• Journal of Periodontal and Implant Science
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• v.48 no.5
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• pp.295-304
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• 2018

Purpose: This study was undertaken to evaluate the clinical and microbiological effects of an erythritol powder air-polishing device (EPAP) as a supplement to scaling and root planing (SRP) therapy in patients with moderate chronic periodontitis. Methods: Clinical and microbiological evaluations were performed at 21 sites treated with SRP (control) and 21 sites treated with SRP+EPAP (test). All examinations were performed before treatment, 1 month after treatment, and 3 months after treatment. Results: There were no significant clinical differences between the test group and the control group. Microbiological analysis revealed that the relative expression level of Porphyromonas gingivalis was significantly lower in the test group than in the control group at 1 month after treatment. Clinical and microbiological results showed improvements at 1 month compared to baseline; in contrast, the results at 3 months after treatment were worse than those at 1 month after treatment. Conclusions: In this study, both SRP and SRP+EPAP were clinically and microbiologically effective as non-surgical periodontal treatments. In particular, the SRP+EPAP group showed an antimicrobial effect on P. gingivalis, a keystone bacterium associated with the onset of chronic periodontitis, in a short-term period. Periodic periodontal therapy, at intervals of at least every 3 months, is important for sustaining the microbiological effects of this treatment.

• International Journal of Aeronautical and Space Sciences
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• v.11 no.3
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• pp.206-220
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• 2010

This paper proposes optimal control techniques for determining translational and rotational maneuvers that facilitate proximity operations and docking. Two candidate controllers that provide translational motion are compared. A state-dependent Riccati equation controller is formulated from nonlinear relative motion dynamics, and a linear quadratic tracking controller is formulated from linearized relative motion. A linear quadratic Gaussian controller using star trackers to provide quaternion measurements is designed for precision attitude maneuvering. The attitude maneuvers are evaluated for different final axis alignment geometries that depend on the approach distance. A six degrees-of-freedom simulation demonstrates that the controllers successfully perform proximity operations that meet the conditions for docking.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.185-191
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• 2013

In this paper, the dynamics of a novel 2-DOF planar Translational Parallel Manipulator (TPM) is analyzed. The suggested TPM is made up of two PPa (Prismatic-planar Parallelogram) legs. Since all the linear actuators are mounted on the base, the proposed TPM can be applied for high speed positioning applications. The Lagrangian equations of the first type is employed to derive the inverse dynamic equations. It is shown that the analytical inverse dynamics equations match very well with ADAMS simulations. These analytical inverse dynamics equations will be used for the real-time computed torque control in the further work.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.6_spc
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• pp.721-728
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• 2016

The combined rotational and translational dynamic vibration absorbers (DVA) with no dampers for the beam vibration control can effectively isolate the vibration within the external excitation force region. This paper investigates the damping efficacy for the combined rotational and translational dynamic vibration absorbers to impose some robustness to the DVA system for the excitation force frequency variation. The beam is assumed to be subjected to a concentrated harmonic excitation force. The solution to the problem is found based on Galerkin method.

• BMB Reports
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• v.50 no.12
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• pp.621-627
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• 2017

We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at various stages. Notably, ZNF143 was selectively expressed in duct and gland epithelium of normal breast tissues, which decreased when the tissue became malignant. To determine the molecular mechanism how ZNF143 affects breast cancer progression, it was knocked down by infecting benign breast cancer cells with short-hairpin (sh) RNA-lentiviral particles against ZNF143 (MCF7 sh-ZNF143). MCF7 sh-ZNF143 cells showed different cell-cell contacts and actin filament (F-actin) structures when compared with MCF7 sh-Control cells. In migration and invasion assays, ZNF143 knockdown induced increased cellular motility in breast carcinoma cells. This was reduced by the recovery of ZNF143 expression. Taken together, these results suggest that ZNF143 expression contributes to breast cancer progression.

• Molecules and Cells
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• v.44 no.5
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• pp.318-327
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• 2021

CD4+ T helper (Th) cells play a crucial role in the modulation of innate and adaptive immune responses through the differentiation of Th precursor cells into several subsets, including Th1, Th2, Th17, and regulatory T (Treg) cells. Effector Th and Treg cells are distinguished by the production of signature cytokines and are important for eliminating intracellular and extracellular pathogens and maintaining immune homeostasis. Stimulation of naive Th cells by T cell receptor and specific cytokines activates master transcription factors and induces lineage specification during the differentiation of Th cells. The master transcription factors directly activate the transcription of signature cytokine genes and also undergo post-translational modifications to fine-tune cytokine production and maintain immune balance through cross-regulation with each other. This review highlights the post-translational modifications of master transcription factors that control the differentiation of effector Th and Treg cells and provides additional insights on the immune regulation mediated by protein argininemodifying enzymes in effector Th cells.

• Structural Engineering and Mechanics
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• v.26 no.4
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• pp.459-477
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• 2007

A bi-directional tuned mass damper (BTMD) in which a mass connected by two translational springs and two viscous dampers in two orthogonal directions has been introduced to control coupled lateral and torsional vibrations of asymmetric building. An efficient control strategy has been presented in this context to control displacements as well as acceleration responses of asymmetric buildings having asymmetry in both plan and elevation. The building is idealized as a simplified 3D model with two translational and a rotational degrees of freedom for each floor. The principles of rigid body transformation have been incorporated to account for eccentricity between center of mass and center of rigidity. The effective and robust design of BTMD for controlling the vibrations in structures has been presented. The redundancy of optimum design has been checked. Non dominated sorting genetic algorithm (NSGA) has been used for tuning optimum stages and locations of BTMDs and its parameters for control of vibration of seismically excited buildings. The optimal locations have been observed to be reasonably compact and practically implementable.

• Molecules and Cells
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• v.41 no.3
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• pp.179-187
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• 2018

Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonstrated an increased number of protein identification in EV. Comparative MS analyses of urinary EV from control subjects and bladder cancer patients identified a total of 1,222 proteins. Statistical analyses provided 56 proteins significantly increased in bladder cancer urine, including proteins for which expression levels varied by cancer stage (P-value < 0.05). While urine represents a valuable, non-invasive specimen for biomarker discovery in urologic cancers, there is a high degree of intra- and inter-individual variability in urine samples. The enrichment of urinary EV demonstrated its capability and applicability of providing a focused identification of biologically relevant proteins in urological diseases.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.1-4
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• 1996

It is difficult that a non-translational motion in a block is estimated by the block matching algorithm (BMA). In this paper, a nodal-displacement-based deformation model is used for this reason. This model assumes that a selected number of control nodes move freely in a block and that displacement of any interior point can be interpolated from nodal displacements. As a special case with a single node this model is equivalent to a translational model. And this model can represent more complex deformation using more nodes. We used an iterative gradient based search algorithm to estimate nodal displacement. Each iteration involves the solution of a simple linear equation. This method is called the deformable block matching algorithm (DBMA).

• 제어로봇시스템학회:학술대회논문집
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• 1990.10b
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• pp.890-895
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• 1990

A theoretical and experimental study of a single link flexible arm a tip mass is presented for the translational end-point positioning. The problem of shifting the end-point from its initial position to the commanded position by the amount of W $_{d}$ is considered for the open loop control such that the base follows up the given path function. The theoretical results are obtained by applying the method of the Laplace transform to the governing equation, and the solution is calculated by the method of numerical inversion. Experimental results are obtained and compared with the theoretical ones.s.