• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.2
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• pp.124-131
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• 2021

In the recent business environment, risks related to product safety problems are increasing. These are arising from various factors such as increasing product and production complexity, supply chain diversification, enhanced PL (product liability) law and strengthening regulations of the government. Accordingly, ISO (international organization for standardization) published standards of PSMS (product safety management system) for suppliers such as ISO 10377 and ISO 10393. Meanwhile, the ISO 9001 QMS (quality management system) was revised in 2015, and it has established itself as an effective tool that can consistently meet the various requirements of stakeholders and promote customer satisfaction. This study aims to suggest an integration framework of QMS and PSMS based on the recent ISO international standards. To this end, firstly, the relationship between QMS and PSMS is studied based on the quality and product safety definitions, PDCA (plan-do-check-act) cycle and risk-based thinking. Secondly, the requirements of ISO 10377 and ISO 9001 are compared and classified as the common and ISO 10377 specific requirements. Finally, integration steps of two systems are suggested and guidelines that can systemize the integrated requirements are presented in the aspect of processes and documentation. This study is expected to be used as a guideline that helps companies those have already acquired QMS certification to build an international-level product safety management system early.

• Biomedical Science Letters
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• v.26 no.4
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• pp.302-309
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• 2020

Human Coxsackievirus B5 (HuCoxV-B5) infection has been associated with various diseases such as myocarditis, aseptic meningitis, hand-foot-and mouth-disease, and insulin-dependent diabetes. HuCoxV-B5 is a virus transmitted through the fecal-oral route and is detected in clinics, aquatic environments, food, shellfish, etc. and is one of the more important viruses in public health because of its incidence rate reported worldwide. In this study, a combination of SYBR Green-based real-time PCR primers for molecular diagnosis including monitoring of HuCoxV-B5 was selected and the optimal reaction conditions were established. Compared with the previously reported TaqMan probe-based real-time PCR method, assessments including a sample applicability test were performed. Results showed that the real-time PCR method developed in this study was suitable for a molecular diagnostic technique for detecting HuCoxV-B5. This study is expected to contribute to efforts in responding to safety accidents in public health because the proposed method facilitates rapid diagnosis of clinical patients. It can also be used as a specific monitoring tool of HuCoxV-B5 in non-clinical areas such as aquatic environments among others.

• Korean Journal of Organic Agriculture
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• v.30 no.1
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• pp.21-35
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• 2022

Measuring the food safety has been focused only on the psychological consumers' recognition of food safety. The actual measurement tool should consist of the evidence-based statistical data to assess the level of national food safety in scientific perspectives. This paper described the development of a concept to measure the food safety of the food chain based on OECD PSR framework. This paper discusses the elaboration of a set of 8 food safety related data issued as statistical data, and which were same weighted. These food safety statistical data (FSDs) were derived as the basis of measuring the variation of food safety during 2013-2019. The values of the primary production indicator (PPI), the processing and manufacturing indicator (PMI), and the distribution and consumption indicator (DCI) are 0.558-0.859, 0.533-0.691, and 0.979-0.982, respectively. The food safety status (FSS) derived from the safety indicator values of each of the three stages is 0.700-0.810. In order to increase the level of food safety, it is necessary to pay attention to PMI and PPI management. In the future, continuously calculating the level of food safety, managing it like the level of psychological safety, and further expanding it to the level of food safety between countries will help establish policies to improve the level of food safety in Korea.

• Animal Bioscience
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• v.35 no.8
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• pp.1141-1150
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• 2022

Objective: To understand the domestication and spread of horses in history, genetic information is essential. However, mitogenetic traits of ancient or medieval horses have yet to be comprehensively revealed, especially for East Asia. This study thus set out to reveal the maternal lineage of skeletal horse remains retrieved from a 15th century archaeological site (Gongpyeongdong) at Old Seoul City in South Korea. Methods: We extracted DNA from the femur of Equus caballus (SNU-A001) from Joseon period Gongpyeongdong site. Mitochondrial (mt) DNA (HRS 15128-16116) of E. caballus was amplified by polymerase chain reaction. Cloning and sequencing were conducted for the mtDNA amplicons. The sequencing results were analyzed by NCBI/BLAST and phylogenetic tool of MEGA7 software. Results: By means of mtDNA cytochrome b and D-loop analysis, we found that the 15th century Korean horse belonged to haplogroup Q representing those horses that have historically been raised widely in East Asia. Conclusion: The horse is unique among domesticated animals for the remarkable impact it has on human civilization in terms of transportation and trade. Utilizing the Joseon-period horse remains, we can obtain clues to reveal the genetic traits of Korean horse that existed before the introduction of Western horses.

