• KSBB Journal
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• 제26권2호
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• pp.131-138
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• 2011

Some computational approaches are needed for clarifying RNAi sequences, because it takes much time and endeavor that almost of RNAi sequences are verified by experimental data. Incorrectness of RNAi mechanism and other unaware factors in organism system are frequently faced with questions regarding potential use of RNAi as therapeutic applications. Our massive parallelized pair alignment scoring between dsRNA in Genebank and expressed sequence tags (ESTs) in Caenorhabditis elegans Genome Sequencing Projects revealed that this provides a useful tool for the prediction of RNAi induced cosuppression details for practical use. This pair alignment scoring method using high performance computing exhibited some possibility that numerous unwanted gene silencing and cosuppression exist even at high matching scores each other. The classifying the relative higher matching score of them based on GO (Gene Ontology) system could present mapping dsRNA of C. elegans and functional roles in an applied system. Our prediction also exhibited that more than 78% of the predicted co-suppressible genes are located in the ribosomal spot of C. elegans.

• 경영정보학연구
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• 제12권2호
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• pp.1-23
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• 2010

엔터프라이즈 정보화를 추진하는데 있어서 가장 심각한 문제 중 하나는 서로 연계 통합되지 않은 사일로(Silo) 시스템 문제이다. 정보전략계획(Information Strategy Planning)은 비즈니스에 필요한 개별시스템 기능성 도출에 국한되어 오히려 이러한 사일로 문제를 가중시키고 있다. 본 연구는 엔터프라이즈 사일로 문제가 엔터프라이즈 제반 요소들이 가지는 관계에 대한 총체적 시각, 곧 '아키텍처적 시각'이 부재하기 때문이라고 보고, 이러한 엔터프라이즈 요소간 관계를 정의하고 체계화할 수 있는 '엔터프라이즈 아키텍처 지향 모델'을 제안한다. 이를 위해 본 연구는 엔터프라이즈 제반 구성요소들 상호간에 수직적, 수평적 관계성을 부여하고 엔터프라이즈가 이들 관계에 있어서 거치는 진화의 단계를 설정한다. 엔터프라이즈 아키텍처 지향 모델에서 수직적 관계는 Kaplan과 Norton의 연구로부터 도출된 성과, 역량, 전략이라는 세 요소가 조직 상하간에 전략적 관리적 측면에서 '연계(Alignment)'되어야 함을 의미한다. 수평적 관계는 Ross 등이 통합 대상으로 다룬 정보기술, 데이터/프로세스, 비즈니스 컴포넌트 요소들이 수평 조직간에 기능적 실행적 측면에서 '통합(Integration)'되어야 함을 강조한다. 본 모델은 엔터프라이즈의 현재와 미래 아키텍처를 사상하는 개념공간으로서 엔터프라이즈의 현재 모습을 파악하고 엔터프라이즈가 지향하는 미래 모습을 도출하며 현재에서 미래로의 이행을 인도하는 개념적 틀로서 작용하게 된다. 끝으로 본 모델의 적용 사례를 들고 모델의 적용이 각 엔터프라이즈가 지향하는 엔터프라이즈 모습에 따라 어떻게 달라질 수 있는지를 논의한다.

• 한국생산제조학회지
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• 제4권3호
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• pp.39-47
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• 1995

This paper suggests generalize mathematica mode for the benefit of volumetric error analysis of a multi-axis machine tool machining a sculptured surfaces. The volumetric error, in this paper, is defined as a three dimensional error at the cutting point, which is caused by the geometric errors and the kinematic errors of each axis and alignment errors of the cutting tool. The actual cutting position is analyzed based on the form shaping model including a geometric error of the moving carriage, where a form shaping model is derived from the homogeneous transformation matrix. Then the volumetric error is obtained by calculating the position difference between the actual cutting position and the ideal one calculated from a Nonuniform Rational B-Spline named as NURES. The simulation study shows the effectiveness for predicting the behavior of machining error and for the method of error compensation.

• 천문학논총
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• 제19권1호
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• pp.71-76
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• 2004

We have developed a tool for measuring optical aberrations of telescope. We adopt curvature sensing technique and use the least square method for finding the amplitudes of the Zernike polynomials. This tool runs under the PC Linux system and the PC windows system with Linux emulators such as Cygwin. The program for UNIX system is used for optical alignment of 1.8M optical telescope at the Bohyunsan Optical Astronomical Observatory (BOAO) and the PC based program is used for the Korea Astronomy Observatory (KAO) wide field telescope (named NEOPAT-3). Our tool is found to be efficient for precise measurement of the optical aberrations of telescopes.

