• Journal of Ginseng Research
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• 제43권4호
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• pp.539-549
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• 2019

Background: 20(S)-Protopanaxadiol (PPD), the aglycone part of 20(S)-protopanaxadiol ginsenosides, possesses antidepressant activity among many other pharmacological activities. It is currently undergoing clinical trial in China as an antidepressant. Methods: In this study, an ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass tandem mass spectrometry method was established to identify the metabolites of PPD in human plasma and urine following oral administration in phase IIa clinical trial. Results: A total of 40 metabolites in human plasma and urine were identified using this method. Four metabolites identified were isolated from rat feces, and two of them were analyzed by NMR to elucidate the exact structures. The structures of isolated compounds were confirmed as (20S,24S)-epoxydammarane-12,23,25-triol-3-one and (20S,24S)-epoxydammarane-3,12,23,25-tetrol. Both compounds were found as metabolites in human for the first time. Upon comparing our findings with the findings of the in vitro study of PPD metabolism in human liver microsomes and human hepatocytes, metabolites with m/z 475.3783 and phase II metabolites were not found in our study whereas metabolites with m/z 505.3530, 523.3641, and 525.3788 were exclusively detected in our experiments. Conclusion: The metabolites identified using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry in our study were mostly hydroxylated metabolites. This indicated that PPD was metabolized in human body mainly through phase I hepatic metabolism. The main metabolites are in 20,24-oxide form with multiple hydroxylation sites. Finally, the metabolic pathways of PPD in vivo (human) were proposed based on structural analysis.

• Journal of Ginseng Research
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• 제41권1호
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• pp.10-22
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• 2017

Background: Asian ginseng and American ginseng are functional foods that share a close genetic relationship and are well-known worldwide. This article aims to investigate the correlation between morphological characteristics and the inherent quality of Asian and American ginsengs. Methods: In this study, an ultra-HPLC-quadrupole/time-of-flight MS (UHPLC-Q/TOF-MS) method was established for the quantitative analysis of 45 ginseng samples. The method developed for determination was precise and accurate. Results: The results showed that Asian ginseng samples with the same growing time (with the same or similar number of stem scars) that had a thinner main root, a longer rhizome and more branch roots contained greater amounts of ginsenosides. For American ginseng, two tendencies were observed in the relationship between the diameter of the main root and contents of ginsenosides. One tendency was that samples with thinner main roots tended to contain higher levels of ginsenosides, which was observed in the samples sold under the commercial name pao-shen. Another tendency was that samples with thicker main roots contained higher contents of ginsenosides, which was observed in the samples sold under the commercial name pao-mian, as well as in samples of American ginseng cultivated in Jilin, China. Conclusion: An approach using ultra-HPLC-quadrupole/time-of-flight MS was successfully established to link morphology and active components for evaluating the quality of Asian and American ginsengs. Clear correlation between visible morphological features and quality of Asian and American ginsengs was found. People can see the difference; this means consumers and vendors can evaluate ginseng by themselves.

• 한국운동역학회지
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• 제28권2호
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• pp.69-78
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• 2018

Objective: The purpose of this study was to investigate the feasibility of a new vault technique through a kinematic comparison of the YANG Hak Seon and Yeo 2 vaults. Method: The photographic images of the YANG Hak Seon and Yeo 2 vaults were collected using a high-speed camera, and their kinematic characteristics were analyzed using three-dimensional image analysis. Results: During the post-flight phase of the Yeo 2 and YANG Hak Seon vaults, the time of flight, height of flight, and flight distance were similar. At the peak of the post-flight phase, the trunk rotation angle of the YANG Hak Seon vault rotated $457^{\circ}$ more than did the Yeo 2 vault. During the post-flight descending period, the twist velocity of the trunk was much faster with the YANG Hak Seon vault ($1,278^{\circ}/s$) than with the Yeo 2 vault ($1,016^{\circ}/s$). Conclusion: To succeed in the new technique, the average twist velocity during post-flight must be maintained at $1,058^{\circ}/s$ and the twist velocity must be increased from the ascending phase.

• 한국항공운항학회지
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• 제5권1호
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• pp.7-16
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• 1997

Airspeed and altimeter calibration of Twin Bee was conducted by the flight test. We have adopted system to system method. Flight test data is corrected for instrumented error and position error, and the resultin data was satisfied. Climb Performance flight test also was conducted. But we could not have all data because of limited flight time. The resulted data was satisfied compare with calculated data.

• 한국항공우주학회지
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• 제31권9호
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• pp.88-93
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• 2003

본 논문은 헬리콥터용 시뮬레이션 프로그램 개발에 관한 연구이다. 일반적으로 헬리콥터 비행시뮬레이션에 사용되는 수학모델은 고 충실도를 가져야 한다. 그러므로 시뮬레이션을 실행할 때 보다 정교하 공력 모델이 필요하게 되며, 계산시간이 많이 걸린다. 어떠한 특수 목적을 수행하는 UAV 비행제어시스템에서는 제어기를 설계할 때 사용되는 선형모델을 비선형모델로부터 얻는 시간을 최소화 하는 것이 중요하다. 이와 같은 목적을 달성하기 위한 첫 번째 단계는 실제로 헬리콥터 동특성을 잘 나타내는 비선형 모델을 완성하는 일이다. 두 번째 단계는 비선형방정식으로부터 특정 비행조건에 맞는 트림값을 계산하는 것이다. 그리고 나서 수치적인 방법으로 안정미계수와 조종미계수를 계산하여 특정 비행 상태 조건에 부합하는 선형모델을 구한다. 이러한 과정을 편리하게 처리하는 프로그램을 MATLAB GUI를 사용해서 개발하였다. 이 논문에서 제안된 방법은 기존의 실물크기 모델헬리콥터 시뮬레이션 방법에 비해 간략화된 것이다. 따라서 선형모델을 얻기까지의 연산시간이 짧아서 무인헬리콥터의 비행제어시스템을 설계하는데 유용할 것이다.

