• 제목/요약/키워드: Trial Division

검색결과 622건 처리시간 0.022초

건강한 지원자에서 두 경혈(신맥, 조해)이 심박변이도에 미치는 영향의 차이 : 무작위, 단일 맹검, 자기 대조군 임상시험 (Differential Effects of Two Individual Acupuncture Points (BL62, KI6) on Heart Rate Variability in Healthy Volunteers : A Randomized, Single-Blind, Self-Controlled Trial)

  • 이지혜;최영준;신병철;구성태
    • Korean Journal of Acupuncture
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    • 제27권4호
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    • pp.85-97
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    • 2010
  • 목적 : 이 연구는 서로 다른 두 경혈이 심박변이도에 미치는 영향을 비교하고, 자율신경계에 미치는 영향을 평가하기 위해 수행하였다. 재료 및 방법 : 13명의 지원자가 3개의 세션에 균등하게 무작위 배정되었다. 각 세션에서 지원자들은 신맥(BL62), 조해(KI6), 또는 비경혈에 각각 침처치를 받았다. 10분간 휴식을 한 후에 자침 전, 유침기간, 발침 후 기간에 5분 동안 심박변이도 측정을 하였다. 유침기간에는 2분 간격을 두고 2회 심박변이도를 측정하였다. 결과 : 신맥에 자침한 군에서는 자침후 기간에 total power(TP)와 standard deviation N-N interval(SDNN)이 유의하게 증가하였다. 유침기간 중 첫 5분 동안의 TP와 SDNN은 자침전 값과 유의한 차이가 없었으며 유침기간 중 마지막 5분 동안에는 다소 증가하는 경향은 있었지만 통계적인 유의성은 없었다. 반면에 조해와 비경혈에 자침한 군에서는 TP와 SDNN에 유의한 변화가 관찰되지 않았다. 발침 후에 신맥자침군에서는 조해와 비경혈 자극군과 비교해서 TP가 유의하게 변화하였다. 그러나 SDNN은 발침 후에 세 군 사이에 유의한 차이가 없었다. 결론 : 이 실험 결과는 조해와 비교했을 때 신맥에 자침한 경우 심장 기능 및 자율신경계와 관련이 있는 대체적인 활성이 증가한다는 것을 보여주었다. 이 결과는 신맥 자침이 자율신경계와 관계되어 있는 심장의 기능에 미치는 영향을 통해서 경혈의 특이성을 관찰할 수 있음을 의미한다.

디지털라디오 방송의 실내외 수신 환경을 고려한 필드 테스트 성능 평가 (Indoor and Outdoor Reception Performance Evaluation of Digital Radio Techniques in Field Trials)

  • 김주석;백명선;이용훈;이용태;김경석
    • 한국정보전자통신기술학회논문지
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    • 제11권1호
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    • pp.1-11
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    • 2018
  • 본 논문은 다양한 환경에서 디지털라디오의 방식별 수신 특징을 확인하고 비교할 수 있는 필드테스트 결과를 도출하였다. In-band 방식으로는 HD Radio와 DRM+를 고려하였으며, out-of-band 방식으로는 DAB/DAB+/T-DMB 방식을 고려하였다. 디지털 라디오의 필드테스트를 위하여 국내의 적합한 지역을 선정하여 송수신기 test bed를 구축하였고, multipath가 많고 적은 19개의 다양한 test point를 선정하여 실내외 수신테스트를 진행하였다. 또한 수신환경 측정 시 수신 가능 여부뿐만 아니라 ATT 마진을 적용하여 최소 수신가능 레벨도 도출하였다. 다양한 분석을 통한 필드 테스트 결과는 소비자들에게 원활한 수신환경을 보장하기 위한 디지털 라디오의 방식 결정의 기준이 될 수 있다.

