• Genomics & Informatics
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• v.12 no.4
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• pp.136-144
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• 2014

Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats, including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNA recombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errors and consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects the high-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genome architecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.

• Phonetics and Speech Sciences
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• v.3 no.1
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• pp.67-75
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• 2011

In Korean, 'Aspiration Merger' is the result of the heteromorphemic sequence of lenis stop and /h/ becoming a single aspirated stop word-medially. However, the contrast between lenis stop-plus-/h/ and an underlying aspirated stop is maintained when they span Phonological Phrase boundaries. By varying the position in the prosodic domain such as APP (Across Phonological Phrase) and PPM (Phonological Phrase Medial) positions, the phonetic properties of the two categories are compared. In the results from noise duration and change of intensity, lenis stop-plus-/h/ show a large difference between the APP and PPM positions. The results from a noise duration comparison show that the two categories are completely neutralized into aspirated stop in the PPM position and the complete neutralization is sensitive to prosodic phrasing.

• Journal of Korean Institute of Industrial Engineers
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• v.25 no.4
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• pp.466-475
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• 1999

A backward Dynamic Programming(DP) model for the optimal facility replacement decision problem during a finite planning horizon is presented. Multiple alternative challengers to a current defender are considered. All facilities are assumed to have finite service lives. The objective of the DP model is to maximize the profit over a finite planning horizon. As for the cost elements, purchasing cost, maintenance costs and repair costs as well as salvage value are considered. The time to failure is assumed to follow a weibull distribution and the maximum likelihood estimation of Weibull parameters is used to evaluate the expected cost of repair. To evaluate the revenue, the rate of operation during a specified period is employed. The cash flow component of each challenger can vary independently according to the time of occurrence and the item can be extended easily. The effects of inflation and the time value of money are considered. The algorithm is illustrated with a numerical example. A MATLAB implementation of the model is used to identify the optimal sequence and timing of the replacement.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.15 no.10
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• pp.829-841
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• 1990

On assuming that the transmission speed of the original information is the fifth-order transmission speed of the Korea digital multiplex hierarchy (564.992Mb/s), this paper proposes a new structure of the transmission line frame at the terminal repeater system, in order to not only maintain and conserve 565Mb/s optical fiber transmission system but also make the B.S.I. of digital communication network for the optical transmission. And the structure uses the mBIZ transmission line code, which is considered the optimal transmission line code of conventional transmission line codes. System hardware of the transmission line frame structure proposed in this paper is consisted by a method of pulse stuffing after converting the speed of the original information signal sequence at the terminal repeater system for 565Mb/s optical transmission. As a result of this, we can prevent the optical transmission system from a domino phenomenon, the phenomenon of the continuous error multiplication of systems by the transmission error, and suppress timing jitter and the identical consecutive digit number. And also we can improve SNR of the optical transmission system about 2dB because of raising total BER at the optical terminal system up to 10.

• Journal of the korean academy of Pediatric Dentistry
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• v.34 no.4
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• pp.700-708
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• 2007

A midline deviation is divided into three types, such as a skeletal midline deviation, a dental midline deviation, and a combination. Among them, the midline deviation which appear in the early mixed dentition without any skeletal problem can be managed differently by the stage of dental development. The location of the permanent incisors can be improved without using artificial force in consideration of the condition of the space, the eruption timing or the eruption path of the adjacent permanent teeth in early mixed dentition, especially when the permanent incisors are erupting. Therefore, the space supervision technique, which can have the teeth align themselves utilizing physiologic events such as sequence or timing of the eruption of permanent teeth, can be an alternative to orthodontic movement. This case report describes midline deviation improvement by space supervision.

• Journal of Communications and Networks
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• v.2 no.1
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• pp.58-68
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• 2000

In this paper we introduce the correlation-aided distributed sample acquisition (CDSA) scheme for fast cell search in IMT-2000 W-CDMA cellular system. The proposed scheme incorporates the state symbol correlation process into the comparison-correction based synchronization process of the original DSA scheme to enable fast acquisition even under very poor channel environment. for its realization, each mobile station (MS) has to store in its memory a set of state sample sequences. which are determined by the long-period scrambling sequences used in the system and the sampling interval of the state samples. CDSA based cell search is carried out in two stages : First, the MS first acquires the slot timing by using the primary synch code (PSC) and then identifies the igniter code which conveys the state samples of the current cell . Secondly. the MS identifies the scrambling code and frame timing by taking the comparison-correction based synchronization approach and, if the identification is not done satisfactorily within preset time. it initiates the state symbol correlation process which correlates the received symbol sequence with the pre-stored state sample sequences for a successful identification. As the state symbol SNR is relatively high. the state symbol correlation process enables reliable synchronization even in very low chip-SNR environment. Simulation results show that the proposed CDSA scheme outperforms the 3GPP 3-step approach, requiring the signal power of about 7 dB less for achieving the same acquisition time performance in low-SNR environments. Furthermore, it turns out very robust in the typical synchronization environment where large frequency offset exists.