• Genomics & Informatics
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• 제7권1호
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• pp.46-48
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• 2009

Finishing is the most time-consuming step in sequencing, and many genome projects are left unfinished due to complex repeat regions. Here, we have developed BACContigEditor, a prototype shotgun sequence finishing tool. It is essentially an editor that visualizes assemblies of shotgun sequence fragment reads as gapped multiple alignments. The program offers some flexibility that is needed to rapidly resolve complex regions within a working session. The sole purpose of the release is to promote collaborative creation of extensible software for fragment assembly editors, foster collaborative development, and reduce barriers to initial tool development effort. We describe our software architecture and identify current challenges. The program is available under an Open Source license.

• Bioinformatics and Biosystems
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• 제1권2호
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• pp.123-127
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• 2006

TIM barrel domain is widely studied since it is one of most common structure and mediates diverse function maintaining overall structure. TIM barrel domain's function is determined by local structural environment at the C-terminal end of barrel structure. We classified TIM barrel domains by local structural alignment tool, LSHEBA, to understand characteristics of TIM barrel domain's functionalvariation. TIM barrel domains classified as the same cluster share common structure, function and ligands. Over 80% of TIM barrels in clusters share exactly the same catalytic function. Comparing clustering result with that of SCOP, we found that it's important to know local structural environment of TIM barrel domains rather than overallstructure to understand specific structural detail of TIM barrel function. Non TIM barrel domains were associated to make different domain combination to form a different function. The relationship between domain combination, we suggested expected evolutional history. We finally analyzed the characteristics of amino acids around ligand interface.

• 한국정밀공학회지
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• 제17권9호
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• pp.75-80
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• 2000

Although laser interferometer is widely accepted as a tool for measurement of motion accuracy the set-up procedure is time-consuming because of the strict requirement on alignment between laser head and optic units. This paper presents a 4-axis auto-aligning system which is useful for easy set-up of laser interferometer so as to evaluate precision of a 2-axis feeding system. This paper proposes two ideas for alignment in laser interferometer set-up: one is use of mirror and retroreflectors. and the other is taking advantage of the pre-defined movement and peculiar characteristic of retroreflecotrs. The pros and cons of the two methods are discussed. Illustrative experimental results are presented in which the developed system is applied to a XY table.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 가을 학술발표논문집 Vol.31 No.2 (1)
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• pp.787-789
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• 2004

People frequently feel the need of a general searching tool that frees from language barrier when they find information through the internet. Therefore, it is necessary to have a multilingual parallel corpus to search with a word that includes a search keyword and has a corresponding word in another language, Multilingual parallel corpus can be built and reused effectively through the several processes which are judgment of the web documents, sentence alignment and word alignment. To build a multilingual parallel corpus, multi-lingual dictionary should be constructed in each language and HTML should be simplified. And by understanding the meaning and the statistics of document structure, judgment on translated web documents will be made and the searched web pages will be aligned in sentence unit.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2013년도 추계학술발표대회
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• pp.103-106
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• 2013

SAMtools는 NGS 데이터의 alignment 결과에 대해 사실상의 표준으로 쓰이고 있는 SAM 포맷의 데이터를 다루는 많은 연구자들에게 애용되는 tool 들을 포함하고 있는 SW 이다. 최근 멀티코어 처리장치 HW 기술이 적용된 alignment SW 들이 속속 공개되어 성능향상을 보여주고 있으나, SAMtools 는 그렇지 못한 실정이어서 점점 더 NGS 데이터 처리의 병목구간으로 작용하고 있다. 이러한 문제를 해결하기 위하여 본 논문에서는 멀티코어 CPU 를 효과적으로 활용한 고성능의 MC-SAMtools SW를 제시하고자 한다.

• 대한기계학회논문집B
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• 제30권10호
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• pp.957-965
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• 2006

A high-performance hot chuck is designed as a heating device for an ultra-precision flip-chip bonder with infrared alignment system. Analysis of design requirements for thermal performance leads to a radiative heating mechanism employing two halogen lamps as heating source. The heating tool is made of silicon carbide characterized by high thermal diffusivity and small thermal expansion coefficient. Experimental tests are performed to assess heat-up performance and temperature uniformity of the heating tool. It is revealed that the initial design of hot chuck results in a good heat-up speed but there exist a couple of troubles associated with control and integrity of the device. As a means to resolve the raised issues, a revised version of heating tool is proposed, which consists of a working plate made of silicon carbide and a supporting structure made of stainless steel. The advantages of this two-body heating tool are discussed and the improved features are verified experimentally.