냉온 부하에 따른 요골동맥 맥파의 변화 특성을 파악하기 위한 무작위 배정·2×2교차설계 탐색적 임상시험계획서 개발 (Development of Clinical Protocol for Acquisition of Change of Radial Pulse Wave Signal in the Cold-Heat Intervention: Explanatory, Randomized, 2×2 cross-over design)

  • 유하나;김지혜;구본초;김현호;전영주
    • 대한한의진단학회지
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    • 제19권2호
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    • pp.91-100
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    • 2015
  • Objectives The aim of this study is to develop a structured clinical protocol related with acquisition of radial pulse wave in the randomized, $2{\times}2$ cross-over design, and cold-heat intervention trial for a pilot and preliminary study. Methods The protocol was contrived based on wide ranging literature searches for cold-heat intervention experiments and radial pulse diagnoses. Results Sample size of 60 subjects was calculated based on an effect size derived from the previous study designed to detect the pre-post cold-heat differences in the radial pulse. Each subjects will be randomly assigned to the cold (first) to heat (last) group (n=30) or heat (first) to cold (last) group (n=30). All subjects will fill out a case report form and questionnaires related with pattern identification, dietary patterns, sleep quality, and physical activity will be surveyed and used as a secondary outcomes. Safety assessment will be reported at the final stage. Conclusions This protocol will provide an additional reference to future studies related with observation of radial pulse during any interventions and also expect to be used as a guideline for acquisition of reliable radial pulse wave data.

체공성능 향상을 위한 확장날개 틸트로터 무인기의 제어법칙설계 (Control Law Design for a Tilt-rotor Unmanned Aerial Vehicle with a Nacelle Mounted WE (Wing Extension))

  • 강영신;박범진;조암;유창선
    • 제어로봇시스템학회논문지
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    • 제20권11호
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    • pp.1103-1111
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    • 2014
  • The results of control law design for a tilt-rotor unmanned aerial vehicle that has a nacelle mounted wing extension (WE) are presented in this paper. It consists of a control surface mixer, stability and control augmentation system (SCAS), hold mode for altitude / speed / heading, and a guidance mode for preprogram and point navigation which includes automatic take-off and landing. The conversion corridor and the control moments derivatives between the original tilt-rotor and its variant of the nacelle mounted WE were compared to show the effectiveness of the WE. The nacelle conversion of the original tilt-rotor starts when the airspeed is greater than 30 km/h but its WE variant starts at 0 km/h in order to reduce the drag caused by the high incidence angle of the WE. The stability margins of the inner loop are presented with the optimization approach. The outer loops for the hold mode are designed with trial and error methods with linear and nonlinear simulation. The main control parameter for altitude control of the helicopter mode is thrust command and it is transferred to the pitch attitude command in airplane mode. Otherwise, the control parameter for the speed of the helicopter mode is the pitch attitude command and it is transferred to the thrust command in airplane mode. Therefore the speed and altitude hold mode are coupled to each other and are engaged at the same time when an internal pilot engages any of the altitude or speed hold modes. The nonlinear simulation results of the guidance control for the preprogrammed mode and point navigation are also presented including automatic take-off and landing in order to prove the full control law.

A Simple and Rapid Method for Functional Analysis of Plant Growth-promoting Rhizobacteria Using the Development of Cucumber Adventitious Root System

  • Bae, Yeoung-Seuk;Park, Kyung-Seok;Lee, Young-Gee;Choi, Ok-Hee
    • The Plant Pathology Journal
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    • 제23권3호
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    • pp.223-225
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    • 2007
  • Many plant growth-promoting rhizobacteria (PGPRs) have been known for beneficial effects on plants including biological control of soilborne pathogens, induced systemic resistance to plant pathogens, phytohormone production, and improvement of nutrient and water uptake of plants. We developed a simple and rapid method for screening potential PGPR, especially phytohormone producing rhizobacteria, or for analyzing their functions in plant growth using cucumber seedling cuttings. Surface-sterilized cucumber seeds were grown in a plastic pot containing steamed vermiculite. After 7 days of cultivation, the upper part 2 cm in length of cucumber seedling, was cut and used as cucumber cuttings. The base of cutting stem was then dipped in a microcentrifuge tube containing 1.5ml of a bacterial suspension and incubated at $25^{\circ}C$ with a fluorescent light for 10 days. Number and length of developed adventitious roots from cucumber cuttings were examined. The seedling cuttings showed various responses to the isolates tested. Some isolates resulted in withering at the day of examination or in reduced number of roots developed. Several isolates stimulated initial development of adventitious roots showing more adventitious root hair number than that of untreated cuttings, while some isolate had more adventitious root hair number and longer adventitious roots than that of untreated control. Similar results were obtained from the trial with rose cuttings. Our results suggest that this bioassay method may provide a useful way for differentiating PGPR's functions involved in the development of root system.