• Health Policy and Management
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• v.3 no.1
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• pp.1-24
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• 1993

This study is designed to find clues to make a plan for efficient hospital bed utilization. Author has tried to estimate the level of appropriateness and to find out factors affecting intra-hospital variation of inappropriate bed utilization using modified Appropriateness Evaluation Protocol of which criteria are based on service intensity and patients' conditions. Systematic random sampling was done from the population of inpatients during one month in on university hospital. Data were collected by concurrent and retrospective medical record review and analysed by multiple logistic regression. In medical services, 83.5% of admission reveals appropriate and the level of inappropriate admission shows significant differences by patients' residence, type of department admitted to, admission 개\ulcorner, and length of stay. In surgical services, 97.3% and 34.7% are appropriate in location and timing of surgery respectively. Inappropriate timing of surgery differs significantly depending on patients' age, type of department admitted to, admission route, and length of stay. Sixty two percent of hospital days shows appropriate and the level of inappropriateness show marked differences by patients'age, type of services, admission routes, part of the month, part of the stay, and length of stay. Inappropriate hospital days are due to inappropriate level of care, premature admission, improper scheduling of diagnostic or therapeutic procedures, and problems in scheduling surgery in sequence. In conclusion, substantially high proportion of inappropriate hospital bed utilization was confirmed. To reduce it, it is necessary to develop alternative services with which can replace inpatient services, and to introduce utilization management system which may include internal peer review.

• Journal of Biomedical Engineering Research
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• v.27 no.1
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• pp.30-37
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• 2006

Injecting currents into an electrically conducting subject, we may measure the induced magnetic flux density distributions using an MRI scanner. The measured data are utilized to reconstruct cross-sectional images of internal conductivity and current density distributions in Magnetic Resonance Electrical Impedance Tomography (MREIT). Injection currents are usually provided in a form of mono-polar or bi-polar pulses synchronized with an MR pulse sequence. Given an MRI scanner performing the MR phase imaging to extract the induced magnetic flux density data, the current source becomes one of the key parts determining the signal-to-noise ratio (SNR) of the measured data. Since this SNR is crucial in determining the quality of reconstructed MREIT images, special care must be given in the design and implementation of the current source. This paper describes a current source design for MREIT with features including interleaved current injection, arbitrary current waveform, electrode switching to discharge any stored charge from previous current injections, optical isolation from an MR spectrometer and PC, precise current injection timing control synchronized with any MR pulse sequence, and versatile PC control program. The performance of the current source was verified using a 3T MRI scanner and saline phantoms.

• Journal of the korean academy of Pediatric Dentistry
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• v.32 no.4
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• pp.693-702
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• 2005

Accurate timing and sequence of eruption of permanent teeth are indicies of growth and essential for pediatric dentistry and pediatric clinical orthodontics. From the children brought to the Yonsei Dental Hospital during 2001 to 2003, 654 boys and 542 girls, ranging in age from five to fourteen years, were selected and analysed. The following was concluded. 1. Eruption time of maxillary teeth is 6.81 years in boys, 6.78 years in girls for central incisor, 8.30 years in boys, 7.98 years in girls for lateral incisor, 10.28 years in boys, 10.04 years in girls for canine, 9.74 years in boys, 9.90 years in girls for first premolar, 10.87 years in boys, 10.41 years in girls for second premolar, 6.25 years in boys, 6.54 years in girls for first permanent molar, 12.21 years in boys, 12.03 years in girls for second permanent molar 2. Eruption time of mandibular teeth is 6.00 years in boys, 6.06 years in girls for central incisor, 6.99 years in boys, 6.74 years in girls for lateral incisor, 9.83 years in boys, 9.17 years in girls for canine, 9.92 years in boys, 9.75 years in girls for first premolar, 10.66 years in boys, 10.39 years in girls for second premolar, 5.99 years in boys, 5.75 years in girls for first permanent molar, 11.92 years in boys, 12.17 years in girls or second permanent molar. 3. The following eruption sequence was observed the first permanent molar erupted first, followed by the central incisor, the lateral incisor, the first premolar, the canine, the second premolar and the second permanent molar in the maxilla. The first permanent molar erupted first, followed by the central incisor, the lateral incisor, the canine, the first premolar, the second premolar and the second permanent molar in the mandible.

• 한국석유지질학회:학술대회논문집
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• spring
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• pp.48-55
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• 1998

The Pohang Basin is located in Pohang City and adjacent coastal areas in the southeastern Korea. It has a sequence of 900 meters of Neogene marine sediments (Yeonil Group) while offshore basins in the East Sea, e.g., the Ulleng basin, is over 10 Km in thickness. An understanding of the marine Yeonil Group in the Pohang Basin may provide insights into the hydrocarbon potential of the offshore East Sea regions. Heulandite, smectite, dolomite, kaolinite and opal-CT are commonly found as diagenetic minerals in the Yeonil Group. Among these minerals, heulandite occurs as a main cement only in sandstones consisting of volcanic matrix, Smectite composition and diagenetic mineral facies such as heulandite and opal-CT may reflect that the Yeonil Group has undergone shallow burial, temperatures below about 60 degrees. This suggest that sandstones have experiened weak diagenetic alteration. In order to reconstruct the thermal history of the basin, apatite fission-track analysis was carried out. Aapparent apatite fission-track ages (AFTAs) exhibit a broader range of ages from 238 Ma to 27 Ma with mean track lengths in the range of $15.24\pm8.0$ micrometers, indicating that these samples had undergone significant predepositional thermal alteration. The Triassic to Cretaceous AFTAs seem In represent the timing of cooling of their sedimentary sources. Late Cretaceous mean AFTA $(79.0\pm8.0 Ma)$ on the Neogene Yeonil Group indicates that the Yeonil Group had not been buried deeper than 2km since its deposition. The organic matters of. the Pohang Basin remain in the immature stage of thermal evolution because burial depth and temperature were not sufficient enough for maturation even in the deep section of the basin.