• International Journal of Control, Automation, and Systems
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• 제5권6호
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• pp.607-613
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• 2007

Eigenstructure assignment provides the advantage of allowing great flexibility in shaping the closed-loop system responses by allowing specification of closed-loop eigenvalues and corresponding eigenvectors. But, the general eigenstructure assignment methodologies cannot guarantee stability robustness to parameter variations of a system. In this paper, we present a novel method that has the capability of exact assignment of an eigenstructure which can consider the probability of instability for LTI (Linear Time-Invariant) systems. The probability of instability of an LTI system is determined by the probability distributions of the closed-loop eigenvalues. The stability region for the system is made probabilistically based upon the Monte Carlo evaluations. The proposed control design method is applied to design a flight control system with probabilistic parameter variations to confirm the usefulness of the method.

• 한국CDE학회논문집
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• 제9권2호
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• pp.148-157
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• 2004

Interactive simulators that simulate mechanical systems are being developed for the purpose of performance evaluation of product design, replacement of physical training, and entertainment game. Use of flight simulator is increasing to reduce risk and cost of physical training, and we need virtual environment which covers large area terrain. We need a method that can reduce development cost and construction time of virtual environment that simulate the real environment. There have been attempts to link GIS or remote sensing field with virtual reality. This paper examines a method that helps to construct virtual environment, and attempts to link geographic information with virtual reality. A construction method of virtual environment based on digital map and satellite image has been studied.

• 한국수소및신에너지학회논문집
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• 제32권6호
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• pp.542-550
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• 2021

As the application of multirotor grows, the demands for multirotor that can fly longer and load more are increasing. Hydrogen has a high energy density, so it can satisfy these demands when used in multirotor. In order to design hydrogen fueled multirotor that satisfies the desired flight time and payload, it is important to calculate the specifications of a fuel cell, battery, and hydrogen storage system. This paper contains detailed information on various energy systems used in multirotor and fuel cell powered multirotor research trends. This study proposed a sizing calculation method that meets the target flight time and payload using thrust and power equations. It has been explained how the two equations derive the particular specifications. The specifications of the multirotor were derived by assuming a payload of 50 kg and a flight time of 1 hour. In addition, the effects of the values of the fuel cell, hydrogen storage system, and motor propeller were analyzed.

• 융합정보논문지
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• 제7권5호
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• pp.137-148
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• 2017

최근, 군사나 산업 응용 목적으로 UAV를 활용하는 연구가 매우 고무적으로 진행되고 있다. 이들 응용 중의 한 가지는 적의 의심스러운 정찰 비행체의 비행경로를 뒤따라 은밀하게 추적할 필요가 있을 때 앞서가는 비행체를 추적하는 것으로, Roll, Yaw, Pitch와 같은 대상 비행체의 비행 자세 정보들을 매 순간마다 실시간으로 추정할 필요가 있다. 본 논문에서는 뒤따르는 비행체에 장착되어 있는 외부 카메라에서 제공하는 비디오 정보를 사용해서 대상 비행체의 자세를 실시간으로 추정할 수 있는 방법을 제시한다. 키 포인트와 오일러 각을 탐지하고 추정하기 위해서 컬러 공간 분할, 템플레이트 정합 등과 같은 여러 가지 영상 처리 방법들과 선형 회귀와 같은 통계적 방법이 적용되었다. 시뮬레이션 실험을 통해서 X-플레인 비행데이터와 추정한 비행데이터를 비교한 결과 제안하는 방법이 앞서가는 비행체의 비행 자세 정보를 추정하는데 효과적인 방법이 될 수 있음을 보여준다.

• 대한기계학회논문집 C: 기술과 교육
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• 제2권2호
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• pp.113-124
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• 2014

항공기를 개발하는데 있어 형상 결정과 요구도 입증은 주로 비행시험 결과에 의존한다. 비행시험은 많은 시간과 비용을 요구하므로 비행시험 계획을 체계적으로 수립하고 분석함으로써 비용절감과 일정단축에 기여할 수 있다. 본 논문에서는 한국형 기동헬기에 적용된 진동 비행시험 사례를 적용하여 비행시험 계획을 체계적으로 수립하고 분석할 수 있는 방안을 제시하였다. 본 논문에서는 주요 부위에서 측정한 진동수준 값을 가지고 종합적인 진동수준 만족도를 하나의 수치로 나타내기 위하여 호감도 함수를 채택하고 진동수준의 측정을 위한 비행시험을 체계적으로 수행하기 위하여 실험계획법의 하나인 부분요인배치법을 사용하였다. 또한 비행시험을 단계적으로 수행하여 비행시험 횟수를 더욱 줄일 수 있는 방법을 제시하였다.