Effects Of Grass/Legume Pasture on Forage Production, Forage Nutritive Values and Live Weight Gain of the Grazing Heifer

  • Seo, Sung;Lee, J.K.;Shin, D.E.;Chung, E.S.
    • Asian-Australasian Journal of Animal Sciences
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    • 제10권3호
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    • pp.289-292
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    • 1997
  • A grazing trial was carried out to determine the effects of different grass/legume pastures on forage production, legume proportion, nutritive value, and animal performance. The pasture mixtures were mainly orchardgrass (OG) + ladino clover (T1), OG + alfalfa (T2), perennial ryegrass + alfalfa (T3), and grass alone mainly OG (T4). The pastures were rotationally grazed 7 times with heifers which had an initial liveweight of about 243 kg in 1991 and 1992. The average plant height at each grazing was 32.4 cm. The annual dry matter yield ranged from 9.19 MT in T4 to 9.61 MT/ha in T3, but no significant difference among different mixture combinations was found. The proportion of ladino clover in T1 mixtures rapidly increased from 21% to 68% during the grazing season. However, the proportion of alfalfa in T2 and T3 ranged from 12% to 23%. The contents of crude protein and calcium, respectively, in the forages were highest in T1 (23.2%, 0.68%) and lowest in T4 (18.5%, 0.13%), while crude fiber content showed the opposite trends. Liveweight gain was greatest on T1 (1.073 kg) and lowest on T4 (643 kg). It was concluded that pasture mixtures containing legume (ladino clover) can increase forage nutritive value and animal performance.

Applicability of Radioguided Occult Lesion Localization for Non-Palpable Benign Breast Lesions, Comparison with Wire Localization, a Clinical Trial

  • Alikhassi, Afsaneh;Saeed, Farzanefar;Abbasi, Mehrshad;Omranipour, Ramesh;Mahmoodzadeh, Habibollah;Najafi, Massoome;Gity, Masoumeh;Kheradmand, Ali
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권7호
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    • pp.3185-3190
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    • 2016
  • Background: This study was designed to compare radioguided versus routine wire localization of nonpalpable non-malignant breast lesions in terms of efficacy for complete excision, ease of use, time saving, and cosmetic outcome. Materials and Methods: Patients with non-palpable breast masses and non-malignant core biopsy results who were candidates for complete surgical lumpectomy were enrolled and randomly assigned to radioguided or wire localization groups. Radiologic, surgical, and pathologic data were collected and analyzed to determine the difficulty and duration of each procedure, ease of use, accuracy, and cosmetic outcomes. Results: This prospective randomized study included 60 patients, randomly divided into wire guided localization (WGL) or radioguided occult lesion localization (ROLL) groups. The mean duration of localization under ultrasound guidance was shorter in the ROLL group (14.4 min) than in the WGL group (16.5 min) (p<0.001). The ROLL method was significantly easier for radiologists (p=0.0001). The mean duration of the surgical procedure was 22.6 min (${\pm}10.3min$) for ROLL and 23.6 min (${\pm}9.6min$) for WGL (p=0.6), a non-significant difference. Radiography of the surgical specimens showed 100% lesion excision with clear margins, as proved by pathologic examination, with both techniques. The surgical specimens were slightly heavier in the ROLL group, but the difference was not significant (p=0.06). Conclusions: The ROLL technique provides effective, fast, and simple localization and excision of non-palpable non-malignant breast lesions.

항산화 기능 사료첨가제가 조피볼락(Sebastes schlegelii)의 성장, 체조성, 혈액성상 및 세균 공격성에 미치는 영향 (Effects of Dietary Antioxidant Supplementation on the Growth, Serum Chemistry, Body Composition and Challenge Test Results of Juvenile Rockfish Sebastes schlegelii)