• Journal of Veterinary Science
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• v.21 no.1
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• pp.4.1-4.9
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• 2020

Fast and accurate detection of viral RNA pathogens is important in apiculture. A polymerase chain reaction (PCR)-based detection method has been developed, which is simple, specific, and sensitive. In this study, we rapidly (in 1 min) synthesized cDNA from the RNA of deformed wing virus (DWV)-infected bees (Apis mellifera), and then, within 10 min, amplified the target cDNA by ultra-rapid qPCR. The PCR products were hybridized to a DNA-chip for confirmation of target gene specificity. The results of this study suggest that our method might be a useful tool for detecting DWV, as well as for the diagnosis of RNA virus-mediated diseases on-site.

• Biomolecules & Therapeutics
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• v.31 no.5
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• pp.573-582
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• 2023

Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins (i.e., muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

• Journal of the Korea Society of Computer and Information
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• v.14 no.7
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• pp.1-8
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• 2009

In this paper, make a study decision problem called an optimal release policies after testing a software system in development phase and transfer it to the user. The optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement is generally accepted. The Bayesian parametric inference of model using log Poisson execution time employ tool of Markov chain(Gibbs sampling and Metropolis algorithm). In a numerical example by T1 data was illustrated. make out estimating software optimal release time from the maximum likelihood estimation and Bayesian parametric estimation.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.32.3-33
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• 2021

We present H I gas kinematics and star formation activities of NGC 6822, a dwarf galaxy located in the Local Volume at a distance of ~ 490 kpc. We perform profile decomposition of the line-of-sight velocity profiles of the high-resolution (42.4" × 12" spatial; 1.6 km/s spectral) H I data cube taken with the Australia Telescope Compact Array (ATCA). For this, we use a new tool, the so-called BAYGAUD (BAYesian GAUssian Decompositor) which is based on Bayesian Markov Chain Monte Carlo (MCMC) techniques, allowing us to decompose a line-of-sight velocity profile into an optimal number of Gaussian components in a quantitative manner. We classify the decomposed H I gas components of NGC 6822 into bulk-narrow, bulk-broad, and non_bulk with respect to their velocity and velocity dispersion. We correlate their gas surface densities with the surface star formation rates derived using both GALEX far-ultraviolet and WISE 22 micron data to examine the impact of gas turbulence caused by stellar feedback on the Kennicutt-Schmidt (K-S) law. The bulk-narrow component that resides within r25 is likely to follow the linear extension of the Kennicutt-Schmidt (K-S) law for molecular hydrogen (H2) at the low gas surface density regime where H I is not saturated.

• Convergence Security Journal
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• v.22 no.1
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• pp.3-9
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• 2022

The role of the integrated development environment is very important in software development of a development project. After many developers develop different modules, software product is completed through compile, debugging, integration, testing, and distribution. However, bugs and various issues in the development process cause problems such as quality deterioration of software product and dissatisfaction with requirements. So the need for automated testing to avoid these problems and improve quality has increased. In this study, we propose test automation modules of four perspectives to improve quality throughout the test automation in an integrated development environment. Each automation module operates through the tool chain of an integrated build framework implemented on the devops.

• Journal of Auto-vehicle Safety Association
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• v.15 no.4
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• pp.39-47
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• 2023

Research on the safety of autonomous vehicle is being conducted in various countries, including the European Union, and computer simulation techniques so called 'Virtual Tool Chain' are mainly used. As part of the crash safety study of autonomous vehicle, 25 car to car collision scenarios were provided as a result of a real accident-based accident reproduction analysis study conducted by a domestic research institution, and a vehicle crash analysis was performed using the FE car to car model of the Honda Accord. In order to analyze the results of the car to car simulation and to construct a database, major crash parameters were selected as impact speed, angle, location, and overlap, and a method of defining them in an indexed form was presented. In order to compare the crash severity of each scenario, a value obtained by integrating the resultant acceleration measured by the ACU of the vehicle was applied. The equivalent collision test mode was derived by comparing the crash severity of the regulation test mode, 30 deg rigid barrier mode, in the same way.