construction projects have been reported due to evaluation systems that lack objectivity and reliability and lack of main bodies that utilize the system. Thus, this study derived implications for improvements of the post-evaluation system in Korea by benchmarking building project evaluation system and management as well as utilization systems of developed nations. Then this study conducted a survey with experts who have experienced activities in the post-evaluation committee and members of post-evaluation for public project owners. Therefore it identified the need of installation of specialized post-evaluation institutions as well as functions and work tasks to be taken by specialized institutions. Based on the analysis results, this paper provided revision drafts of related legislations and guidelines to be effective in post-evaluation. Through the study results, many trial and errors can be reduced in similar projects in the future by performing in-depth analysis on large-scale construction projects and repeatedly applied building project practices can be improved to raise technical competitiveness if the specialized institution is installed.

Determination of Optimal Unit Hydrographs and Infultration Rate Functions from Single Rainfall-Runoff Event (단순 강우-유출 사상으로부터 최적단위도와 침투율의 결정)

  • An, Tae-Jin;Ryu, Hui-Jeong;Jeong, Gwang-Geun;Sim, Myeong-Pil
    • Journal of Korea Water Resources Association
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    • v.33 no.3
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    • pp.365-374
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    • 2000
  • This paper is to present the determination of the optimal Joss rate parameters and urnt bydrographs from the observed single rainfall-runoff event using optimization models coupled with a stochastic technique for the global solution. Two kinds of the linear program models are formulated to derive the optimal unit hydrographs and loss rate parameters for gaged basins; one mimmizes the summation of the absolute residual between predlCted and observed runoff ordinates and the other, the maximum absolute residuaL Multistart algorithm which is one or stochastic techniques for the global optimum is adopted to perturb the parameters of the loss rate equations. Multistart efficiently searches the feasIble region to identify the global optimlUll for loss rate parameters, which yields the optimal loss rate parameters and unit hydrograph for Kostiakov's, Plulip's, and Horton's equation. The unique unit hydrograph ordinates for a gIven rainfall-runoff event iS exclusrvely obtained WIth $\Phi$ index, but unit hydrograph ordinates depend upon the parameters [or each loss rate equations. The parameters of Green-Ampt's are determined through a trial and error method. In this paper the single rainfall-nmoff event observed from a watershed is considered to test the proposed method. The optimal unit hydrograph herein found has smaller deviations than the ones reported previously by other researchers.

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Relationship between Physical Function Factors and Discrimination Experiences of the Elderly in Korea: The 2014 and 2017 National Survey on Living Conditions and Welfare Needs of Korean Older Persons (우리나라 노인의 신체기능 요인과 차별경험의 관련성 연구: 노인실태조사(2014, 2017) 자료 분석)

  • Lee, Kyuhee;Yong, Wangshik;You, Changhoon;Lee, Yongjae;Chung, Woojin
    • Health Policy and Management
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    • v.29 no.4
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    • pp.454-468
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    • 2019
  • Background: Supporting the elderly population is presented as a social issue, and it affects age discrimination, which forms a negative perception and avoids the elderly. Since age discrimination lowers the quality of life of the elderly and hinders social unity, it may be important to research related factors. This study examined the physical function as a factor that influences discrimination experiences and aimed to identify the relationship between physical function factors and discrimination experiences. Methods: In this study, we analyzed 20,225 elderly from the 2014 and 2017 survey of living conditions and welfare needs of Korean older persons, conducted nationwide among older than 65 years. Physical function factors are activities of daily living, instrumental activities of daily living, sight discomfort, hearing discomfort, chewing discomfort, and leg strength as factors of interest. We performed multivariable logistic regression that reflected survey characteristics, adjusting for socio-demographic factors, health related factors, and social-support factors. Results: The number of elderly who faced discrimination experiences was 1,175 (5.8%). The results showed that the odds ratio of facing a discrimination experience in the dependent group was significantly higher compared to the independent group when being transferring out of the room (4.05; 95% confidence interval [CI], 1.50-10.88) and difficulty in hearing (1.25; 95% CI, 1.05-1.49). Even with respect to chewing ability, which was significant in models 1 and 2, they face more discrimination experiences (1.30; 95% CI, 1.11-1.53). Conclusion: These research results indicate that an important strategy for preventing age discrimination is to understand the physical function conditions of the elderly and promote the physical functions of the elderly related to transferring, hearing, and chewing; it is necessary to develop a practical intervention plan that considers these aspects.

A Study of the Apply Proximity Sensor for Improved Reliability Axle Detection (열차 차축검지 신뢰성 향상을 위한 근접센서 방식 Axle Counter 적용 연구)

  • Park, Jae-Young;Choi, Jin-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.8
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    • pp.5534-5540
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    • 2015
  • This In the railway signaling system, applications of axle counter in addition to track circuit goes on increasing for detecting train position. Consequently, this paper compares sensor methods of axle counter with between geo-magnetism method and proximity sensor method. And it presents differences and results, to improve reliabilities of train detection and axle counting. Also, this article presents an applied result which is based on field experience, with regard to installation, considering attachment condition of sensor part for accurate axle counting. This study acquires expandability that is able to perform not only axle counting function but also various other functions (direction detection of train, speed detection of train, and so on). It was a result of a change of design in order to judge phase difference of sensors, to improve reliability of axle counting. Furthermore, it does not subordinate to characteristics (type, weight of train). And it is confirmed that the omission of axle counting was not occurred in 350km/h. This was the result of Lab test after the construction of transfer equipment of trial axle and Test Bed for axle counting. Both of them are self-productions. Through this, it prepares foundation which is able to apply not only to train detection but also to speed of passing trains, formation number of trains, detector locking condition - when the train passes the section of switch point, and level crossing devices. Furthermore, it would be judged to contribute safety train operation if proximity sensor method applies to the whole railway signaling system from now on.

Vibration and Dynamic Sensitivity Analysis of a Timoshenko Beam-Column with Ends Elastically Restrained and Intermediate Constraints (중간구속조건을 갖는 양단탄성구속 Timoshenko 보-기동의 진동 및 동특성감도 해석)

  • J.H. Chung;W.H. Joo;K.C. Kim
    • Journal of the Society of Naval Architects of Korea
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    • v.30 no.1
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    • pp.125-133
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    • 1993
  • Most studies on the vibration analysis of a beam-column with ends elastically restrained and various intermediate constraints have been based on the Euler beam theory, which is inadequate for beam-columns of low slenderness ratios. In this paper, analytical methods for vibration and dynamic sensitivity of a Timoshenko beam-column with ends elastically restrained and various intermediate constraints are presented. Firstly, an exact solution method is shown. Since the exact method requires considerable computational effort, a Rayleigh-Ritz analysis is also investigated. In the latter two kinds of trial functions are examined for comparisions : eigenfunctions of the base system(the system without intermediate constraints) and polynomials having properties corresponding to the eigenfunctions of the base system. The results of some numerical Investigations show that the Rayleigh-Ritz analysis using the characteristic polynomials is competitive with the exact solutions in accuracy, and that it is much more efficient in computations than using the eigenfunctions of the base system, especially in the dynamic sensitivity analysis. In addition, the prediction of the changes of natural frequencies due to the changes of design variables based on the first order sensitivity is in good agreements with that by the ordinary reanalysis as long as the changes of design variables are moderate.

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