  • 윤아영;김희성;서영완;조성환;배준영
    • 한국수산과학회지
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    • 제49권3호
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    • pp.323-329
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    • 2016
  • The effects of dietary antioxidant [saltwort (SW), leek (LK), and dandelion (DD)] supplementation on the growth, body composition, serum chemistry, and challenge test results of juvenile rockfish, Sebastes schlegelii, were determined. In an experiment, 320 fish were randomly distributed into eight, 50-L flow-through tanks (40 fish per tank). Four experimental diets were prepared: the control diet (Con) with synthetic antioxidant: and diets with SW, LK, or DD from natural sources. Each diet was randomly assigned to duplicate tanks of fish, which were hand-fed to satiation twice daily for 8 weeks. After the 8-week feeding trial, 20 fish from each tank were artificially infected with Streptococcus iniae and monitored for 6 days. The dietary additives did not affect survival, weight gain, specific growth rate, feed efficiency (FE), protein efficiency ratio (PER), or plasma chemistry. However, the cumulative mortality of fish fed the SW, LK and DD diets was lower than that of fish fed the control diet beginning 4 days after infection. In conclusion, dietary supplementation with SW, LK, and DD did not affect the growth, FE, PER, or plasma chemistry of rockfish. However, dietary inclusion of SW, LK, and DD lowered the mortality of rockfish following infection with S. iniae.

다양한 Rotifer (Brachionus plicatilis) 영양강화가 태평양 대구(Gadus macrocephalus) 자어의 성장 및 지방산 조성에 미치는 영향 (Effect of Different Rotifer Enrichment Products on Survival, Growth, and Fatty Acid Composition of Larval Pacific Cod Gadus macrocephalus)

  • 최진;한경식;변순규;임현정;이창환;이다연;김희성
    • 한국수산과학회지
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    • 제53권4호
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    • pp.530-537
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    • 2020
  • This study compared the survival rates, growth, and fatty acid content of larval Pacific cod Gadus macrocephalus fed with rotifers raised on different enrichment diets. We used four commercial rotifer enrichment products (one domestic, ER1, and three imported, ER2, ER3 and ER4). Twelve 200-L tanks were used, with three replicates per treatment. Larvae were fed rotifers 3 times daily at a rate of 5 rotifers/ml/feeding from 7 to 21 days post-hatch. At the end of the feeding trial, the survival rate and total length of larvae fed ER3 were greater than those of larvae fed ER1, ER2, or ER4. ER3 had the highest proportions of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and polyunsaturated acid (PUFA). Partially reflecting this composition, larvae fed ER3 had the highest proportions of DHA and PUFA. These results show a positive effect of rotifer DHA and PUFA proportions on the survival and growth rates of Pacific cod larvae.

Effects of α-tocopherol on hemolysis and oxidative stress markers on red blood cells in β-thalassemia major

  • Sovira, Nora;Lubis, Munar;Wahidiyat, Pustika Amalia;Suyatna, Franciscus D.;Gatot, Djajadiman;Bardosono, Saptawati;Sadikin, Mohammad
    • Clinical and Experimental Pediatrics
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    • 제63권8호
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    • pp.314-320
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    • 2020
  • Background: The accumulation of unpaired α-globin chains in patients with β-thalassemia major may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood transfusions and iron overload cause cellular oxidative damage. However, α-tocopherol, an antioxidant, is a potent scavenger of lipid radicals in the membranes of red blood cells (RBCs) of patients with β-thalassemia major. Purpose: To evaluate the effects of α-tocopherol on hemolysis and oxidative stress markers on the RBC membranes of patients with β-thalassemia major. Methods: Forty subjects included in this randomized controlled trial were allocated to the placebo and α-tocopherol groups. Doses of α-tocopherol were based on Institute of Medicine recommendations: 4-8 years old, 200 mg/day; 9-13 years old, 400 mg/day; 14-18 years old, 600 mg/day. Hemolysis, oxidative stress, and antioxidant variables were evaluated before and after 4-week α-tocopherol or placebo treatment, performed before blood transfusions. Results: Significant enhancements in plasma haptoglobin were noted in the α-tocopherol group (3.01 mg/dL; range, 0.60-42.42 mg/dL; P=0.021). However, there was no significant intergroup difference in osmotic fragility test results; hemopexin, malondialdehyde, reduced glutathione (GSH), or oxidized glutathione (GSSG) levels; or GSH/GSSG ratio. Conclusion: Use of α-tocopherol could indirectly improve hemolysis and haptoglobin levels. However, it played no significant role in oxidative stress or as an endogen antioxidant marker in β-thalassemia major.