Effects of α-tocopherol on hemolysis and oxidative stress markers on red blood cells in β-thalassemia major |
Sovira, Nora
(Division of Pediatric Emergency & Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Syiah Kualal/Dr. Zainoel Abidin Hospital)
Lubis, Munar (Division of Pediatric Emergency & Intensive Care, Department of Pediatrics, Faculty of Medicine, University of Sumatera Utara/University of Sumatera Utara Hospital) Wahidiyat, Pustika Amalia (Division of Hematology Oncology, Department of Pediatrics, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital) Suyatna, Franciscus D. (Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital) Gatot, Djajadiman (Division of Hematology Oncology, Department of Pediatrics, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital) Bardosono, Saptawati (Department of Nutrition, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital) Sadikin, Mohammad (Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital) |
1 | Laksmitawati DR, Handayani S, Udyaningsih-Freisleben SK, Kurniati V, Adhiyanto C, Hidayat J, et al. Iron status and oxidative stress in betathalassemia patients in Jakarta. Biofactors 2003;19:53-62. DOI |
2 | Bhagat SS, Sarkar PD, Suryakar AN, Padalkar RK, Karni AC, Ghone RA, et al. A study on the biomarkers of oxidative stress: the effects of oral therapeutic supplementation on the iron concentration and the product of lipid peroxidation in beta thalassemia major. J Clin Diagn Res 2012;6:1144-7. |
3 | Das N, Das Chowdhury T, Chattopadhyay A, Datta AG. Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Pol J Pharmacol 2004;56:85-96. |
4 | Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004;134:489-92. DOI |
5 | Ribas V, Garcia-Ruiz C, Fernandez-Checa JC. Glutathione and mitochondria. Front Pharmacol 2014;5:151. DOI |
6 | Mahdi EA. Relationship between oxidative stress and antioxidant status in beta thalassemia major patients. Acta Chim Pharm Indica 2014;4:137-45. |
7 | Qaiser S, Hoque MZ, Iqbal M, Mudin DK. Evaluation of antioxidant status in beta thalassemia major patients in Sabah, Malaysian Borneo. Biores Commun 2015;1:45-7. |
8 | Sherief LM, Abd El-Salam SM, Kamal NM, El Safy O, Almalky MA, Azab SF, et al. Nutritional biomarkers in children and adolescents with Beta-thalassemia-major: an Egyptian center experience. Biomed Res Int 2014;2014:261761. |
9 | Westergren T, Kalikstad B. Dosage and formulation issues: oral vitamin E therapy in children. Eur J Clin Pharmacol 2010;66:109-18. DOI |
10 | Fibach E, Rachmilewitz EA. Pathophysiology and treatment of patients with beta-thalassemia: an update. F1000Res 2017;6:2156. DOI |
11 | Kwiatkowski JL. Hemoglobinopathies. In: Lanzkowsky P, Lipton JM, Fish JD, editors. Lanzkowskys's manual of pediatric hematology and oncology. 6th ed. London: Elsevier, 2016:166-96. |
12 |
Voskou S, Aslan M, Fanis P, Phylactides M, Kleanthous M. Oxidative stress in |
13 | Smith A, McCulloh RJ. Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders. Front Physiol 2015;6:187. |
14 | Schaer CA, Deuel JW, Bittermann AG, Rubio IG, Schoedon G, Spahn DR, et al. Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death Differ 2013;20:1569-79. DOI |
15 | Kormoczi GF, Saemann MD, Buchta C, Peck-Radosavljevic M, Mayr WR, Schwartz DW, et al. Influence of clinical factors on the haemolysis marker haptoglobin. Eur J Clin Invest 2006;36:202-9. DOI |
16 | Lawson M, Jomova K, Poprac P, Kuca K, Musilek K, Valko M. Free radicals and antioxidants in human disease. In: Al-Gubory KH, Laher I, editors. Nutritional antioxidant therapies: treatment and perspectives. Basel: Springer International, 2017:283-305. |
17 | Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW. Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development. Front Physiol 2014;5:415. |
18 | Chow J, Phelan L, Bain BJ. Evaluation of single-tube osmotic fragility as a screening test for thalassemia. Am J Hematol 2005;79:198-201. DOI |
19 | Mahjoub S, Tamadoni A, Zanjanchi NM, Moghadamnia AA. The effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in betathalassemia patients. J Res Med SCI 2007;12:301-7. |
20 |
Kalpravidh RW, Tangjaidee T, Hatairaktham S, Charoensakdi R, Panichkul N, Siritanaratkul N, et al. Glutathione redox system in |
21 | Srichairatanakool S, Fucharoen S. Antioxidants as complementary medication in thalassemia. In: Atroshi F, editor. Pharmacology and nutritional intervention in the treatment of disease. London: InTech, 2014:119-58. |
22 | Attia MM, Sayed AM, Ibrahim FA, Mohammed AS, El-Alfy MS. Effects of antioxidant vitamins on some hemoglobin properties and erythrocytes in homozygous beta-thalassemia. Romanian J Biophys 2011;21:116. |
23 | Angastinotis M. Lifestyle and quality of life. In: Capellini MD, Porter J, Taher A, Viprakasit V, editors. Guidelines for management of transfusion dependent thalassemia (TDT). 3rd ed. Cyprus: Thalassemia International Foundation, 2014:224-35. |
24 | Vichinsky E, Levine L, Bhatia S, Bojanowski J, Coates T. Standards of care guidelines for thalassemia. Oakland: Children's Hospital and Research Centre Oakland, 2012:1-14. |
25 |
Freisleben SK, Hidayat J, Freisleben HJ, Poertadji S, Kurniawan B, Bo NP, et al. Plasma lipid pattern and red cell membrane structure in |
26 | Amelia N, Amalia P, Windiastuti E, Lubis B. Thalassemia. In: Pudjiadi AP, Hegar B, Handryastuti S, Idris NS, Gandaputra EP, Harmoniati ED, editors. Pedoman pelayan medis. Jakarta: Ikatan Dokter Anak Indonesia, 2009:299-302. |
27 | Ragab SM, Safan MA, Badr EA. Study of serum haptoglobin level and its relation to erythropoietic activity in Beta thalassemia children. Mediterr J Hematol Infect Dis 2015;7:e2015019. DOI |
28 | Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 2005;293:1653-62. DOI |
29 | Cutillo S, Meloni T. Serum concentrations of haptoglobin and hemopexin in favism and thalassemia. Acta Haematol 1974;52:65-9. DOI |
30 | Thomsen JH, Etzerodt A, Svendsen P, Moestrup SK. The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavenging. Oxid Med Cell Longev 2013;2013:523652. |
31 | Ghone RA, Kumbar KM, Suryakar AN, Katkam RV, Joshi NG. Oxidative stress and disturbance in antioxidant balance in beta thalassemia major. Indian J Clin Biochem 2008;23:337-40. DOI |
32 | Zhong S, Yin H. Lipid peroxidation: role of vitamin E. In: Niki E, editor. Chemistry and nutritional benefits. Cambridge: The Royal Society of Chemistry, 2019:118-133. |
33 | Giardini O, Cantani A, Donfrancesco A, Martino F, Mannarino O, D'Eufemia P, et al. Biochemical and clinical effects of vitamin E administration in homozygous beta-thalassemia. Acta Vitaminol Enzymol 1985;7:55-60. |
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